Microfluidics and Nanofluidics
·
2021
·Vol. 25
·期 2
·1-13
·
IF 2.529
Ge Xue-hui,Du Yu-han,Huang Xiaolian,Mo Liangji,Wang Hongxing,Qiu Ting
In this paper, the peppermint oil/HP-β-CD (2-hydroxypropyl-β-cyclodextrin)/chitosan composite microcapsules were prepared. The release ability of these microcapsules was improved for peppermint oil through the combination of molecular encapsulation by HP-β-CD and physical encapsulation by chitosan shell. First, stable peppermint oil/HP-β-CD pre-emulsion was prepared by stirring, based on which the optimal conditions were determined for producing the pre-emulsions with the highest encapsulation efficiency. Then, the pre-emulsion was moved into the flow-focusing microfluidic device as the inner phase and was cut into droplets by chitosan aqueous solution as the middle phase and the octanol as the outer phase to obtain templated emulsions. They were collected using a Petri dish with n-octane coagulation bath containing glutaraldehyde and 2 wt% span80 to be cured into microcapsules. The crosslinking time and the ratio of HP-β-CD in the templated emulsions were adjusted to investigate their impact on the microcapsule structures and correspondingly the capability of the microcapsules to retain peppermint. It was found out that the extended crosslinking time and the addition of HP-β-CD can improve the capability of the composite microcapsules to retain peppermint oil. It provides a straightforward method to produce composite microcapsules. Besides, the microcapsules with improved retaining ability were obtained by combing molecular and physical encapsulation, thus laying a foundation for the exquisite, efficient and polylaminate protection of the volatile perfume or other physically or chemically active components.
研究领域:
食品科学
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材料科学
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DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2014
·
IF 1.357
Fen Wang,Bo Yang,Yulin Zhao,Xiali Liao,Chuanzhu Gao,Ruijian Jiang,Bin Han,Jian Yang,Man Liu,Rongguang Zhou
The inclusion complexation behavior of scutellarein (SCUE) with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) has been investigated in both solution and in the solid state. SCUE/HP-β-CD solid system was prepared by suspension method. The formation of SCUE/HP-β-CD complex in aqueous solution was demonstrated by fluorescence spectroscopy, and the Job plot showed a maximum at a molar fraction of 0.5, indicating 1:1 inclusion complexation between SCUE and HP-β-CD. However, SCUE/HP-β-CD inclusion complex was characterized by means of XRD, DSC, 1H, and two-dimensional NMR. Through the complexation between HP-β-CD and SCUE, the water solubility and antitumor activity of SCUE were obviously increased. This satisfactory water solubility and high antitumor activity of the SCUE/HP-β-CD complex will be potentially useful for its application on human colon cancer chemotherapies.
研究领域:
药学
·
肿瘤学
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DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2013
·
IF 0
Zujin Yang,Hongbing Ji
2-Hydroxypropyl-β-cyclodextrin was immobilized onto cellulose with epichlorohydrin as a cross-linker. The obtained polymer, as biomimetic catalyst, was used to mediate synthesis of benzaldehyde in aqueous solution. The functionalized mimetic enzyme played a crucial role on catalytic oxidation of cinnamaldehyde with remarkable substrate conversion and product selectivity. Synergistic effect based on weak interactions between the polymer and the substrate results in significant promotion of the catalytic performance. The catalyst could be recycled without apparent loss of the original activity.
研究领域:
生物化学
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催化化学
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DOI
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Mengying Long,Luhui Yang,Chao Yang,Niaz Ali Khan,Dongmin An,Yuxiang Liu,Yihan Yang
Two-dimensional (2D) materials, known for their atomically thin profiles and micrometer transverse dimensions, have garnered considerable attentions in membrane technology. Despite their potential, 2D membranes comprising stacked nanosheets often suffer from low permeability and poor stability. Addressing these challenges, we applied collaborative intercalation and reduction strategies to enhance permeability and stability of graphene oxide (GO)-based membranes. We intercalated 2-hydroxypropyl-β-cyclodextrin (2β-CD) into the GO nanosheet dispersion under heat treatment and employed vacuum assisted self-assembly to fabricate the 2β-CD intercalated reduced GO (CD-rGO) membrane. During this process, GO nanosheets underwent reduction, facilitating the formation of hydrogen bonds between 2β-CD and GO. The resulting CD-rGO membrane exhibited markedly improved water permeance at 96.9 L m −2 h −1 bar −1 and an impressive rejection rate at 99.5 % towards Congo red, alongside enhanced stability under a 20 min ultrasonic test at 180 W, and pressure and long-term stability under the cross-flow filtrate tests. The introduction of 2β-CD during heat treatment not only increased the interlayer distance but also utilized the intrinsic pores of 2β-CD and enhanced surface hydrophilicity, contributing to superior separation performance These collaborative strategies offer a facile and promising approach towards high-performance 2D laminated GO-based membranes.
研究领域:
材料科学
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环境工程
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化学工程
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DOI
高影响因子
Scientific Reports
·
2019
·Vol. 9
·期 1
·1-11
·
IF 4.011
Geng Qianqian,Li Tian,Wang Xin,Chu Weijing,Cai Mengling,Xie Jingchan,Ni Hanwen
In this work, the inclusion complexes of hydrophobic herbicide bensulfuron-methyl (BSM) with β-cyclodextrin (β-CD) and (2-hydroxypropyl)-β-CD (2-HP-β-CD) were prepared and characterized. Phase solubility study showed that both β-CD and 2-HP-β-CD increased the solubility of BSM. Three-dimensional structures of the inclusion complexes were simulated by the molecular docking method. The docking results indicated that guest BSM could enter into the cavities of host CDs, folded, and centrally aligned inside the inclusion complexes. The benzene ring of the guest molecule was close to the wide rim of the host molecules; the pyrimidine ring and side chains of the guest molecule were oriented toward the narrow rim of the host molecule. The inclusion complexes were successfully prepared by the coprecipitation method. The physiochemical characterization data of 1 H NMR, FT-IR, XRD, and DSC showed that the guest and host molecules were well included. BSM had lower soil adsorption and higher herbicidal activity in the complexation form with β-CD or 2-HP-β-CD than in the pure form. The present study provides an approach to develop a novel CDs-based formulation for hydrophobic herbicides.
研究领域:
农业科学
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环境科学
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药剂学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xielong Dong,Qian Sun,Juan Xu,Ting Wang
Meeting the diverse requirements of effective wound repair while surpassing the single-function limitations of traditional wound dressings is a significant challenge. In this study, we successfully synthesized an inclusion complex of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and iodine using the saturated aqueous solution method. Additionally, dialdehyde cellulose (DAC) was extracted from fat-free cotton through oxidation. To enhance wound healing, l-glutamine (l-glu) was utilized as a functional molecule, resulting in composite hydrogels with hemostatic, sterilizing, and wound-healing-promoting properties that were achieved by adsorbing the resulting inclusion complex. Through TG and SEM analysis, we confirmed that iodine was effectively accommodated by cyclodextrin and was uniformly attached to the hydrogel. The hydrogel exhibits exceptional long-term moisturizing and bactericidal properties, while also demonstrating excellent swelling, oxygen permeability, hemolytic, and mechanical properties, fully satisfying the requirements of wound treatment. External coagulation tests revealed that the hydrogel can rapidly coagulate 4.5 times its own weight of blood. Moreover, in a full-thickness scald mouse model, the hydrogel effectively promotes wound healing. The development of this multifunctional composite hydrogel presents a novel approach to advance wound dressing research, holding substantial potential for practical applications.
研究领域:
材料科学
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生物医学工程
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伤口护理研究
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DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 88
·71749-71755
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IF 3.84
Xueni Li,Longzhen Zheng,Yimin Wang,Nan Zhang,Yan Lou,Ting Xiao,Jiani Liu
This paper reports on an experimental research of a 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) enveloped 10-methylphenothiazine (MPT) catalyst (MPT-HP-β-CD) with high sensitivity and wonderful electrical conductivity for the electrochemical detection of reduced glutathione (GSH) in a neutral environment. We obtained a linear response range from 10−6 mol L−1 to 5.8 × 10−4 mol L−1 for GSH with a low detection limit of 2.87 × 10−7 mol L−1, providing a potentially usefulness in the development of sensors for non-enzyme detection of GSH.
研究领域:
分析化学
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生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2023
·Vol. 103
·期 7
·3628-3637
·
IF 4.1
Yuanyuan Xue,Youwu Liao,Haiqiao Wang,Shuang Li,Zhengqing Gu,Michael Adu-Frimpong,Jiangnan Yu,Ximing Xu,Hugh D. C Smyth,Yuan Zhu
BACKGROUND Astaxanthin is a type of food-derived active ingredient with antioxidant, antidiabetic and non-toxicity functions, but its poor solubility and low bioavailability hinder further application in food industry. In the present study, through inclusion technologies, micellar solubilization and electrospray techniques, we prepared astaxanthin nanoparticles before optimizing the formulation to regulate the physical and chemical properties of micelles. We accomplished the preparation of astaxanthin nanoparticle delivery system based on single needle electrospray technology through use of 2-hydroxypropyl-β-cyclodextrin and Soluplus® to improveme the release behavior of the nanocarrier. RESULTS Through this experiment, we successfully prepared astaxanthin nanoparticles with a particle size of approximately 80 nm, which was further verified with scanning electron microscopy and transmission electron microscopy. Furthermore, the encapsulation of astaxanthin molecules into the carrier nanoparticles was verified via the results of attenuated total reflectance intensity and X-ray powder diffraction techniques. The in vitro release behavior of astaxanthin nanoparticles was different in media that contained 0.5% Tween 80 (pH 1.2, 4.5 and 6.8) buffer solution and distilled water. Also, we carried out a pharmacokinetic study of astaxanthin nanoparticles, in which it was observed that astaxanthin nanoparticle showed an effect of immediate release and significant improved bioavailability. CONCLUSION 2-hydroxypropyl-β-cyclodextrin and Soluplus® were used in the present study as a hydrophilic nanocarrier that could provide a simple way of encapsulating natural function food with repsect to improving the solubility and bioavailability of poorly water-soluble ingredients. © 2023 Society of Chemical Industry.
研究领域:
食品科学
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药物递送系统
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纳米技术
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Xiaoyuan Wang,Dacheng Zhong,Jingjing Wang
Nanofibrous membranes are often obtained by electrospinning of polymer solutions . Because organic solvents are usually poisonous, it is desirable to develop green electrospinning for wide application of nanofibrous membranes. In the present research, water-soluble 2-hydroxypropyl-β-cyclodextrin, poly(acrylic acid) and poly(vinyl alcohol) were used as raw materials to prepare nanofibrous membranes by electrospinning of their aqueous solutions. The pristine membranes were subsequently crosslinked by thermal treatment in order to improve water resistance of membranes. The obtained membranes were used as adsorbents for removal of levofloxacin hydrochloride from aqueous solutions. The adsorption amount of levofloxacin hydrochloride increased with the content of 2-hydroxypropyl-β-cyclodextrin in the electrospinning solution because the cavity of 2-hydroxypropyl-β-cyclodextrin could capture levofloxacin hydrochloride by inclusion complexation. The adsorption of levofloxacin hydrochloride achieved equilibrium within 12 h and the maximum adsorption capacity was 100.8 mg/g at 298 K. Thermodynamic parameters suggested that the adsorption process was spontaneous and endothermic with increased degree of freedom at the solution/membrane interface. The adsorption mechanism was related to electrostatic attraction, hydrogen bonding and inclusion interactions. Moreover, the membrane still exhibited relatively stable adsorption capacity after five adsorption/desorption cycles. The current study presented a facile and green approach for preparing nanofibrous membranes with excellent adsorption performance for levofloxacin hydrochloride from aqueous solutions.
研究领域:
材料科学
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环境科学
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制药工程
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DOI
高影响因子
AAPS PHARMSCITECH
·
2023
·Vol. 24
·期 7
·1-12
·
IF 3.3
Lv Jianhua,Wu Pan,Fang Yaru,Zhang Wenchang,Liu Dongwen,Wu Mi,Shang Lei,Li Huaiguo,Zhao Yan
By selecting L-arginine as the hydrogen bond acceptor (HBA) and 2-hydroxypropyl-β-cyclodextrin (2HPβCD) as the hydrogen bond donor (HBD), deep eutectic solvents (DESs) with various water content were prepared at the 4:1 mass ratio of L-arginine to 2HPβCD with 40 to 60% of water, and were studied for its application in transdermal drug delivery system (TDDS). The hydrogen bond networks and internal chemistry structures of the DESs were measured by attenuated total reflection Fourier transform infrared (ATR-FTIR) and 1 H-nuclear magnetic resonance spectroscopy ( 1 H-NMR), which demonstrated the successful synthesis of DESs. The viscosity of DES was decreased from 10,324.9 to 3219.6 mPa s, while glass transition temperature (Tg) of the DESs was increased from − 60.8 to − 51.4 °C, as the added water was increased from 45 to 60%. The solubility of ibuprofen, norfloxacin, and nateglinide in DES with 45% of water were increased by 79.3, 44.1, and 3.2 times higher than that in water, respectively. The vitro study of transdermal absorption of lidocaine in DESs showed that the cumulative amounts of lidocaine reached 252.4 µg/cm 2 , 226.1 µg/cm 2 , and 286.1 µg/cm 2 at 8 h for DESs with 45%, 50%, and 60% of water, respectively. The permeation mechanism of DES with lower content of water (45%) was mainly by changing the fluidization of lipids, while changing the secondary structure of keratin in stratum corneum (SC) at higher water content (50% and 60%). These nonirritant and viscous fluid like DESs with good drug solubility and permeation enhancing effects have broad application prospect in the field of drug solubilization and transdermal drug delivery system. Graphical Abstract
研究领域:
药剂学
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药物递送系统
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药物化学
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产品关联
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2021
·
IF 5.89
Yang Shilong,Sun Lu,Song Zhiwen,Xu Li
Rutin (R), a representative flavonoid found in various biomasses, can be used to prepare different fluorescent sensors for environmental, biological and medical fields. In this work, the natural R in Sophora japonica was extracted and purified to prepare fluorescent-responding sensor systems intended to recognize copper ions with both strong selectivity as well as appropriate sensitivity. Results showed that neat R had no obvious fluorescent emission peak in PBS buffer solution. However, when R and (2-hydroxypropyl)-β-cyclodextrin (CD) were introduced within buffer solution, fluorescent emission intensity was significantly increased due to the resultant R-CD inclusion complex. In addition, the formed R-CD inclusion complex was shown to behave as the aforementioned fluorescent sensor for copper ions through a mechanism of quenched fluorescent emission intensity when R-CD became bound with copper ions. The binding constant value for R-CD with copper ions was 1.33 × 106, allowing for quantification of copper ions between the concentration range of 1.0 × 10–7–4.2 × 10–6mol⋅L–1. Furthermore, the minimum detection limit was found to be 3.5 × 10–8mol⋅L–1. This work showed the prepared R-CD inclusion complex was both highly selective and strongly sensitive toward copper ions, indicating that this system could be applied into various fields where copper ions are of concern.
研究领域:
环境科学
·
分析化学
·
生物技术
·
材料科学
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Feiyan He,Jilai Gong,Juan Li,Jun Zhao,Huaiyang Zhou,Yewei Wang,Yanzhao Hu
Nanofiltration (NF) membranes are part of the promising technologies for treating antibiotic wastewater. However, current NF membranes are constrained by the trade-off between the water permeability and selectivity. To address this challenge, a (2-Hydroxypropyl)-β-cyclodextrin (OH-β-CD) incorporated into nitrogen-doped quantum dots (N-GQDs) aqueous phase to form the membrane (N-CD 0.1 ). The integration of the OH-β-CD manipulated the structural properties of selective layer and improved the water permeability. This was attributed to the fact that OH-β-CD not only provided an additional priority water channel, but also regulated the interfacial polymerization process of the membrane by slowing down the diffusion rate of N-GQDs. In addition, the hydrophilicity and electronegativity of the membrane were optimized by OH-β-CD. The results showed that the N-CD 0.1 membrane achieved a high antibiotic rejection (Ciprofloxacin: 98.28 %, Norfloxacin: 97.9 % and Ofloxacin: 97.46 %). The N-CD 0.1 membrane had a remarkable water permeability of 15.82 L⋅m −2 ⋅h −1 ⋅bar −1 , which was 2.05-fold that of the N-GQDs membrane. Furthermore, the N-CD 0.1 membrane exhibited good high-pressure stability. When the operating pressure was 3 ∼ 7 bar, the N-CD 0.1 membrane still had a high Ciprofloxacin rejection (> 97 %). Therefore, by the addition of OH-β-CD, the water permeability of NF membrane could be further improved almost without sacrificing the rejection of Ciprofloxacin, which provided a green and efficient strategy for the fabrication of high-performance NF membranes.
研究领域:
环境工程
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膜科学
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纳米技术
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材料科学
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水处理
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）