JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2022
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IF 3.119
Guang Yang,Shaoming Fang,Jianqiang Zhang,Ruijuan Wang,Ruixue Liu,Renjie Xu,Chunjuan Huang
The solubility of 2-amino-3-chloropyrazine (ACPY) in some binary cosolvent mixtures of (methanol, isopropyl alcohol, ethylene glycol (EG), N,N-dimethylformamide (DMF)) plus water and the experimental solubility of 2-amino-3,5-dibromopyrazine (ADPY) in (ethanol + water), (isopropyl alcohol + water), (EG + water), and (PG + water) were all determined by the isothermal saturation method from 278.15 K to 323.15 K at 101.2 kPa. The trend of the system temperature and the change of the solvent partner are both factors that affect the dissolution. As the temperature goes higher, the amount of dissolution follows, but the higher is the water content of the solvent, the less solute will be dissolved. The combination of DMF and water is best for the dissolution of ACPY, and the addition of ethanol to water shows an advantage of dissolving ADPY over other combinations. The experimentally obtained dissolution data were then calculated by using three models for the two miscible solvent systems. For ADPY, RAD and RMSD maximums were 2.63 × 10–2 and 2.10 × 10–5. For ACPY, RAD and RMSD were no greater than 6.55 × 10–2 and 6.83 × 10–4.
研究领域:
物理化学
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化工
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药学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2022
·Vol. 23
·期 10
·5715
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IF 6.208
He Wang,Jingjing Li,Qian Yang,Lan Wang,Jing Wang,Yaxin Zhang,Yanjing Guo,Rui Li,Ruiqi Zhang,Xiaorong Tao,Bernal E. Valverde,Sheng Qiang,Hazem M. Kalaji,Shiguo Chen
2-Amino-3-methylhexanoic acid (AMHA) was synthetized as a non-natural amino acid more than 70 years ago; however, its possible function as an inducer of plant resistance has not been reported. Plant resistance inducers, also known as plant elicitors, are becoming a novel and important development direction in crop protection and pest management. We found that free AMHA accumulated in the mycelia but not in fermentation broths of four fungal species,Magnaporthe oryzaeand threeAlternariaspp. We unequivocally confirmed that AMHA is a naturally occurring endogenous (2S, 3S)-α-amino acid, based on isolation, purification and structural analyses. Further experiments demonstrated that AMHA has potent activity-enhancing resistance against extreme temperature stresses in several plant species. It is also highly active against fungal, bacterial and viral diseases by inducing plant resistance. AMHA pretreatment strongly protected wheat against powdery mildew,ArabidopsisagainstPseudomonas syringaeDC3000 and tobacco againstTomato spotted wilt virus. AMHA exhibits a great potential to become a unique natural elicitor protecting plants against biotic and abiotic stresses.Keywords:agricultural production;natural product;plant resistance inducer;biopesticide;biotic and abiotic stress
研究领域:
植物学
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农业科学
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分子生物学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry C
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2022
·Vol. 11
·期 1
·151-160
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IF 8.067
Wentao Chen,Kuo Su,Yuqiong Huang,Keith Gregory Brooks,Sachin Kinge,Bao Zhang,Yaqing Feng,Mohammad Khaja Nazeeruddin,Yi Zhang
Tin–lead (Sn–Pb) mixed perovskite has received widespread attention due to its suitable band gap width and high optical absorption coefficients. However, the power conversion efficiency (PCE) of Sn–Pb mixed perovskite solar cells (PSCs) is still low due to the fact that Sn2+ could be easily oxidized to Sn4+ and an excessively rapid crystallization rate was observed for the Sn–Pb mixed perovskite materials. Herein, we introduced 2-amino-3-hydroxypyridine (AHPD), which contains a pyridine nitrogen and an –NH2 group in the molecule, as a bidentate anchoring additive in the FA0.7MA0.3Pb0.5Sn0.5I3 precursor solution to improve device performance. Incorporation of AHPD into the FA0.7MA0.3Pb0.5Sn0.5I3 precursor solution was found to effectively suppress the Sn2+ oxidation and thus the p-doping level defects. Furthermore, the pyridine nitrogen and the enamine-like –NH2 could retard the nucleation and crystallization rate by forming a coordinating interaction with PbI2/SnI2, forming compact large-grained films and also improving the carrier transport by passivation of the grain boundaries. Overall, compared with the control device (a PCE of 15.72%), an optimized device incorporating 2 mol% AHPD exhibited a PCE of 19.18% for narrow band gap perovskite solar cells, an increase of nearly 22%, with a high level of reproducibility.
研究领域:
材料科学
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能源科学
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2016
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IF 4.758
Jun Lv,Chen Chen,Chao Qian,Wanyi Chen,Yang Xiang,Juan Zhang
A colorimetric sensing method has been proposed for the detection of β-lactamase (β-Lac) activity and the screening of the inhibitors in this work. The method is based on the aggregation of AuNPs induced by 2-amino-3-mercapto-3-methylbutanoic acid (AMMBA) through the formation of Au-S bond and electrostatic interaction . Since AMMBA can form through β-Lac catalyzed hydrolysis and Cu(II)-mediated redox with penicillin as enzyme substrate, β-Lac activity is related to the extent of AuNPs aggregation. The enzyme activity can be determined at levels as low as 0.556 U/mL and over a linear detection range as wide as from 0 U/mL to 30 U/mL. Furthermore, the inhibitory effects of clavulanic acid and sulbactam on the activity of β-Lac have also been tested and given IC 50 values of 0.92 μM and 0.06 μM, respectively. The proposed method can be not only used for the detection of β-Lac activity but also the screening of the inhibitor.
研究领域:
生物化学
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医学诊断
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分析化学
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DOI
高影响因子
SENSORS
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2021
·Vol. 22
·期 1
·8
·
IF 3.576
Xufang Huang,Wei Sheng,Haonan Chen,Biao Zhang,Na Huang,Shuo Wang
A competitive fluorescence immunoassay for the quantitative detection of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in pan-fried meat patties was developed, using magnetic nanoparticles coupled with coating antigen as the capture probe and anti-IQ antibody coupled with NaYF4: Yb, Er upconversion nanoparticles as the signal probe. Under optimal conditionals, the wide detection range for IQ in phosphate buffer saline is from 0.01 to 100 μg·L−1(R2= 0.991) with a detection limit of 0.007 μg·L−1. This proposed method has been applied to detect IQ in two different types of pan-fried meat patties at varying frying times, and the IQ content in chicken patties and fish patties are 2.11–3.47 μg·kg−1and 1.35–2.85 μg·kg−1, respectively. These results are consistent with that of the ultraperformance liquid chromatography-tandem mass spectrometry. In summary, this method can serve as a sensitive and specific test tool for the determination of IQ in processed meat.Keywords:2-amino-3-methylimidazo [4,5-f] quinoline;upconversion nanoparticles;magnetic separation;fluorescence immunoassay;heat processed meat
研究领域:
食品安全
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分析化学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Food Frontiers
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2022
·Vol. 4
·期 1
·289-296
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IF 0
Hongting Deng,Yuanju He,Hui Cao,Lei Chen,Hui Teng
The aim of the present work was to evaluate different structures of flavonoids interfering with the cytotoxicity of heterocyclic amines (HCA). Eight flavonoids with similar structure including myricetin, rutin, fisetin, quercetin, myricetrin, quercetrin, kaempferol, and galangin were coincubated with 2-amino-4-methylimidazo[4,5-f]quinolone (IQ) respectively to determine the cytotoxicity. The results revealed that IQ at low doses showed no cytotoxicity; however, in the presence of myricetin and rutin, the cytotoxicity significantly elevated. It seems that C-3′, C-4′, C-5′, and C-5 hydroxyl substituents on the flavonoid skeleton of B ring play important role in the increasing cytotoxicity induced by IQ in HepG2 cells. Interestingly, the data obtained from the present study revealed an unexpected adverse effect of the supposed beneficial food ingredient myricetin, which appears to be able to increase the cytotoxicity of the procarcinogen HCA.
研究领域:
药理学
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毒理学
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癌症研究
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产品关联
DOI
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
·
IF 5.895
Ya Jiang,Qingqing Jiang,Daming Fan,Mingfu Wang,Yueliang Zhao
The effect of acrolein, a lipid oxidation product, on the formation of the heterocyclic aromatic amine 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) was investigated in a chemical model containing glycine, creatinine, and glucose. Acrolein addition at 0.02–0.2 mmol increased MeIQx formation, while high levels of acrolein (>0.2 mmol) did not further increase MeIQx formation. Moreover, acrolein addition decreased the residue of glycine and creatinine but increased the residue of glucose; it also increased the formation of volatile intermediates in the MeIQx-producing chemical model. Further analysis indicated that acrolein can react with glycine, creatinine, and MeIQx to eliminate them. These results revealed that acrolein was able to contribute to MeIQx formation as a consequence of the comprehensive ability of acrolein to facilitate Strecker degradation of glycine, increase the formation of volatile intermediates, and react with glycine, creatinine, and MeIQx. In addition, the oxidation of minced salmon increased the content of MeIQx in the roasted salmon patties, further supporting the potential contribution role of lipid oxidation products in the formation of MeIQx.
研究领域:
食品科学
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化学
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毒理学
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DOI
高影响因子
Food Science & Nutrition
·
2024
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IF 3.5
Jialing Lin,Chuanhui Zeng,Xueli Li,Qin Tang,Jing Liao,Yan Jiang,Xianchun Zeng
Heterocyclic amines (HAs) are a group of mutagenic and carcinogenic compounds produced from the processing of high-protein foods, which include 2-amino-3-methylimidazo[4, 5-f]quinoline (IQ) showing the strongest carcinogenic effect. Camels are able to digest HAs in foods, which provide rich microbial resources for the study. Thus, camel rumen and intestinal microbiota were used to degrade IQ, and the dominant microorganisms and their degradation characteristics were investigated. After three generations of culture with IQ as the sole carbon source, the highest abundance in rumen and intestinal microbes was found in the Proteobacteria phylum. The strains of third generation of the rumen contents were mainly attributed to the genera Brevundimonas and Pseudomonas , and the dominant genera in intestine were Ochrobactrum , Bacillus , and Pseudomonas . Microorganisms were further isolated and purified from the third generation cultures. These 27 strains from the rumen (L1–L27) and 23 strains from the intestine (C1–C23) were obtained. Among them, four strains with the most effective degrading abilities were as follows: L6 (28.55% of IQ degrading rate) and C1 (25.19%) belonged to the genus Ochrobactrum , L15 (23.41%) belonged to the genus Pseudomonas , and C16 (20.89%) were of the genus Bacillus . This study suggested the application of abundant microbial resources from camels' digestive tract to biodegrade foodborne toxins.
研究领域:
微生物学
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环境科学
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食品科学
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毒理学
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DOI
高影响因子
Journal of Marine Science and Engineering
·
2023
·Vol. 11
·期 2
·282
·
IF 2.9
Zhiguang Song,Shiyuan Cui,Cuiping Tang,Yong Chen,Deqing Liang,Sibo Wang
Polyvinylcaprolactam (PVCap) is an economic kinetic inhibitor for hydrate formation in pipelines during oil and gas transportation. However, its application is limited because of the low inhibition performance under certain conditions. In this work, a modified PVCap on its chain end is proposed. 2-amino-3-propionic acid mercapto-terminated polyvinyl caprolactam (PVCap-NH2-COOH) was synthesized and its performance as a KHI for methane hydrate formation was evaluated under different conditions. Results showed that the performance of PVCap-NH2-COOH as a KHI was better than that of PVCap at the same concentrations. Gas hydrate samples with 1 wt.% PVCap-NH2-COOH were measured using Raman spectroscopy, XRD, and cryo-SEM. PVCap-NH2-COOH had a selective action on a specific crystal surface of the hydrates and could prevent methane molecules from entering large cages. Its inhibition ability increased with the decrease in the occupancy rate of large cages. The morphology of the gas hydrate crystal changed from porous in a pure water system to a chaotic but compact structure state in the system with PVCap-NH2-COOH.Keywords:natural gas hydrate;formation;inhibition;modification
研究领域:
化学工程
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材料科学
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物理化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）