Nanoscale
·
2013
·Vol. 5
·期 13
·5833-5840
·
IF 6.233
Li-qiang Luo,Zhao Zhang,Ya-ping Ding,Dong-mei Deng,Xiao-li Zhu,Zhen-xin Wang
In this work, we proposed a novel simple protocol for preparing 1-aminopyrene/graphene (ApG) hybrids for fabricating label-free electrochemical impedance genosensor. Graphene, with the structure of a single-atom-thick sheet of sp2-bonded carbon atoms, was anchored to 1-aminopyrene (1-Ap) with the pyrenyl group via π-stacking interaction. The morphology, conductivity, and interaction of ApG hybrids were characterized by transmission electron microscopy (TEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), UV-visible (UV-vis) and fluorescence spectra. The amino-substituted oligonucleotide probe was conjugated to 1-Ap by the cross-linker glutaraldehyde. The DNA hybridization reaction of oligonucleotide probe with target DNA was monitored by EIS. Under optimum conditions, the proposed biosensor exhibited high sensitivity and a low detection limit for detecting the complementary oligonucleotide. The target oligonucleotide could be quantified in a wide range of 1.0 × 10−12 to 1.0 × 10−8 M with good linearity (R = 0.9900) and low detection limit of 4.5 × 10−13 M (S/N = 3).
研究领域:
纳米材料
·
生物传感器
·
电化学
·
遗传学
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DOI
PubMed
高影响因子
TALANTA
·
2024
·
IF 5.6
Jingwen Zhao,Zhuxuan Shi,Mixia Chen,Fengna Xi
Inspired by the iron porphyrin structure of natural horseradish peroxidase (HRP), an efficient carbon-based nanozyme was fabricated using nitrogen-doped graphene quantum dots (NGQDs) and iron ion (Fe 3+ ) nanocomposite, enabling selective distinguishment of hydroquinone (HQ) from its isomers. NGQDs with good dispersibility and uniform size were synthesized via a one-step hydrothermal process. NGQDs lacked peroxidase-like activity but the formed nanocomposite (Fe 3+ -NGQDs) upon Fe 3+ addition possessed high peroxidase-like activity. Fe 3+ -NGQDs nanocomposite exhibited shuttle-shaped structure (∼30 nm), the lattice structure of NGQDs and electron transfer between Fe 3+ and NGQDs. The Fe 3+ -NGQDs nanocomposite can catalyze the production of superoxide radicals (•O 2 − ) from H 2 O 2 . The Michaelis constant ( K m ) of Fe 3+ -NGQDs (0.115 mM) was lower than that of natural HRP (0.434 mM) with 3,3′,5,5′-tetramethylbenzidine (TMB) as the substrate and the maximum initial reaction rate ( V max , 16.47 × 10 −8 M/s) was nearly 4 times higher than that of HRP using H 2 O 2 substrate. HQ, unlike its isomers catechol (CC) and resorcinol (RE), could consume •O 2 − generated from the decomposition of H 2 O 2 catalyzed by Fe 3+ -NGQDs nanocomposite, reducing the oxidation of TMB. This principle enabled selective colorimetric determination of HQ ranged from 1 μM to 70 μM and a limit of detection (LOD) of 0.2 μM. Successful determination of HQ in pond water was also realized.
研究领域:
生物化学
·
环境科学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 6
·1347
·
IF 4.6
Zhengzheng Yan,Lujie Wang,Fei Yan
Carcinoembryonic antigen (CEA) is an important tumor biomarker for the early clinical diagnosis of various cancers, and, therefore, the accurate and sensitive quantitative determination of CEA is of vital significance. In this study, we demonstrated the in situ growth of Au nanoparticles (AuNPs) on nitrogen-doped graphene quantum dots (N-GQDs) decorated reduced graphene oxide (rGO) nanocomposites by using simple drop-coating and electrochemical deposition methods. N-GQDs@rGO can be formed through the π–π stacking interaction and possesses a high specific surface area and many functional groups, providing lots of anchor sites (amino moieties in NGQDs) for the in situ electrochemical growth of AuNPs without the addition of reductants and protective agents. Such AuNPs/N-GQDs@rGO ternary nanocomposites combine the characteristics of three nanomaterials, showing a large surface area, excellent solubility, good conductivity, catalytic activity, a simple fabrication process, and notable stability, which are further used to construct a label-free electrochemical immunosensor for the determination of CEA. Under the optimized experimental conditions, the AuNPs/N-GQDs@rGO-based electrochemical immunosensor achieves a broad linear response, ranging from 1 pg/mL to 0.5 μg/mL and a low detection limit of 0.13 pg/mL. Moreover, the AuNPs/N-GQDs@rGO-based electrochemical immunosensor shows exceptional selectivity, anti-interference, and anti-fouling capabilities for the direct analysis of CEA amounts in fetal bovine serum samples, showing vast potential in the clinical screening of cancer.
研究领域:
生物医学工程
·
分析化学
·
肿瘤学
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产品关联
DOI
PubMed
高影响因子
POLYMER
·
2026
·
IF 5.1
Tingxiao Yang,Ying Qi,Qingsong Wang,Kening Ma,Shaojian Lin,Jianwu Lan,Jiaojiao Shang
Transparent polymer films are widely used in optical devices, packaging, and information display, but most of them are derived from non-renewable petrochemical resources and show limited environmental sustainability. Cellulose represents an attractive natural polymer alternative owing to its high abundance and biodegradability. However, its pronounced hydrophilicity and limited functional integration restrict the development of advanced transparent cellulose-based films. In this work, highly transparent, water-resistant, and fluorescent cellulose-based films were fabricated from bleached forestry pulp through sequential carboxymethylation, periodate oxidation, silane coupling, diamine-assisted crosslinking, and post-functional fluorophore grafting. Carboxymethylation enabled the formation of transparent films, while silane modification and network construction significantly improved the surface hydrophobicity and water durability of the cellulose matrix. Subsequent immobilization of N-(1-pyrene)maleimide endowed the films with distinct fluorescence. The resulting films maintained high optical transparency after multistep functionalization, with a transmittance of about 90% in the visible region, exhibited a water contact angle of 101.6°, and a tensile strength of about 70 MPa. In addition, the fluorescent films showed clear optical responses under UV irradiation. This work provides an effective strategy for constructing a transparent cellulose-based platform that simultaneously integrates hydrophobicity, fluorescence functionality, and mechanical reinforcement through sequential covalent modification, and highlights their potential in optical labeling, smart packaging, flexible substrates, and security marking.
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DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Jiang Jinhui,Pan Yiwen,Zhao Jingyi,Zhang Siwei,Ma Fulong,Zhang Zicong,Liu Mengli,Qiu Zijie,Zhao Zheng,Sun Jianwei,Kwok Ryan T. K.,Xiong Yu,Lam Jacky W. Y.,Han Wei,Tang Ben Zhong
Organic circularly polarized room-temperature phosphorescence (CPRTP) materials represent an emerging research frontier with broad application prospects. However, achieving efficient and controllable CPRTP remains challenging due to inefficient chirality transfer and the limited ability to regulate chiral environments. Here, we develop a strategy involving self-assembled chiral homopolypeptides to realize manipulable CPRTP. Chiral homopolypeptides functionalized with achiral phosphorescent terminals are first designed, which self-assemble into vesicles exhibiting weak CPRTP. Remarkably, dispersing these vesicles into a poly(vinyl alcohol) matrix induces structural reorganization, leading to inversion and significant amplification of CPRTP. Experimental and computational studies reveal the critical role of matrix-assistance in chirality propagation, inversion, and amplification. Moreover, multicolor afterglow films with tunable emissions are readily achieved by varying the terminal phosphor. This work not only establishes a universal platform for constructing tunable CPRTP materials through homopolypeptide self-assembly but also provides deep mechanistic insights into supramolecular chirality manipulation.
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DOI
PubMed
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 52
·44909-44918
·
IF 4.6
Huihua Zhang,Lanlan Wu,Fengna Xi,Baolin Zhang
The detection of superoxide dismutase (SOD) is crucial for monitoring the antioxidant defense system. In this study, an electrochemical-assisted self-assembly (EASA) method was used to in situ grow amino-functionalized vertically ordered mesoporous silica film (NH2-VMSF) on an ITO electrode, creating highly ordered nanochannel structures. Nitrogen-doped graphene quantum dots (NGQDs) were then confined within these channels via electrophoretic deposition, resulting in a composite electrode, NGQDs@NH2-VMSF/ITO. The introduction of NGQDs significantly enhanced the electrode's catalytic activity for the oxygen reduction reaction (ORR), facilitating the generation of superoxide anion radicals (O2˙−) and promoting the electrochemical oxidation of luminol, which substantially increased the electrochemiluminescence (ECL) signal of the luminol–dissolved oxygen (DO) system. In the presence of SOD, O2˙− is selectively eliminated by SOD, leading to a decrease in the ECL signal as the SOD concentration increases. This “signal-off” response enables highly sensitive detection of SOD. The developed ECL sensor demonstrated a linear relationship within the SOD concentration range of 0.005–5 µg mL−1, with a limit of detection (LOD) as low as 0.87 ng mL−1 (S/N = 3). This work offers a reliable sensing platform for analyzing antioxidant activity and related disease biomarkers.
研究领域:
分析化学
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电化学
·
生物传感器
·
纳米材料
·
生物分析化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2020
·
IF 3.28
Cheng Zhang,Xihao Pan,Siyao Cheng,Aming Xie,Wei Dong
With the increasingly severe international situation, explosive detection has become an important topic of national security, and the rapid and efficient chemical sensors have attracted people's attention. In this work, a novel sensor CSA was synthesized through cholesterol succinate and 1-Aminopyrene. UV–vis and fluorescence spectra showed that CSA had a typical aggregation-induced emission （AIE） effect in THF/H 2 O solution, and explosive CL-20 could effectively quench this fluorescence. Also, the seal and cotton swab prepared by CSA can specifically detect CL-20, providing a platform for the practical application of CSA in public safety.
研究领域:
化学
·
材料科学
·
国家安全
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Sen Liu,Hao Ling,Juan Lv,Hongxia Gao,Yanqing Na,Zhiwu Liang
The sulfolane was, surprisingly, found to be a universal phase-splitting solvent in a serial of aqueous primary alkanolamine solution for CO2 removal; the reaction product of carbamate and hydrophilicity of amine can be the key factor for triggering phase change; also, the phase change can have a significant effect on CO2 capture performance. To comprehensively understand the effect of phase change on absorption, stripping, and phase separation performance, MEA sulfolane-based solution was chosen as a typical biphasic system for investigation. First, the experimental results revealed that the phase change can dramatically decrease the absorption rate and lead to less CO2 capacity in absorption processes. Second, the enriched MEA in separated solution can substantially decrease the energy consumption for CO2 stripping but exorbitant concentration of MEA can significantly reduce the CO2 removal efficiency in a quasicycle of absorption and desorption processes. Third, the phase separation rate of emulsion of MEA/sulfolane solution can be obviously improved by the increasing temperature, and fortunately, the increasing temperature had less effect on miscible solubility of MEA and sulfolane in two separated phases. Finally, on consideration of the absorption rate, energy consumption, and phase separation rate, a new technological process was proposed for CO2 capture using primary alkanolamine sulfolane-based solution to achieve the goal of relative high CO2 removal efficiency and energy saving.
研究领域:
化学工程
·
环境科学
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产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Kunlin Chen,Han Liu,Jianlin Zhou,Yangyi Sun,Kejing Yu
The introduction of self-healing ability into conductive materials has been the subject of great concern in recent years. In this work, a flexible and superhydrophobic nanocomposite coating with intrinsic and superficial dual self-healing ability was prepared. The fabric coating is empowered with the intrinsic self-healing ability that is performed by the disulfide bonds in the main chains of polyurethane (PU) as well as the multiple hydrogen bonds between silica-nanoparticle-modified graphene and PU. Meanwhile, the hydrophobic long chains in the side chains of PU can migrate on the surface to repair the superficial damaged parts of the coating. Owing to the integration of silica-nanoparticle-modified graphene and self-healing PU, the obtained multifunctional flexible coating not only shows excellent piezoresistive sensing performance but also exhibits superhydrophobic ability. This self-healing multifunctional flexible coating has potential applications in the fields of antistatic electricity, wearable electronics, battery, electromagnetic shielding, and so on.
研究领域:
材料科学
·
柔性电子
·
传感技术
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产品关联
DOI
高影响因子
ACS Nano
·
2022
·
IF 18.027
Xingyue Liu,Zhao Chen,Tao Wang,Xinrong Jiang,Xuetong Qu,Wei Duan,Fengna Xi,Zhengfu He,Jianmin Wu
Spatially resolved tissue lipidomics is essential for accurate intraoperative and postoperative cancer diagnosis by revealing molecular information in the tumor microenvironment. Matrix-free laser desorption ionization mass spectrometry imaging (LDI-MSI) is an emerging attractive technology for label-free visualization of metabolites distributions in biological specimens. However, the development of LDI-MSI technology that could conveniently and authentically reveal molecular distribution on tissue samples is still a challenge. Herein, we present a tissue imprinting technology by retaining tissue lipids on 2D nanoflakes-capped silicon nanowires (SiNWs) for further mass spectrometry imaging and cancer diagnosis. The 2D nanoflakes were prepared by liquid exfoliation of molybdenum disulfide (MoS2) with nitrogen-doped graphene quantum dots (NGQDs), which serve as both intercalation agent and dispersant. The obtained NGQD@MoS2 nanoflakes were then decorated on the tip of vertical SiNWs, forming a hybrid NGQD@MoS2/SiNWs nanostructure, which display excellent lipid extraction ability, enhanced LDI efficiency and molecule imaging capability. The peak number and total ion intensity of different lipids species on animal lung tissues obtained by tissue imprinting LDI-MSI on NGQD@MoS2/SiNWs were ∼4–5 times greater than those on SiNWs substrate. As a proof-of-concept demonstration, the NGQD@MoS2/SiNWs nanostructure was further applied to visualize phospholipids on sliced non small cell lung cancer (NSCLC) tissue along with the adjacent normal tissue. On the basis of selected feature lipids and machine learning algorithm, a prediction model was constructed to discriminate NSCLC tissues from the adjacent normal tissues with an accuracy of 100% for the discovery cohort and 91.7% for the independent validation cohort.
研究领域:
生物医学工程
·
分析化学
·
癌症研究
·
纳米技术
·
质谱学
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 18
·6443
·
IF 4.6
Chaoyan Zhang,Xiaoyu Zhou,Fei Yan,Jing Lin
Herein, we describe a fast and highly sensitive electrochemical sensor for doxorubicin (DOX) detection based on the indium tin oxide (ITO) modified with a binary material consisting of vertically-ordered mesoporous silica films (VMSFs) and N-doped graphene quantum dots (NGQDs). VMSFs, with high permeability and efficient molecular transport capacity, is attached to the ITO electrode via a rapid and controllable electrochemical method, which can serve as a solid template for the confinement of numerous NGQDs through facile electrophoresis. By virtue of the excellent charge transfer capacity, π-π and electrostatic preconcentration effects of NGQDs, as well as the electrostatic enrichment ability of VMSF, the presented NGQDs@VMSF/ITO shows amplified electrochemical signal towards DOX with a positive charge, resulting in good analytical performance in terms of a wide linear range (5 nM~0.1 μM and 0.1~1 μM), high sensitivity (30.4 μA μM−1), and a low limit of detection (0.5 nM). Moreover, due to the molecular sieving property of VMSF, the developed NGQDs@VMSF/ITO sensor has good selectivity and works well in human serum and urine samples, with recoveries of 97.0~109%, thus providing a simple and reliable method for the direct electrochemical analysis of DOX without complex sample pretreatment procedures.
研究领域:
分析化学
·
生物医学工程
·
材料科学
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产品关联
DOI
PubMed
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2023
·
IF 9.1
Kunlin Chen,Zhonghua Yuan,Sheng Dai,Jianlin Zhou,Kejing Yu
Flexible conductive materials for wearable applications have seen remarkable advancements in recent years. However, a significant challenge that must be addressed is their susceptibility to accidental mechanical damage. In this study, a self-healing superhydrophobic flexible fabric sensor by incorporating fluorinated polyurethane with fluorinated side chains and graphene modified with Fe 3 O 4 nanoparticles . The fabric composite coating exhibited excellent hydrophobicity and self-cleaning ability, allowing easy removal of dirt and dust by rainwater or other liquids. Due to its excellent conductivity and stretch recovery properties, the composite coating can be applied as a wearable fabric sensor. The sensor demonstrates remarkable sensitivity to strain and can be used to monitor the movements of fingers, wrists, elbows, and other joints . Most importantly, the damaged fabric coating could restore surface integrity, repair conductivity, and maintain superhydrophobicity, which is attributed to the dynamic reversible nature of disulfide bonds and the induced dipole polarization effect of fluorinated side chains. Moreover, the fabric sensor exhibits stable photothermal conversion performance based on the joint effect of graphene and Fe 3 O 4 . This property provides a foundation for light-induced self-healing. The combination of a fluorine-modified self-healing polyurethane, Fe 3 O 4 nanoparticles-modified graphene (FFNs-iaG), and an elastic fabric creates a self-healing superhydrophobic conductive fabric coating. This coating has excellent properties for various applications, enhancing the longevity and reliability of the fabric sensor. The combination of these materials greatly improves the performance of the fabric composite coating, resulting in a versatile fabric sensor with unique characteristics suitable for a wide range of applications.
研究领域:
材料科学
·
传感技术
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）