ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Guoqing Wang,Jianfei Wang,Xinping Wang,Yuanyuan Meng,Xiangzhen Feng,Gaoli Liu,Dong-An Wang,Changjiang Fan
Uncontrolled traumatic hemorrhage is a leading cause of preventable death. As two main forms of hemostatic materials, however, both sponges and hydrogel adhesives usually fail to control massive hemorrhage due to their respective shortcomings. Hemostatic sponge shows weak tissue adhesion, while the gelation process of hydrogel makes it difficult to seal high-pressure bleeding wounds. There is an urgent need to develop next-generation hemostats combining the advantages of sponges and hydrogel adhesives. Herein, a general methodology to prepare novel Fe 3+ -laden porous material (Fe 3+ @GCS) for rapid hemostasis of the high-pressure and severe hemorrhages is proposed, which is fabricated by loading ferric chloride with ethanol into the catechol-modified carboxylated gelatin sponge (GCS). Notably, porous Fe 3+ @GCS can undergo water-triggered rapid transformation to robust-adhesive hydrogels. The sealing strength of Fe 3+ @GCS on wet tissues reaches an astonishing ≈600 mm Hg. Rapid water uptake of Fe 3+ @GCS around wound not only concentrates blood components but also excludes interfacial water, facilitating blood clotting and wound sealing with the in situ formed sticky hydrogel. Fe 3+ @GCS can efficiently stop the high-pressure hemorrhaging from traumatic injuries of arteries and hearts in rats and pigs, respectively, via a simple and short-time pressing. Furthermore, the wound sealing by Fe 3+ @GCS promotes wound repair and healing.
研究领域:
生物材料
·
止血
·
组织工程
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Bioactive Materials
·
2024
·
IF 18
Yinghao Li,Dongling Xiao,Weixi Yan,Meilin Jiang,Ju Tan,Zhongliang Qin,Jingting Zhou,Yue Sun,Mingcan Yang,Guanyuan Yang,Yawei Gu,Yong Liu,Chuhong Zhu
Timely and stable sealing of uncontrolled high-pressure hemorrhage in emergency situations outside surgical units remains a major clinical challenge, contributing to the high mortality rate associated with trauma. The currently widely used hemostatic bioadhesives are ineffective for hemorrhage from major arteries and the heart due to the absence of biologically compatible flexible structures capable of simultaneously ensuring conformal tough adhesion and biomechanical support. Here, inspired by the principle of chromatin assembly, we present a tissue-conformable tough matrix for robust sealing of severe bleeding. This hierarchical matrix is fabricated through a phase separation process, which involves the in-situ formation of nanoporous aggregates within a microporous double-network (DN) matrix. The dispersed aggregates disrupt the rigid physical crosslinking of the original DN matrix and function as a dissipative component, enabling the aggregate-based DN (aggDN) matrix to efficiently dissipate energy during stress and achieve improved conformal attachment to soft tissues. Subsequently, pre-activated bridging polymers facilitate rapid interfacial bonding between the matrix and tissue surfaces. They synergistically withstand considerable hydraulic pressure of approximately 700 mmHg and demonstrate exceptional tissue adhesion and sealing in rat cardiac and canine aortic hemorrhages, outperforming the commercially available bioadhesives. Our findings present a promising biomimetic strategy for engineering biomechanically compatible and tough adhesive hydrogels, facilitating prompt and effective treatment of hemorrhagic wounds.
研究领域:
生物材料
·
生物医学工程
·
组织工程
·
止血
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2019
·Vol. 10
·期 1
·1-11
·
IF 11.878
Hong Yi,Zhou Feifei,Hua Yujie,Zhang Xianzhu,Ni Chengyao,Pan Dihao,Zhang Yiqing,Jiang Deming,Yang Long,Lin Qiuning,Zou Yiwei,Yu Dongsheng,Arnot David E.,Zou Xiaohui,Zhu Linyong,Zhang Shufang,Ouyang Hongwei
Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo-reactive adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60–160 mm Hg). Most importantly, the hydrogel can stop high-pressure bleeding from pig carotid arteries with 4~ 5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated and appears to offer significant clinical advantage as a traumatic wound sealant.
研究领域:
生物材料
·
组织工程
·
止血
·
外科技术
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）