JOURNAL OF ALLOYS AND COMPOUNDS
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2017
·
IF 3.133
Yan-xia Wang,Feng Li,Feng Wang,Yan-feng Pu,Ning Zhao,Fu-kui Xiao
The effects of the polymerization conditions on the yield of insoluble sulfur were investigated by using olefin, such as the 1,-dodecene, 1,-tetradecene, 1,-octadecene as well as acids, such as the salicylic acid, lauric acid and the oleic acid as polymerization stabilizers . The properties of the as-prepared insoluble sulfur were characterized by mu-Raman spectrometer and differential scanning calorimetry (DSC). The results demonstrated that both the olefin and acid stabilizers could couple with the end groups of the IS, thus improved the thermal stability of the IS, and the olefin stabilizers were superior to the acid stabilizers. The stabilizing effect of oleic acid was the best for the acid stabilizers, and the C C in the oleic acid played a crucial role in the stabilization of the IS.
研究领域:
化学
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材料科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Haoran Ma,Wei Zhao,Ping Li,Ailing Huang
Alkylbenzene (LAB) is an important benzene derivative that can be used as a raw material for high-performance anionic surfactants such as alkylbenzene sulfonates (LAS) to meet the new requirements for surfactants in many fields. LAB can be synthesized through Friedel-Crafts reaction in the presence of acidic catalysts as alkylating agents, which is commonly used in the production of fine chemicals. In this work, a novel and efficient continuous flow micro reaction system was introduced to enhance the production of long-chain alkylbenzene catalyzed by [(CH 3 ) 3 NH][Al 2 Cl 7 ] ionic liquid. The optimal conditions were investigated for the synthesis of long-chain alkylbenzenes with the 1-tetradecene and mixing α-alkenes of C 14 -C 16 from Fischer-Tropsch process. The results showed that the yield of benzene alkylation can achieve 99 % under the optimal process conditions which the reaction tube length was 2000 mm, the reaction temperature was 30 ℃, the catalyst dosage was 0.30 mL/min and the molar ratio of aluminum chloride to trimethylamine hydrochloride was 2:1. In addition, α-alkenes with C 14 -C 16 lead to deactivation of the ionic liquids catalyst easier because of transfer of AlCl 3 from the ionic liquid to the organic phase compared to the pure 1-tetradecene as an alkylating agent. Continuous synthesis of the long-chain alkylbenzenes catalyzed by ionic liquids can achieve in the microchannel reaction system by controlling the flow patterns.
研究领域:
化学工程
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催化化学
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DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
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2024
·
IF 4.1
Haoran Ma,Ping Li,Ailing Huang,Wei Zhao,Xuelan Zhang
Sulfonation of 1-tetradecene with liquid-phase sulfur trioxide generates simultaneously the alkene sulfonic acid and alkene sulfonate. The kinetics study is contributed to a deeper understanding of the sulfonation reaction and better controlling the process. The continuous microfluidic system was established to determine the kinetic parameters of 1-tetradecene sulfonation. A comprehensive kinetic model was developed, and the kinetic parameters were obtained. The activation energy is 14.7 ± 0.8 kJ mol −1 , with a pre-exponential factor of 118.4 ± 1.4. The reaction order for 1-tetradecene is second-order, and for sulfur trioxide, the reaction order is 0.3. By discretizing the reactor into microelements and conducting mass balance on each differential element method, integrating the obtained reaction kinetics model, calculating the required reaction time, and comparing it with experimental data within a reasonable range of error, the correctness of the derived reaction kinetics model has been verified.
研究领域:
化学工程
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物理化学
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微流控技术
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DOI
高影响因子
RSC Advances
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2024
·Vol. 14
·期 18
·12853-12863
·
IF 3.9
Hong-Bin Ju,Li-Zhi Zhang,De-Bao Li,Tao Geng,Ya-Jie Jiang,Ya-Kui Wang
In this study, two types of catalysts were prepared by the combination of gemini quaternary ammonium salt with two distinct species of phosphotungstic acid. Catalysts prepared by the Wells–Dawson type of phosphotungstic acid and Keggin-type phosphotungstic acid both exhibited dual-phase catalytic behavior, demonstrating both heterogeneous and homogeneous catalytic activities. In comparison to the catalyst prepared by the Keggin-type phosphotungstic acid, due to the higher size of Wells–Dawson type of phosphotungstic acid, hydrogen bonding could not effectively affect the catalyst prepared by H6P2W18O62. Subsequently, the influential factors on the catalytic reaction were investigated. Through the utilization of techniques such as XPS, FT-IR, Raman spectra and other characterization methods, two distinct structure and reaction mechanisms for these catalysts were elucidated under the influence of hydrogen bonding.
研究领域:
催化化学
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材料科学
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有机合成
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产品关联
DOI
PubMed
高影响因子
Advanced Fiber Materials
·
2025
·
IF 21.3
Li Qianyi,Chen Liang,Yu Jie,Zhao Jingwen,Shi Nuo,Saiding Qimanguli,Du Yawei,Yao Wenfei,Lu Yiming,Wang Juan,Cui Wenguo
Neural cell senescence hinders spinal cord nerve function recovery, and existing therapies that target senescent cell clearance haven’t effectively addressed cellular senescence. In this study, injectable short fibers that accurately maintain genome homeostasis in real time were developed, which for the first time reversed neural cell senescence by blocking the excessive intervention of cell inspection points. First, the oxidization-sensitive hybrid liposomes were prepared by combining Bakuchiol (BAK), a natural plant extract with the ability of DNA protection, with the oxidization-sensitive phospholipid S-PC. Subsequently, the short fibers regulating the cell inspection points (ISN@n-BAK) were constructed by further complexing the oxidation-sensitive hybrid liposomes with short fibers through π – π conjugation and catechol groups mussel-stimulated polydopamine (PDA). In vitro experiments demonstrated that ISN@n-BAK promotes neural stem cell differentiation into neurons and has anti-aging effects across various aging stages. In vivo, ISN@n-BAK responded to excessive ROS by triggering oxidation-sensitive liposomes to release BAK, protecting against DNA damage, suppressing aging-related gene expression in Cdkn2a and Cdkn2c and inhibiting inspection point restrictions. Bioinformatics showed that ISN@n-BAK reversed neural cell senescence and aided spinal cord nerve regeneration by activating the endogenous cell cycle, downregulating the PI3K-Akt pathway and upregulating the Rap1 pathway. This study introduces a novel therapeutic approach using short fibers that inhibit inspection points intervention to rejuvenate injured spinal cords. Graphical
研究领域:
生物医学工程
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神经科学
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分子生物学
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DOI
高影响因子
Materials
·
2026
·Vol. 19
·期 5
·
IF 3.7
Jiazhen Qiu,Xin Tian,Kaihua Li,Jiangqi Zhao,Shiqing Tian,Jinsong Liu,Xin Yang,Jun Li,Ying Liu
The purity of titanium sponge is crucial for determining the performance of final titanium alloys, underscoring the importance of impurity control in its precursor, TiCl4. Among these impurities, VOCl3is particularly challenging to remove due to its similar boiling point and complete miscibility with TiCl4. Although organic reagents are widely employed for vanadium removal, their complex compositions complicate the identification of key active components. This study systematically compares the vanadium removal efficiency of six organic compounds bearing different functional groups. Results demonstrate that 1-dodecene exhibits superior performance, achieving a VOCl3removal efficiency of 93.35%. Mechanistic studies reveal that 1-dodecene initially undergoes cyclization to form cyclododecane, followed by aromatization and subsequent carbonization through stacking, dehydrogenation, and coking, ultimately yielding partially graphitized amorphous carbon. In this process, VOCl3interacts not only with the incompletely carbonized organic precursor but also directly with the alkenes. These findings elucidate the reaction pathway and central role of linear α-alkenes in vanadium removal, providing a theoretical foundation for developing efficient and stable vanadium removal agents.
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2021
·
IF 2.694
Zenghui Wang,Wenyang Fan,Dongmei Xu,Shanshan He,Huiwen Huang,Jun Gao,Yinglong Wang
Clean utilization of catalytically cracked diesel is of paramount importance in the industry. The separation of polycyclic aromatic hydrocarbons (PAHs) from catalytically cracked diesel can significantly reduce the content of aromatics and increase the cetane number to improve the quality of diesel. In this work, for extracting the PAH 1-methylnaphthalene from the model fluid catalytic cracking diesel, the liquid–liquid equilibrium phase behavior for the quaternary systems (n-decane + 1-tetradecene + 1-methylnaphthalene + sulfolane/dimethyl sulfoxide) were explored at 303.15, 323.15, and 343.15 K under 0.1 MPa. The separation performance was characterized by the separation factor and distribution coefficient. The results showed that sulfolane was a suitable extractant compared to DMSO. The reliability of the measured phase equilibrium data was evaluated by the Hand and Othmer–Tobias equations. The UNIQUAC and NRTL models were applied to fit the tie-line data of the investigated mixtures with the AARD and rmsd lower than 0.01. The intermolecular interaction was explored by the σ-profile analysis to compare the separation performance of sulfolane and DMSO.
研究领域:
化学工程
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分离科学
·
石油加工
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DOI
高影响因子
Bioactive Materials
·
2022
·
IF 16.874
Yimeng Shu,Ming Ma,Xiaoxia Pan,Muhammad Shafiq,Huizhu Yu,Hangrong Chen
Mesenchymal stem cells (MSCs) transplantation is a promising approach for pulmonary fibrosis (PF), however it is impeded by several persistent challenges, including the lack of long-term tracking, low retention, and poor survival of MSCs, as well as the low labeling efficiency of nanoprobes. Herein, a cobalt protoporphyrin IX (CoPP) aggregation-induced strategy is applied to develop a multifunctional nano-self-assembly (ASCP) by combining gold nanoparticle (AuNPs), superparamagnetic iron oxide nanoparticles (SPIONs), and CoPP through a facile solvent evaporation-driven approach. Since no additional carrier materials are employed during the synthesis, high loading efficiency of active ingredients and excellent biocompatibility are achieved. Additionally, facile modification of the ASCPs with bicyclo[6.1.0]nonyne (BCN) groups (named as ASCP-BCN) enables them to effectively label MSCs through bioorthogonal chemistry. The obtained ASCP-BCN could not only help to track MSCs with AuNP-based computed tomography (CT) imaging, but also achieve an SPIONs-assisted magnetic field based improvement in the MSCs retention in lungs as well as promoted the survival of MSCs via the sustained release of CoPP. The in vivo results demonstrated that the labeled MSCs improved the lung functions and alleviated the fibrosis symptoms in a bleomycin–induced PF mouse model. Collectively, a novel ASCP-BCN multifunctional nanoagent was developed to bioorthogonally-label MSCs with a high efficiency, presenting a promising potential in the high-efficient MSC therapy for PF.
研究领域:
纳米技术
·
生物医学工程
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干细胞治疗
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医学影像
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药学
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肺科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2015
·Vol. 132
·期 31
·
IF 1.768
Haitao Huang,Tao Yue,Yanyun Xu,Ke Xu,Haibo Xu,Shiyuan Liu,Jiahui Yu,Jin Huang
To enhance biocompatibility and physiological stability of hydrophobic MnO nanoparticles as contrast agent of T 1 -weighted magnetic resonance imaging (MRI), dopamine-functionalized poly(ethylene glycol) (PEG) was used to coat the surface of about 5 nm MnO nanoparticles. Although hydrophilic coating might decrease longitudinal relaxivity due to inhibiting the intimate contact between manganese of nanoparticle surface and proton in water molecules, higher longitudinal relaxivity was still maintained by manipulating the PEGylation degree of MnO nanoparticles. Moreover, in vivo MRI demonstrated considerable signal enhancement in liver and kidney using PEGylated MnO nanoparticles. Interestedly, the PEGylation induced the formation of about 120 nm clusters with high stability in storing and physiological conditions, indicating passive targeting potential to tumor and prolonged circulation in blood. In addition, the cytotoxicity of PEGylated MnO nanoparticles also proved negligible. Consequently, the convenient PEGylation strategy toward MnO nanoparticles could not only realize a good “trade-off” between hydrophilic modification and high longitudinal relaxivity but also contribute additional advantages, such as passive targeting to tumor and long blood circulation, to MRI diagnosis of tumor. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42360.
研究领域:
材料科学
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医学影像学
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生物医学工程
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DOI
高影响因子
CRYSTENGCOMM
·
2017
·Vol. 19
·期 26
·3600-3606
·
IF 3.474
Suli Wu,Xiaoqian Sun,Zhipeng Meng,Shufen Zhang
Doping, incorporating appropriate and functional atoms or ions into host lattices of colloid nanoparticles, is an important approach to modifying the shapes and sizes of nanoparticles and endowing them with new and useful properties. Herein, we demonstrate a “core–shell” synthetic strategy to control the shape of core–shell structured NaGdF4 upconversion nanoparticles (UCNPs) by introducing an impurity dopant in the core region. We introduced Cr3+ ions in the core region of NaGdF4 to synthesize “Jasminum sambac flower” shaped non-classic core–shell NaGdF4:Cr3+@NaGdF4:Yb3+,Tm3+ UCNPs. First of all, the effect of doping concentration on the shape of NaGdF4 core was investigated. Then, the core–shell strategy was applied to obtain a shape-controlled hierarchical nanostructure, and the effects of Cr3+ concentration on the phases, shapes and sizes of the products were investigated in detail. TEM images indicate that NaGdF4:Cr3+@NaGdF4:Yb3+,Tm3+ nanocrystals with Cr3+ concentration of 40–50% show highly uniform “Jasminum sambac flower” shaped structures. TEM images and XRD patterns of NaGdF4:Cr3+@NaGdF4:Yb3+,Tm3+ at different reaction times indicate that, initially, the flower shaped products are cubic phase and the size of the flowers is about 50 nm; with an increase of the reaction time, the cubic phase nanocrystals discompose to small ones and then transform to a bigger hexagonal phase “Jasminum sambac flower”. This “core/shell” doping strategy presents a general route to achieving controlled morphology in lanthanide-doped nanocrystal systems.
研究领域:
材料科学
·
纳米技术
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 134
·期 33
·45070
·
IF 1.86
X. Y. Li,X. X. Wang,X. Y. Jiang,F. Xu,H. Y. Liu,L. G. Bai,H. Y. Yan,X. Q. Qiao
A multiwalled carbon nanotube (MWCNT) composite monolithic column was prepared by the redox initiation method, and MWCNTs were embedded into the monolithic material. In this experiment, 1-octene was used as monomer, triethylene glycol dimethacrylate was used as the crosslinking agent, propanol and 1-dodecanol were used as porogens, hydroxyl-functionalized MWCNTs were used as the inorganic material, and dibenzoyl peroxide and N,N -dimethyl aniline were used as initiators. The MWCNT composite monolithic column was characterized by scanning electron microscopy, mercury intrusion porosimetry, and nitrogen adsorption–desorption isotherm measurements. The MWCNT composite monolith showed a uniform structure and a high permeability. The MWCNT composite monolithic column uses the high-performance liquid chromatography to analyze the sample. Compared with the monolithic column without MWCNTs, the MWCNT composite monolith not only improved the column efficiency but also shortened the separation time. Six small molecules were successfully separated by the MWCNT composite monolith in 3 min, with the highest column efficiency reaching 36,000 plates/m In addition, the monolith was also used to separate complex protein samples, including snailase, plasma, and egg white. Therefore, the monolithic column was suitable both for the separation of macromolecules and small molecules. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45070.
研究领域:
分析化学
·
材料科学
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产品关联
DOI
高影响因子
ACS Nano
·
2021
·
IF 15.881
Zhongyuan Chen,Yueting Peng,Yichao Li,Xiaoxue Xie,Xiaodan Wei,Geng Yang,Hanxi Zhang,Ningxi Li,Tingting Li,Xiang Qin,Shun Li,Chunhui Wu,Fengming You,Hong Yang,Yiyao Liu
The combination of magnetic hyperthermia and chemotherapy within a nanosystem is thought to be a promising approach for cancer therapies. However, the nonspecific accumulation and fast clearance of magnetic nanoparticles in the physiological environment limited their further biomedical applications. Herein, we report a highly selective theranostic nanocomplex, ZIPP-Apt:DOX/siHSPs, built with superparamagnetic zinc-doped iron oxide nano-octahedral core, cationic PAMAM dendrimer, and functional surface modifications such as PEG, AS1411 aptamer, and fluorescent tags (FITC or Cy5.5), together with the loading of hydrophobic anticancer drug doxorubicin (DOX) and HSP70/HSP90 siRNAs. Our results demonstrate that the cellular uptake and the tumor-specific accumulation of ZIPP-Apt:DOX/siHSPs were significantly increased due to the AS1411-nucleolin affinity and further confirmed that the simultaneous depletion of HSP70 and HSP90 sensitized magnetic hyperthermia and chemotherapy-induced cell death both in vitro and in vivo. Altogether, our study provides a theranostic nanoplatform for aptamer-targeted, NIR/MR dual-modality imaging guided, and HSP70/HSP90 silencing sensitized magnetochemotherapy, which has the potential to advance versatile magnetic nanosystems toward clinical applications.
研究领域:
纳米技术
·
生物医学工程
·
癌症研究
·
分子生物学
·
药学
·
医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）