ENVIRONMENTAL POLLUTION
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2024
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IF 7.6
Yingying Liu,Xudong Jin,Yanan Ye,Zeqiong Xu,Zhongkun Du,Huachang Hong,Haiying Yu,Hongjun Lin,Xianfeng Huang,Hongjie Sun
3-bromine carbazole (3-BCZ) represents a group of emerging aromatic disinfection byproducts (DBP) detected in drinking water; however, limited information is available regarding its potential cardiotoxicity. To assess its impacts, zebrafish embryos were exposed to 0, 0.06, 0.14, 0.29, 0.58, 1.44 or 2.88 mg/L of 3-BCZ for 120 h post fertilization (hpf). Our results revealed that ≥1.44 mg/L 3-BCZ exposure induced a higher incidence of heart malformation and an elevated pericardial area in zebrafish larvae; it also decreased the number of cardiac muscle cells and thins the walls of the ventricle and atrium while increasing cardiac output and impeding cardiac looping. Furthermore, 3-BCZ exposure also exhibited significant effects on the transcriptional levels of genes related to both cardiac development ( nkx2.5 , vmhc , gata4 , tbx5 , tbx2b , bmp4 , bmp10 , and bmp2b ) and cardiac function ( cacna1ab , cacna1da , atp2a1l , atp1b2b , atp1a3b , and tnnc1a ). Notably, N-acetyl-L-cysteine, a reactive oxygen species scavenger, may alleviate the failure of cardiac looping induced by 3-BCZ but not the associated cardiac dysfunction or malformation; conversely, the aryl hydrocarbon receptor agonist CH131229 can completely eliminate the cardiotoxicity caused by 3-BCZ. This study provides new evidence for potential risks associated with ingesting 3-BCZ as well as revealing underlying mechanisms responsible for its cardiotoxic effects on zebrafish embryos.
研究领域:
环境科学
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毒理学
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发育生物学
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水生毒理学
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Li-Xin Kou,Xiao-Yu Zhang,Zi-Cen Zuo,Na Liu,Zhen He,Gui-Peng Yang
Polyhalogenated carbazoles (PHCZs), an emerging class of halogenated organic pollutants, have been widely detected in various environmental media, including sediments, soil, air, and organisms. The East China Sea (ECS) is a vital region for marine and fishery resource development in China, yet research on the pollution levels and sources of PHCZs in its sediments remains limited. This study reports the occurrence of seven PHCZs in the surface sediments of the ECS, with detection rates exceeding 90%. The concentrations of Σ 7 PHCZs ranged from 3.5 to 27 ng/g, with an average of 9.9 ng/g. The predominant congeners were 1368-BCZ and 3-ICZ. The sources of PHCZs included a non-specific source transported via terrestrial runoff (39%), industrial wastewater discharge (35%), and optoelectronic material pollution (26%), as identified by the positive matrix factorization model. The ecological risk assessment, based on TEQ, indicated a range of 0.18–5.0 pg TEQ/g across the study area. These findings highlight the potential ecological concerns associated with PHCZs in the ECS and emphasize the need for enhanced environmental monitoring and source mitigation efforts to reduce their potential environmental impacts.
研究领域:
环境科学
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海洋学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2025
·
IF 12.4
Wenjian Lao,Xiaoyan Shang,Shuiqiang Yu,Huiquan Xiao,Yingying Lou,Cuihua Song,Jinmao You
Passive sampling methods can provide valuable insights for monitoring hydrophobic organic compounds (HOCs) in aquatic environments. As the list of target HOCs expands, there is an increasing demand for passive samplers that can detect a broader range of these compounds. This study aimed to assess the efficacy of a three-layer co-extruded polyethylene/ethylene vinyl acetate (TLC-EVA) film alongside three existing materials (polyethylene (PE), polydimethylsiloxane (PDMS), and poly(methyl methacrylate) (PMMA)) for passive sampling of carbazole and five halogenated carbazoles (PHCZs), a group of dioxin-like chemicals, in water. The films were calibrated through batch experiments to determine the partition coefficients between the polymer and water ( K PW ). The performance of the samplers and the presence of PHCZs were evaluated through 7- and 14-day exposures in the Xiaoyi River, which flows through Qufu City, China. The log K PW values varied significantly among the compounds and were generally consistent across the four films, ranging from 2.73 to 4.14 for EVA, 2.65 to 4.21 for PE, 2.85 to 3.98 for PMMA, and 2.62 to 4.22 for PDMS. These findings indicate that the films can effectively function as passive samplers for PHCZs. Additionally, a comparison of log K PW results with physicochemical parameters (log K OW and log K OC ) highlighted the negative impact of halogen substituents and steric hindrance on sorption, particularly for 1,3,6,8-tetrabromocarbazole. The passive sampling reached equilibrium within the 7-day exposure period, with all PHCZs detected in the river water. Increased concentrations at urban and wastewater treatment plant outlet sampling sites suggested specific sources of PHCZs. Our results advocate for the application of multilayer co-extrusion films as a novel material for passive sampling of HOCs.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）