CELLULOSE
·
2016
·Vol. 23
·期 4
·2539-2548
·
IF 3.195
He Hui,Hou Xunan,Ma Beibei,Zhuang Linzhou,Li Chuanfa,He Shihong,Chen Shuixia
Viscose fiber was oxidized with sodium periodate to prepare a reactive dialdehyde viscose fiber (DAVF) containing abundant aldehyde groups. A solid amine adsorbent (DAVF-PEI) with high amino density for CO 2 capture was then prepared by modifying DAVF with polyethylenimine (PEI). Response surface methodology (RSM) based on a three-level, three-factorial design was used to optimize the synthesis conditions of DAVF, in which multiple linear regression equations of aldehyde content and fiber mass loss degree were constructed. The well-designed DAVF was then employed as a support to graft with PEI via Schiff base reaction to prepare a solid amine fiber (DAVF-PEI) for CO 2 adsorption. The experimental results verified that DAVF-PEI possessed good thermo-stability and high CO 2 adsorption capacity (4.11 mmol/g). DAVF-PEI also showed promising regeneration performance, which could maintain almost the same adsorption capacity for CO 2 after ten adsorption and desorption recycles.
研究领域:
材料化学
·
环境科学
·
高分子科学
·
化学工程
·
吸附分离
·
碳捕集技术
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yanzhen Lou,Xinxiang Chai,Minglin Ji,Yanfang Sun,Foziljon M. Turakulov,Khaydar E. Yunusov,Guohua Jiang
In this study, a dual-network, dynamically cross-linked composite hydrogel was developed for wound closure and healing. The combined action of dopamine iron coordination reaction and Schiff base linkage between dopamine-modified oxidized hyaluronic acid (OHA) and polyacrylamide (PAM) was employed to form a dual-network, dynamically cross-linked structure in hydrogel. Then viscid germander herb (Vgb) extracted from total saponins was incorporated into the composite hydrogel to fabricate hydrogel wound dressing. The resultant hydrogel wound dressing demonstrated good biocompatibility in accelerating cell proliferation and migration. In vivo results demonstrated that compared with commercial dressings, the resultant hydrogel wound dressing facilitated wound healing on an infected full-thickness skin defect model by upregulating the gene expression of growth factors such as CD-31 and downregulating that of inflammatory factor IL-6. The transcriptomic results revealed that the biological mechanism by which Vgb regulated NF-κB and the innate immune system signaling pathways in the wound closure and healing processes.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2024
·
IF 3.6
Shanjiang Chen,Jianjian Yang,Fuli Liu
Celastrol (CEL) belongs to the group of non-steroidal immunosuppressants with the potential to improve cardiac hypertrophy (CH). However, the poor biocompatibility and low bioavailability of CEL limit its in vivo application. This study was aimed to develop a targeted drug delivery system that can efficiently and safely deliver CEL to target tissues, providing a research basis for the application of CEL in CH therapy. A novel ROS-sensitive drug-loaded nanomicelle, dodecanoic acid (DA)-phenylboronic acid pinacol ester-dextran polymer encapsulating CEL (DBD@CEL), was synthesized using chemical synthesis. Then, the morphology, particle size, drug-loaded content, and ROS-responsive release behavior of DBD@CEL were studied. Pharmacokinetics and biocompatibility were evaluated using healthy mice. Finally, the ability and mechanism of DBD@CEL in improving CH in vivo were investigated using a mouse CH model. DBD@CEL was successfully prepared with a drug loading of 18.9%. It exhibited excellent stability with an average particle size of 110.0 ± 1.7 nm. Within 48 h, DBD@CEL released only 19.4% in the absence of H2O2, while in the presence of 1 mM H2O2, the release rate increased to 71.5%. Biocompatibility studies indicated that DBD@CEL did not cause blood cell hemolysis, had no impact on normal organs, and did not result in abnormal blood biochemical indicators, demonstrating excellent biocompatibility. In vivo studies revealed that DBD@CEL regulated the activation of NF-κB signaling, inhibits pyroptosis and oxidative stress, and thereby ameliorates CH. The ROS-responsive DBD@CEL nanodrug delivery system enhances the therapeutic activity of CEL for CH, providing a promising drug delivery system for the clinical treatment of CH.
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FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Baoyi Zhang,Weijuan Huang
This study elucidates how the spatial distribution of carboxymethyl chitosan (CMCS) governs the architecture and properties of emulsion gels formed via reversible Schiff base linkages. A methodology centered on regulating the oil-water interfacial area was employed to manipulate CMCS distribution between the interface and the continuous phase. Multiscale characterization revealed that the macroscopic properties of this polysaccharide-based dynamic gel are predominantly governed by the continuous phase network, which is fundamentally distinct from interface-dominated protein-based gel systems. Specifically, increasing the interfacial area drove CMCS migration to the interface, reducing the effective cross-linking density in the continuous phase. This led to prolonged gelation, weaker gel strength, a more porous network, and enhanced water mobility. Interestingly, the reduced network density facilitated polymer chain diffusion, significantly accelerating the self-healing process. This work clarifies the dominant role of the continuous phase network in dynamic polysaccharide gels. It establishes a general methodology for programming material properties by controlling polymer spatial distribution. These insights provide a new paradigm for the rational design of functional soft materials.
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Food Bioscience
·
2026
·
IF 6.2
Yaqing Liu,Duo Xu,Ying Dong,Canghai An,Zikun Jia,Tianci Wang,Ling Su
The stem of Tremella fuciformis , an abundant byproduct of edible mushroom processing, is typically discarded despite containing higher levels of crude polysaccharide than the fruiting body. To valorize this agricultural residue, a series of polysaccharide-based hydrogels was fabricated via Schiff base crosslinking between carboxymethyl chitosan (CMCS) and oxidized T. fuciformis stem polysaccharide (OTP) with tunable aldehyde contents. The oxidation degree of OTP critically influenced the crosslinking density, thereby modulating the gelation kinetics, microstructure, rheological properties, and swelling behavior. Specifically, increasing the polysaccharide oxidation degree from 17.30 ± 1.66% to 32.85 ± 1.47% and subsequently to 40.75 ± 1.96% progressively shortened the gelation time from 12 min to 3 min and decreased the pore size from 219.2 ± 12.50 μm to 93.16 ± 16.60 μm. Concurrently, the storage modulus increased from 49 Pa to 388 Pa, and the CMOT3 hydrogel achieved the highest equilibrium swelling rate of 99.6%. All hydrogel formulations exhibited excellent cytocompatibility. In a full-thickness skin defect model, the optimally crosslinked CMOT3 hydrogel significantly accelerated wound closure, which was associated with reduced pro-inflammatory cytokine levels, elevated VEGF expression, and improved collagen organization. These findings suggest that the T. fuciformis stem polysaccharide-based hydrogel effectively promotes skin tissue repair, highlighting its potential as a sustainable functional biomaterial derived from agricultural byproducts.
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Polymers
·
2026
·Vol. 18
·期 14
·1688
·
IF 5.8
Shiqi Gao,Minzhen Liu,Jiteng Sun,Zhicheng Su,Ziyun Liao,Peiyu Li,Yunqi Jiang,Can Fu,Guangyu Pan
To address the challenges associated with prolonged inflammatory phases and delayed healing in clinically infected wounds, this research developed a multifunctional PB@GC@OD hydrogel integrating self-healing properties, injectability, and photothermal antibacterial efficacy. The hydrogel was constructed using oxidized dextran (OD) and glycol chitosan (GC) as the matrix, which were dynamically cross-linked via a Schiff-base reaction to form the GC@OD hydrogel. Subsequently, the photothermal agent prussian blue (PB) was incorporated to fabricate the PB@GC@OD hydrogel. The resulting PB@GC@OD hydrogel demonstrated robust self-healing capabilities and excellent injectability. Upon exposure to 808 nm near-infrared (NIR) irradiation, the hydrogel achieved efficient photothermal conversion, rapidly inducing localized hyperthermia that effectively eliminatedStaphylococcus aureus,Escherichia coli, and methicillin-resistantStaphylococcus aureus(MRSA). In a mouse model of MRSA-infected wounds, the hydrogel not only maintained a moist wound microenvironment but also eradicated pathogenic bacteria via photothermal therapy, thereby significantly accelerating the healing process. Moreover, the hydrogel demonstrated favorable biocompatibility and long-term safety. Therefore, the PB@GC@OD hydrogel integrates photothermal sterilization, self-healing, injectability, hemostasis, and biocompatibility into a single platform, presenting a promising strategy for synergistic therapy and tissue regeneration in bacterially infected wounds.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Xueyan Hou,Yanan Lu,Tenglong Xu,Chunyan Li,Saifei Lv,Chenxu Lv,Guoyi Yan,Xue Yang,Xiqing Yan,Yongli Shi
Wound management, especially for infected and diabetic ulcers, poses a persistent clinical challenge, largely attributed to sustained inflammation, bacterial colonization, and compromised tissue regeneration. Herein, a multifunctional hydrogel (CBOS) with integrated therapeutic properties was developed through Schiff base reaction between betaine-modified chitosan (CSBT) and oxidized sodium alginate (OSA), with poly(vinyl alcohol) and sodium borate incorporated to enhance network stability. The resulting CBOS hydrogel exhibited a uniform porous microstructure, robust viscoelasticity, high swelling capacity, and appropriate water vapor transmission. Comprehensive biocompatibility assessments confirmed its negligible cytotoxicity and applicable hemocompatibility. The hydrogel demonstrated broad-spectrum tissue adhesion and potent hemostatic efficacy in murine tail incision and liver hemorrhage models. Moreover, CBOS displayed antioxidant activity by scavenging multiple free radicals and reducing intracellular reactive oxygen species in H2O2-stressed fibroblasts. Antibacterial evaluations revealed potent activity against S. aureus, with molecular docking studies suggesting multitarget interactions with key bacterial proteins, including AgrA, ClpP, and FtsZ. In vitro, CBOS significantly enhances fibroblast migration. In vivo, the hydrogel accelerated healing in both S. aureus-infected full-thickness wounds and diabetic chronic wounds, as evidenced by reduced bacterial burden, attenuated inflammatory responses, enhanced collagen deposition, and promoted neovascularization. With its integrated hemostatic, antioxidant, antibacterial, and pro-regenerative properties, the CBOS hydrogel offers a viable and attractive therapeutic approach for complex wound tissue repair.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Nuoya Chen,Xin Tan,Weikun Li,Yanling Liang,Diyi Feng,Liqin Ge
Ca 2+ serves as both dynamic crosslinker and coagulation Factor IV in the hydrogel. • Hydrogel can be injected in suit and form robust wet-tissue adhesion. • Dynamic bonds endow the hydrogel with rapid self-healing capability. Uncontrolled hemorrhage remains a major clinical challenge, particularly in non-compressible and highly vascularized tissues. Injectable hydrogels are promising hemostatic materials because they can rapidly conform to irregular wound and undergo in situ gelation. However, many systems rely on additional procoagulant agents such as thrombin, platelet derivatives and nanoclay, where the hydrogel matrix mainly acts as a passive carrier. Herein, an injectable hydrogel that integrated hydrogel network formation with activation of the coagulation cascade was reported through a Ca 2+ -mediated strategy. The hydrogel was constructed from phenylboronic acid modified chitosan (PBA–CS) and dopamine-functionalized oxidized hyaluronic acid (OHA–DA). The incorporation of Ca 2+ not only enabled the formation of an injectable hydrogel network but also activated the coagulation cascade. As a result, the hydrogel simultaneously provided rapid physical sealing and biochemical coagulation activation, leading to enhanced hemostatic performance. This work provided a bioactive crosslinking strategy that coupled hydrogel assembly with coagulation cascade activation for efficient hemostasis.
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Advanced Science
·
2026
·
IF 14.1
Delu Zhao,Qiuyi Li,Lingyun Wang,Chongao Zhang,Yutian Cheng,Shuang Liu,Fulan Wei,Zheqin Dong
Early mechanical stabilization within the osteogenic niche is a key regulator of bone regeneration fate, and maintaining stability in material-driven repair remains a clinical challenge in dynamic, non-retentive, and anatomically complex bone defects, where implant materials are difficult to achieve stable fixation. However, most existing repair systems lack satisfactory strategies for addressing it. Here, this study reports an interfacial-fixation–centered scaffold design realized by a bioadhesive-integrated multilayer architecture fabricated via 3D-printing, comprising a soft-tissue–blocking barrier layer, a wet-adhesive interface, and a porous osteogenic framework. The scaffold exhibits rapid and robust adhesion to bone under blood-rich physiological conditions, enabling immediate stabilization of the osteogenic niche. In rabbit mandibular and tibial augmentation models, it significantly outperforms non-adhesive scaffolds and the specific guided-bone-regeneration-like comparator. Mechanistically, adhesive-mediated stabilization reduced scaffold micromotion and was associated with a pro-regenerative mechano-immune profile, including increased M2-like macrophage polarization and enhanced VEGF/BMP2-associated angiogenic–osteogenic coupling. By highlighting the interface-fixation-mediated mechanical stabilization of the osteogenic niche, this work offers a new framework for enhancing bone augmentation in dynamic and complex defect settings, provides insights into potential mechano-immune cues for mechanical-stability-secured bone augmentation, and demonstrates the scaffold's potential in bone repair.
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Materials Today Bio
·
2026
·
IF 11
Shuang Liu,Zhongming Zhao,Ziyi Wang,Xianghe Pi,Weiqin Zhao,Huiju Hu,Xinmei He,Pengcheng Che,Junjie Li,Hong Sun
Developing integrated, drug-free therapeutic platforms that simultaneously address oxidative stress, immune dysregulation, and gut microbiota dysbiosis remains a significant challenge in UC management. Although hydrogels offer localized delivery advantages, their clinical versatility is frequently hindered by a reliance on exogenous drug encapsulation. To overcome this limitation, we developed a multifunctional, ROS-responsive hydrogel (ODCAS) that functions as an inherently bioactive platform. The ODCAS network is constructed via dynamic Schiff base crosslinking between ODex and thiolated arginine chitosan, further reinforced by ROS-triggered disulfide bonds leveraging. This sophisticated architecture undergoes ROS-responsive programmed degradation, driving in situ NO generation to trigger a therapeutic cascade. Specifically, the TPA-derived thiol moieties facilitate inflammation-targeted mucoadhesion via disulfide exchange with the mucosal layer, while simultaneously providing potent, direct ROS scavenging (72.21 ± 2.47% DPPH· radical scavenging). Furthermore, the metabolic byproducts of the hydrogel network provide prebiotic support to restore microbial equilibrium. In a DSS-induced murine colitis model, oral administration of ODCAS significantly attenuated disease severity, reducing the DAI by 52.08%, downregulating pro-inflammatory cytokines, and restoring both intestinal barrier integrity and microbial homeostasis. These findings highlight the ODCAS hydrogel as a robust, ROS-responsive biomaterial platform that orchestrates disulfide-mediated anchoring and an arginine-driven NO cascade for the effective management of chronic inflammatory diseases.
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MATERIALS & DESIGN
·
2026
·
IF 8.2
Jinze Li,Na Li,Zebin Wang,Hao Cao,Zhaoyi Lin,Yunbiao Wang,Jiana Huang,Yan Li
The hydrogel powder dressing is fabricated by lyophilization and mechanical ground. • The dressing shows adaptability to irregular wounds and good dimensional stability. • Dry powder-to-gel transition facilitates easy and painless dressing replacement. • The dressing enriches matrix metalloproteinase-9 and fastens diabetic wound healing. Diabetic wounds remain a major clinical challenge due to the dysregulation of inflammatory phase and impaired cellular activity. Although hydrogel sheet dressings have demonstrated a great potential, their application to irregular wounds and the ability to improve wound healing are often limited. In this study, a practical hydrogel powder dressing (O3C-H30LP) was developed from the OGCB precursor suspension which contained oxidized sodium alginate, gelatin, calcium carbonate microspheres and borax. The suspension exhibited an excellent injectability. After gelation and crosslinking, the hydrogel was freeze-dried and mechanical ground to obtain O3C-H30LP. The swelling ratio was 517.02 ± 11.02% and showed a good dimensional stability. The particle size was 109.8 ± 8.9 μm; after rehydration, they were integrated together to demonstrate a high self-healing ability. In addition to favorable biodegradability, in vitro studies showed that the sample possessed good hemocompatibility and promoted adhesion and proliferation of murine fibroblasts. Furthermore, in vivo tests based on diabetic rat model revealed that O3C-H30LP significantly accelerated wound closure during the critical stages of healing, enriched matrix metalloproteinase-9 (MMP-9), modulated the wound microenvironment, and effectively promoted tissue remodeling. This multifunctional dressing provides a simple yet efficient strategy for the management of diabetic wounds. Schematic illustration for the preparation of OGCB dry powder and its application on a diabetic wound. Download: Download high-res image (181KB) Download: Download full-size image
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ACS Nano
·
2026
·Vol. 20
·期 30
·21245-21262
·
IF 17.3
Lin Jiayi,Li Junyi,Wu Yue,Hu Xinqiang,Wei Hao,Li Menghuan,Hu Xue,Luo Zhong,Cai Kaiyong,Hu Yan
Rheumatoid arthritis (RA) is a systemic autoimmune disease
that
causes serious joint damage and functional loss, which is predominantly
associated with the aberrant activation of synovial macrophages. Herein,
we report an injectable ion-coordinated bionic lubricant to efficiently
reprogram synovial macrophages into pro-regenerative phenotypes for
RA treatment. For this purpose, rhein (Rh)-modified PEGylated liposomes
were integrated with coenzyme Q10 (CoQ10) for macrophage-targeted
delivery (LipQ10-Rh), which were subsequently embedded into dynamic
hyaluronic acid (HA)-based hydrogel matrices cross-linked by acylhydrazone
bonding and Zn 2+ ion-mediated coordination (HALZ). Owing
to the intrinsic reversibility of the dynamic bonding network, the
HALZ lubricant could be facilely injected into RA-affected joint cavity
and provide immediate relief through biolubrication. Meanwhile, the
LipQ10-Rh liposomes and Zn ions could be gradually released from the
dynamic hydrogels and taken in by synovial macrophages, where the
Zn ions could activate the anti-inflammatory metabolism while CoQ10
alleviated mitochondrial ROS stress to restore their reparative functions,
which acted in a cooperative manner to reprogram the inflammatory
synovial macrophages into pro-regenerative phenotypes. In vivo results
evidently suggested that the injectable HALZ biolubricant efficiently
abolished RA-associated joint damage on rat models in a durable manner,
providing an approach for improving RA recession in the clinic.
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