JOURNAL OF SOLID STATE CHEMISTRY
·
2024
·
IF 3.2
Le Chen,An Xie,Nan Zhang,Jianjun Yin,Qun Chen,Mingyang He,Zhihui Zhang
Zeolitic-Imidazolate Framework 8 (ZIF-8), a porous crystalline absorbent, could be synthesized from the coordination reaction of zinc ions and 2-methylimidazole (2-mIM). ZIF-8 has a large specific surface area and a high adsorption capacity for n -hexane ( n HEX). However, ZIF-8 suffers from low selectivity for both linear and mono-chain alkanes. Therefore, ZIF-8 was modified through 2-mIM ligand being partly replaced by 2-nitroimidazole (2-nIM) through Vapor-Phase post-synthesis modification. The modified materials were denoted as ZIF-8-2-nIM-X (X = 24h, 48h, 72h). ZIF-8-2-nIM-X has a higher specific surface area and better thermal stability than ZIF-8. Further thermodynamic and kinetic calculations show that the affinity of hexane isomers on ZIF-8-2-nIM-X is spontaneous physical adsorption combined with an exothermic process. In contrast, kinetic studies show that the adsorption of hexane isomers on ZIF-8-2-nIM-X is a pseudo-second-order kinetic model. The batch and dynamic adsorption and separation properties of ZIF-8-2-nIM-X for hexane isomers were studied. The results of the one-component vapor adsorption equilibrium experiment show that ZIF-8-2-nIM-72h has the best adsorption separation coefficient at 293 K. The adsorption capacity of n HEX and 3-methylpentane (3MP) were 211.63 mg/g and 33.91 mg/g, respectively. Compared with ZIF-8 (selectivity coefficient: 1.08), the adsorption selectivity coefficient of the modified material is greatly improved. The adsorption selectivity coefficient of n HEX/3MP is 6.24 (ZIF-8-2-nIM-72h).
研究领域:
材料科学
·
物理化学
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DOI
高影响因子
Materials Today Bio
·
2026
·
IF 11
Bin Wang,Na Yin,Xinrui Liu,Yi Guan,Haiyang Xu,Ying Yu,Yang Bai,Yue Cao,Ziqian Wang,Shiqi Bai,Shaopeng Zhang,Donghao Qu,Wanying Li,Zhijia Lv,Yunqian Li,Hongquan Yu,Yinghui Wang
Glioma’s metabolic reprogramming fortifies antioxidant defenses and fosters an immunosuppressive microenvironment, thus resulting in robust resistance to ferroptosis-immunotherapy. In this study, a biomimetic sequentially gated amorphous MOF-based nanotuner (ZB@HM) was constructed, which could cascade depletion of metabolic substrates of ferroptosis defense and redistribution of methionine for reprogramming metabolism-ferroptosis-immunity crosstalk. Specifically, we engineered a methionine-inhibitor-loaded amorphous ZIF-82, followed by coating with E. coli-glioma hybrid membrane to improve its blood-brain barrier penetration and gliomas-targeting. The amorphous MOF undergoes acidic-triggered disintegration, releasing 2-nitroimidazole that is selectively activated via NADPH reduction in hypoxia. The activated ligand subsequently covalently binds with thiol-containing cysteine. The cascade depletion of NADPH and cysteine, synergizing with Zn 2+ overload, effectively triggers robust ferroptosis and immunogenic cell death. Moreover, ZB@HM selectively restricts methionine uptake in gliomas, suppressing the transsulfuration pathway for cysteine biosynthesis and enhancing the competitive uptake of methionine by T cells. The reduced intracellular methionine pool in gliomas diminishes S-adenosylmethionine biosynthesis, downregulating immune checkpoint expression. This cascade reverses T-cell exhaustion and reinforces antitumor immunity. RNA sequencing analysis revealed that treatment with ZB@HM resulted in a modulation of gene signatures associated with the GSH metabolism and tumor immunotherapy. Collectively, ZB@HM reprograms the metabolism-ferroptosis-immune crosstalk through orchestrating multiple key metabolites.
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DOI
PubMed
高影响因子
Advanced Therapeutics
·
2024
·
IF 3.7
Wenjuan Yang,Lingling Tian,Ning Zhao,Lingyan Feng,Bingpu Zhou,Yongheng Zhu,Xinghua Gao,Yuan Zhang
Zeolitic imidazole frameworks (ZIFs), which combine the favorable characteristics of tunable porosity, controlled structure, and facile functionalization, are explored as a novel class of nanocarriers for biomedical applications. In this study, different ZIF materials are investigated, including ZIF-8, ZIF-67, ZIF-90, ZIF-92, and ZIF-108, with the same sodalite topology as the adenosine-5′-triphosphate (ATP)-triggered drug delivery systems. Results indicated that ZIF-90 and ZIF-108 displayed good biological compatibility and efficiently accumulated in the mitochondria through competitive coordination between the metal nodes of the ZIFs and ATP, suggesting efficient intracellular delivery. With further interactions between these metal ions and ATP, the encapsulated drugs are released from the ZIF nanoparticles, thereby achieving optimal anti-tumor activity. Through a systematic evaluation of the physicochemical properties of different ZIFs, it demonstrates that the surface charges of ZIFs have a significant impact on the cytotoxicity of cells, whereas the Lewis basicity of imidazole-based ligands plays an essential role in the competitive coordination between the metal ions and ATP. These findings provide a potential method for screening ZIFs based nanocarriers with minimal toxicity and explain the different delivery efficiencies of these materials with similar topologies.
研究领域:
纳米技术
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药学
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生物医学工程
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材料科学
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Yumei Zhang,Yunqi Song,Kemin Xie,Yujie Tang,Yao Yao
A novel chemical sensor featuring an In 2 O 3 -O v /In-nIm heterostructure was facilely fabricated through the in-situ growth of In 2 O 3 -O v on an In 3+ ions-based 2-nitroimidazole metal-organic material (In-nIm MOM). The proposed synthetic strategy effectively enhances the sensing performance. The oxygen vacancies provided by In 2 O 3 -O v can increase the number of reaction centers and active sites, and the abundant porous channels offered by the In-nIm are very beneficial for gas interaction and diffusion. As expected, the In 2 O 3 -O v /In-nIm gas sensor demonstrates outstanding performance, including ultrahigh sensitivity (9853) to 200 ppm ethanol at 230℃, rapid response/recovery speeds (2 s/6 s), an extremely low detection limit (0.003 ppb), superior selectivity, and robust stability. This work provides a potential strategy for fabricating advanced sensing materials by synergistically integrating the merits of metal oxide semiconductors and metal-organic materials, rendering the heterostructure a promising candidate for high-performance chemical sensors.
研究领域:
材料科学
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传感器技术
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纳米材料
·
表面化学
·
分析化学
·
功能材料
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半导体物理
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产品关联
DOI
高影响因子
Science Advances
·
2025
·Vol. 11
·期 36
·
IF 12.5
Fengxiang Liu,Shipeng Ning,Xia Wang,Xiaoyuan Fan,Bin Wan,Fei Sun,Lili Du,Kefan Shi,Xinpeng Zou,Ruihong Zhu,Mingxing Li,Wenwen Shen,Zhonggui He,Kaiyuan Wang,Jin Sun
Cancer stem cells (CSCs) and myeloid-derived suppressor cells (MDSCs) contribute to chemoresistance and immunosuppression, constraining chemoimmunotherapy outcomes. Differentiation therapy, aiming to mature CSCs and MDSCs, shows great promise. However, its efficacy is hindered by limited accessibility in hypoxic deep tumor regions. Inspired by the apoptotic body (ApoBD)–mediated deep tumor penetration, we design a pulsatile sequential drug release system with a core-shell structure. The reversible acid-responsive shell protonates and swells in lysosomes to release doxorubicin, inducing lysosomal escape and cell apoptosis. In ApoBDs, it deprotonates and contracts to prevent excessive drug release. After deep penetration via ApoBDs, the hypoxia-responsive core releases all-trans retinoic acid to reverse CSCs and MDSCs, overcoming chemoresistance and modulating the immuno-microenvironment. This strategy targets the heterogeneous distribution of CSCs and MDSCs in solid tumors, enhancing chemo-intervention and immune checkpoint blockade therapy while presenting encouraging potential for cascade deep tumor penetration and differentiation therapy.
研究领域:
纳米医学
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癌症治疗
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药物递送
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免疫治疗
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生物材料
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肿瘤微环境
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DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2026
·
IF 9.5
Qing Cheng,Yuqi Zhang,Yingying Cao,Long Liu,Yanqiang Zhang
The novel ionic liquid-H2O2 propellants are urgently to solve the intrinsic ignition problem for achieving the aerospace applications. We addressed this issue by tuning the d-band center to adjust the catalyst's adsorption strength for IL/H2O2 toward the optimal value, thus enhancing catalytic activities for the efficient decomposition of H2O2 to generate reactive oxygen species. Herein, the regulation of the d-band center of Cu(I) in Cu(I)-MOF catalyst by precise ligand engineering design was studied. Remarkably, The Cu-S3 coordination of Cu-SH' shifts its d-band center closer to the Fermi level, promoting the adsorption of [BMIM]N(CN)2 and H2O2. Cu-SH' enables efficient H2O2 activation and robust •OH and 1 O2 generation to trigger the rapid self-ignition of [BMIM]N(CN)2-H2O2 propellant. The resulted tid as low as 18.4 ms is nearly 34% lower than that of homogeneous catalyst [FcCH2N(CH3)3]2[Cu2I4]. This work provides fundamental insights into the design of efficient ligand-based combustion catalysts for the higher performance of rockets and spacecrafts.
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DOI
高影响因子
Small
·
2024
·
IF 13
Quanliang Mao,Mengyin Gu,Chengyuan Hong,Huiying Wang,Xinzhong Ruan,Zhusheng Liu,Bo Yuan,Mengting Xu,Chen Dong,Lei Mou,Xiang Gao,Guangyu Tang,Tianxiang Chen,Aiguo Wu,Yuning Pan
Personalized radiotherapy strategies enabled by the construction of hypoxia-guided biological target volumes (BTVs) can overcome hypoxia-induced radioresistance by delivering high-dose radiotherapy to targeted hypoxic areas of the tumor. However, the construction of hypoxia-guided BTVs is difficult owing to lack of precise visualization of hypoxic areas. This study synthesizes a hypoxia-responsive T 1 , T 2 , T 2 mapping tri-modal MRI molecular nanoprobe (SPION@ND) and provides precise imaging of hypoxic tumor areas by utilizing the advantageous features of tri-modal magnetic resonance imaging (MRI). SPION@ND exhibits hypoxia-triggered dispersion-aggregation structural transformation. Dispersed SPION@ND can be used for routine clinical BTV construction using T 1 -contrast MRI. Conversely, aggregated SPION@ND can be used for tumor hypoxia imaging assessment using T 2 -contrast MRI. Moreover, by introducing T 2 mapping, this work designs a novel method (adjustable threshold-based hypoxia assessment) for the precise assessment of tumor hypoxia confidence area and hypoxia level. Eventually this work successfully obtains hypoxia tumor target and accurates hypoxia tumor target, and achieves a one-stop hypoxia-guided BTV construction. Compared to the positron emission tomography-based hypoxia assessment, SPION@ND provides a new method that allows safe and convenient imaging of hypoxic tumor areas in clinical settings.
研究领域:
医学影像
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放射学
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肿瘤学
·
分子成像
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纳米技术
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DOI
PubMed
高影响因子
Nanoscale
·
2019
·Vol. 11
·期 13
·5960-5966
·
IF 6.97
Jinxing Chen,Liang Huang,Qingqing Wang,Weiwei Wu,He Zhang,Youxing Fang,Shaojun Dong
Nanozymes provide comparative advantages over natural enzymes and conventional artificial enzymes for catalytic reactions. However, nanozymes are only suitable for limited types of reactions, whose catalytic principles are not yet fully revealed. Herein, a new nanozyme based on a bionic zeolitic imidazolate framework is proposed. Zeolitic imidazolate framework-8 (ZIF-8) possesses a similar geometric structure to that of the active center of human carbonic anhydrase II (hCAII) and exhibits catalytic performance analogous to that of the hCAII. The less imidazolate coordinated zinc cations on the external surface of ZIF-8 can act as Lewis acid sites, lowering the pKa of Zn-bound H2O molecules from 14 to 8.4, which facilitates the deprotonation of H2O molecules and generation of zinc-bound hydroxide nucleophiles. The esterase-like ZIF-8 nanozyme shows a similar affinity to p-nitrophenyl acetate compared with hCAII. The ZIF-8 nanozyme also promotes CO2 hydration and acetylthiocholine hydrolysis reaction, and a series of ZIFs are also found with intrinsic enzyme-like activities due to similar compositions and spatial structures. These results imply that the bionic nanoparticles can be developed to fabricate a new generation of nanozymes by mimicking the active sites of natural enzymes.
研究领域:
催化
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材料科学
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生物化学
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纳米技术
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DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2013
·
IF 5.695
Wenjie Ma,Qin Jiang,Ping Yu,Lifen Yang,Lanqun Mao
This study demonstrates the first exploitation of zeolitic imidazolate frameworks (ZIFs) as the matrix for constructing integrated dehydrogenase-based electrochemical biosensors for in vivo measurement of neurochemicals, such as glucose. In this study, we find that ZIFs are able to serve as a matrix for coimmobilizing electrocatalysts (i.e., methylene green, MG) and dehydrogenases (i.e., glucose dehydrogenase, GDH) onto the electrode surface and an integrated electrochemical biosensor is readily formed. We synthesize a series of ZIFs, including ZIF-7, ZIF-8, ZIF-67, ZIF-68, and ZIF-70 with different pore sizes, surface areas, and functional groups. The adsorption capabilities toward MG and GDH of these ZIFs are systematically studied with UV–vis spectroscopy, confocal laser scanning microscopy, and Fourier transfer-infrared spectroscopy. Among all the ZIFs demonstrated here, ZIF-70 shows excellent adsorption capacities toward both MG and GDH and is thus employed as the matrix for our glucose biosensor. To construct the biosensor, we first drop-coat a MG/ZIF-70 composite onto a glassy carbon electrode and then coat GDH onto the MG/ZIF-70 composite. In a continuous-flow system, the as-prepared ZIF-based biosensor is very sensitive to glucose with a linear range of 0.1–2 mM. Moreover, the ZIF-based biosensor is more highly selective on glucose than on other endogenous electroactive species in the cerebral system. In the end, we demonstrate that our biosensor is capable of monitoring dialysate glucose collected from the brain of guinea pigs selectively and in a near real-time pattern.
研究领域:
生物医学工程
·
分析化学
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Shuofeng Li,Weihua Liu,Qianqian Wang,Mingming Xu,Yangjuan An,Lin Hao,Chun Wang,Qiuhua Wu,Zhi Wang
A magnetic covalent organic framework (COF) was constructed with ethidium bromide (EB) and 1,3,5-triformylphloroglucinol as building blocks. The prepared magnetic COF (named as EB-COF@Fe 3 O 4 ) exhibited high adsorption ability for five benzoylurea insecticides (BUs). By combining EB-COF@Fe 3 O 4 based magnetic solid-phase extraction with high performance liquid-phase chromatographic detection, a novel method was developed for determination of five BUs in water and food samples. Under the optimized conditions, a good linearity was obtained to be 0.03–100.0 ng mL −1 for water and juice, 0.9–500 ng g −1 for tomato. The detection limits of the method were 0.01–0.09 ng mL −1 , 0.03–0.3 ng mL −1 and 0.3–2.0 ng g −1 for water, juice and tomato samples, respectively. Satisfactory method recoveries were achieved in the range of 80.0%-116.0% with the intra-day and inter-day relative standard deviations below 10%. Moreover, the EB-COF@Fe 3 O 4 can be reused at least 25 times. Therefore, the established method is sensitive and robust for determining BUs in real samples.
研究领域:
分析化学
·
环境科学
·
食品科学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Mengjie Pu,Daqi Ye,Jinquan Wan,Bentuo Xu,Wei Sun,Wei Li
A novel peroxymonosulfate (PMS) catalyst, zinc-based metal–organic framework electrospinning (ES) nanofibers membrane (short for ZIF-65/PAN) was firstly fabricated and used for the degradation of aqueous ciprofloxacin (CIP). Physicochemical properties, catalytic performance, stability, reusability, and the regeneration of ZIF-65/PAN was observed and conducted. Influence of various parameters including ZIF-65 loading content, reaction temperature, initial pH, and competitive organic molecules on CIP degradation was investigated. Reactive active species and degradation intermediates that involved in ZIF-65/PAN/PMS/CIP process were identified. Corresponding reaction mechanisms were speculated. The results indicate that the easy-separation ZIF-65/PAN nanofibers exhibit high efficiency for PMS activation, 89.2 % of CIP was degraded within 60 min, with up to 87.5 % of PMS utilization efficiency. ZIF-65/PAN was renewable through simple layer-by-layer self-assembly, thus shows good prospect in future applications. 26.4 % of surface Zn 2+ of ZIF-65/PAN exists in the form of + III oxidation state after activation, indicating the role of zinc catalytic site. Through activation, oxidative active species SO 4 ·− , ·OH, and 1 O 2 was generated, CIP was thus degraded through mainly-three pathways. This study provides novel ideas for the application of MOF-based membrane on PMS based advanced oxidation processes.
研究领域:
环境科学
·
化学工程
·
材料科学
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Ying Xu,Peng Chen,Lei Tang,Xiaojun Zhang,Feng Shi,Xuyang Ning,Jingli Bi,Yang Qu,Hongfei Liu
Most chemotherapy agents have serious side effects due to lack of tumor targeting, which affects their clinical application. In addition, as an essential characteristic of malignant tumor, hypoxia is attracting exclusive research focus regarding its non-invasive real-time tracing in novel targeting delivery system. Herein, we designed a mixed micelle with tumor targeting and hypoxia responsiveness for tumor therapy and imaging. In particular, the dual-modified mix micelles were self-assembled by folic acid (FA) and 2-(2-nitroimidazole) ethylamine (NI) conjugated polymers , in which paclitaxel (PTX) and quantum dots (QDs) were co-loaded into the hydrophobic core. The drug loaded micelles showed satisfactory drug encapsulation, good storage stability, and sustained release properties. In vitro cell experiments showed that the mixed micelles exhibited enhanced cytotoxic effect and improved the cellular uptake, especially under hypoxic conditions, which was due to the FA mediated active targeting effect and NI induced hypoxic responsive release. In vivo experiments further proved that the mixed micelles possessed outstanding tumor targeting and hypoxia responsive properties. Furthermore, the drug loaded micelles showed excellent anti-tumor effect and can realize real-time in vivo imaging. This work demonstrates that the dual-modified mixed micelles co-loading with PTX and QDs might provide a novel approach for tumor therapy and imaging.
研究领域:
药剂学
·
肿瘤学
·
生物材料
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）