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JOURNAL OF ORGANIC CHEMISTRY · 2020 · IF 4.335

Ru-Catalyzed ortho-Selective Diborylation of 2-Arylpyridines toward the Construction of π-Conjugated Functions

Wubing Yao,Jiali Wang,Lili He,Dongdong Cao,Jianguo Yang

A ruthenium catalytic ortho-C–H diborylation of 2-arylpyridine derivatives, including challenging 2-phenoxypyridine functions, using a remarkably low catalyst loading and a low-cost and bench-stable boron source, has been developed. The novel strategy shows high activity with excellent selectivity and may offer a versatile and green alternative to currently employed high loadings of noble metals or extra additives for the selective borylations.

研究领域: 有机化学 · 催化化学

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Asian Journal of Organic Chemistry · 2018 ·Vol. 7 ·期 12 ·2527-2533 · IF 2.496

Reaction of Quinoline N-Oxides and Pyridine N-Oxides with Arylzinc Reagents: Synthesis of 2-Arylquinolines and 2-Arylpyridines

Wei-Ze Li,Zhong-Xia Wang

Graphical Reaction of quinoline N -oxides and pyridine N -oxides with arylzinc reagents under transition-metal-free conditions was studied. The reaction was carried out in toluene (for quinoline N -oxides) or THF (for pyridine N -oxides) at 100 °C and required 2 equiv. of arylzinc loadings and the presence of 2.5 equiv. of TFAA, affording 2-arylquinolines and 2-arylpyridines, respectively, in 24% to 95% yields. Reaction of quinoline N -oxides and pyridine N -oxides with arylzinc reagents under transition-metal-free conditions was studied. The reaction was carried out in toluene (for quinoline N -oxides) or THF (for pyridine N -oxides) at 100 °C and required 2 equiv. of arylzinc loadings and the presence of 2.5 equiv. of TFAA, affording 2-arylquinolines and 2-arylpyridines, respectively, in 24% to 95% yields. Functional groups OMe, F, Cl, Br, CF 3 , C(O)NH 2 , COOR and NO 2 were tolerated. Mechanistic studies showed that the reaction of quinoline N -oxides proceeded via a 2-arylquinolin-1(2 H )-olate intermediate, and the reaction of pyridine N -oxides via a 5-arylpenta-2,4-dienal oxime intermediate.

CAS / MDL: 7439-95-4

研究领域: 有机化学 · 合成化学

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Ru-Catalyzed ortho-Selective Diborylation of 2-Arylpyridines toward the Construction of π-Conjugated Functions

Reaction of Quinoline N-Oxides and Pyridine N-Oxides with Arylzinc Reagents: Synthesis of 2-Arylquinolines and 2-Arylpyridines