JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
·
2017
·
IF 0.697
Xiaoting Zhang,Jiahua Niu,Yixin Yang,Peige Qin,Shufang Tian,Jinhua Zhu,Minghua Lu
In this work, a magnetic solid-phase extraction protocol followed with high-performance liquid chromatography analysis was developed for the determination of maltol and ethyl maltol in food samples. The Fe3O4 nanoparticles were prepared by one-step hydrothermal method and was used as adsorbent for clean and preconcentrated maltol and ethyl maltol in food samples. The as-prepared Fe3O4 nanoparticle was characterized by transmission electron microscope, Fourier transform infrared spectroscopy, X-ray diffraction, and vibrating sample magnetometer. The extraction conditions including the amount of material, extraction time, pH, temperature, and desorption solvents were investigated, respectively. Under the optimized conditions, the detection limits of 0.04 and 0.05 µg mL−1 could be achieved for maltol and ethyl maltol. The recoveries between 84.2 and 103.4% with RSDs lower than 2.30% were obtained for the analysis of spiked plum candy sample. The developed method was successfully applied to the analysis of real samples, such as juice, chocolate, and plum candy.
研究领域:
分析化学
·
食品科学
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2019
·
IF 3.206
Xin Fu,Dongliang Zhu,Lan Huang,Xiangyang Yan,Shaomin Liu,Chenghui Wang
A highly sensitive and selective method for the simultaneous extraction and determination of trace vanillin , ethyl vanillin , maltol and ethyl maltol in beverage samples using magnetic solid-phase extraction coupled with high-performance liquid chromatography (HPLC) was developed. The novel superparamagnetic dummy template molecularly imprinted polymers (Fe 3 O 4 @MDMIP) were prepared by adopting a sol-gel approach using 3-hydroxy-2,6-bis(hydroxymethyl) -4-pyrone, whose structure was similar to that of the vanillin and maltol, as the dummy template for selective extraction of vanillin, ethyl vanillin, maltol and ethyl maltol. The obtained Fe 3 O 4 @MDMIP exhibits high uniformity and monodispersity. Besides, Fe 3 O 4 @MDMIP has an outstanding magnetic susceptibility (56.33 emu g −1 ) than common obtained samples. The maximal adsorption capacity (Q max ) of the resulting Fe 3 O 4 @MDMIP for the four food additives was up to 609.99 mg g −1 . The imprinting factors of the Fe 3 O 4 @MDMIP ranged from 2.07 to 2.71 for the four food additives, which indicated that the obtained adsorbents have high selectivity. Under the optimum experimental conditions, the Fe 3 O 4 @MDMIP was successfully applied to the magnetic solid-phase extraction of vanillin, ethyl vanillin, maltol and ethyl maltol followed by HPLC determination in beverage samples. Validation experiments indicated that the developed method presented good linearity (2.07–463 ng mL −1 ), satisfactory precision (RSD, 2.68–6.91%), and high recovery (91.2–107.1%). The limits of detection ranged from 44 to 201 ng L −1 , and the enrichment factors were in the range of 432–484. The results demonstrated great potential of the optimized method for sample preparation in routine analysis of trace food additives.
研究领域:
食品科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Hui Dong,Linlin Zheng,Zhenlong Jiang,Tao Wang,Xinyue Li,Yangyang Ma,Zhu Chang,Xuechuan Lv,Xiaohan Gao,Maotian Xu,Yanli Zhou
Maltol (MA) is a common additive used in many fields, and its detection is of great importance to human health. Here, we synthesized a bimetallic MOF (CuNiMOF) based on graphite paper by a fast, simple, and green electrodeposition method. Then, we constructed a self-calibrated MOF to detect maltol. CuNiMOF was based on graphite paper by a fast, simple, and green electrodeposition method, and then constructed a self-calibrated flexible biosensor for the detection of maltol. In this work, we utilized the amperometric i-t curve (IT), cyclic voltammetry (CV), and multipotential step (STEP) methods to electrosynthesize three modified electrodes (Gp/CuNiMOF/IT, Gp/CuNiMOF/CV, Gp/CuNiMOF/STEP). The MA was characterized by differential pulse voltammetry electrochemical reactions on the electrode surface were investigated. The results showed that compared with the other two electrodeposition processes, the IT method was used to the sensor prepared by the IT method exhibits superior performance compared to the other two electrodeposition processes. The nonlinear response of the sensor to MA was in the concentration range of 0.5 ∼ 450 μM with a detection limit of 0.17 μM.
研究领域:
分析化学
·
材料科学
·
电化学传感器
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2019
·
IF 5.399
Yun-Jiao Ma,An-Qi Bi,Xiao-Yuan Wang,Lei Qin,Ming Du,Liang Dong,Xian-Bing Xu
The dispersion solid-phase microextraction (DSPE) combined with dispersion liquid–liquid microextraction (DLLME) was developed as a rapid, simple and effective pretreatment method for the determination of flavor enhancers (maltol, ethyl maltol, vanillin, methyl vanillin, ethyl vanillin) of ready-to-eat seafood products (dried squid, baked squid, fried fish, steamed abalone). Under the optimized DSPE–DLLME method, the developed method exhibited low limits of quantitation (0.20–0.50 μg g −1 ) and excellent linearity (R 2 ≥ 0.995). The recoveries of flavor enhancers in the actual samples were 83.7%–114.9%. Compared with traditional pretreatment methods, the developed DSPE–DLLME method was rapid (17 min) and easy to determine the flavor enhancers by high performance liquid chromatography with photodiode array detector (HPLC-PDA). In the actual samples, creamy compounds such as vanillin, methyl vanillin and ethyl vanillin were hardly found. However, the flavor compounds produced by thermal reactions such as maltol (except for dried squid 3) and ethyl maltol were present in all samples.
研究领域:
食品科学
·
分析化学
·
色谱学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Xingyue Wang,Yu Jiang,Shuangshuang Wang,Luyao Zhang,Tinghong Zhang,Ping He
An effective electrochemical sensor based on electrodeposition of nickel selenide nanoparticles (Ni 3 Se 4 ) on the surface of a glass carbon electrode (GCE) modified with hydroxylated multiwalled carbon nanotubes (MWCNTs-OH) has been successfully developed for determination of maltol. The chemical composition and morphology of Ni 3 Se 4 /MWCNTs-OH composites are characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) are employed to investigate the electrochemical behavior of maltol at Ni 3 Se 4 /MWCNTs-OH/GCE. Consequently, electrochemical sensor based on Ni 3 Se 4 /MWCNTs-OH/GCE for detection of maltol displays good electrocatalyst performance. The obtained oxidation peak current of maltol at Ni 3 Se 4 /MWCNTs-OH/GCE increases linearly with the increase in concentration of maltol in the range of 0.1 μM–2000 μM, and the calculated detection limit (LOD) is 17.5 nM (S/N = 3). In addition, the fabricated electrochemical sensor shows satisfactory stability, reliable reproducibility and excellent selectivity, and is successfully used to detect maltol in real samples with acceptable accuracy.
研究领域:
分析化学
·
材料科学
·
食品检测
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Yue Huang,Xiaojing Si,Mei Han,Chen Bai,Sijie Liu
In this paper, a novel electrochemical sensor based on carboxylated multi-walled carbon nanotubes (C-MWCNTs) and chromium black T (EBT) composites modified electrodes (EBT/C-MWCNTs/GCE) were proposed for the sensitive determination of ethyl maltol (EMA). Cyclic voltammetry and differential pulse voltammetry techniques were used to investigate the performance of EMA on EBT/C-MWCNTs/GCE. The results showed that the peak current of EMA was significantly enhanced by the EBT/C-MWCNTs/GCE compared with the bare glassy carbon electrode. The peak current showed a good linear relationship with the mass concentration of EMA in the range of 10 ∼ 1000 μg/L and the detection limit is 3.3 μg/L. Moreover, the sensor is easy to prepare and shows long term stability, which has great potential application for the determination of EMA in edible oil.
研究领域:
分析化学
·
食品科学
✓ 已验证
DOI
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2013
·Vol. 18
·期 3
·621-628
·
IF 2.279
Ma Xinying,Chao Mingyong
A novel poly(methylene blue)/graphene composite glassy carbon electrode was fabricated and the electrochemical behavior of maltol at the modified electrode was studied by cyclic voltammetry. In phosphate-buffered solution, the modified electrode exhibited excellent electrocatalytic activity towards the electrochemical oxidation of maltol. Under optimized conditions, the oxidation peak current showed a linear relationship with the concentrations of maltol in the ranges of 8.00 × 10 −7 to 4.00 × 10 −5 and 4.00 × 10 −5 to 5.40 × 10 −4 mol L −1 , with a detection limit of 6.50 × 10 −8 mol L −1 . The performance of the developed method was validated in terms of linearity ( r = 0.9981 and 0.9955), recovery (97.0−99.3 %), reproducibility (relative standard deviations ≤ 3.1 %, n = 6), and robustness. The method shows excellent sensitivity, selectivity, and reproducibility and has been successfully applied to analyzing maltol in a wide variety of food products.
研究领域:
食品科学
·
电化学分析
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2013
·Vol. 5
·期 20
·5823-5829
·
IF 1.855
Xinying Ma,Mingyong Chao
Herein, a poly(L-phenylalanine) modified glassy carbon electrode (PLPA/GCE) was fabricated by electrochemical polymerization and a convenient method for the determination of maltol in food products was developed using the fabricated PLPA/GCE. The electrochemical behavior of maltol at the modified electrode was studied by cyclic voltammetry. Experimental results show that the modified electrode exhibits excellent electrocatalytic activity towards the electrochemical oxidation of maltol and the oxidation is a one-proton–one-electron process. In pH 8.0 phosphate buffer solution, the oxidation peak current obtained by cyclic voltammetry is linearly proportional to the concentration of maltol in the range of 8.0 × 10−7 to 5.00 × 10−4 mol L−1 with a limit of detection of 9.5 × 10−8 mol L−1. The stability and reproducibility of the fabricated electrode was evaluated and the performance of the proposed method was validated in terms of linearity (r = 0.9989), recovery (95.2–101.4%), reproducibility (RSD < 3.7%, n = 6) and robustness. The applicability of the developed method has been successfully demonstrated by the determination of maltol in a variety of food products such as cake, beer and red wine.
研究领域:
分析化学
·
食品科学
·
电化学传感
·
生物医学工程
·
食品安全检测
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2016
·
IF 4.052
Tian Gan,Junyong Sun,Miaomiao Yu,Kaili Wang,Zhen Lv,Yanming Liu
The study presents a new approach for rapid and ultrasensitive detection of maltol using a glassy carbon electrode (GCE) modified with graphene oxide-wrapped tin oxide@carbon nanospheres (SnO 2 @C@GO). The morphological and components properties of SnO 2 @C@GO nanocomposites were investigated by means of X-ray diffraction spectroscopy, Raman spectroscopy, field emission scanning electron microscopy, high resolution transmission electron microscopy, and electrochemical impedance spectroscopy. SnO 2 @C@GO nanocomposite on a GCE had a synergetic effect on the electrochemical oxidation of maltol by means of square wave voltammetry. Under the optimum conditions, anodic peak current response of maltol was linear with its concentration in the range of 80 nM–10 μM, and a detection limit of 12 nM was achieved for maltol. The experiment results presented that the method showed good selectivity, sensitivity, reproducibility, and long-term stability, as well as excellent potential for use as an ideal inexpensive voltammetric method applicable for complex food matrices.
研究领域:
食品科学
·
分析化学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2017
·Vol. 164
·期 14
·H1033
·
IF 3.259
Fei Wang,Kang Ding,Can Zhang,Wenke Jia,Kui Lu,Yingjie Ye
In this work, pulse potential method (PPM) was presented to fabricate directly three dimensional graphene-carbon nanotubes (3DG-CNTs) network on the surface of glassy carbon electrode (GCE). The morphological and characteristic of 3DG-CNTs network were investigated by means of Raman spectra, scanning electron microscopy (SEM) and electrochemical experiments. The 3DG-CNTs network as a new voltammetric material was applied in developing a high-sensitive electrochemical sensor for determination of maltol. Under the optimum conditions, the electrochemical response showed a linear relationship with maltol concentrations in the range of 5.0 × 10−8 ∼ 4.5 × 10−6 mol L−1 and 1.0 × 10−5 ∼ 2.0 × 10−3 mol L−1, and a low detection limit of 1.0 × 10−8 mol L−1 was achieved for maltol. Moreover, the proposed method exhibited an excellent selectivity, stability, reproducibility and repeatability, which make it very suitable for a potential choice for determination of maltol in food matrices.
研究领域:
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
PHARMACEUTICAL BIOLOGY
·
2021
·
IF 3.503
Jiaqi Lu,Lili Gu,Qin Li,Ningzi Wu,Hongxing Li,Xinyue Zhang
Context Andrographolide (Andro) has a neuroprotective effect and a potential for treating Alzheimer’s disease (AD), but the mechanism has not been elucidated.Objective The efficacy of Andro on p62-mediated Kelch-like ECH-associated protein 1(Keap1)-Nuclear factor E2 related factor 2 (Nrf2) pathways in the aluminium maltolate (Al(mal)3)-induced neurotoxicity in PC12 cell was explored.Materials and methods PC12 cells were induced by Al(mal)3 (700 μM) to establish a neurotoxicity model. Following Andro (1.25, 2.5, 5, 10, 20, 40 μM) co-treatment with Al(Mal)3, cell viability was detected with MTT, protein expression levels of β-amyloid precursor protein (APP), β-site APP cleaving enzyme 1 (BACE1), Tau, Nrf2, Keap1, p62 and LC3 were measured via western blotting or immunofluorescence analyses. Nrf2, Keap1, p62 and LC3 mRNA, were detected by reverse transcription-quantitative PCR.Results Compared with the 700 μM Al(mal)3 group, Andro (5, 10 μM) significantly increased Al(mal)3-induced cell viability from 67.4% to 91.9% and 91.2%, respectively, and decreased the expression of APP, BACE1 and Keap1 proteins and the ratio of P-Tau to Tau (from 2.75- fold to 1.94- and 1.70-fold, 2.12-fold to 1.77- and 1.56-fold, 0.68-fold to 0.51- and 0.55-fold, 1.45-fold to 0.82- and 0.91-fold, respectively), increased the protein expression of Nrf2, p62 and the ratio of LC3-II/LC3-I (from 0.67-fold to 0.93- and 0.94-fold, 0.64-fold to 0.88- and 0.87-fold, 0.51-fold to 0.63- and 0.79-fold, respectively), as well as the mRNA expression of Nrf2, p62 and LC3 (from 0.48-fold to 0.92-fold, 0.49-fold to 0.92-fold, 0.25-fold to 0.38-fold). Furthermore, Nrf2 and p62 nuclear translocation were increased and keap1 in the cytoplasm was decreased in the presence of Andro. Silencing p62 or Nrf2 can significantly reduce the protein and mRNA expression of Nrf2 and p62 under co-treatment with Andro and Al(mal)3.Discussion and conclusions Our results suggested that Andro could be a promising therapeutic lead against Al-induced neurotoxicity by regulating p62-mediated keap1-Nrf2 pathways.
研究领域:
神经科学
·
药理学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2024
·
IF 11.4
Xu Shi,Tong Xu,Meichen Gao,Yanju Bi,Jiaqi Wang,Yilin Yin,Shiwen Xu
Pesticides and plastics bring convenience to agriculture and life, but also bring residual pollution in the environment. Emamectin benzoate (EMB) is the most popular pesticide at present. The harm of microplastics (MPs) to water and aquatic organisms is gradually increasing, and the possibility that it appears synchronously with various pesticides increases. However, the damage of EMB and MPs to the carp midgut and its mechanism have not been clarified. Therefore, based on the EMB or/and MPs exposure models, this study explored the mechanism of midgut injury through transcriptomics, immunofluorescence, western blot methods, and so on. Studies in vivo and in vitro showed that EMB or MPs exposure caused cilia shortening, lysosome damage, and ROS overproduction, which led to Fe 2+ content increase, GSH/GSSG system disorder, lipid peroxidation, and ferroptosis. This process further led to the down-regulation of Cx43, Occludin, Claudin, and ZO-1, which further caused barrier damage, immune-related genes (immunoglobulin, IFN-γ) decrease and inflammation-related genes (TNF-α, IL-1β) increase. Combined exposure was more significant than that of single exposure, and the addition of EN6 and NAC proved that lysosome/ROS/ferroptosis regulated these midgut damages. In conclusion, EMB or/and MPs exposure induce tight junction disorder, immune disorder and inflammation in carp midgut through the lysosome/ROS/ferroptosis pathway.
研究领域:
环境科学
·
水生毒理学
·
分子生物学
·
免疫学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）