Scientific Reports
·
2017
·Vol. 7
·期 1
·1-13
·
IF 4.259
Zhao Wenwen,Feng Haitao,Guo Shuhui,Han Yantao,Chen Xiuping
ICAM-1 overexpression and subsequent adhesion of leukocytes to endothelial cells play critical roles in the early stage of atherosclerosis. Danshenol A (DA) is an abietane-type diterpenoid isolated from traditional Chinese herb Salvia miltiorrhiza Bunge. The mechanisms under its regulation of adhesion of molecular expression are explored. Here, the effect of DA on TNF-α-induced ICAM-1 expression was investigated in endothelial cells. TNF-α-induced ICAM-1 expression and subsequent adhesion of monocytes, as well as elevated reactive oxygen species (ROS) generation and NOX4 expression were all significantly reversed by DA, siNOX4 and NOX4 inhibitor GKT137831. Furthermore, TNF-α-induced ICAM-1 expression, which was increased via IKKβ/IκBα-mediated activation of NF-κB p65, was also inhibited by DA. Interestingly, NOX4 overexpression suppressed the ICAM-1 expression, and this finding may be ascribed to the activation of Nrf-2. Additionally, NF-κB inhibitor PDTC, siNOX4, or DA can decrease the TNF-α-induced ICAM-1 expression and suppress the adhesion of monocytes. In all, DA inhibited TNF-α-induced ICAM-1 expression and subsequent monocyte adhesion to endothelial cells through the NOX4-dependent IKKβ/NF-κB pathway. Besides, NOX4 played dual role in regulating ICAM-1 expression via diverse signal pathway. This novel bioactivity will make DA a good candidate to be further explored for therapeutic or preventive application for atherosclerosis.
研究领域:
药理学
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心血管疾病
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Energy Storage Materials
·
2021
·
IF 17.789
Weibo Huang,Yan Wang,Linze Lv,Wei Wang,Chengchang Jin,Guobin Zhu,Qiang Shi,Qunting Qu,Chao Jin,Honghe Zheng
Fluoroethylene carbonate (FEC) is an important electrolyte additive in silicon (Si) anodes. However, it is easily defluorinated by Lewis acids (PF 5 − ) to form harmful corrosive substances (HF). To overcome this problem, 1-Hydroxyethylidene-1, 1-diphosphonic acid (HEDP), a novel multifunctional surface modifier is developed on the Si surface. It can not only consume HF, but also participate in the formation of a solid electrolyte interphase (SEI) film with excellent electrochemical stability, high lithium conductivity, and good thermal stability. In addition, Si@HEDP anode with polyvinylidene fluoride (PVDF) binder exhibits much improved electrochemical performance. After 500 cycles at 30 °C, a high reversible capacity of 1831.8 mAh g − 1 is obtained; and after 200 cycles at 60 °C, it still maintains 2163.8 mAh g − 1 ; which are in sharp contrast to the reference Si anode of almost zero capacity after 25 cycles. This work overcomes the fundamental challenges of using FEC electrolyte additive and PVDF binder in Si-based batteries.
研究领域:
材料科学
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电化学
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电池技术
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DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 3
·1-11
·
IF 5.3
Liu Huamin,Li Chenghong,Wang Lina,Fang Lichao,Huang Hui,Deng Jun,Hu Yue,Li Mimi,Ran Xiaoping,Li Lulu,Zheng Junsong
A “signal-off” photoelectrochemical (PEC) sensing platform has been designed for the ultrasensitive detection of DNA methylation levels and multiple methylated sites. The platform employs tungsten trioxide and TpPa-1-COF loaded by gold nanoparticle (AuNPs@WO 3 @TpPa-1-COF) composite material as the photoactive component and p-type reduced graphene (rGO) as an efficient quencher. The PEC signal of AuNPs@WO 3 @TpPa-1-COF composite is effectively quenched in the presence of p-type rGO, because p-type rGO can compete with AuNPs@WO 3 @TpPa-1-COF to deplete light energy and electron donors. In addition, a hybrid strand reaction (HCR) amplification strategy fixes more target DNA and then combines with rGO-modified anti-5-methylcytosine antibody to facilitate ultrasensitive DNA methylation detection. Under optimal conditions, DNA methylation can be measured within a linear concentration range of 10 –14 to 10 –8 M, with an exceptionally low detection limit of 0.19 fM (S/N = 3). At the same time, the platform can conduct quantitative determination of multi-site methylation, with the linear equation △I = 44.19Log A + 61.43, and the maximum number of methylation sites is 5. The sensor demonstrates high sensitivity, excellent selectivity, and satisfactory stability. Furthermore, the proposed signal-off PEC strategy was successfully employed to detect DNA methylation in spiked human serum samples, with recoveries ranging from 93.17 to 107.28% and relative standard deviation (RSD) ranging from 1.15 to 5.49%. Graphical
研究领域:
生物化学
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分析化学
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材料科学
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DOI
PubMed
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2017
·Vol. 27
·期 1
·101-109
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IF 1.577
Li Qian,Liu Li,Zhong Xin-Xin,Li Fa-Bao,Asiri Abdullah M.,Alamry Khalid A.,Zhu Nian-Yong,Wong Wai-Yeung,Qin Hai-Mei
Abstract A series of neutral luminescent tetranuclear and mononuclear copper(I) halide complexes, [Cu 4 I 4 (dpna) 4 ] ( 1 ) and [CuX(dpna) 2 ] dpna = 1-(diphenylphosphino)naphthalene, X = Br ( 2 ), Cl ( 3 ), were synthesized, and their molecular structures and photophysical properties were investigated. Complex 1 has a cubane-like structure with four Cu atoms pseudo -tetrahedral and four I atoms serving as μ 3 -bridges. The coordination geometry of the copper centers in 2–3 are trigonal-planar. In the solid state, complexes 1–3 display blue photoluminescence (λ max = 423–463 nm) at 298 K. The emission of the complexes originate from the (σ+X)→π* transition. All three complexes displayed good thermal stability. Graphical Abstract
研究领域:
无机化学
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材料科学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2019
·
IF 3.131
Jianhua Kang,Sultan Ahmed Khoso,Yuehua Hu,Wei Sun,Zhiyong Gao,Runqing Liu
A selective organic depressant was investigated to promote the separation of scheelite from calcite and fluorite . 1-Hydroxyethylidene-1, 1-diphosphonicacid (HEDP) could efficiently reduce the recoveries of calcite and fluorite to less than 20%, while that of scheelite remained above 85%. The selective interaction mechanism was demonstrated via Zeta potential and X-ray photoelectron spectroscopy (XPS) analyses. The conceivable adsorption models of reagents on mineral surfaces were constructed to explain their adsorption mechanism. HEDP exhibited an excellent ability to selectively depress calcite and fluorite attributed to the intense adsorption on their surfaces, whereas its adsorption on scheelite surface was feeble. The technology feasibility of using HEDP to improve the scheelite flotation performance was verified through laboratory and industrial tests. The roughing grade was dramatically improved from 1.22% to 1.68%, and the product grade was enhanced from 24.66% to 28.26% with a noteworthy improvement of cleaning recovery by 6.93%, which would produce a considerable economic benefit.
研究领域:
矿物加工工程
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表面化学
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产品关联
DOI
高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2013
·Vol. 66
·期 1
·84-90
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IF 1.66
Kong Gengjin,Guo Zhihan,Shen Chunhui,Chen Cheng
Proton conductive inorganic–organic hybrid membranes were synthesized from Epoxycyclohexylethyltrimethoxysilane (EHTMS) and 1-hydroxyethane-1,1-diphosphonic acid (HEDPA) by the sol–gel method. In this paper, the effect of gel temperature, membrane-forming temperature and Si/P on hybrid membranes performance were discussed. FT-IR studies revealed the phosphonic acid was chemically bonded to the siloxane network. When the membrane-forming temperature is 150 °C, thermal analysis including TG and DTG confirmed that the hybrid membranes were thermally stability up to 250 °C and SEM images showed that the membranes surface smooth and dense, eliminating the phase separation phenomenon. The hybrid membranes with a molar ratio of Si/P = 6/1 possess better thermal stability and preferable flexibility.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2020
·Vol. 27
·期 14
·16745-16753
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IF 3.056
Yu Cheng,Zhang Yi,Fang Yu,Tan Yujie,Dai Ke,Liu Shilin,Huang Qiaoyun
Shewanella oneidensis MR-1 (MR-1)-impregnated alginate capsules with 3D porous structure were prepared through cation crossing-linking and was used for the Cr(VI) reduction and removal. After being encapsulated by alginate, the endurance of the MR-1 was largely enhanced under conditions of high Cr(VI) concentrations (up to 4 mM) and low pH (pH 5). The Cr(VI) reduction over the MR-1-impregnated alginate capsules could be fitted by pseudo first-order kinetic model. With the Cr(VI) initial concentration increasing from 1 to 4 mM, the first-order rate constant for the encapsulated MR-1 ( k capsules ) and free cells ( k cells ) fell by 26.3% and 82.4%, respectively. At pH 5, the k capsules value was 0.19 h − 1 , which was about 3.7 times higher than k cells . Moreover, the encapsulated MR-1 held 90.5% of the Cr(VI) reduction ability after 15 days of resting time, while the free MR-1 held 19.7%. After bioreduction, 73.6% of total chromium was adsorbed on the MR-1 impregnated Ca-alginate capsules. XPS results showed 85% of the adsorbed chromium was Cr(III). The mechanism for chromium removal over the MR-1-impregnated Ca-alginate capsules was proposed with the following steps: (1) Cr(VI) was bioreduced via the encapsulated MR-1; (2) the reduced soluble Cr(III) was adsorbed by alginate selectively. In the study, the Ca-alginate shell of the cabbage-like MR-1 impregnated capsules could be a shelter for encapsulated MR-1 to endure unfavorable conditions (e.g., low pH and high concentration of Cr(VI)) and immobilize the soluble chromium. Considering the obtained capsules derived from biomolecules were environment-friendly, the MR-1-impregnated Ca-alginate capsules were potential for the application in the remediation of environmental pollution.
Graphical abstract
研究领域:
环境科学
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微生物学
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DOI
高影响因子
EMBO JOURNAL
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2020
·Vol. 39
·期 16
·e103631
·
IF 9.889
Xianping Wang,Jihong Gong,Le Zhu,Shen Wang,Xiaoyu Yang,Yuanyuan Xu,Xiaofei Yang,Cong Ma
Priming of synaptic vesicles involves Munc13-catalyzed transition of the Munc18-1/syntaxin-1 complex to the SNARE complex in the presence of SNAP-25 and synaptobrevin-2; Munc13 drives opening of syntaxin-1 via the MUN domain while Munc18-1 primes SNARE assembly via domain 3a. However, the underlying mechanism remains unclear. In this study, we have identified a number of residues in domain 3a of Munc18-1 that are crucial for Munc13 and Munc18-1 actions in SNARE complex assembly and synaptic vesicle priming. Our results showed that two residues (Q301/K308) at the side of domain 3a mediate the interaction between the Munc18-1/syntaxin-1 complex and the MUN domain. This interaction enables the MUN domain to drive the opening of syntaxin-1 linker region, thereby leading to the extension of domain 3a and promoting synaptobrevin-2 binding. In addition, we identified two residues (K332/K333) at the bottom of domain 3a that mediate the interaction between Munc18-1 and the SNARE motif of syntaxin-1. This interaction ensures Munc18-1 to persistently associate with syntaxin-1 during the conformational change of syntaxin-1 from closed to open, which reinforces the role of Munc18-1 in templating SNARE assembly. Taken together, our data suggest a mechanism by which Munc13 activates the Munc18-1/syntaxin-1 complex and enables Munc18-1 to prime SNARE assembly.
研究领域:
神经科学
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细胞生物学
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分子生物学
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DOI
PubMed
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2015
·Vol. 41
·期 11
·8307-8315
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IF 1.221
You Kuiyi,Zhou Zhongcang,Jian Jian,Deng Renjie,Liu Pingle,Ai Qiuhong,Luo He’an
A simple method for the preparation of dinitronaphthalene from the nitration reaction of 1-nitronaphthalene with NO 2 as nitration reagent under the mild conditions has been successfully developed in this work. The results indicated that Ni(CH 3 COO) 2 ·4H 2 O catalyst shows better catalytic performances, and the conversion of 1-nitronaphthalene is 33.10 % with 34.10, 23.56, 19.30, and 3.56 % of the selectivity to 1,5-DNN, 1,3-DNN, 1,4-DNN, and 1,8-DNN, respectively, under the optimal reaction conditions. This is a mild, environmentally benign, and economical method for the preparation of dinitronaphthalene.
研究领域:
化学
·
环境科学
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DOI
高影响因子
CATALYSIS LETTERS
·
2024
·
IF 2.3
Yin Pengyu,Nie Jiayuan,Wen Xiangyu,Li Zhihui,Zhang Dongsheng,Zhao Xinqiang,Wang Yanji
ε-Caprolactam (CPL) is an important organic chemical raw material used as a monomer in the production of nylon 6. The traditional production process employs fuming sulfuric acid as a catalyst, leading to serious equipment corrosion and environmental pollution. While vapor-phase Beckman rearrangement reaction offers a solution to these issues. Unfortunately, the catalyst used is susceptible to carbon deposition and deactivation during the vapor-phase Beckman rearrangement process. Herein, a kind of mixed acid-modified hollow TS-1 zeolite was prepared in this study. It is a hollow structure of TS-1 zeolite formed by secondary crystallization, which is conducive to the shortening of the reaction path and the improvement of the anti-carbon accumulation performance. Further investigation revealed that modification of the hollow TS-1 zeolite with mixed acids facilitates the removal of non-skeletal titanium, and reduces the amount of Lewis acid in the catalyst, thereby improving its catalytic performance. Under optimal conditions, the cyclohexanone oxime (CHO) conversion rate reached 100%, with a caprolactam selectivity exceeding 98%. Notably, the catalytic activity of the catalyst remained stable after 500 h of continuous operation. Graphical Abstract
研究领域:
催化化学
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材料科学
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产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2019
·Vol. 26
·期 12
·12237-12246
·
IF 2.914
Yang Mi,Shi Xianyang
Biosynthesized nanocomposites are attracting growing interests because they are environmentally friendly. Ag 2 S nanoparticles (Ag 2 S NPs) are deposited in situ on the surfaces of TiO 2 nanotubes (TNTs) via Shewanella oneidensis MR-1 to form Ag 2 S/TNT nanocomposites. The prepared Ag 2 S/TNTs nanocomposites are characterized using high-resolution transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and energy-dispersive X-ray spectroscopy. The results show that Ag 2 S NPs smaller than 8 nm are successfully synthesized and fabricated on the TNT surfaces with relatively uniform distribution. The catalytic performance of the Ag 2 S/TNT nanocomposites is evaluated for catalytic reduction in the presence of NaBH 4 and the photocatalytic degradation of 4-nitrophenol (4-NP) under visible light. The Ag 2 S/TNT nanocomposites show excellent catalytic activity and good stability in the 4-NP reduction process. The 4-NP degradation ratio reaches 98.3% in 50 min, and 87% conversion was achieved after eight cycles. The Ag 2 S/TNT nanocomposites also exhibit excellent photocatalytic activity for 4-NP at a rate of 0.69 h −1 , and the complete degradation of 4-NP was observed within 5 h. Therefore, this study offers an environmentally friendly approach to synthesize nanocomposites for practical applications.
研究领域:
环境科学
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纳米生物学
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催化化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2020
·
IF 2.888
Xingchuan Yang,Xiangmeng Chen,Chunmei Cao,Li Xu,Guoji Liu
Solubility and liquid–liquid equilibria data for ternary systems for (water + 1,6-hexanediol + 1-butanol/2-methyl-1-propanol) were obtained at (293.15–323.15) K under atmospheric pressure. The LLE data were determined using a double-jacketed glass vessel, and the solubility curves were acquired by the cloud-point method. The distribution coefficient and separation factors were calculated and the reliability of experimental data was assessed by the Othmer–Tobias equation and Hand equation. The measured LLE data were fitted by NRTL and UNIQUAC models and binary parameters were obtained by using of Aspen Plus software. The calculated root-mean-square deviation values show that the calculated results from models showed good agreement with experimental data.
研究领域:
化学工程
·
热力学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）