Chinese Journal of Integrative Medicine
·
2017
·
IF 1.116
Wei Ping,Tang Qing-fa,Huo Hui-ling,Chen Fei-long,Song Shuai,Xing Xue-feng,Luo Jia-bo
Objective To investigate the pharmacokinetic characteristics of three phenylpropanoids (cinnamic acid, cinnamic alcohol and coumarin) in Ramulus Cinnamomi (GZ) and Ramulus Cinnamomi-Ephedrae Herba (MH) herb-couple (GZMH). Methods Twelve male Sprague-Dawley rats were randomly and equally divided into the GZ and GZMH herb-couple groups. Blood samples were collected at 0, 0.08, 0.25, 0.5, 0.75, 1.5, 3, 4, 6, 8, 12, 24, 36 and 48 h after oral administration. The three phenylpropanoids in rat plasma were quantified using an ultra-performance liquid-chromatography with tandem mass spectrometry (UPLC-MS/MS) method for pharmacokinetic study. Results In GZMH group, the area under the curve (AUC), mean retention time (MRT) of cinnamic acid and coumarin were increased significantly ( P <0.01, respectively), and biological half-life (t 1/2z ) was obviously shorter ( P <0.05) compared with the GZ group. There were no significant differences in the mean retention time from 0 to ∞ (MRT 0-∞ ), the peak concentration (C max ), the time to peak (T max ) and t 1/2z , except for AUC and MRT 0-t (the mean retention time from 0 to t) of cinnamic alcohol in the GZMH group by comparison to the GZ group ( P <0.01, respectively). The AUC, MRT (both P <0.01) and t 1/2z ( P <0.05) of coumarin were increased significantly, while C max , and T max were decreased slightly by comparison to the GZ group ( P >0.05). Conclusions There were statistically significant differences in some pharmacokinetic parameters of the three compounds between GZ and GZMH groups, which meant that MH could affect the absorption and elimination of the three compounds.
研究领域:
中药学
·
药理学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2022
·Vol. 45
·期 5
·1051-1058
·
IF 3.614
Chunying Song,Dongping Yu,Gaowa Jin,Junjie Ding,Han Zhou,Zhimou Guo,Xinmiao Liang
Ephedrae Herba is one of the most commonly used herbal medicines, and it has been shown that most of the clinical efficacy for cold and asthma is exerted by its alkaloidal components. A simple and sensitive high-performance liquid chromatography method was developed using a perfluorooctyl column for the simultaneous determination of five alkaloids (norephedrine, norpseudoephedrine, ephedrine, pseudoephedrine, and methylephedrine) in Ephedrae Herba . The mobile phase comprising acetonitrile and 15 mM ammonium trifluoroacetate was used to elute the targets in isocratic elution mode. The method was validated for linearity ( R 2 > 0.999), repeatability, intraday and interday precision, recoveries with trueness (93.87–110.99%), limits of detection (5.35–5.76 µg/mL), and limits of quantification (20 µg/mL). The quantitative results revealed that the developed method was precise and accurate. Then it was successfully applied to determine the difference in the contents of three batches of Ephedrae Herba from three pharmaceutical companies.
研究领域:
药学
·
分析化学
✓ 已验证
DOI
高影响因子
IONICS
·
2019
·Vol. 25
·期 8
·3907-3914
·
IF 2.289
Liu Jingjiang,Kang Ruixue,Yan Zhiwei,Guan Jianglin,Quan Zhengjun
In this article, we propose a one-step strategy, utilizing calcium chloride and urea as co-activation, to synthesize 3D-interconnected porous carbon (3D-IPC) from ephedra herb. The 3D-IPC-based electrode displays excellent electrochemical performance for supercapacitors, such as a high specific capacitance of 240 F g −1 at 0.5 A g −1 and good rate capability. Especially, the symmetric supercapacitor assembled based on the 3D-IPC electrode material presents considerable energy density of 12.6 W h kg −1 at a power density 225 W kg −1 , and 6.0 W h kg −1 at 9000 W kg −1 in 0.5 M Li 2 SO 4 electrolyte. On the one hand, the urea was utilized as both activating agent for microporous pore formation in pyrolysis and nitrogen source to nitrogen doped into the 3D-IPC framework, as well as ideal synchronous carbonization and graphitization. On the other hand, ephedra herb collected from the Gobi Desert is reused as a high-value carbon material.
3D-interconnected porous carbons, obtaining from a one-step calcium chloride and urea as co-activation activation of ephedra herb, exhibit high capacitance, excellent rate and cycle performance for supercapacitors
研究领域:
材料科学
·
能源技术
·
植物资源利用
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 36
·16648-16657
·
IF 3.591
Jing-Jiang Liu,Zhi-Wei Yan,Rui-Xue Kang,Jin-Hui Wang,Xun Feng
Herein, unique N,O-codoped porous biocarbon (PB) was prepared using Ephedra Herb (EH) as a precursor via a green and sustainable NaCl-sealing strategy and subsequent pyrolysis method. PB possesses vast microstructure, interlinked pores, and high specific surface area, which can facilitate ion adsorption and buffering to improve its properties as an electrode material. In addition, the high specific surface area, well-developed porosity, and abundant heteroatoms in EH are retained well owing to the salt-sealing approach, contributing to additional pseudocapacitance. Therefore, a typical PB sample (S12), obtained from the NaCl-sealing and pyrolysis of the mixture of EH and NaCl at a mass ratio of 1 : 2, is endowed with high specific capacitance, excellent rate performance, and performance retention over long-term cycling. Most importantly, an aqueous symmetrical supercapacitor (S12//S12) assembled with S12 electrodes has a superior specific energy density of 11.6 W h kg−1 at a specific power density of 450.1 W kg−1 in Li2SO4 electrolyte. This work confirms the utility of a NaCl-sealing strategy for designing high specific surface area biocarbon materials that are ultra-rich in micropores, and it sheds some light on the use of sustainable and low-cost synthetic carbon that is ultra-rich in micropores to meet energy-storage device requirements.
研究领域:
材料科学
·
能源存储
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
BIOMEDICAL CHROMATOGRAPHY
·
2022
·Vol. 37
·期 2
·e5541
·
IF 1.911
Yongjing Liu,Suxia Zhang,Li Lou,Tang Yan,Wei Xu
In this study, deep eutectic solvent (DES), as a new green solvent, was used to extract bioactive alkaloids from Ephedrae Herba using supersonic extraction. In a variety of tested hydrophilic and hydrophobic DESs, DES composed of choline chloride and xylitol was proved to be the most efficient solvent. Factors affecting extraction efficiency, including the mole ratio of hydrogen bond acceptor/hydrogen bond donor, water contention, and solid/liquid ratio, were optimized individually. Under optimal conditions, the yield of ephedrine (EP) and pseudoephedrine obtained using this new method was 14.24 and 4.32 mg/g, respectively, which was higher than that using the traditional solvent (acidified water and methanol). Furthermore, the extraction mechanism of DES and EP was investigated using molecular dynamics simulation study. Structural properties such as radial distribution functions and average number of hydrogen bonds were then computed. The results showed that hydrogen bonds and van der Waals forces are important driving forces of extraction; in addition, the hydrogen bonds between the Cl atom of choline chloride and N atom of EP played a dominant part in the extraction process. Based on the extraction principle, the extraction method using choline chloride as extraction solvent was also discussed.
研究领域:
药学
·
分析化学
·
绿色化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）