ACS Applied Nano Materials
·
2022
·
IF 6.14
Jialin Pan,Meiling Zhang,Gege Fu,Li Zhang,Huimei Yu,Xu Yan,Fangmeng Liu,Peng Sun,Xiaoteng Jia,Xiaomin Liu,Geyu Lu
Although the advent of two-dimensional (2D) MXenes has substantially increased the family of 2D materials and diverse applications, the rational design of MXene-based composites and their specialized applications in theranostic biomedicine remain a challenge. In this work, we developed, for the first time, Ti3C2 MXene nanosheets for near-infrared (NIR)-IIb (1530 nm) and magnetic resonance (MR) imaging-guided photothermal therapy. Surface engineering and functionalization of 2D Ti3C2 MXene nanosheets with NaErF4:0.5%Tm@NaLuF4 (NaErF4) nanoparticles result in NaErF4@Ti3C2 composites that emit in the NIR-IIb region at 1530 nm under 808 nm excitation, conferring NIR-IIb imaging guidance and monitoring capabilities during tumor hyperthermia. Due to the inherent magnetic properties of the Er3+ ions, the NaErF4@Ti3C2 composite can also be used for efficient T2-weighted MR imaging. In particular, based on the high photothermal conversion capability (43.62% at 808 nm irradiation) and photothermal stability, the designed composites were further explored for efficient tumor ablation with an inhibition ratio of 92.9%, which was systematically demonstrated both in vitro and in vivo. No significant nanocomposite toxicity was observed at the injected dose. This work not only expands the performance of MXene-based multifunctional nanostructures but also highlights the promise of their versatile applications in cancer therapy.
研究领域:
材料科学
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生物医学工程
·
纳米医学
·
癌症治疗
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 17
·14283-14289
·
IF 3.289
Peng Zhang,Yangyang He,Jianhua Liu,Jing Feng,Zhiqiang Sun,Pengpeng Lei,Qinghai Yuan,Hongjie Zhang
Lanthanide-doped nanocrystals have been researched extensively and used for bioimaging because of their optical properties, magnetic properties and X-ray absorption. Core–shell-structured lanthanide-doped nanocrystals have been developed and characterized by TEM and XRD analysis. The nanocrystals are composed of BaYbF5:0.5% Tm as the core and BaGdF5:20% Yb, 0.5% Tm as the shell. Apart from characterization of the nanocrystals, evaluation of both their cytotoxicity via MTT assays and their long-term toxicity via histological analysis showed that their cytotoxicity was low, indicating the possibility of further in vivo imaging. This work combined the functions of trimodal imaging into one nanoplatform and then UCL, CT, and MR imaging with core–shell-structured nanocrystals were investigated both in vitro and in vivo. Taking into consideration its structural characteristics and trimodal imaging abilities, it is expected that the developed multifunctional nanoplatform may be potentially useful for diagnosing diseases at an early stage.
研究领域:
生物医学工程
·
材料科学
·
影像医学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2023
·Vol. 39
·期 6
·1070-1076
·
IF 3.1
Liu Deye,Lu Yang,Li Xu,Liu Fengmin,Liu Xiaomin,Lu Geyu
I n this study, we synthesized a core-shell structure of up-conversion nanoparticles (UCNPs) and deposited it on the surface of fluorine-doped tin oxide (FTO). Subsequently, we assembled a series of perovskite solar cells with FTO/UCNPs/c-TiO 2 /mp-TiO 2 /MAPbI 3 /Spiro-OMeTAD/Au structures with an effective area of 0.04 cm 2 . To optimize the devices, we adjusted the concentration of UCNPs precursor. The optimized device showed a power conversion efficiency (PCE) of 16.73% and a short-circuit current density ( J sc ) of 26.94 mA/cm 2 at AM 1.5. These values are 9.20% and 10.47% higher than those of the best performing control device (15.32% for PCE and 24.12 mA/cm 2 for J sc ), respectively. Furthermore, we characterized the perovskite layer, charge transport layer, and perovskite solar cells using various analytical methods. The results showed that the addition of UCNPs not only improved the charge extraction and transfer, but also enhanced the stability of electron transport layer devices. In conclusion, our findings offer a process for optimizing perovskite cells using UCNPs and preliminarily analyzing their principles.
研究领域:
材料科学
·
能源研究
✓ 已验证
DOI
高影响因子
ACS Nano
·
2018
·
IF 13.709
Jing Zuo,Langping Tu,Qiqing Li,Yansong Feng,Ivo Que,Youlin Zhang,Xiaomin Liu,Bin Xue,Luis J. Cruz,Yulei Chang,Hong Zhang,Xianggui Kong
Photoswitchable materials are important in broad applications. Recently appeared inorganic photoswitchable upconversion nanoparticles (PUCNPs) become a competitive candidate to surmount the widespread issue of the organic counterparts —photobleaching. However, current PUCNPs follow solely Yb3+/Nd3+ cosensitizing mode, which results in complex multilayer doping patterns and imperfectness of switching in UV–blue region. In this work, we have adopted a new strategy to construct Nd3+ free PUCNPs—NaErF4@NaYF4@NaYbF4:0.5%Tm@NaYF4. These PUCNPs demonstrate the superior property of photoswitching. A prominent UV–blue emission from Tm3+ is turned on upon 980 nm excitation, which can be completely turned off by 800 nm light. The quasi-monochromatic red upconversion emission upon 800 nm excitation—a distinct feature of undoping NaErF4 upconversion system—endows the PUCNPs with promising image-guided photoinduced “off–on” therapy in biomedicine. As a proof-of-concept we have demonstrated the imaging-guided photodynamic therapy (PDT) of cancer, where 800 nm excitation turns off the UV–blue emission and leaves the emission at 660 nm for imaging. Once the tumor site is targeted, excitation switching to 980 nm results in UV–blue emission and the red emission. The former is used to induce PDT, whereas the latter is to monitor the therapeutic process. Our study implies that this upconversion photoswitching material is suitable for real-time imaging and image-guided therapy under temporal and spatial control.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
·
诊疗学
·
光学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）