Applied Sciences-Basel
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2018
·Vol. 8
·期 9
·1481
·
IF 1.689
Yao Ren,Haoyu Xie,Li Liu,Dongying Jia,Kai Yao,Yuanlong Chi
β-glucan extract (GE) was obtained from highland barley bran using alkaline–acid–alcohol extraction method. The stability, solubility, foaming ability, and prebiotics characteristics of GE were assessed consecutively. GE demonstrated excellent heat stability (hardly degraded at 220 °C) and pH stability, especially at neutral or alkaline condition, and its solubility was significantly influenced by temperature instead of pH or NaCl, achieving 0.91 g/100 g at 100 °C. Good foaming ability and foam stability of GE were observed during low temperatures (≤40 °C), neutral or alkaline condition. GE indicated a strong anti-digestibility capacity of resisting the hydrolysis of α-amylase and simulated human gastric acid. Interestingly, GE could effectively promote the growth ofLactobacillus bulgaricusandBifidobacterium adolescentis, which was close to fructooligosaccharide. The results of this study could offer valuable information for the application of β-glucan from highland barley as prebiotics in promoting human intestinal health metabolism.Keywords:β-glucan;highland barley;processing characteristics;prebiotics
研究领域:
食品科学
·
营养学
✓ 已验证
产品关联
DOI
高影响因子
Heliyon
·
2024
·
IF 3.4
Yihang Yue,Xiaoju Yue,Xiaofeng Tang,Lin Han,Jinnong Wang,Shifeng Wang,Chun Du
The discharge of organic pollutants by the textile and dyeing industries presents an escalating threat to aquatic environments, necessitating the development of effective remediation strategies. This study introduces the utilization of graphite-like structured activated carbon (AC), derived from highland barley straw—a biomass unique to the Plateau regions of China, including Tibet, Qinghai, and Gansu—as a support material for the TiO 2 catalyst. TiO 2 /AC composites with different TiO 2 loadings were synthesized by ultrasonic impregnation. The TiO 2 /AC composites were found to be polycrystalline materials composed of anatase and rutile phases. The TiO 2 nanoparticles are well-dispersed over the surface of the AC. The photocatalytic activity of these composites was evaluated through their capacity to degrade a methylene blue (MB) solution upon irradiation. It was observed that the inclusion of TiO 2 increases the number of adsorption sites and active sites for methylene blue, with the photocatalytic activity being notably higher at a 3-wt% TiO 2 loading, achieving a remarkable 99.6 % degradation efficiency for 100 mg/L MB within 100 min. The experimental kinetic data for the photocatalytic process follow the pseudo-first-order kinetic model. Furthermore, TiO 2 /AC retains high photocatalytic activity after five reaction cycles. This research provides valuable insights into the application of biomass-derived materials for the purification of water, offering a sustainable solution to both pollution and agricultural waste challenges in Plateau areas of China.
研究领域:
环境科学
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材料科学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Yao Li,Maolan You,Haibo Liu,Xiong Liu
Highland barley grains were roller-milled to produce five different fractions (B-1, B-2, B-3, B-4, and B-5). The distribution and physicochemical properties of β-glucans from five roller-milled fractions were investigated. The B-4 fraction contained the highest concentration of β-glucan (4.40%), and the outermost bran (B-1) had the lowest β-glucan content (1.01%). Besides, β-glucans from inner core B-5 (BG-5) had higher M w (6.482 × 10 5 g/mol), whereas β-glucans from outer bran B-1 (BG-1) showed lower M w (5.859 × 10 4 g/mol) than those from other fractions. Accordingly, the viscosity of BG-5 was highest (0.038-0.365 Pa·s), and the water solubility index of BG-1 was highest (50.43–90.71%). BG-5 showed stronger foam stability and emulsifying properties but weaker foaming capability, while BG-1 exhibited stronger foaming capability. The foaming capability and emulsifying properties of β-glucan samples were better under the neutral condition (pH = 7). The foam capabilities of all β-glucan samples displayed higher values at 65 °C, and emulsifying properties exhibited higher values at 45 °C. This study is expected to promote the application of highland barley β-glucans in food industry.
研究领域:
食品科学
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植物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-11
·
IF 3.8
Xie S. D.,Cai X. Y.,Wu H. B.,Wang Q.,Guo Z. R.,Chen Z. Y.,Ma C. S.
To study the effect of internal particle size on the microstructure properties and thermal decomposition characteristics of site mixed emulsion explosive at different altitudes. Site mixed emulsion explosive was prepared with different shear rate. The particle size, viscosity, sensitized bubbles, detonation velocity and peak pressure of the emulsion explosive were tested after stored at different simulated altitudes. The thermal decomposition characteristics of emulsion matrix prepared at three different rotational speeds were measured by thermogravimetric analyzer and kinetic analysis was performed by non-isothermal model Kissinger–Akah–Sunose (KAS) method. The results show that with the increase in altitude, the internal phase size showed a trend of first increasing and then decreasing, and the number of sensitized bubbles within the emulsion explosive decreases. At an altitude of 0 m, the detonation velocity and peak overpressure of the emulsion explosive prepared by 1600 r min −1 increased 4.78% and 29.09%, respectively compared with 1200 r min −1 , and at an altitude of 4500 m, the detonation velocity increased 11.87%, the peak overpressure increased 43.98%. The thermal decomposition activation energy of the emulsion matrix at 1600 r min −1 increased 13.14% compared to 1200 r min −1 . It shows that in the production of site mixed emulsion explosive at high altitude, reducing the particle size of the internal phase of emulsion explosives in a certain range can effectively improve the performance of emulsion explosives.
研究领域:
爆炸力学
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化学工程
✓ 已验证
DOI
PubMed
高影响因子
RESPIRATORY RESEARCH
·
2025
·
IF 5
De-zhi Sun,Xi-ru Yang,Cong-shu Huang,Zhi-jie Bai,Pan Shen,Zhe-xin Ni,Chao-ji Huang-fu,Yang-yi Hu,Ning-ning Wang,Xiang-lin Tang,Yong-fang Li,Yue Gao,Wei Zhou
Background High altitude pulmonary edema (HAPE) poses a significant medical challenge to individuals ascending rapidly to high altitudes. Hypoxia-induced cellular morphological changes in the alveolar-capillary barrier such as mitochondrial structural alterations and cytoskeletal reorganization, play a crucial role in the pathogenesis of HAPE. These morphological changes are critical in understanding the cellular response to hypoxia and represent potential therapeutic targets. However, there is still a lack of effective and valid drug discovery strategies for anti-HAPE treatments based on these cellular morphological features. This study aims to develop a pipeline that focuses on morphological alterations in Cell Painting images to identify potential therapeutic agents for HAPE interventions. Methods We generated over 100,000 full-field Cell Painting images of human alveolar adenocarcinoma basal epithelial cells (A549s) and human pulmonary microvascular endothelial cells (HPMECs) under different hypoxic conditions (1%~5% of oxygen content). These images were then submitted to our newly developed segmentation network (SegNet), which exhibited superior performance than traditional methods, to proceed to subcellular structure detection and segmentation. Subsequently, we created a hypoxia scoring network (HypoNet) using over 200,000 images of subcellular structures from A549s and HPMECs, demonstrating outstanding capacity in identifying cellular hypoxia status. Results We proposed a deep neural network-based drug screening pipeline (CPHNet), which facilitated the identification of two promising natural products, ferulic acid (FA) and resveratrol (RES). Both compounds demonstrated satisfactory anti-HAPE effects in a 3D-alveolus chip model (ex vivo) and a mouse model (in vivo). Conclusion This work provides a brand-new and effective pipeline for screening anti-HAPE agents by integrating artificial intelligence (AI) tools and Cell Painting, offering a novel perspective for AI-driven phenotypic drug discovery. Supplementary Information The online version contains supplementary material available at 10.1186/s12931-025-03173-1.
研究领域:
医学
·
生物信息学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Rui Lei,Mingbao Gu,Jinyan Li,Wenjun Wang,Qian Yu,Rizwan Ali,Jiajia Pang,Meilun Zhai,Yang Wang,Kunxi Zhang,Jingbo Yin,Jinghong Xu
To avoid chronic wound formation caused by hypoxia and cold in high-altitude areas, developing an injectable, strongly adhesive hydrogel bandage with controllable oxygen generation and inflammation regulation functions is of great value. Poly(lipoic acid) (PLA)-based adhesives have been well-developed from polymerization of α -Lipoic acid (LA), showing attractive performances including simple preparation, strong adhesion, anti-inflammatory. However, injection of PLA-based adhesives has not been well-practiced because of its high viscosity and strong adhesion. Herein, LA and trometamol are firstly found to rapidly gel into a supramolecular hydrogel within 5 min at room temperature, exhibiting well-performed injectability. Further presence of Ce 3+ significantly accelerates this gelation within 2 min. Meanwhile, dopamine (DA) and g -C 3 N 4 nanosheet synergistically endow the injectable hydrogel with photothermal function, which can convert near-infrared-light (NIR) into heat, triggering LA polymerization and achieving post-injection enhancement. In terms of bandage performance after molding, the introduction of Ce 3+ , DA, and g -C 3 N 4 contributes to the improvement of mechanical and adhesion properties. The injectable hydrogel bandage not only possesses highly tough and adhesive features, but also produces oxygen under NIR irradiation, effectively alleviating wound hypoxia, creating anti-inflammatory microenvironment, and significantly promoting healing of incision in a low-pressure oxygen environment.
研究领域:
生物医学工程
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材料科学
·
创伤修复
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Low-Carbon Technologies
·
2023
·
IF 2.3
Yue Yihang,Yu Zexu,Yue Xiaoju,Zhou Wenkai,Wang Saiyu,Yang Yanxi,Lao Youliang,Yang Mengdi,Du Chun,Wang Shifeng
Biomass activated carbon has been widely used in the field of wastewater treatment because of its unique properties, such as high specific surface area and porosity, good adsorption capacity, good mechanical strength, rich functional groups and thermal stability. In this work, highland barley straw is recycled and made into activated carbon using hydrothermal carbonization and alkaline activation processes in which the dependence of the product properties on the activation temperature, as one of the critical parameters, is intensively investigated. Under the optimum conditions at an activation temperature of 1100 °C, activated carbon in the form of mesoporous structure and polycrystalline graphite was produced with a specific surface area as large as 1906 m2/g, which is superior to that of commercial products. To investigate the absorption capacity of the prepared samples for pollutants in water, such as heavy metals and organics, potassium dichromate and methylene blue were utilized as the simulated pollutants. The removal efficiency of Cr6+ and methylene blue in water reached 90.3 % within eight hours and 87.7 % within four hours, respectively, and this demonstrated an excellent absorption capacity for activated carbon converted from agricultural waste. Th e successful fabrication of activated carbon with a super large specific surface area and remarkable adsorption ability derived from highland barley straw through a hydrothermal carbonization and alkaline treatment demonstrated the feasibility of the “turning waste into wealth” recycling strategy. It has also shown great potential for use in environmental protection applications, especially for water purification.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FOOD SCIENCE
·
2024
·
IF 3.2
Lu Liu,Jingwen Xu,Ge Zhang,Nisi Gao,Xuebing Xu,Renyong Zhao
Effects of ultrafine grinding on the nutritional profile, physicochemical properties, and antioxidant activities of whole-grain highland barley (HB) including white highland barley (WHB) and black highland barley (BHB) were studied. Whole-grain HB was regularly ground and sieved through 80 mesh get 80 M powder, and HB was ultrafine grounded and sieved through 80 mesh, 150 mesh, and 200 mesh get 80UMM, 150UMM, and 200UMM samples. Particle size of WHB and BHB reduced significantly after ultrafine grinding. As the particle size decreased, moisture content of WHB and BHB decreased significantly, whereas fat content increased significantly. Redistribution of fiber components in WHB and BHB from insoluble to soluble fractions was also observed. Wherein, content of soluble pentosan of WHB and BHB increased significantly from 0.56% and 0.78% (80 M) to 0.91% and 1.14% (200UMM), respectively. Damaged starch of WHB and BHB increased significantly from 8.16% and 8.21% (80 M) to 10.29% and 10.07% (200UMM), respectively. Content of phenolic acid and flavonoid of WHB and BHB and associated antioxidant capacity were increased after ultrafine grinding. Color of L * value increased significantly, a * and b * values decreased significantly, indicating the whiteness of WHB and BHB was increased after ultrafine grinding. Pasting temperature of WHB and BHB decreased, whereas peak viscosity increased. X-ray diffraction patterns of HB showed typical A- and V-style polymorphs and the relative crystallinity of HB decreased as the particle size decreased. Taken together, ultrafine grinding has shown great potential in improving the nutritional, physiochemical, and antioxidant properties of whole-grain HB. Our research findings could help better understand the ultrafine grinded whole grain HB in food industry.
研究领域:
食品科学
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植物学
·
营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CEREAL SCIENCE
·
2025
·
IF 3.7
Yongliang Bai,Junwei Yin,Zuanhao Liang,Yu Xia,Shuyan He,Ming Yu,Haiqiang Chen
To investigate the impact of germination on the development of deep-processed products from highland barley starch, this study systematically examined changes in the structure, composition, physicochemical properties, and related enzyme activities of starch during germination. After 72 h of germination, the contents of total starch and amylopectin in highland barley starch decreased significantly ( p < 0.05). The activities of α-amylase and β-amylase increased dramatically by 19.6-fold and 6.3-fold, respectively. Concurrently, the gelatinization enthalpy ( ΔH ) of the starch decreased significantly, whereas the syneresis rate showed a significant increase ( p < 0.05). Correlation analysis revealed that the germination treatment enhanced the activities of α-amylase and β-amylase in highland barley, which promoted the enzymatic degradation of amylopectin. This led to a significantly increased starch solubility, syneresis rate, and initial gelatinization temperature( T 0 ), while decreasing starch transparency, termination gelatinization temperature ( T c ), peak temperature ( T p ), and Δ H . The results demonstrate that germinated highland barley starch is suitable for noodle products.
✓ 已验证
DOI
高影响因子
Inorganics
·
2024
·Vol. 12
·期 9
·250
·
IF 3.1
Ye Li,Huiqing Yue,Quanli Zhang,Dumin Yan,Ziyi Li,Zhiwei Liu,Yingshu Liu,Yongyan Wang,Shifeng Wang,Xiong Yang
In oxygen production on plateaus, pressure swing adsorption (PSA) oxygen production is currently the most commonly used oxygen production method. In plateau regions, low pressure leads to a decrease in adsorbent nitrogen–oxygen separation performance, which affects the performance of PSA oxygen production, so it is particularly important to enhance adsorbent nitrogen–oxygen separation performance. In this paper, Li-LSX (lithium low-silicon aluminum X zeolite molecular sieve) adsorbents were modified using the liquid phase ion exchange method, and five kinds of modified adsorbents were obtained, namely AgLi-LSX, CaLi-LSX, ZnLi-LSX, CuLi-LSX, and FeLi-LSX, respectively. The influences of different metal ions and modification time lengths on the adsorbent nitrogen adsorption and nitrogen–oxygen separation coefficients were analyzed. Through theoretical calculations, the nitrogen and oxygen adsorption and separation performances of the modified adsorbents at different altitudes and low adsorption pressures were investigated. It is shown that the nitrogen adsorption capacity of the AgLi-LSX-1 adsorbent obtained from the modification experiment reaches 27.92 mL/g, which is 3.24 mL/g higher than that of Li-LSX; the nitrogen–oxygen separation coefficients of S1 and S2 are 19.24 and 7.54 higher, respectively; and the nitrogen–oxygen separation coefficients of S4 are 20.85 and 7.54 higher than those of Li-LSX, respectively. With the increase in altitude from 50 m to 5000 m, the nitrogen–oxygen separation coefficient of the AgLi-LSX-1 adsorbent increased rapidly from 20.85 to 57, and its nitrogen–oxygen separation coefficient S4 exceeded that of the Li-LSX adsorbent to reach 47.61 at an altitude of 4000 m. Therefore, the modified adsorbent AgLi-LSX-1 in this paper can enhance the performance of the PSA oxygen process for oxygen production in plateau applications.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
Food Chemistry-X
·
2024
·
IF 6.5
Wentao Qian,Xiaobing Wang,Hongliang Li,Yinhua Zhu,Pengjie Wang,Xiaolu Geng,Jinhui Yang,Huiyuan Guo,Menghui Wang,Chong Chen
Introducing Holstein cows on Qinghai-Tibetan Plateau is a potential solution to enhance local milk production. However, the relationship between milk quality and altitude in China remains unknown. Therefore, the components and plasmin (PL) system of raw milk from different altitudes (sea level, 1600, 2700, and 3800 m) were investigated. The daily milk production of Holstein cows and PL activity decreased as the altitude increased. However, the components content of raw milk, plasminogen (PLG)/PL ratio, activities of PLG and plasmin activator (PA) increased with altitude. The pasteurization resulted a significant decrease in PA activity of all milk and a significant increase in PL activity in milk collected at higher altitudes (2700 and 3800 m), suggesting the pasteurization was unsuitable for preserving milk at higher altitudes. This study offered references for the production and storage of milk after introducing Holstein cows on Qinghai-Tibetan Plateau.
研究领域:
农业
·
乳品科学
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食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2019
·
IF 3.579
Lingxi Guo,Yeming Luo,Yuan Zhou,Ciren Bianba,Hui Guo,Yemeng Zhao,Hongfei Fu
Highland barley wine (HBW) is a well-known grain wine in Qinghai-Tibet Plateau, China and is mainly fermented by local Qu (a traditional starter) with highland barley ( Hordeum vulgare , Qingke (Tibetan hulless barley)), and the flavors profiles associated with microbiota succession during HBW fermentation are unrevealed. Hence, high-throughput sequencing (HTS) technology was used to investigate the dynamic changes of microbial community for the duration of the fermentation. In addition, metabolites were analyzed by gas chromatography-mass spectrometry (GC–MS) and high performance liquid chromatography (HPLC). A total of 66 volatile compounds and 7 organic acids were identified during the traditional brewing process. Results showed that the composition of microbiota varied over the fermentation process. The bacterial genera (relative abundance > 0.1%) decreased from 13 at 0 h to 4 encompassing Leuconostoc (13.53%) and Acetobacter (74.60%) after 48 h fermentation, whilst the structure of fungal community was more uniform in comparison with bacteria, as Rhizopus and Saccharomyces were predominant throughout the fermentation. Furthermore, the correlations between microbiota and the detected compounds were also explored, which highlighted that three bacterial genera, including Acetobacter , Leuconostoc , Bacillus and one fungal genus Rhizopus were significantly correlated with main flavours compounds (|r| > 0.7, FDR < 0.01). To conclude, the detailed information provided by this study offer screening strategies of beneficial bacterial and fungal strains to improve the quality of HBW.
研究领域:
食品科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）