FOOD CHEMISTRY
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2026
·
IF 10.4
Mingzhu Liu,Xueyan He,Bo Peng,Jin Wu,Zunquan Zhao,Jialei Bai,Jingran Sun,Yanjun Fang
Highly mimetic enzymatic Mn₃O₄/gold nanoparticle (AuNP) composites were prepared, which catalyze the oxidation of tert-butylhydroquinone (TBHQ) to red 2-tert-butyl-1,4-benzoquinone (TBBQ) for TBHQ detection. Absorbance at 487 nm (A₄₈₇) correlates linearly with TBHQ concentrations in the range of 0.52–50 μg/mL, with a limit of detection (LOD) of 0.063 μg/mL, and a limit of quantification (LOQ) of 0.21 μg/mL. TBBQ quenches the fluorescence of copper/iodine-doped carbon dots (Cu,I-CDs) at 500 nm via the inner filter effect (IFE), forming an “on-off” fluorescence probe for TBHQ. TBHQ concentration correlates linearly with the fluorescence intensity difference (F₀ − F) in the range of 0.31–54 μg/mL, with an LOD of 0.054 μg/mL and an LOQ of 0.18 μg/mL. This study uses a dual-mode detection approach to determine TBHQ in various food samples, with recovery rates ranging from 82.5% to 103.0%. The method is sensitive, accurate, cost-effective, and suitable for the rapidly analyzing of TBHQ in food.
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INORGANIC CHEMISTRY COMMUNICATIONS
·
2026
·
IF 5.9
Le Wang,Jinwen Zhao,Siqing Zhang,Yanqin Zhu,Qinhong Yin
The hazards of bisphenol A (BPA) represent a significant public health concern, and developing accurate methods for its detection in water is of great importance for both human health and environmental protection. To address this, we have developed a dual-quantum dots fluorescent (FL) probe for highly efficient BPA recognition. This probe is fabricated by embedding iron‑manganese quantum dots (Fe Mn QDs) and copper‑zinc quantum dots (Cu Zn QDs) into a molecularly imprinted polymer matrix using a one-pot synthesis method. The constructed Fe Mn QDs/Cu-Zn QDs@MIPs sensor integrates dual FL emissions at 575 nm (Fe Mn QDs) and 525 nm (Cu Zn QDs) for specific recognition of BPA. Upon interaction with BPA, the sensor exhibits enhanced yellow fluorescence from Fe Mn QDs while the blue-green fluorescence of Cu Zn QDs is quenched. The fluorescence intensity ratio (F575 nm/F525 nm) demonstrates a single-exponential function relationship with BPA concentration. The employment of a dual-signal transduction mechanism enables the sensor to exhibit exceptional selectivity and ultrahigh sensitivity, with a wide linear detection range of 2.283–228.3 μg/L and a low detection limit (LOD) of 1.142 μg/L. To demonstrate its practical applicability, the sensor was employed for the quantitative detection of BPA in commercially bottled water, achieving satisfactory recoveries ranging from 96.0% to 104.4%. This work presents a practical and innovative approach for developing a ratiometric sensing system with dual fluorescence signals integrated with a smartphone-based visual detection platform for monitoring trace-level BPA.
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BIOCHEMICAL ENGINEERING JOURNAL
·
2022
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IF 4.446
Xiao Li,Yan Xu,Dimei Ouyang,Kefan Ye,Yiwen Chen,Qiulan Li,Qinghai Xia,Xiaomei Wu,Yaling Yang
Nanozymes are next-generation antifungal agents with enzyme-like characteristics and negligible biological toxicity owing to their ability to catalyze the production of reactive oxygen species. Herein, copper- and iodine-doped carbon dots (Cu/I-CDs) with intrinsic peroxidase-like antifungal activity are synthesized via a simple one-step hydrothermal approach. These Cu/I-CDs enhance the decomposition of H 2 O 2 to generate •OH and efficiently kill Candida albicans . With an exogenous H 2 O 2 concentration of only 0.5 mM, a low Cu/I-CDS concentration of just 0.585 mg/mL is required to achieve a 10% survival rate of C. albicans upon irradiation for 90 min with a light-emitting diode (16 W). The Cu/I-CD nanozyme effectively destroys C. albicans biofilms without causing significant toxicity both in vitro and in vivo. The prepared Cu/I-CDs accelerate the death of C. albicans in mouse wounds and vaginal models, thereby promoting wound healing and treating vulvovaginal candidiasis (VVC) in mice. The high biocompatibility of the Cu/I-CDs was verified by hemolysis and MTT assays . The Cu/I-CD nanozyme synthesized in this study shows great potential for application as an antifungal agent and may replace common existing antifungal drugs.
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MICROCHIMICA ACTA
·
2021
·Vol. 189
·期 1
·1-9
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IF 5.833
Yang Dezhi,Li Qiulan,Zhang Qian,Wang Yijie,Li Hong,Tammina Sai Kumar,Yang Yaling
An Au-based nanozyme composite (AuNPs/Cu,I) was constructed by using Cu,I-doped carbon dots (Cu,I-CDs) as the reducing agent as well as the nanozyme. Notably, AuNPs/Cu,I nanozyme not only possessed the intrinsic activity of mimicking enzymes of superoxide dismutase, peroxidase, and catalase at different conditions but was also employed as surface-enhanced Raman spectroscopy (SERS) enhancer. The combination of Cu,I-CDs and AuNPs promoted the electron transferability, leading to increased peroxidase-like activity and superoxide-like activity. Compared to the individual Cu,I-CDs and AuNPs nanozyme, the AuNPs/Cu,I composite demonstrated promising peroxidase-like activity by transferring electrons instead of generating OH. Interestingly, the multienzyme-like activity of AuNPs/Cu,I nanozyme could be finely tuned by changing the composition of Cu 0 /Cu + and Au. The tert -butyl hydroquinone (TBHQ) as the substrate could be catalyzed with AuNPs/Cu,I nanozyme to produce red substances, resulting in a significant Raman enhancement effect at the same time, showing good linear range from 0.11 to 10 mg L −1 . Overall, the current investigation provides a flexible and controllable way to design multifunctional nanozymes along with the Raman enhancement strategy based on the catalysis of nanozyme. Graphical abstract
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ANALYTICAL BIOCHEMISTRY
·
2023
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IF 2.9
Qinhong Yin,Xiaolan Yang,Lihua Yang,Dezhi Yang,Yaling Yang,Yanqin Zhu
As newly developed synthetic enzymes with exceptional catalytic capabilities and outstanding stability, nanozymes have drawn considerable interest in the realm of sensing. Using a simple hydrothermal process, iodine and copper-doped carbon dots (Cu,I-CDs) with simulated enzymes were fabricated in the current investigation. Cu,I-CDs demonstrate peroxidase-mimicking function together with high catalytic effectiveness due to aforementioned features. This led to generation of a colorimetric sensor for quick and accurate quantitative assessment of morphine (MOR). The outcomes showed the method's usefulness for the colorimetric detection of MOR. The linear range for MOR detection is 0.25–25 μg/mL having a reduced detection limit of 64 ng/mL. This sensor's successful use in the analysis of MOR in biological material is more noteworthy.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yifan Cui,Dezhi Yang,Qiulan Li,Zhongmei Peng,Zitao Zhong,Yuzhu Song,Qinqin Han,Yaling Yang
Nanozyme-mediated antioxidative therapy is a promising star for treating a myriad of important diseases through eliminating excessive reactive oxygen species (ROS) such as O2·– and H2O2, a critical mechanism for inflammatory bowel disease (IBD). This work provides a high biocompatibility iodine–copper–zinc covalent doped carbon dots (Cu,Zn,I-CDs) with the catalase (CAT)-, superoxide dismutase (SOD)- and glutathione peroxidase (GPx)-like catalytic activities for treating ulcerative colitis (UC) by scavenging overproduced ROS. We found that I dopant aids in counteracting the positive charge at Cu,Zn dopants brought on by low pH, enabling Cu,Zn,I-CDs to process strong triple antioxidant nanozyme activities rather than Cu,Zn-CDs. Vitro experiments displayed that the Cu,Zn,I-CDs could scavenge the excessive ROS to protect cellular against oxidative stress and reduce the expression of proinflammatory cytokines, such as TNF-α, IL-1β, and IL-6. In sodium dextran sulfate (DSS)-induced colitis mice models, Cu,Zn,I-CDs with excellent biocompatibility could effectively relieve the inflammation of the colon, containing the reduction of the colon length, the damaged epithelium, the infiltration of inflammatory cells, and upregulation of antioxidant genes. Therefore, the therapy of Cu,Zn,I-CD antioxidant nanozymes is an effective approach and provides a novel strategy for UC treatment.
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