Pharmaceutics
·
2022
·Vol. 14
·期 1
·197
·
IF 6.525
Chuanqi Wang,Manting Wang,Peng Chen,Jiexin Wang,Yuan Le
In this work, dasatinib (DAS) nanoemulsion and nanocrystal are produced by high-gravity technology that approaches to practical mass production. The drug nanoformulations were systematically characterized and evaluated. At a low high-gravity level (β) = 47, nanoemulsion droplets were 16.15 ± 0.42 nm with a PDI of 0.122 ± 0.021. The nanoemulsion’s size and active pharmaceutical ingredient (API) content remained stable at long-term (4 months) freeze–thaw and dilution experiments. At a high β = 188, the as-prepared nanocrystal was lamellar with a short diameter of about 200 nm and a long diameter of about 750 nm. In vitro performances demonstrated the nanoemulsion displayed higher cytotoxicity on MDA-MB-231 tumor cells, Caco-2 cell permeability and drug release than that of the nanocrystal, indicating that nanoemulsion should be an ideal alternative for dasatinib oral administration.Keywords:dasatinib;nanoemulsion;nanocrystal;high-gravity technology;in vitro performances
研究领域:
药学
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纳米技术
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药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOTECHNOLOGY
·
2025
·
IF 3.9
Chengtuo Niu,Huating Chen,Jinjing Wang,Chunfeng Liu,Qi Li
In beer production, lager yeasts are subjected to harsh environment in high-gravity brewing (HGB, 24°P or more), thus leading to reduced fermentation performance, increased mortality and formation of off-flavors. This study aimed to improve the vitality, viability and fermentation characteristics of lager yeast during HGB through the accumulation of intracellular proline and to reveal the potential mechanism. A mutant lager yeast Y-100 with significantly increased intracellular proline fluorescence intensity of 37.37 % was obtained by Atmospheric and Room Temperature Plasma (ARTP) mutagenesis. Compared to parental YY, the mutant Y-100 had 13.94 % higher intracellular ATP content, 23.01 % lower ROS accumulation and 77.71 % lower mortality rate at the end of serial batch fermentation for 5 times. Moreover, the time for beer matureness by Y-100 strain was shorted by one day while the real degree of fermentation value was 2.76 % higher using 24°P wort. Through genome resequencing, RT-qPCR analysis and gene knockout and overexpression, the up-regulation of GNP1 and SUA7 genes in Y-100 strain might contribute to the proline accumulation in lager yeast cells, thus resulting in energy supply and stress protection for lager yeast during HGB. The results not only provided new insights into the role of proline in lager yeast towards unfavorable industrial condition, but also obtained a high-efficient Y-100 strain for potential HGB application.
研究领域:
微生物学
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发酵工程
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食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2019
·
IF 2.584
Simin Cui,Xianglei He,Dan Wang,Jie-Xin Wang,Yuan Pu,Jian-Feng Chen
The ideal product of rare-earth-doped phosphors should have uniform particle size distribution and homogeneous doping ions in each particle, and therefore, intensified micromixing at mesoscale is highly required. In this article, inspired by the concept of “mesoscience”, we demonstrate the tuning of Eu3+ doping in GdBO3 microparticles at mesoscale by a high-gravity-assisted reactive precipitation-coupled calcination process. The high-gravity environment and tiny droplets generated by the high-gravity rotating packed bed (RPB) reactor lead to significant intensification of mass transfer and micromixing, which are beneficial for the homogeneous doping of Eu3+ in the host material during reactive precipitation in liquid solution. Under excitation at 395 nm, the emission spectra of the Eu3+-doped phosphors exhibit a narrow-band red emission centered at 625 nm and the highest intensity was observed at x = 0.2. The RPB products show higher intensity than that of the control group even when the reaction time was shortened to 1/6. After calculation, the quenching in the sample most likely results from dipole–dipole interactions. The chromaticity coordinates for the RPB sample was measured as (0.598, 0.341) with a quantum yield of up to 78.11%, and the phosphors exhibit good thermal stability at 423 K. The phosphors were used as the luminescent materials for light-emitting diodes (LEDs), and the devices showed good performance. Our preliminary study illustrated that high-gravity-assisted approaches are promising for tuning the doping of rare-earth ions in microparticles at mesoscale toward efficient production of phosphors for LEDs.
研究领域:
材料科学
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发光材料
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Shang-Yuan Cheng,Chen-Peng Zhang,Meng-na Chao,Shu-Wei Guo,Gui-Sheng Qi
Suspended nanodroplets affect the transfer process within fluids through micro-perturbation or micro-convection effects. Therefore, adding dispersed nanodroplets as the dispersed phase into the liquid phase to form nanoemulsions can enhance the CO 2 absorption process. The quality of nanoemulsions mainly depends on the emulsification equipment. Traditional physical mechanical effects can only achieve large-scale macroscopic mixing, which usually takes a long time to complete, resulting in issues such as low production efficiency, batch operation, and long preparation cycles. This paper uses an impinging stream-rotating packed bed as a reactor, with span60 and tween60 as surfactants, and adopts a high-gravity process intensification technology to prepare undecane/methanol nanoemulsions with good dispersion stability. Nanoemulsion absorbents for CO 2 capture applications have been developed. The effects of different operating conditions on the dispersion stability of nanoemulsion were investigated. Furthermore, CO 2 absorption performance of nanoemulsion absorbents and methanol were investigated in a bubbling reactor. Based on the results, the reasonable mechanism for the enhancement of mass transfer was also discussed in detail. Further experiments on CO 2 absorption using nanofluids were conducted and compared with pure methanol. The results indicate that when the undecane volume fraction is 0.01 %, the high-gravity factor is 27, the impinging velocity is 14.1 m·s −1 , and the circulation time is 20 min, the nanoemulsion exhibits the highest stability, with the narrowest particle size distribution of oil droplets, an average particle size of 20.5 nm, and the highest uniformity. Simultaneously, the change in turbidity over time is minimal. The corresponding thermal conductivity at 25°C is 0.2003 W/m·K. The addition of nano-oil droplets significantly accelerates the CO 2 absorption rate, allowing the absorbent to reach saturation earlier, while the total amount of CO 2 absorbed remains the same. Compared with pure methanol, the nanoemulsion enhances the CO 2 absorption rate by 4.48 %. This work may provide a promising green method for efficient production of nanoemulsions for carbon dioxide capture.
研究领域:
化学工程
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环境科学
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能源技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2023
·
IF 4.7
Fuming Miao,Shuai Zhang,Xueliang Sun,Yamin Li,Ruize Shang,Wenli Wu,Weizhou Jiao,Youzhi Liu
In this study, Mn-CoO X / γ -Al 2 O 3 (MCA) was prepared by impregnation for catalytic ozonation of phenol in a rotating packed bed (RPB), and the effects of high gravity factor ( β ), liquid flow rate ( Q L ), initial solution pH and gaseous ozone concentration ( C O 3 ) on the mineralization of phenol were explored. The results show that the degradation rate of phenol ( η phenol ) reaches 100% at 9 min and the mineralization rate ( η TOC ) reaches 95.01% at 45 min under conditions of β = 104, C O 3 = 80 mg L -1 , Q L = 80 L/h, and pH = 6. Compared with the bubbling reactor (BR)/MCA/O 3 and O 3 /RPB systems, the η TOC of the MCA/O 3 /RPB system is increased by 25.81% and 40.85%, respectively. The electron paramagnetic resonance (EPR) results reveal that hydroxyl radical (·OH) plays a critical role in the degradation of phenol by MCA catalyzed ozonation. The quenching experiment using tertiary butyl alcohol (TBA) as a scavenger of ·OH reveals that the ratio of direct and indirect degradation of phenol is 16:9. The intermediates generated during the degradation of phenol were detected by gas chromatography-mass spectrometry (GC–MS), and possible degradation pathways were proposed. In conclusion, MCA-catalyzed ozonation and RPB have a synergistic effect on ·OH initiation and improve the degradation and mineralization of phenol. This study provides a new perspective for the degradation of phenol.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Chao Jiang,Caijun Luo,Xiaolin Liu,Lei Shao,Youqing Dong,Yingwei Zhang,Feng Shi
The layer-by-layer (LbL) assembled multilayer has been widely used as good barrier film or capsule due to the advantages of its flexible tailoring of film permeability and compactness. Although many specific systems have been proposed for film design, developing a versatile strategy to control film compactness remains a challenge. We introduced the simple mechanical energy of a high gravity field to the LbL assembly process to tailor the multilayer permeability through adjusting film compactness. By taking poly(diallyldimethylammonium chloride) (PDDA) and poly{1–4[4-(3-carboxy-4-hydroxyphenylazo)benzenesulfonamido]-1,2-ethanediyl sodium salt} (PAzo) as a model system, we investigated the LbL assembly process under a high gravity field. The results showed that the high gravity field introduced effectively accelerated the multilayer deposition process by 20-fold compared with conventional dipping assembly; the adsorption rate was positively dependent on the rotating speed of the high gravity equipment and the concentration of the building block solutions. More interestingly, the film compactness of the PDDA/PAzo multilayer prepared under the high gravity field increased remarkably with the growing rotational speed of the high gravity equipment, as demonstrated through comparisons of surface morphology, cyclic voltammetry curves, and photoisomerization kinetics of PDDA/PAzo multilayers fabricated through the conventional dipping method and through LbL assembly under a high gravity field, respectively. In this way, we have introduced a simple and versatile external form of mechanical energy into the LbL assembling process to improve film compactness, which should be useful for further applications in controlled ion permeability, anticorrosion, and drug loading.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Innovative Food Science & Emerging Technologies
·
2025
·
IF 6.8
Yu-Cheng Yang,Shu-Hao Cheng,Yi-Xiong Zhang,Jie Mao,Bing-De Zheng,Na Zhang,Ya-Yan Huang,Xue-Qin Zhang,Jing Ye,Mei-Tian Xiao
To effectively prepare value-added low molecular weight chitosan with improved molecular weight uniformity, a novel high-gravity reactor—the Rotating Foam Stirrer Reactor (RFSR)—is proposed to enhance the chemical degradation process of chitosan. The study reveals that the combined H₂O₂-Vc degradant significantly increases degradation efficiency compared to H₂O₂ or Vc alone, attributed to synergistic effects in hydroxyl radical production. Specifically, the degradation efficiency of the H₂O₂-Vc combination increased by 56.41 % and 32.88 %, respectively, within 5 min. Increased rotational speed improves degradation efficiency and narrows the molecular weight distribution, particularly at higher chitosan concentrations. The weight-average molecular weight rapidly decreases within the first 30 min and then stabilizes, while maintaining a more uniform distribution. Positioning the degradant feed at the stirrer's outer edge further enhances degradation. The RFSR outperforms traditional reactors, producing chitosan with lower molecular weight and better uniformity. Additionally, a predictive correlation for the reaction rate constant, incorporating mass transfer effects, shows good agreement with experimental results, with an error margin of approximately ±20 %, supporting large-scale industrial applications in polysaccharide degradation.
研究领域:
生物化学
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材料科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2014
·
IF 2.063
Yibo Zhao,Moses Arowo,Wei Wu,Haikui Zou,Jianfeng Chen,Guangwen Chu
Polyaniline/graphene (PANI/GN) nanocomposites were synthesized by in situ high gravity chemical oxidative polymerization in a rotating packed bed (RPB). The effects of graphene dosage, ammonium persulfate/aniline mole ratio, aniline concentration and reactor type on their morphology and electrochemical performances were discussed in detail. Results indicated that this process can synthesize PANI/GN nanocomposites easily under relatively extensive conditions. Particularly, it was demonstrated that it is appropriate for higher aniline concentration condition, which is favorable for large scale production. Furthermore, RPB produced PANI/GN nanocomposites of more uniform morphology and thinner coating than those synthesized in a stirred tank reactor (STR). These advantages resulted in nanocomposites of higher specific capacitance of up to 403 F/g as compared to 255 F/g for those of STR at 0.5 A/g. This process is not only simple and efficient, but also has a good prospect for industrial application.
研究领域:
材料科学
·
纳米科技
·
电化学
·
能源存储
·
化学工程
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2022
·
IF 4.326
Jing Cao,Ting-Ting Hu,Dan Wang,Jie-Xin Wang
Rare earth ion doped upconverison (UC) luminescence nanophosphors have attracted much attention owing to their wide applications. It is known that homogeneous doping of ions in matrixes and particle size distribution (PSD) determine the luminescent properties. In this study, we reported a novel approach to prepare CaF2:Er3+ and CaF2:Yb3+/Er3+ UC nanophosphors by high-gravity reactive precipitation in a rotating packed bed (RPB) combining hydrothermal process, which is applied for noninvasive temperature detection. The intensified micromixing in the RPB reactor contributes to the achievement of CaF2 nanoparticles with a narrower PSD, more homogeneous doping of Er3+ and Yb3+ ions in the CaF2 matrix, and higher doping efficiency compared to a conventional stirred tank reactor (STR). In particular, the luminescent intensities of the as-prepared CaF2:Er3+(2%) and CaF2:Yb3+(10%)/Er3+(1%) are respectively 12 and 2 times higher than those of the corresponding products prepared in the STR. Furthermore, the maximum absolute sensitivity of RPB-prepared CaF2:Yb3+(10%)/Er3+(1%) is calculated to be 0.0049 K–1, comparable with those of other reported Yb3+/Er3+-codoped materials. This exhibits a great potential of CaF2:Yb3+/Er3+ UC nanophosphors as promising noncontact temperature measuring materials.
研究领域:
材料科学
·
光学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Frontiers of Chemical Science and Engineering
·
2020
·Vol. 14
·期 6
·1087-1099
·
IF 3.552
Zhang Weihong,Wang Dan,Wang Jie-Xin,Pu Yuan,Chen Jian-Feng
In this work, we developed a continuous preparation strategy for the production of high-solidscontent waterborne polyurethane (WPU) emulsions via high-gravity-assisted emulsification in a rotating packed bed (RPB) reactor. By adjusting the experimental parameters and formula, WPU emulsions with a high solids content of 55% and a low viscosity were prepared. Preliminary applications of the high-solids-content WPU as a thermally insulating material were demonstrated. RPB emulsification is an economical and environmentally friendly production strategy because of the low energy consumption, short emulsification time, and effective devolatilization. This study demonstrated an effective method for preparation of high-solids-content WPU, moving toward commercialization and industrialization.
研究领域:
化学工程
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
AICHE JOURNAL
·
2022
·Vol. 69
·期 3
·e17864
·
IF 4.167
Yun Zhao,Xiaogang Yu,Xin Wen,Yong Luo,Zhonghua Xiang,Jian-feng Chen
The scale-up synthesis of covalent organic frameworks (COFs) with uniform structure and properties is of great importance for their practical applications. Here, we proposed a facile way to massively produce phthalocyanine-like COFs (COF BTC ) via high-gravity intensified synthesis. Alcoholic solvent and basic catalyst were discovered synergically improved the formation of COF BTC . High concentration and reaction temperature were beneficial for high production as well. The intensified mass and heat transfer at high-gravity promoted the scaling-up of COF BTC with homogeneous structures and properties. A high space time yield of 305.9 kg∙(m 3 D) −1 was achieved for Fe-COF BTC under optimized condition. The massively produced Fe-COF BTC presented good solubility in alkaline and polar organic solvents, thus allow to process as homogeneous or heterogenous electrocatalyst for oxygen reduction reaction. The catalyst exhibited good performance of 0.79 V (vs. RHE, half-wave) and >95% recovery in homogeneous electroreduction of O 2 in 0.1 M KOH. A superior performance of 0.86 V was achieved by sol–gel-like processing of Fe-COF BTC on carbon paper due to the enhanced conductivity. The scale-up soluble catalysts with uniform properties provide more opportunities for practical applications of COF BTC .
研究领域:
材料科学
·
化学工程
·
催化科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Water Process Engineering
·
2023
·
IF 7
Yibo Zhao,Lu Chang,Yueyang Li,Wenjing He,Keling Liu,Minjie Cui,Muhammad Usman Hameed,Jiyan Xie
Oxygen can generate reactive oxygen species in photocatalysis , promoting organic matter's mineralization. Therefore, enhanced oxygenation of the photocatalytic degradation system will help improve photocatalytic degradation efficiency. This study developed a novel high-gravity photocatalytic degradation method, which leverages the robust gas–liquid mass transfer capability of a supergravity rotating bed to realize the enhanced oxygenation of the photocatalytic degradation system. Specifically, this study used graphitic carbon nitride as the catalyst and tetracycline hydrochloride as the model pollutant. The effects of packing thickness, catalyst concentration, liquid flow rate, rotor speed , gas flow rate, and initial pH value on photocatalytic degradation performance were investigated. The results showed that the degradation rate of tetracycline hydrochloride reached 84.6 % under the optimal conditions of the rotating packed bed, which was 14.8 % higher than that of the traditional photocatalytic degradation process.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）