BIOMACROMOLECULES
·
2023
·
IF 6.2
Tao Wang,Haowei Fang,Subate Yalikun,Jinyan Li,Yuqing Pan,Kunxi Zhang,Jingbo Yin,Haiyan Cui
Developing strong anti-inflammatory wound dressings is of great significance for protecting inflammatory cutaneous wounds and promoting wound healing. The present study develops a nanocomposite Pluronic F127 (F127)-based hydrogel dressing with injectable, tissue adhesive, and anti-inflammatory performance. Briefly, Ce3+/tannic acid/ulinastatin nanoparticles (Ce3+/TA/UTI NPs) are fabricated. Meanwhile, α-lipoic acid is bonded to the ends of F127 to prepare F127-lipoic acid (F127LA) and its nanomicelles. Due to the gradual viscosity change instead of mutation during phase transition, the mixed Ce3+/TA/UTI NPs and F127LA nanomicelles show well-performed injectability at 37 °C and can form a semisolid composite nanohydrogel that can tightly attach to the skin at 37 °C. Furthermore, ultraviolet (UV) irradiation without a photoinitiator transforms the semisolid hydrogel into a solid hydrogel with well-performed elasticity and toughness. The UV-cured composite nanohydrogel acts as a bioadhesive that can firmly adhere to tissues. Due to the limited swelling property, the hydrogel can firmly adhere to tissues in a wet environment, which can seal wounds and provide a reliable physical barrier for the wounds. Ce3+/TA/UTI NPs in the hydrogel exhibit lipopolysaccharide (LPS)-scavenging ability and reactive oxygen species (ROS)-scavenging ability and significantly reduce the expression of inflammatory factors in wounds at the early stage, accelerating LPS-induced wound healing.
研究领域:
材料科学
·
医学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2012
·
IF 3.628
Su Yixue,Chu Bin,Gao Yuan,Wu Chaoxi,Zhang Lingmin,Chen Peng,Wang Xiaoying,Tang Shunqing
In order to improve bioactivity of agarose, we modified agarose by carboxylation and grafting dopamine. Under alkaline condition, carboxylated agarose was prepared using 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO) oxidation system by oxidizing C 6 hydroxyl on d -galactose ring into carboxyl group, and the maximum value of the degree of carboxylation reached 30%. With the increase of the amount of oxidant, the molecular weight of the carboxylated agarose decreased to 4 kDa by gel permeation chromatography (GPC) measure. Carboxylated agarose reacted with dopamine through EDC condensation reaction to obtain agarose grafting dopamine (Ag-g-DA), and the grafting rate of dopamine was determined to be 9.3% by UV spectroscopy at 280 nm. The structures of these modified agaroses were determined by FT-IR and 13 C NMR. Both carboxylated agarose and Ag-g-DA showed no cytotoxicity and promoted cell-adhesiveness.
研究领域:
生物材料学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2022
·
IF 9.224
Aicheng Zhang,Xuwen Wu,Xinping Ouyang,Hongming Lou,Dongjie Yang,Yong Qian,Xueqing Qiu
Inspired by the UV-blocking of lignin in plants and the adhesion of catechol in mussel dopamine, light-colored lignin-based microcapsules ((OMC + BMDM)/LS-OH3-T) with strengthened UV-blocking and good bioadhesion were obtained by demethylation modification of sodium lignosulfonate (LS) and encapsulation of chemical sunscreen actives. The results show that the adhesion between LS and skin improved from 0.158 to 0.173 mN/m due to the formation of catechol groups. When (OMC + BMDM)/LS-OH3-T was used as the unique active ingredient in the sunscreen, the sun protection factor (SPF) reached 86.67, fully meeting the daily sunscreen requirement. In addition, the color of microcapsule-based sunscreen was close to pure white, which effectively solves the dark color problem of the existing lignin-based sunscreens. As it demonstrates good biocompatibility, this new light-colored lignin-based sunscreen agent has good application potential in the skincare field.
研究领域:
材料科学
·
生物学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2015
·Vol. 17
·期 2
·1-11
·
IF 2.184
Zhang Yan,Yang Zhijie,Hu Xi,Zhang Ling,Li Feng,Li Meimei,Tang Xing,Xiao Wei
The objective of this study was to develop pH-sensitive Eudragit L100–cysteine/reduced glutathione (Eul–cys/GSH) nanoparticles (NPs), which provided the mucoadhesion and protection for protein drugs against enzymatic degradation. Insulin was chosen as a model biomolecule for testing this system. The Eul–cys conjugate, which was obtained by grafting cysteine onto the carboxy group of Eudragit L100, was analyzed by HNMR and SEM, and the swelling degree (SD), cation binding, and enzymatic inhibition were also determined. The results obtained showed that the Eul–cys conjugate represent a pH-sensitive delivery system which effectively protected the insulin from being degraded by the proteases, and this is related to the mechanism of Ca 2+ binding. Insulin-loaded Eul–cys/GSH NPs were prepared by a diffusion method involving an electrostatic interaction between the network structure of the polymer and the embedded proteins, including insulin and GSH. TEM images indicated that Eul–cys/GSH existed as smooth and spherical NPs in aqueous solution with particle sizes of 260 ± 20 nm. The X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) findings showed the presence of amorphous insulin in thiolated NPs and higher free thiol oxidation than the result obtained by Ellman’s reagent method. In addition, thiolated NPs showed excellent binding efficiency to the mucin in rat intestine, indicating that Eul–cys/GSH NPs have great potential to be applied as safe carriers for the oral administration of protein drugs.
研究领域:
药剂学
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生物材料
·
药物传递系统
·
纳米医学
·
蛋白质递送
✓ 已验证
DOI
高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2019
·
IF 1.479
Rongli Zhang,Hui Hao,Cuige Zhang,Renchun Yang,Mingyue Sun,Ching-Ping Wong,Ying Xu
A kind of bioadhesive hydrocaffeic acid modified chitosan colloidal particles (HCA-CS/TPP CPs) containing synthetic catecholamine groups was prepared via amidation reaction and ionic gelation. The formation process and property of the HCA-CS/TPP CPs were characterized by ultraviolet visible spectrophotometry and Zeta PALS instruments. The prepared HCA-CS/TPP CPs were then used as particulate emulsifier to stabilize Pickering emulsions. The stability of the Pickering emulsion droplet was characterized by digital camera and optical microscope. The results revealed that HCA-CS/TPP CPs exhibited good emulsifying property at a wide pH value range, which will endow the potential application of the Pickering emulsions stabilized by HCA-CS/TPP CPs in various fields.
研究领域:
材料科学
·
食品科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Xin Guo,Xingling Zeng,Yeqing He,Xiaoxia Zhang,Wenli Shi,Ruimin Ran,Guoying Li
Acute hemorrhage death on battlefields, during clinical surgeries, and in major accidents is a widespread worldwide problem. Clay-based hemostatic materials have received considerable attention for their low cost and reliable clotting activity, especially in cases of severe bleeding, such as QuikClot, which is a kaolin-based hemostatic gauze that is preferred for battlefield resuscitation. However, the easy detachment of clay particles and the associated risk of thrombosis have seriously hindered the development of clay-based hemostatic materials. Here, inexpensive palygorskite (Pal) nanoclay was integrated into the collagen (COL) matrix by loading Ca2+ in the clay and further using gallic acid (GA) to mediate the robust assembly of clay on the COL matrix. This targeted interfacial design is a simple and gentle method that effectively improves the dispersion of the Pal particles and reduces the risk of shedding. Unlike QuikClot where the aqueous solution was significantly turbid after 2 min of ultrasonic washing, the aqueous solution of the composite sponge (Ca-Pal-GA-COL) remained clear and was accompanied by 82.71% of the mass residue after 10 min of ultrasonic washing. The composite sponge also exhibited excellent antibacterial (87.93% inhibition rate of Escherichia coli), antioxidant, and tissue adhesion properties. Importantly, the Ca-Pal-GA-COL sponge exhibited less blood loss (632 mg) and a shorter hemostasis time (151 s) in a rat femoral artery hemorrhage model than the medical gauze (3850 mg and 299 s), pure COL sponge (1627 mg and 201 s), and Pal-COL sponge (1494 mg and 193 s) in a co-mingled mode, which are comparable to those of QuikClot (559 mg and 142 s). Furthermore, certain tissue adhesion properties render the Ca-Pal-GA-COL sponge more suitable than QuikClot for severe femoral artery active bleeding scenarios. Cellular experiments confirmed that the composite dressing has a certain biosafety.
研究领域:
生物材料
·
医学工程
·
创伤修复
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Yali Zhao,Jiayue Chen,BingXi Wang,Li Wei
An ideal and highly desired wound dressing for the repair of infectious wounds should provide a moist environment, close adhesion to the wound site, and self-healing and antibacterial properties. Thus, in the present study, we manufactured multifunctional, mussel-inspired hydrogels CACS-Fe 3+ -CYCS and CACS-Fe 3+ using catechol-grafted-chitosan (CACS) and cysteine-modified-chitosan (CYCS) as raw materials and ferric chloride as a cross-linking agent. The CACS-Fe 3+ -CYCS hydrogel exhibited excellent adhesion because of metal coordination between the ferric ion (Fe 3+ ) and catechol groups and a strong covalent bond between the catechol groups and the amino and sulfhydryl groups. Its self-healing quality was attributed to the dynamic and reversible properties of metal coordination. The loading of the total flavones of Resina Draconis (RDF) provided the hydrogel with good antibacterial properties. The antibacterial rates of the CACS-Fe 3+ -CYCS and RDF-CACS-Fe 3+ -CYCS hydrogels for Escherichia coli and Staphylococcus aureus were 90.62% and 96.45% and 99.98% and 100.00%, respectively. The RDF-CACS-Fe 3+ -CYCS hydrogel at pH 5.0, 6.8, and 8.0 in phosphate-buffered saline exhibited slow, sustained cumulative release rates of 53.94%, 71.97%, and 85.13% at 60 h, respectively. Complete wound healing was observed by day 12 in the CACS-Fe 3+ -CYCS hydrogel group (healing ratio = 96.59%). In the RDF-CACS-Fe 3+ -CYCS hydrogel group, complete healing was achieved by day 9 (healing rate = 94.46%; highest value at all treatment times). Thus, both hydrogels can be used as an ideal dressing for treating infectious wounds. The combination of traditional Chinese medicine and novel wound dressings can work synergistically, providing a novel strategy for designing biomimetic hydrogels for potential applications in wound healing.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2020
·
IF 3.862
Youjun He,Jiming Chen,Irum Rafique,Zaijun Lu
The catechol groups in mussel adhesive proteins exhibit excellent adhesion property to the skin and tissue surfaces. Inspired by catechol groups, the aim of this study is to synthesize the star-shaped polycaprolactone bio-adhesive bearing catechol end-groups (s-PCL 19 -CA 9 ). Firstly, star-shaped polycaprolactone was synthesized through ring-opening polymerization of caprolactone monomers initiated by β-cyclodextrin, and then the s-PCL 19 -CA 9 was obtained through end-group functionalization using succinic anhydride and dopamine. The structure of s-PCL 19 -CA 9 was characterized by 1 H NMR, FTIR, and static light scattering. Adhesive strength measurements demonstrate that the incorporation of multifunctional catechol groups endows the crosslinked s-PCL 19 -CA 9 with an excellent adhesion property (102 ± 10 kPa). The swelling ratio of crosslinked s-PCL 19 -CA 9 is as low as 3.4 ± 0.2% owing to the hydrophobicity of PCL and the crosslinking structures. Besides, the cytotoxicity studies show that s-PCL 19 -CA 9 is noncytotoxic. The TGA measurements indicate that s-PCL 19 -CA 9 possesses a good thermal stability. Therefore, this work provides a new way for developing multifunctional bio-adhesives with excellent adhesion property and low swelling ratio.
研究领域:
材料科学
·
生物医学工程
·
化学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2020
·
IF 3.408
Xiaoyuan Yin,Wencheng Liang,Youchang Wang,Yan Xiao,Yan Zhou,Meidong Lang
Antifouling materials are highly demanded in global marine market due to increasingly aggravated marine biofouling problem and unbalanced marine ecology . Herein, poly (vinyl imidazole- co -hydroxypropyl methacrylate- co -butyl acrylate) (P(VIm- co -HPMA- co -BA)) was prepared via free radical polymerization of commercially available monomers of vinyl imidazole (VIm), hydroxypropyl methacrylate (HPMA) and butyl acrylate (BA). Then the zwitterionic terpolymer (P(VPS- co -HPMA- co -BA)) was obtained by ionicalization of P(VIm- co -HPMA- co -BA) with 1, 3-propionate lactone (1, 3-PS) in EtOH solutions. Furthermore, the membrane samples, P(VIm- co -HPMA- co -BA) and P(VPS- co -HPMA- co -BA) were prepared by tape casting method with DI water bath. Significantly, P(VPS- co -HPMA- co -BA) membranes have shown better bactericidal activity against Gram-negative Escherichia coli ( E. coli ) and Gram-positive Staphylococcus aureus ( S. aureus ) with a mean area size of 3.5 cm 2 . Meanwhile, the bacterial adhesion assay showed that P(VPS- co -HPMA- co -BA) membranes were found the absence of adherent bacteria, and exhibited excellent anti-adhesion property with the increase of molar ratios of PVPS by the observation of bacteria population density. The mechanical testing results indicated that the molar ratios of 65/10/25 in P(VIm- co -HPMA- co -BA) membranes and P(VPS- co -HPMA- co -BA) membranes had high breaking elongation ratio and great tensile strength . Specifically, the maximum tensile strength of P(VPS- co -HPMA- co -BA) membrane could reach up to 10.9 MPa. The results showed that the novel P(VPS- co -HPMA- co -BA) membrane exhibited both anti-bacterial, anti-adhesion property and mechanical performance, manifesting its prospectively potential applications in new highly efficient and eco-friendly marine antifouling coatings.
研究领域:
材料科学
·
生物学
·
海洋科学
✓ 已验证
产品关联
DOI
高影响因子
Applied Materials Today
·
2025
·
IF 6.9
Mengyao Dong,Yunlong Sun,Gang Wang,Qing Ning,Qingjin Meng,Yi Zhao,Huige Wei
Ionic-conductive hydrogels with controllable adhesiveness are essential for bioelectrical signal monitoring. However, highly adhesive hydrogels may cause discomfort to human skin, such as redness, swelling and pain when peeled off, which hinders their applications. Here, we designed a temperature-triggered adhesiveness-controllable ionic-conductive P(Acrylamide-co-1-vinyl-3 butylimidazolium bromide)/gelatin (short for PILG) hydrogel based on body temperature. Due to the temperature sensitivity of gelatin(the gelatin triple helix unfurls and exposes a large number of side groups when reaching the phase transition temperature), the developed hydrogel shows a rapid increase in adhesiveness when exposed to body temperature and a rapid decrease in a short time (10 s) after cooling, enabling pain-free and residue-free removal. At the same time, PILG hydrogel has excellent sensitivity ( GF =4.16) and can detect various bioelectrical signals and accurately identify movements. The conductive hydrogel with temperature-triggered adhesive changes shows great potential in this work for biomedical applications.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Yujia Wu,Wen Zhang,Jianyu Huang,Zichen Luo,Junsong Li,Lingchong Wang,Liuqing Di
As polysaccharide from Bletilla striata (BSP) was anticipated with mucoadhesive improvement in sodium alginate (SA) microspheres, BSP was mixed with SA to construct a composite microsphere to retain in the gastrointestinal tract for a long time. The morphological properties, particle size and thermodynamic properties of the microspheres in combination with comprehensive evaluations in the swelling properties, mucin adsorption, ex vivo and in vivo gastric retention were determined to characterize the mucoadhesion of SA-BSP blend microspheres. Results showed that the prepared microspheres were discrete and spherical. The addition of BSP increased flexibility and reduced rigidity of SA microsphere. Furthermore, the swelling property, mucin adsorption ability and the retention rate on the gastric mucosa of SA matrix were increased after blending with BSP. Mucoadhesion tests showed the SA-BSP microspheres stayed much longer in rats' stomach than the SA microsphere did. Above all, the SA-BSP microspheres with the enhanced mucoadhesion suggested being a potential drug carrier in developing the gastroretentive drug delivery system.
研究领域:
药学
·
药物递送系统
·
生物药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Zhiqiang Zheng,Shaoquan Bian,Zhiqiang Li,Zhiyang Zhang,Yuan Liu,Xinyun Zhai,Haobo Pan,Xiaoli Zhao
Wound dressings based on injectable thermo-sensitive hydrogel possess several advantages over preformed conventional dressings such as rapid reversible sol-gel transition behavior and the capacity of filling the irregular wound defect. Nevertheless, its clinical application is hindered by the weak tissue adhesiveness. Therefore, in this study, the catechol modified quaternized chitosan (QCS-C) was fabricated and incorporated into poly(d,l-lactide)-poly(ethylene glycol)-poly(d,l-lactide) (PLEL) hydrogel to develop an injectable hydrogel with the properties of thermo-sensitive, antibacterial and tissue adhesive . QCS-C could lower the LCST of hydrogel for easy gelation at physiological temperature, and significantly enhanced the tissue adhesion. For wound generation, nano-scaled bioactive glass (nBG：80 SiO 2 , 16 CaO and 4 P 2 O 5 ; mol%) was loaded into hydrogel to promote angiogenesis. The mice partial laceration experiment showed that PLEL-nBG-QCS-C hydrogel could effectively seal the ruptured skin and significantly accelerate wound healing. Thus, our findings established a new type of clinical treatment technology for complicated wounds.
研究领域:
生物材料学
·
医学工程
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）