JOURNAL OF CHEMICAL THERMODYNAMICS
·
2015
·
IF 2.679
Cui Wang,Jitai Guo,Kai Cheng,Yao Chen
(Liquid + liquid) equilibrium data for the ternary systems of {water + ethanol + 1,1′-oxybis(butane)} and {water + 2-propanol + 1,1′-oxybis(butane)} at T = (293.15, 298.15, 303.15, 308.15) K have been measured under atmospheric pressure. The experimental results were correlated by using the modified and extended UNIQUAC models. Distribution coefficients and separation factors of ethanol and 2-propanol were calculated and discussed in detail. The temperature influence on liquid-phase regions was analysed.
研究领域:
化学工程
·
物理化学
✓ 已验证
DOI
高影响因子
FLUID PHASE EQUILIBRIA
·
2019
·
IF 2.514
Chuhan Fu,Wenli Song,Conghua Yi,Shaoqu Xie
In light of the advantages of liquid-liquid extraction, it is important to reduce the mutual solubility of extractant and solvent in the liquid feed. Highly efficient novel aqueous two-phase systems composed of 2-propanol and water were created by the introduction of highly soluble salts at high salt concentrations. The water + 2-propanol + K 2 HPO 4 /K 4 P 2 O 7 systems are recommended for the extraction of the value-added chemicals since they lead to trace amounts of 2-propanol in the aqueous phase and salt in the organic phase. The e-NRTL-RK model was employed to correlate the aqueous two-phase systems (organic phase and aqueous phase) with high accuracy. With the roles of the salting-out effects and the solubility of the salt in mind, we are able to exploit the highly efficient novel aqueous two-phase systems composed of 2-propanol, water, and other highly soluble salts.
研究领域:
生物化学
·
分离科学
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2014
·
IF 3.259
Jianxia Sun,Shun Bai,Weibin Bai,Feiyan Zou,Lei Zhang,Guoqiang Li,Yunfeng Hu,Mingwei Li,Rian Yan,Zhijian Su,Yadong Huang
1,3-Dichloro-2-propanol (1,3-DCP) is a well-known food processing contaminant that has been shown to impede male reproductive function. However, its mechanism of action remains elusive. In this study, the effects of 1,3-DCP on progesterone production were investigated using the R2C Leydig cell model. 1,3-DCP significantly reduced cell viability from 7.48% to 97.4% at doses comprised between 0.5 and 6 mM. Single cell gel/comet assays and atomic force microscopy assays showed that 1,3-DCP induced early phase cell apoptosis. In addition, 1,3-DCP significantly reduced progesterone production detected by radioimmunoassay (RIA). The results from quantitative polymerase chain reaction and western blotting demonstrated that the mRNA expression levels of steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase were significantly down-regulated in R2C cells. Particularly, the change rhythm of Star expression was highly consistent with progesterone production. Furthermore, the cyclic adenosine monophosphate (cAMP) and the mitochondrial membrane potential mediated by ROS, which are involved in regulating progesterone synthesis were also decreased in response to the 1,3-DCP treatment. Overall, the data presented here suggested that 1,3-DCP interferes with the male steroidogenic capacity mainly by down-regulating the level of cAMP and the key enzymes involved in the androgen synthesis pathway.
研究领域:
生殖生物学
·
毒理学
·
内分泌学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 19
·4709
·
IF 4.2
Xinyu Liu,Shu Wang,Mingxia Wang,Lifang Chen,Zhiwen Qi
The esterification of 1-methoxy-2-propanol (PM) and acetic acid (AA) is an important reaction for the production of 1-methoxy-2-propyl acetate (PMA). Herein, we used the macroporous ion-exchange resin Amberlyst-35 as a catalyst to explore the effects of reaction conditions on the reaction rate and equilibrium yield of PMA. Under the optimized conditions of a reaction temperature of 353 K, using the initial reactant PM/AA with a molar ratio of 1:3, and a catalyst loading of 10 wt%, the PMA equilibrium yield reached 78%, which is the highest equilibrium yield so far. The reaction equilibrium constants and activity coefficients were estimated to obtain reaction thermodynamic properties, indicating the exothermicity of the reaction. Furthermore, pseudo-homogeneous (PH), Eley–Rideal (ER), and Langmuir–Hinshelwood–Hougen–Watson (LHHW) kinetic models were fitted based on experimental reaction kinetic data. The results demonstrate that the LHHW model is the most consistent with experimental data, indicating a surface reaction-controlled process and exhibiting an apparent activation energy of 62.0 ± 0.2 kJ/mol. This work represents a valuable example of calculating reaction thermodynamics and kinetics, which are particularly essential for promising industrial reactor designs.
研究领域:
化学工程
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催化科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2020
·
IF 2.888
Lemeng Wang,Chi Fang,Xiaoqian Du,Kun Fu,Xiangfeng Tian,Pan Zhang,Dong Fu
The surface tensions ( γ ) and viscosities ( η ) of 1-dimethylamino-2-propanol (DMA2P) − 1-(2-aminoethyl)piperazine (AEP) and DMA2P − 1,5-diamino-2-methylpentane (DAMP) were measured and correlated. According to the CO 2 capture temperature from the thermal power plant flue gas (around 313 K), the experimental temperatures were selected to be 303.2 K, 313.2 K and 323.2 K. The mass fractions of DMA2P ranged from 0.300 to 0.500, and those for activators (AEP and DAMP) ranged from 0.050 to 0.150. Temperature and composition dependences of γ and η were demonstrated on the basis of experiments and calculations. The activation energy ( E a) was estimated from the temperature dependence of viscosity. Analytical formulations of surface entropy ( S S ) and surface enthalpy ( H S ) were deduced from the analytical equation of γ . S S and H S were calculated and their variations with respect to mass fraction were analyzed.
研究领域:
物理化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Catalysis Science & Technology
·
2019
·Vol. 10
·期 1
·70-78
·
IF 5.726
Zeyu Yang,Hengwei Fu,Wenjie Ye,Youyu Xie,Qinghai Liu,Hualei Wang,Dongzhi Wei
Alcohol dehydrogenases (ADHs) together with the economical substrate-coupled cofactor regeneration system play a pivotal role in the asymmetric synthesis of chiral alcohols; however, severe challenges concerning the poor tolerance of enzymes to 2-propanol and the adverse effects of the by-product, acetone, limit its applications, causing this strategy to lapse. Herein, a novel ADH gene smadh2 was identified from Stenotrophomonas maltophilia by traditional genome mining technology. The gene was cloned into Escherichia coli cells and then expressed to yield SmADH2. SmADH2 has a broad substrate spectrum and exhibits excellent tolerance and superb activity to 2-propanol even at 10.5 M (80%, v/v) concentration. Moreover, a new thermostatic bubble column reactor (TBCR) system is successfully designed to alleviate the inhibition of the by-product acetone by gas flow and continuously supplement 2-propanol. The organic waste can be simultaneously recovered for the purpose of green synthesis. In the sustainable system, structurally diverse chiral alcohols are synthesised at a high substrate loading (>150 g L−1) without adding external coenzymes. Among these, about 780 g L−1 (6 M) ethyl acetoacetate is completely converted into ethyl (R)-3-hydroxybutyrate in only 2.5 h with 99.9% ee and 7488 g L−1 d−1 space–time yield. Molecular dynamics simulation results shed light on the high catalytic activity toward the substrate. Therefore, the high 2-propanol tolerance SmADH2 with the TBCR system proves to be a potent biocatalytic strategy for the synthesis of chiral alcohols on an industrial scale.
研究领域:
生物化学
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工业生物技术
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2024
·Vol. 16
·期 13
·1863
·
IF 4.7
Yan Qiu,Xinyang Zhao,Hong Li,Sijun Liu,Wei Yu
The viscosity and viscoelasticity of polyelectrolyte solutions with a single electrostatic interaction have been carefully studied experimentally and theoretically. Despite some theoretical models describe experimental results well, the influence of multiple interactions (electrostatic and hydrophobic) on rheological scaling is not yet fully resolved. Herein, we systematically study the microstructures and rheological properties of short-side-chain perfluorosulfonic acid (S-PFSA), the most promising candidate of a proton exchange membrane composed of a hydrophobic backbone with hydrophilic side-chains, in water/2-propanol. Small-angle X-ray scattering confirms that semiflexible S-PFSA colloidal particles with a length of ~38 nm and a diameter of 1–1.3 nm are formed, and the concentration dependence of the correlation length (ξ) obeys the power law ξ~c−0.5consistent with the prediction of Dobrynin et al. By combining macrorheology with diffusing wave spectroscopy microrheology, the semidilute unentangled, semidilute entangled, and concentrated regimes corresponding to the scaling relationships ηsp~c0.5, ηsp~c1.5, and ηsp~c4.1are determined. The linear viscoelasticity indicates that the entanglement concentration (ce) obtained from the dependence of ηspon the polymer concentration is underestimated owing to hydrophobic interaction. The true entanglement concentration (cte) is obtained by extrapolating the plateau modulus (Ge) to the terminal modulus (Gt). Furthermore, Geand the plateau width, τr/τe(τrand τedenote reptation time and Rouse time), scale as Ge~c2.4and τr/τe~c4.2, suggesting that S-PFSA dispersions behave like neutral polymer solutions in the concentrated regime. This work provides mechanistic insight into the rheological behavior of an S-PFSA dispersion, enabling quantitative control over the flow properties in the process of solution coating.
研究领域:
材料科学
·
物理化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Ruijun Zhang,Qianzhi Sun,Jiayu Tian,Bart Van der Bruggen,Junyong Zhu
Sharpening the pore size distribution is challenging but highly efficacious to boost the performance of polyamide (PA) membranes in nanofiltration (NF). Herein, a facile and applicable strategy for narrowing the pore size distribution of a piperazine (PIP)-based NF membrane is proposed by introducing 1,3-diamino-2-propanol (DAP) into the aqueous phase. The results show that the selective layer can be effectively remodeled via the incorporation of DAP. A thicker, rougher and more hydrophilic selective layer with a narrowed pore size distribution can be attained by adding 0.03 w/v% DAP to the 0.1 w/v% PIP solution, which exhibited a pure water permeance (PWP) of 20.7 L m −2 h −1 ·bar −1 and a MgSO 4 rejection up to 97.4 %. This transformation can be attributed to the stronger polarity and higher reactivity of DAP compared to PIP. During the IP process modified by DAP, the strong polarity of DAP could result in a slower and more homogeneous diffusion of PIP into the organic phase through hydrogen interaction to facilitate a uniform interfacial polymerization reaction. Meanwhile, the higher reactivity of DAP could remedy the probably produced defects. This work provides a straightforward route for the regulation of NF membrane structure and performance.
研究领域:
材料科学
·
膜技术
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2019
·
IF 2.29
Lemeng Wang,Xiangfeng Tian,Dong Fu,Xiaoqian Du,Junhong Ye
Experimental data of CO 2 absorption capacity for high concentrated 1-dimethylamino-2-propanol (DMA2P)–monoethanolamine (MEA) aqueous blends are presented under atmospheric pressure in a temperature range of 303.2–323.2 K, at different mass fractions of DMA2P (30 wt%–50 wt%) and MEA (5 wt%–15 wt%). The mass fraction and temperature dependences of the absorption capacity are illustrated. The addition of small amount of MEA into DMA2P aqueous solution leads to an obvious increase in the absorption rate of CO 2 . However, the absorption rate increases not so significantly when w MEA is of high value. Moreover, the temperature affects the absorption rate not so significantly as compared to solution concentration. The CO 2 absorption heat of DMA2P-MEA based on the Gibbs-Helmholtz equation was found to be −55.0 kJ/mol. Besides, the viscosities of both CO 2 -unloaded and CO 2 -loaded aqueous solutions were measured and modeled in a temperature range of 303.2–323.2 K, and in atmospheric pressure. The effects of temperature, composition and CO 2 loading on viscosities were demonstrated. The Weiland equation gave a good prediction with an average relative deviation of 2.42%. Moreover, the activation energy ( E a) was estimated based on the viscosity.
研究领域:
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Green Energy & Environment
·
2019
·
IF 0
Yu-Mei Liu,Yan Zhou,Wen-Qiang Gong,Zhang-Min Li,Chao-Li Wang,Duan-Jian Tao
The catalysis of ionic liquids (ILs) in the traditional stirred reactor suffers from insufficient mass and heat transfer, which always needs a long reaction time and results in a low reaction rate. In this work, highly efficient synthesis of 1-methoxy-2-propanol via the alcoholysis reaction of propylene oxide (PO) with methanol was proposed and achieved by the combination of micro-tubular circulating reactor with the IL [N 4444 ][Buty] catalyst. Compared with the stirred reactor, the rate of alcoholysis reaction in a micro-tubular circulating reactor was found to be significantly improved. The reaction time was remarkably shortened to 20 min from 180 min as well as the yield of 1-methoxy-2-propanol reached 92%. Moreover, the kinetic study further demonstrated that the main reaction rate to 1-methoxy-2-propanol (K 1 ) was about 20 times larger than the side reaction rate to byproduct 2-methoxy-1-propanol (K 2 ) in the temperature range of 363–383 K. Such combination of micro-tubular circulating reactor with IL catalysts is believed to be a class of effective process intensification technique for highly efficient synthesis of 1-methoxy-2-propanol.
研究领域:
化学工程
·
催化化学
✓ 已验证
产品关联
DOI
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2021
·
IF 2.694
Qing Yi,Wei-Peng Chen,Xiang-yang Zhang,Yan-Yang Wu,Bin Wu,Kui Chen,Li-Jun Ji
The isobaric vapor–liquid equilibrium (VLE) data of 2-phenylethanol (2-PE) + 2-ethylphenol (2-EP), 1-phenyl-2-propanol (1,2-PP) + 2-ethylphenol (2-EP), 2-phenylethanol (2-PE) + 1-phenyl-2-propanol (1,2-PP) and 2-phenyl-1-propanol (2,1-PP) + 2-ethylphenol (2-EP) were measured by a modified Rose type still under 101.3 kPa. Both the Fredenslund test and Redlich–Kister area test were employed to verify the consistency of the experimental data. Besides, the experimental isobaric VLE data were correlated by Wilson, nonrandom two-liquid, and universal quasi-chemical models, and the corresponding parameters were obtained accordingly. All three models showed good agreement with the experimental data, and among which the Wilson model performed slightly better than the others.
研究领域:
化学工程
·
物理化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
·
IF 2.298
Lemeng Wang,Xiangfeng Tian,Chi Fang,Hao Huang,Dong Fu,Yuheng Quan
In this work, the surface tensions (γ) of the aqueous blends of 1-dimethylamino-2-propanol (DMA2P) + amino acid ionic liquids (AAILs) were studied using the Wilhelmy plate method at temperatures from 303.2 to 323.2 K and atmospheric pressure. The AAILs include tetramethylammoniumglycinate ([N1111][Gly]), 1-butyl-3-methylimidazolium glycinate ([Bmim][Gly]), and 1-butyl-3-methylimidazolium-l-lysinate ([Bmim][Lys]). The concentrations of DMA2P and AAILs were varied between 0.300 and 0.500 wt % and 0.025 and 0.075 wt %, respectively. A thermodynamic correlation approach with respect to the mass fraction and temperature was employed to correlate the surface tension of DMA2P–AAILs aqueous solutions. The surface entropy (SS) and surface enthalpy (HS) were calculated from the analytical formulation, and their variation with mass fraction and temperature was demonstrated. The effects of the types of AAILs on the surface properties were also analyzed and compared.
研究领域:
物理化学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）