In this article, five kinds of 1,3-diketones and their chelates with different molecular structures were prepared, and their tribological properties were tested. The experimental results show that the running-in time and friction coefficient of the friction pairs lubricated by 1,3-diketones containing a benzene ring increased with the increase of the carbon chain length. In addition, only the friction pair lubricated by 1-(4-ethylphenyl)-butane-1,3-dione (0201) and 1-(4-ethylphenyl)-nonane-1,3-dione (0206) could achieve stable superlubricity. When the benzene ring was replaced with a carbon six-membered ring, it was found that although the friction pair lubricated by this lubricant could achieve superlubricity, the wear of the friction pair was severe, and obvious abrasive wear occurred. In addition, the lubricants prepared by mixing 1,3-diketones and the corresponding chelates in a ratio of 4:6 had greatly improved lubricating properties compared to 1,3-diketones. Through X-ray photoelectron spectroscopy (XPS) analysis of the surface of the friction pair after the test and Fourier transform infrared (FT-IR) and nuclear magnetic resonance (NMR) analyses of 1,3-diketones before and after the experiment, we found that the necessary conditions for the friction pair lubricated by 1,3-diketone to achieve superlubricity were formation of tribochemical adsorption films and the presence of chelates in solution.
We herein demonstrate the use of 1,3-di(2-dipyridyl)propan-1,3-dione (DPPD) as a fluorogenic label for oligosaccharides. A number of milk-derived oligosaccharide standards were successfully labeled with this reagent, with the advantage of greatly simplified sample preparation compared to other commonly used fluorescent tags. DPPD shows a selectivity for oligosaccharides which do not possess a 2-acetamido-2-deoxy-hexose moiety at the reducing terminus, potentially aiding in the identification of complex mixtures of carbohydrates. The use of DPPD for the structural determination of oligosaccharides through exoglycosidase treatment, quantitative analysis of reactions, and in the synthesis of labeled oligosaccharides was also explored. This reagent has, in addition to the analysis of individual and mixed oligosaccharides, potential applications in the study of glycosidases and glycosyltransferases and as such represents a valuable addition to the tools available to the glycoscientist.
Li-Xia Zhao,Wei Hu,Zi-Bin Jiang,Jia-Yu Wang,Kui Wang,Shuang Gao,Ying Fu,Fei Ye
4-Hydroxyphenylpyruvate dioxygenase inhibitors (Echinochloa crus-galli 1.13.11.27, HPPD) have gained significant popularity as one of the best-selling herbicides worldwide. To identify highly effective HPPD inhibitors, a rational design approach utilizing bioisosterism was employed to create a series of 2-(arylformyl)cyclohexane-1,3-dione derivatives. A total of 29 novel compounds were synthesized and characterized through various techniques, including IR, 1H NMR, 13C NMR, and HRMS. Evaluation of their inhibitory activity against Arabidopsis thaliana HPPD (AtHPPD) revealed that certain derivatives exhibited superior potency compared to mesotrione (IC50 = 0.204 μM). Initial herbicidal activity tests demonstrated that compounds 27 and 28 were comparable to mesotrione in terms of weed control and crop safety, with compound 28 exhibiting enhanced safety in canola crops. Molecular docking analyses indicated that the quinoline rings of compounds 27 and 28 formed more stable π–π interactions with the amino acid residues Phe-360 and Phe-403 in the active cavity of AtHPPD, surpassing the benzene ring of mesotrione. Molecular dynamics simulations and molecular structure comparisons confirmed the robust binding capabilities of compounds 27 and 28 to AtHPPD. This study provides a valuable reference for the development of novel triketone herbicide structures, serving as a blueprint for future advancements in this field.
危险品化学品经营许可证（带存储）