SEPARATION SCIENCE AND TECHNOLOGY
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2026
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IF 2.5
Renfan Chen,Zhen Wang,Wenpu Zhang,Weilong Wu,Kunxi Huang,Hongbin Wang,Yaohui Yang,Kaile Zhao
The efficient recovery of strategic cobalt (Co) and nickel (Ni) from complex secondary resources is crucial for resource security. This study addresses a key bottleneck hindering short-process all-flotation routes: the difficulty in direct separation of reagent-coated sulfur-cobalt bulk concentrate derived from pre-concentrated vanadium titanomagnetite tailings. A synergistic reagent system featuring a calcium-based composite modifier (CCM) and a mercapto-based depressant (3-MP) was developed, enabling flotation separation of industrial reagent-laden sulfide feed without any pretreatment. In laboratory closed-circuit tests, a Co-Ni concentrate assaying 2.16% Co and 4.95% Ni was produced from 0.35% Co feed, with 80.82% Co and 79.65% Ni recoveries and a Co/S selectivity coefficient of 5.9, which compares favorably with traditional pretreatment-dependent processes. The process was scaled up to a 30,000 tonne per annum industrial production line. Stable operation yielded a Co-Ni concentrate (1.82% Co, 4.35% Ni), salable sulfur concentrate with sulfur content of no less than 30%, and confirmed simultaneous copper recovery. This work offers a practically and industrially tested framework for short-process clean recovery of critical metals from sulfide ores.
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高影响因子
ADVANCED MATERIALS
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2026
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IF 29.1
Minglu Tang,Chenwei Jiang,Mingmei Guo,Qi Chen,Qi Shang,Lin Xiong,Wen Zhang,Liang Dong,Qi Yue,Xihui Gao,Feihu Wang
Personalized vaccines represent a promising approach for cancer treatment by eliciting tumor-specific immune responses. However, their development faces persistent challenges, including the laborious and costly process of neoantigen identification, which substantially delays vaccine production. Moreover, conventional platforms suffer from rapid systemic clearance and inefficient delivery to antigen-presenting cells (APCs), leading to only transient and weak immune activation. Here, we report a STING-agonist-integrated hydrogel system designed for localized delivery of tumor-derived extracellular vesicles (TEVs) to achieve robust and durable antitumor immunity. Upon subcutaneous administration, the in situ formed hydrogel vaccine acts as a depot for antigen-rich TEVs and STING agonists. We demonstrate that this vaccine promotes dendritic cells (DCs) recruitment and establishes an immune-permissive niche through spatiotemporal control over antigen-adjuvant distribution and prolonged APC-antigen engagement. Within this niche, DCs efficiently internalize and process TEVs under STING-mediated activation. These matured DCs subsequently migrate to draining lymph nodes, where they initiate potent and sustained tumor-specific T-cell responses. Our results show that rapidly producible personalized vaccines derived from melanoma TEVs effectively inhibit tumor growth. In a postoperative breast cancer model, patient-tailored TEV vaccines also markedly prevent tumor recurrence and metastasis. This readily customizable platform represents a robust and translatable strategy for personalized cancer immunotherapy.
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PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
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IF 4.4
Lingyi Zhao,Yi Wei,Hao Fu,Ruiqin Yang,Qian Zhao,Hongwen Zhang,Weiping Cai
The accurate, sensitive and portable detection of morphine is important to handle judicial cases, but remains to be a great challenge. In this work, a flexible route is presented for the accurate identification and efficient detection of trace morphine in solutions based on surface-enhanced Raman spectroscopy (SERS) and a solid substrate/chip. A gold-coated jagged silicon nanoarray (Au-JSiNA) is designed and prepared via Si-based polystyrene colloidal template-reactive ion etching and sputtering deposition of Au. Such Au-JSiNA has three-dimensional nanostructure with good structural uniformity, high SERS activity and hydrophobic surface . Adopting this Au-JSiNA as SERS chip, trace morphine in solutions could be detected and identified in both dropping and soaking ways, and the limit of detection is below 10 -4 mg/mL. Importantly, such chip is especially suitable for the detection of trace morphine in aqueous solutions and even domestic sewage. The good SERS performance is attributed to the high-density nanotips and nanogaps on this chip as well as its hydrophobic surface. Additionally, the appropriate surface modification of this Au-JSiNA chip with 3-mercapto-1-propanol or 3-mercaptopropionic acid/1-(3-dimethylaminopropyl)-3-ethylcarbodiimide can further increase its SERS performances to morphine. This work provides a facile route and practical solid chip for SERS detection of trace morphine in solutions, which is significant to develop the portable and reliable instruments for on-site analysis of drugs in solutions.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2021
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IF 7.46
Huiyi Yang,Qiyi He,Junkang Pan,Mingxia Lin,Zhiting Lao,Qinglan Li,Xiping Cui,Suqing Zhao
Nanozymes are a type of artificial enzymes that can replace traditional natural enzymes for biotechnology to biosensing, biocatalysis , and biological imaging. Nevertheless, it is still a huge challenge in the pursuit of new mimic enzymes or multiple enzyme-like activities mimics. In this work, PtCu nanocages (PtCu NCs) with hollow interior and rough exterior was prepared. PtCu NCs displayed superior tetra-enzyme mimetic activities including peroxidase (POD)-, superoxide dismutase (SOD)-, catalase (CAT)- and ascorbic acid oxidase (AAO)-like activities. Meaningfully, attributed to the POD mimic activity, sensitive and convenient colorimetric biosensors for L -Cysteine ( L -Cys), homocysteine (Hcy) and glutathione (GSH) were developed with wide linear range (LR) and low limit of detection (LOD) of 0.28 μM, 1.48 μM and 0.75 μM (S/N = 3), respectively. Moreover, based on the AAO mimic activity, the cascade reaction was proposed including the oxidation of ascorbic acid (AA) to dehydroascorbic acid (DHAA) by PtCu NCs and the formation of the fluorescent quinoxaline (DFQ) coming from the reaction between DHAA and o-phenylenediamine (OPD). A novel fluorescent biosensor for dehydroepiandrosterone (DHEA) was successfully constructed based on the immunoassay method combined with the cascade reaction for AA, with the LR of 0.6–464.9 ng·mL −1 and LOD of 0.5 ng·mL −1 . These colorimetric and fluorescent biosensors displayed outstanding performance in terms of sensitivity, specificity, and accuracy for real samples, suggesting that PtCu NCs was a promising candidate for biosensing.
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高影响因子
ACS Applied Polymer Materials
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2024
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IF 4.4
Hangzhou Wang,Xiaobin Li,Jun Shi,Xiaoyan Xiong,Chenguang Kong,Cunzhi Li,Youcheng Huang,Shumin Jiang,Kun Wu,Li Yang
The shrinkage of UV-curable polymers is directly related to the structural changes in the monomer behavior of the system. The issue of shrinkage in these systems can be mitigated by leveraging the dynamic behavior of disulfide bonds. However, it remains unclear how light induction affects the contraction of the system through processes such as bond cleavage, migration, and recombination of disulfide bonds. In this study, we modified the polyurethane core of a UV-curable system by incorporating three different topologies of disulfide bonds. We examined the impact of these different arrangements and their dynamic adjustment on reducing shrinkage using scanning electron microscopy, shrinkage rate tests, and theoretical analysis based on the Gauss-type radial distribution probability density function. Our findings show that the modified sample exhibited lower curing shrinkage and a smoother surface compared to unmodified polyurethane. Specifically, while the shrinkage rate before modification (PU) was 5.16%, after modification (DSBT-PU, DSBP-PU, DSBE-PU) it decreased to 1.24% for DSBT-PU, 0.67% for DSBP-PU, and 0.95% for DSBE-PU. We also observed that longer chain lengths in disulfide-containing fragments aided in dynamically adjusting the system structure. However, the increase in the molecular fragment length makes it more difficult to migrate dynamic disulfide bonds. Furthermore, our synthetic sample demonstrated high transmittance levels, exceeding 98%. Additionally, we conducted comprehensive examinations including testing 180° peel strength, differential scanning calorimetry, thermogravimetric analysis, tensile characteristics, and transmittance properties, among others. This work not only sheds light on how dynamic bonds influence system structure but also holds practical implications for applications in liquid optical clear adhesive (LOCA) and unique pressure-sensitive adhesives.
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高影响因子
ACS Applied Materials & Interfaces
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2025
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IF 8.2
Yongchao He,Yu Huang,E. Xu,Xiaochao Xia,Chong Xiao,Feng Wang,Xudong Cui,Mingbo Yang,Hang Chen,Yanhao Huang
Azobenzene-based polymers have been prominent photochromic materials (PCMs) for decades but still suffer from low efficiency and instability in photallochromy due to hindered isomerization in the solid state. Here, a controlled charge interaction between additive SnO2 nanoparticles and azophenyl polyether was designed and established using density functional theory (DFT) prediction and experimental verification, aiming to disrupt π–π stacking among azobenzene moieties. Theoretical calculations, time-resolved fluorescence spectra, and zeta potential tests have proven that negative charges generated on the surface of SnO2 nanoparticles under UV-A (330–370 nm) irradiation transfer to positively charged carboxyl groups of azobenzene moieties, accelerating the isomerization speed (response time ≤ 10 s) and stabilizing the cis conformation of azobenzene. Compared to the pristine azophenyl polyether films, the azophenyl polyether/SnO2 composite film exhibits a more rapid and pronounced color-change behavior under both 450 nm blue light and 365 nm UV irradiation, enabling a stable and durable pattern writing/erasing functionality triggered by 450/365 nm light. Interestingly, owing to a 13.53% difference in reflectance at 410 nm between cis and trans isomers, the imprinted patterns on the composite films are nearly invisible under ambient light yet show a high contrast ratio (CR) of up to 2.4 under 405 nm violet light, demonstrating promising potential applications in anticounterfeiting and information encryption.
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PubMed
高影响因子
危险品化学品经营许可证（带存储）