Food Bioscience
·
2025
·
IF 5.9
Shuai Wang,Jiayang Li,Cong Xie,Wanhui Chen,Huajie Feng,Wenying He
Our previous study found that 1-(4-bromophenyl)-5-phenyl-1H-1,2,3-triazole (BPT) exhibited very low toxicity and higher biology activity. In the present study, BPT was used to investigate its mechanism against Colletotrichum gloeosporioides in mango by chemical proteomics and chemicobiological methods. The experimental results of some phenotypic traits and cytotoxicity indicated that there are some changes in permeability of the cell membranes and BPT has fungistatic activity with lower cytotoxicity. Next, a biotin probe named BPTN with a higher activity (EC 50 value of 11.08 mg/L) than that of BPT(EC 50 value of 14.13 mg/L) was designed and synthesized by the chemical proteomics approach. The major differentially expressed proteins between BPT or BPTN and Colletotrichum gloeosporioides were identified and analyzed by Matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF-MS) and bioinformatics. The results indicated that there are 25 differentially expressed proteins in Colletotrichum gloeosporioides under BPT intervention, and 29 target proteins in Colletotrichum gloeosporioides captured by BPTN. For BPTN-anthracnose system, the protein No. 8 belonged to cytochrome P450 proteins (CYP) family can be taken as a target protein of BPTN, which confirmed by bioinformatics analysis. Further, a classic fungal target protein of triazoles, sterol 14α-demethylase (CYP51) was used to verify the interaction in the presence of BPT by various spectroscopic and molecular docking methods. The results showed that BPT exhibited strong interactions with CYP51 and it was predominantly driven by hydrophobic forces and hydrogen bonds. The present study has significant theoretical and practical implications for the development of novel 1,2,3-triazole antifungal agents.
研究领域:
植物病理学
·
药理学
·
分子生物学
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DOI
高影响因子
Scientific Reports
·
2016
·Vol. 6
·期 1
·1-10
·
IF 5.228
Wu Haobo,Shen Jinyou,Wu Ruiqin,Sun Xiuyun,Li Jiansheng,Han Weiqing,Wang Lianjun
The highly recalcitrant 1H-1,2,4-triazole (TZ) is widely used in the synthesis of agricultural pesticide and considered to be an environmental pollutant. In this study, a novel strain NJUST26 capable of utilizing TZ as the sole carbon and nitrogen source, was isolated from TZ-contaminated soil, and identified as Shinella sp. The biodegradation assays suggested that optimal temperature and pH for TZ degradation by NJUST26 were 30 °C and 6–7, respectively. With the increase of initial TZ concentration from 100 to 320 mg L −1 , the maximum volumetric degradation rate increased from 29.06 to 82.96 mg L −1 d −1 , indicating high tolerance of NJUST26 towards TZ. TZ biodegradation could be accelerated through the addition of glucose, sucrose and yeast extract at relatively low dosage. The main metabolites, including 1,2-dihydro-3H-1,2,4-triazol-3-one (DHTO), semicarbazide and urea were identified. Based on these results, biodegradation pathway of TZ by NJUST26 was proposed, i.e., TZ was firstly oxidized to DHTO, and then the cleavage of DHTO ring occurred to generate N-hydrazonomethyl-formamide, which could be further degraded to biodegradable semicarbazide and urea.
研究领域:
环境微生物学
·
生物修复
·
有机化学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 82
·52321-52326
·
IF 3.108
Zhenzhen Wu,Juan Li,Xian-Ming Zhang
In this study, we introduced 1H-1,2,4-triazole into the ordered nanochannels of propyl amino functioned MCM-41 and then investigated the hybrids' proton conducting performance. A high proton conductivity of 8.34 × 10−3 S cm−1 has been obtained at 120 °C, with 5 mol% mole ratio of dangling propyl amino and fully loaded 1H-1,2,4-triazole in the silica. The activation energy is 0.55 eV and 1.303 eV in the temperature range below and above 80 °C respectively, indicating that the charge transfer mechanism of the material involved both vehicle and Grotthuss process. The above results showed that loading of 1-H-1,2,4-triazole molecules into silica's ordered mesopores is a good strategy for excellent proton conductivity under intermediate temperature.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 54
·48590-48598
·
IF 3.289
Yu Shang,Bo Jin,Rufang Peng,Zhicheng Guo,Qiangqiang Liu,Jun Zhao,Qingchun Zhang
A series of nitrogen-rich heterocyclic 1H,1′H-5,5′-bistetrazole-1,1′-diolate salts, namely, 1,2,4-triazolium (2), 3-amino-1,2,4-triazolium (3), 4-amino-1,2,4-triazolium (4), 3,5-diamino-1,2,4-triazolium (5), 2-methylimidazolium (6), imidazolium (7), pyrazolium (8), 3-amino-5-hydroxypyrazolium (9), dicyandiamidine (10), and 2,4-diamino-6-methyl-1,3,5-triazin (11), was synthesized with cations. These energetic salts were fully characterized through FT-IR, 1H NMR, 13C NMR, and elemental analysis. The structures of 2, 3·7H2O, 6·2H2O, 8, and 10·4H2O were further confirmed through single crystal X-ray diffraction. Their thermal stabilities were investigated through differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The results indicated that all of the salts possess excellent thermal stabilities with decomposition temperatures ranging from 225.7 °C to 314.0 °C. On the basis of the Kamlet–Jacobs formula, we carefully calculated their detonation velocities and detonation pressures. All of the salts, except 11, exhibit promising detonation performances with a detonation pressure of 20.23–28.69 GPa and a detonation velocity of 7050–8218 m s−1. These values are much higher than those of TNT. The impact sensitivities of the compounds were determined via a Fall hammer test. All of the compounds show excellent impact sensitivities of >50 J, and this finding is higher than that of TATB (50 J). Therefore, these ionic salts with excellent energetic properties could be applied as new energetic materials.
研究领域:
化学
·
材料科学
·
高能材料
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DOI
高影响因子
Journal of Hazardous Materials Advances
·
2023
·
IF 0
Yonghao Zhang,Wen Li,Lulu Huang,Zhaoyi Zhang,Liu Liu,Jie Zhang,Qian Li,Jing Yang,Kajia Wei
In this work, a novel Ti/TiO 2 -NTA/meso-flower PbO 2 electrode (TMF-PbO 2 ) was developed by anodic oxidation and modified oxygen bubble-template electrodeposition. Characterization of the electrode confirmed that the meso-flower layer exhibited a unique 3D and hierarchical structure with a rough morphology. N 2 adsorption-desorption isotherms and cyclic voltammetry suggested that TMF-PbO 2 possessed a 2.18 times larger specific surface area and at least a 1.46 times larger electroactive area than the electrode with a porous PbO 2 layer. The investigation of the effect of the operation parameters indicated that the optimal conditions were a pH value of 3, supporting electrolyte concentration of 10.0 g L −1 and current density of 25 mA cm −2 . The electrochemical degradation of 1H-1,2,4-triazole (Tz) by TMF-PbO 2 was studied by HPLC and LC‒MS with the assistance of quantum chemical calculations. The TMF-PbO 2 achieved 100% removal of Tz and 70.4% removal of COD on the advanced treatment of actual pesticide tailwater with an energy consumption of 29.40 kWh kg −1 COD. The EC 50, 48 h value and BOD 5 /COD ratio of the treated wastewater were 70.6±5.9% and 0.64, respectively, indicating significantly low toxicity and high biodegradability. Cyclic testing also suggested that TMF-PbO 2 was stable during application. The excellent performance of TMF-PbO 2 in this study indicated that this kind of electrode is highly applicable for the treatment of pesticide tailwater.
研究领域:
环境科学
·
电化学工程
✓ 已验证
DOI
THERMOCHIMICA ACTA
·
2024
·
IF 3.1
Zhen-Li Yang,Ya-Dong Yao,Jian-Guo Zhang,Qiang Xie,Feng Liu,Zhi-Wei He,Zu-Jia Lu
The construction and comprehensive characterization of energetic ionic salts 5-amino-3-hydrazinyl-1 H -1,2,4-triazolium diperchlorate (2) and 5-amino-3-hydrazinyl-1 H -1,2,4-triazolium 3-nitro-1,2,4-triazolate-5-one (3), which are based on 5-amino-3-hydrazinyl-1 H -1,2,4-triazole, were conducted. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were employed to explore the thermal and kinetic behaviors of the novel energetic ionic salts. An isoconversional approach and non-linear regression analysis were employed to propose accurate kinetic models for characterizing the decomposition of the energetic ionic salts based on the data from DSC and the most possible mechanism functions governing the decomposition of 2 and 3 was determined. Furthermore, experimental measurements and theoretical calculations were employed to examine diverse physicochemical characteristics, including densities, mechanical sensitivities, heat of formation as well as detonation parameters. The findings suggest that salt 2 exhibits a good detonation pressure of 37.4 GP and a satisfactory detonation velocity of 9031 m/s, exceeding RDX in terms of energy content and suggesting its potential as a viable high-energy explosive substitute for RDX. While salt 2 exhibits a slightly lower level of detonation performance than HMX, it possesses better sensitivity, which mean that salt 2 retains a considerable potential for valuable applications.
研究领域:
化学
·
材料科学
·
爆炸科学
✓ 已验证
产品关联
DOI
高影响因子
Energetic Materials Frontiers
·
2022
·
IF 0
Zhi-qiang Wang,Zhen-qi Zhang,Shan-hu Sun,Mi Yan,Shi-liang Huang,Shuang-qi Hu,Jin-jiang Xu,Li-shuang Hu
Polymorphs of energetic materials generally exhibit distinct features, such as density, thermal stability, sensitivity, and detonation performance. These features are important in determining the appropriate applications of a given polymorph. To understand the thermal stability of new high explosive 4,4′,5,5′-tetranitro-1H,1′H- [2,2′-biimidazole]-1,1′-diamine (DATNBI), we systematically investigated its polymorphic transition (PT) under thermal stimulation and discovered a novel stable γ form of DATNBI. The results showed that the solid-solid PT path was β → α → γ . In this study, the three polymorphs of DATNBI were prepared through solvent recrystallization, and their PT processes in solution were explored. Crystal structure analysis of γ -DATNBI suggested that its special cross-cross grid crystal packing may be the main reason for its stable existence at room temperature and its lack of PT process before chemical decomposition, which starts at 240 °C. To further explore the PT process of DATNBI, the solid phase transition mechanism of DATNBI was analyzed using non-isothermal kinetics. The results demonstrated that the two high-temperature PT processes— β → α and α → γ —were not single-step reactions but complex multi-step reactions. The PT activation energy of the β → α process was slightly higher than that of the α → γ process. In addition, the influences of different polymorphs on the performance of DATNBI were explored. The results revealed that safety and detonation performance should decrease as a result of the incorporation of γ -DATNBI. This study contributes to understanding the PT behavior and the crystal structure evolutionary mechanism of DATNBI. This study provides practical support for formula design, process condition selection, and thermal stability evaluation of DATNBI explosives.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
DESALINATION
·
2013
·
IF 3.041
Ben Zhang,Dapeng Zhou,Xiaogai Lv,Ying Xu,Yuanchen Cui
A novel scale and corrosion inhibitor , polyaspartic acid/3-amino-1H-1,2,4-triazole-5-carboxylic acid hydrate graft copolymer was synthesized by maleic anhydride , urea and 3-amino-1H-1,2,4-triazole-5-carboxylic acid hydrate. The graft copolymer possesses good corrosion inhibition properties and outstanding scale inhibition performance for CaCO 3 , Ca 3 (PO 4 ) and CaSO 4 in the simulation experiment. The inhibition efficiency of graft copolymer is close to 100% for Ca 3 (PO 4 ) scale, polyaspartic acid (PASP) and only 22% when inhibitor concentration is 12 mg/L. Moreover, the inhibition corrosion efficiency can reach up to 75%, with PASP just 45% when inhibitor concentration is 16 mg/L.
研究领域:
材料科学
·
腐蚀与防护
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2022
·
IF 3.841
Xue Li,Jun Wu,Tianjiao Hou,Hongping Li,Lei Wang,Jing Ding,Hui Wan,Guofeng Guan
As a new generation of potential rocket fuel, hypergolic ionic liquids, especially boron-containing hypergolic ionic liquids, have emerged as attractive alternatives for unsymmetrical dimethylhydrazine (UDMH). Herein, a series of bis(1H-1,2,3-triazole-1-yl) dihydroborate (BTDB) hypergolic ionic liquids were successfully synthesized, which had a melting point below -60 °C, high density ranging from 1.134 g/cm 3 to 1.173 g/cm 3 , and superior density-specific impulse from 374.2 to 386.5 s g/cm 3 . In particular, 1,3-diallyl-1H-imidazol-3-ium bis(1H-1,2,3-triazole-1-yl) dihydroborate owned an ignition-delay time of 36 ms and the enthalpy of formation about 1.78 kJ/g, exhibiting that it was a good potential for the rocket fuels.
研究领域:
化学
·
材料科学
·
航空航天工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Ping Ye,Weimiao Wang,Xiaodong Li,Zhiqiang Qiao,Yirui Lu,Bing Huang,Liangfei Bai,Liang Chen,Xiaoqing Tu,Rui Li,Guangcheng Yang,Guoqing Lv
Although laser ignition is considered to be one of the most promising ways to detonate energetic materials due to its high safety and reliability, it is still a challenge to achieve direct ignition of energetic materials by a laser with low-power and near-infrared (NIR) band. In this paper, a molecular self-assembly strategy based on recrystallization was utilized to prepare 4,4′,5,5′-tetranitro-1H,1′H-[2,2′-biimidazole]-1,1′-diamine (DATNBI) crystals with various micro-nano structures. The characterization results suggest that DATNBI crystals with different degrees of roughness and defects by the induction of solvents and surfactants. The crystal defects can not only bring about the enhancement of light absorption of DATNBI in NIR band, but also advance its thermal decomposition, providing reliable support for direct laser ignition of DATNBI profit from the hot spot ignition theory. Combined with density functional theory, it is speculated that electrons of defect states achieve electron-hole recombination by laser radiation, thereby enhancing photothermal conversion. Compared with raw DATNBI, DATNBI crystals with rough surface and abundant defects can be directly ignited by a NIR laser and exhibits self-sustainable combustion. In summary, a direct NIR laser-ignitable energetic material has been prepared via appropriate crystal structure design.
研究领域:
材料科学
·
光学工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Research
·
2022
·
IF 11.036
Jin-Meng Heng,Hao-Lin Zhu,Zhen-Hua Zhao,Da-Shuai Huang,Jun-Yi Li,Pei-Qin Liao,Xiao-Ming Chen
Inorganic solids are a kind of important catalysts, and their activities usually come from sparse active sites, which are structurally different from inactive bulk. Therefore, the rational optimization of activity depends on studying these active sites. Copper is a widely used catalyst and is expected to be a promising catalyst for the electroreduction of CO2 to C2H4. Here, we report a conductive dinuclear cuprous complex with a short Cu···Cu contact for the electroreduction of CO2 to C2H4. By using 1H-[1,10]phenanthrolin-2-one and Cu(I) ions, a dinuclear cuprous complex [Cu2(ophen)2] (Cuophen) with a remarkable conductivity (3.9 × 10−4 S m−1) and a short intramolecular Cu···Cu contact (2.62 Å) was obtained. Such a short Cu···Cu contact is close to the distance of 2.54 Å between 2 adjacent Cu atoms in the edge of the copper(100)/(111) plane. Detailed examination of Cuophen revealed a high activity for the electroreduction of CO2 to C2H4 with a Faradaic efficiency of 55(1)% and a current density of 580 mA cm−2, and no obvious degradation was observed over 50 h of continuous operation. Comparing the properties and mechanisms of Cuophen and 2 other copper complexes with different Cu···Cu distances, we found that the shorter Cu···Cu distance is conducive not only for a *CO species to bridge 2 copper ions into a more stable intermediate transition state but also for C–C coupling.
研究领域:
无机化学
·
电催化
·
材料科学
·
能源转换
✓ 已验证
DOI
高影响因子
E-POLYMERS
·
2021
·Vol. 21
·期 1
·590-605
·
IF 2.025
Li Zhao,Xianzhi Hu,Futing Zi,Yingmei Liu,Deqiong Hu,Peng Li,Huiling Cheng
In this study, a novel functional monomer N -(1-(2,4-difluorophenyl)-2-(1 H -1,2,4-triazol-1-yl)ethyl)acrylamide (NDTEA) was designed and synthesized, and was used to prepare Ni( ii ) ion-imprinted polymers (Ni( ii )-IIPs). Sixteen kinds of Ni( ii )-IIP (Ni( ii )-IIP 1–16 ) and corresponding non-imprinted polymers (NIP 1–16 ) were prepared by precipitation polymerization method. After optimized condition experiment, Ni( ii )-IIP 5 possessed maximum adsorption capacity and better imprinting factor under optimal experimental conditions which indicated by equilibrium adsorption experiments. The morphology and structural characteristics of Ni( ii )-IIP 5 were characterized by scanning electron microscopy (SEM) and Brunauer–Emmett–Teller (BET). The adsorption selectivity of Ni( ii )-IIP 5 was analyzed by ICP-OES, and the results showed that Ni( ii )-IIP 5 had favorable selectivity recognition ability for Ni( ii ) when Cu( ii ), Co( ii ), and Cd( ii ) are used as competitive ions. The kinetic experiment indicated that the performance of Ni( ii ) adsorption on the surface of Ni( ii )-IIP 5 obeyed the pseudo-first-order model, and adsorption equilibrium was attained after 15 min. Isothermal adsorption process fitted to Langmuir and Freundlich isothermal adsorption models, simultaneously. The results showed that Ni( ii )-IIP 5 prepared by using a new functional monomer had better permeation selectivity and higher affinity for Ni( ii ), which also verified the rationality of the functional monomer design. At the same time, it also provided a broad application prospect for removal of Ni( ii ) in complex samples.
研究领域:
高分子科学
·
环境化学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）