Nature Communications
·
2026
·
IF 18.1
An Yechen,Mei Liang,Yang Ruijie,Cui Jun,Zhang Wenhai,Han Jing-Long,Jiang Wenli,Ren Ruiyun,Gao Xiaoxu,He Zhihui,Xu Haoran,Yan Ruifeng,An Quan-Fu,Li Zhiling,Cheng Haoyi,Tao Yu,Wang Aijie,Zeng Zhiyuan
Membrane-based separation offers a sustainable route for resource recovery from high-salinity organic wastewater, yet graphene oxide (GO) membranes remain constrained by poor selectivity, limited solvent stability, and challenges in scale-up. Here, we report a hydroxylated single-walled carbon nanotube (SWCNT-OH) reinforced GO membrane, in which SWCNT-OH promotes robust inorganic crosslinking with sodium tetraborate (Na 2 B 4 O 7 ) to form rapid transport channels for water and ions, while suppressing organic passage. This architecture enhances the moxifloxacin (MXF)/NaCl separation factor more than fivefold (from 4.2 to 22.2) and increases water permeability over fourfold (from 7.2 to 30.1 l m −2 h −1 bar −1 ). The membrane was scaled up to 11 m 2 and deployed for continuous treatment of MXF crystallization mother liquor over seven days, delivering a stable recovery of 10 kg MXF per day under industrially relevant conditions. These findings establish a scalable strategy for the design of robust nanocarbon-based membranes, advancing resource-efficient treatment of high-salinity wastewater.
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PubMed
高影响因子
Food Analytical Methods
·
2022
·Vol. 16
·期 2
·386-400
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IF 3.498
Xie Lixia,Li Zhineng,Li Haitao,Sun Jiayu,Liu Xueying,Tang Jianxin,Lin Xizhu,Xu Laijun,Zhu Yuefang,Liu Zhi,Wang Tong
Rosemary is an essential source of natural antioxidants, and its extracts have been practised as a preserving agent in foods. A simple, fast, and efficient quantitative determination of principal phenolic antioxidants in rosemary with efficient sample preparation is of great importance for evaluating the quality of rosemary scientifically. This paper presented a chemometrics-enhanced high-performance liquid chromatography with photodiode-array detector (HPLC–DAD) method for simultaneous determination of rosmarinic acid (RA), carnosol (CAR), and carnosic acid (CA) in ultrasound-assisted rosemary extracts. After ultrasound-assisted extraction, the chromatographic procedure in less than 10 min performed with UV detection in the range of 200–390 nm. The alternating trilinear decomposition algorithm in second-order calibration has been applied in extracting relevant qualitative and quantitative information from the three-dimensional chromatographic data. The correlations between the recovered spectra and their normalized pure spectra for RA, CAR, and CA were 0.9906, 0.9988, and 0.9998, respectively. The average recoveries for RA, CAR, and CA were 94.1 ± 3.1%, 92.1 ± 4.1% and 91.8 ± 4.9%, respectively. Due to the second-order advantage, satisfactory resolution and acceptable quantification results were obtained in the presence of overlapping peaks. It expected that this study can provide some valuable references for the simultaneous determination of principal phenolic antioxidants in the quality control of rosemary. Graphical Abstract
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高影响因子
MOLECULES
·
2019
·Vol. 24
·期 14
·2537
·
IF 3.06
Yusong Jin,Yunhui Zhang,Dongmei Liu,Dewen Liu,Chunying Zhang,Huijuan Qi,Huiyan Gu,Lei Yang,Zhiqiang Zhou
To explore the optimum conditions for the extraction of anthocyanins and flavonols from bog bilberry (Vaccinium uliginosumL.) marc on a single-factor experimental basis, a response surface methodology was adopted for this intensive study. The extraction procedure was carried out in a Waring blender and followed an ultrasonic bath, and the natural antioxidant carnosic acid was added to inhibit oxidation. The optimum extraction conditions were as follows: a volume fraction of ethanol of 70%, an antioxidant content of 0.02% (the mass of sample) carnosic acid, a liquid–solid ratio of 16 mL/g, a homogenization time of 3 min, a reaction temperature of 55 °C, an ultrasound irradiation frequency of 80 kHz, an ultrasound irradiation power of 200 W, and an ultrasound irradiation time of 40 min. Satisfactory yields of anthocyanins (13.95 ± 0.37 mg/g) and flavonols (3.51 ± 0.16 mg/g) were obtained. The experimental results showed that the carnosic acid played an effective antioxidant role in the extraction process of anthocyanins and flavonols with a green and safety guarantee.Keywords:antioxidant capacity;polyphenol;fruit marc;natural antioxidant;response surface methodology
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高影响因子
Journal of Pharmaceutical Analysis
·
2025
·
IF 8.9
Xin Wei,Mingzhu Zuo,Qiongwen Liang,Shiwei Zhang,Jingmei Wang,Zhanfeng Li,Wenguang Yang,Fang Ma,Wangxiao He,Tianya Liu
Microsatellite-stable colorectal cancer (MSS-CRC) is characterized by poor immune infiltration and immune evasion, leading to rapid tumor progression and limited efficacy of current immunotherapies. The bioinformatics analysis revealed that the hyperactivation of the Wnt/β-catenin signaling pathway in MSS-CRC is instrumental in mediating immune suppression. Although inhibiting this pathway presents a therapeutic opportunity, no Wnt inhibitors have been clinically approved due to Wnt's essential role in maintaining tissue homeostasis, with inhibition in normal cells causing significant toxicity. To address it, we discovered that Wnt activation in colorectal cancer cells enhances macropinocytosis, particularly favoring the uptake of glycosylated proteins to meet increased nutrient demands. Building on this insight, we developed a glycosylated human serum albumin (GHSA) co-assembled with carnosic acid (CA), termed glycosylated human serum albumin-carnosic acid (GHSACA), which is selectively internalized by Wnt-activated colorectal cancer cells. This approach not only reduces off-target toxicity but also effectively inhibits the Wnt pathway, resulting in notable tumor inhibition and immune reactivation in murine models, while maintaining a favorable safety profile. This strategy offers a promising therapeutic solution by combining selective Wnt inhibition with enhanced immune activation in MSS-CRC, and highlights the potential of leveraging disease-specific cellular uptake mechanisms for designing nanomedicines, advancing the development of precision-targeted cancer therapies.
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高影响因子
Journal of Future Foods
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2025
·
IF 7.2
Haiyan Wen,Jianping Li,Jiaheng Yin,Yutong Hu,Rong Wang,Haohuan Li,Siqi Zhou
Osteoarthritis (OA), the most prevalent degenerative joint disease, currently lacks effective disease-modifying therapeutic agents. Accumulating evidence has highlighted the involvement of gut microbiota in OA via gut-joint axis. This study demonstrated that dietary carnosic acid (CAD) supplementation significantly modulated the gut microbiota composition and metabolites to improve the intestinal barrier integrity and mitigate joint damage in the anterior cruciate ligament transection (ACLT)-induced OA mice. Integrated analyses of 16S rRNA sequencing and untargeted metabolomics revealed that specific gut microbial families (Lachnospiraceae and Akkermansiaceae) and the plasma metabolite carnosol are key contributors to the protective effects of CAD intervention. Mechanistically, RNA-sequencing and experimental validation showed that CAD suppressed the inflammatory response in IL-1β-induced chondrocytes via the inhibition of the CCAAT/enhancer binding protein β (CEBPβ)/nuclear factor-κB (NF-κB) signaling pathway. Collectively, these findings provide a potential dietary intervention strategy for the management of OA.
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高影响因子
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