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Nanomedicine · 2024 · IF 4.7

Design and in vitro evaluation of 223Ra/99mTc-loaded spherical nano-hydroxyapatite in bone tumor therapy

Yumei Wang,Yue Zhou,Dongliang Zhai,Hao Deng,Xiaoliang Chen

Aim: Nano-hydroxyapatite (nHA) is a good nanocarrier to load 223Ra, but the low specific activity (sp.act.) of 223Ra@nHA limits its application in medicine. Methods: We proposed a method for preparing nHA using PEG as a template, which significantly increases the sp.act of 223Ra@nHA and a new method to loaded 99mTc for in vivo tracking. Results: The nHA synthesized using PEG as a template was associated with higher sp.act for 223Ra in comparison to nHA with identical particle size and without PEG. The nHA load 99mTc-MDP was associated with higher labeling rate and stability in comparison to 99mTc. Conclusion: All these findings suggest that using PEG as a template and 99mTc-MDP could be the most effective of synthetic 223Ra/99mTc@nHA.

CAS / MDL: 7772-99-8

研究领域: 纳米技术 · 放射药学 · 癌症治疗 · 材料科学

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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY · 2026 · IF 1.7

Optimized ion-chromatographic method for determining 226Ra in aerosols using 223Ra as a tracer

Xu Ping,Wu Qingbiao,Li Yemian,Zhuang Sixuan,Wang Yufei,Zhu Zuolong,Li Lun,Ma Yinglin

This study presents an ion-chromatographic method for determining 226 Ra in aerosol samples using 223 Ra as a radiochemical yield tracer. A purified 227 Ac– 223 Ra tracer solution was prepared from certified uranium–radium equilibrium material and applied to optimize single-column chromatographic separation of radium on AG 50W resin with CyDTA eluents. The procedure enables accurate quantification of trace 226 Ra in aerosol filters with low minimum detectable activity and reliable chemical recoveries. For spiked samples containing 226 Ra, recoveries ranged from about 50%–80% with relative deviations below 5%, and an MDA of approximately 2 mBq was achieved for 24 h counting at the 95% confidence level. The optimized separation scheme is suitable for routine environmental monitoring of NORM-bearing aerosols and can also serve as a pre-concentration and purification step prior to ICP-MS-based 226 Ra analysis.

CAS / MDL: 162303-59-5 482-54-2 67-43-6

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Design and in vitro evaluation of 223Ra/99mTc-loaded spherical nano-hydroxyapatite in bone tumor therapy

Optimized ion-chromatographic method for determining 226Ra in aerosols using 223Ra as a tracer