SENSORS AND ACTUATORS B-CHEMICAL
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2019
·
IF 6.393
Chenglin Zheng,Feng Jin,Yuanyuan Zhao,Meiling Zheng,Jie Liu,Xianzi Dong,Zhong Xiong,Yanzhi Xia,Xuanming Duan
Light-driven micro/nano-actuators are one of the most important topics in the biomedical micro-electromechanical systems (MEMS) field. Currently, their development is hampered due to the difficulties in designing and fabricating biocompatible light-driven microactuators with the dimensions less than one hundred micrometres and a response time in the order of seconds. In this work, gel photoresists were prepared by embedding photothermal surface-modified Fe 3 O 4 nanoparticles (NPs) into a mixture that included a photoinitiator, photosensitizer, monomers, crosslinkers and solvents. Macroscopic poly( N -isopropylacrylamide) (PNIPAM)/nano-Fe 3 O 4 hydrogels were prepared by ultraviolet photopolymerization of gel photoresists, which showed good temperature-responsive volume changes and light-triggered bending deformation. Then the two-photon polymerization (TPP) microfabrication properties of gel photoresists with 0, 0.48 and 0.95 wt% Fe 3 O 4 NPs were investigated in detail. Importantly, after the TPP microfabrication and subsequent solvent-exchange procedure, a double-armed near-infrared (NIR)-light-driven three-dimensional (3D) hydrogel microcantilever with a size of ∼26 μm was successfully fabricated. The hydrogel microactuator had a fast response time of ∼0.033 s in water under NIR radiation and showed good reversibility. Furthermore, the distance between the two arms of the hydrogel microcantilever could be manipulated by controlling the laser focus and incident laser power.
研究领域:
生物医学工程
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材料科学
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微机电系统(MEMS)
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DOI
高影响因子
DESALINATION
·
2025
·
IF 9.8
Youyuan Xu,Yakun Tang,Lang Liu,Yue Zhang,Xiang Bai,Biao Zhang,Zhiguo Jia
Due to lower evaporation enthalpy and controllable water management, the efficiency of 3D hydrogel-based evaporators has attracted significant attention in solar desalination. However, challenges such as the closed pore structure, the strong adhesive force between salt deposition and photothermal material, and the byproducts of high-saline wastewater have limited long-term application in high-saline brine. To address these limitations, a 3D zero liquid discharge evaporator has been innovatively constructed. It is composed of a high porosity 3D CNT/PDA@PVA sponge-like hydrogel in optimal ionic conditions (the Hofmeister effect) and pearl-patterned cotton towels. The assembled evaporator has achieved excellent water evaporation performance of 3.0 kg m −2 h −1 (1.08 kg m −2 h −1 , in the dark) through side area-assistance and environmental energy. The non-contact salt deposition design can avoid direct salt deposition on the surface of the photothermal material. Thus, due to diffusion-convection and Marangoni flow in highly porous material and pearl-patterned cotton towels, the formed zero liquid discharge evaporator has remained a stable water evaporation rate of 2.65 ± 0.1 kg m −2 h −1 and recovered salt (59.16 g m −2 h −1 ) in 10 wt% NaCl solution for over 100 h. Most importantly, replacing the cotton towel with a new one allows the assembled evaporator to continuously operate in a 20 wt% NaCl solution while protecting it from damage. Significantly, the collected water can be directly used for drinking and wheat cultivation. This work offers new insights for designing a 3D-zero liquid discharge evaporator that can operate long-term in high-salinity brine, thereby expanding its practical applications.
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
ACS Nano
·
2025
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IF 16
Yanyan Zhang,Huimin Zheng,Yu Zhao,Cong Du,Jian Zhang,Jinying Liu,Shengjie Jiang,Yan Wei,Chuan-Liang Feng
Chirality is a pivotal determinant in stem cell differentiation, yet discerning the individual effects of chirality across different scales within native three-dimensional (3D) environments remains challenging. Here, a strategy is employed using nanostructures with controlled chirality to precisely assess the impact of molecular and supramolecular chirality on mesenchymal stem cell (MSC) osteogenic differentiation. We synthesized two pairs of enantiomers, l/d-phenylalanine (l/D-Phe) and l/d-1-naphthylalanine (L/D-1-Nap) derivatives, which could form four distinct chiral fibrous hydrogels with different molecular and supramolecular chiralities: L-supP and D-supP (supP indicates supramolecular right-handed helix), and L-supM and D-supM (supM denotes supramolecular left-handed helix). Both experimental and computational analyses reveal that the supramolecular supM/supP helicity is governed by conformational changes in aromatic side chains, switching between outward and inward orientations. Intriguingly, MSCs encapsulated within these chiral fibers displayed osteogenic differentiation that was predominantly influenced by higher-order supramolecular chirality rather than molecular chirality. Specifically, supM-nanofibrils significantly promoted the MSC commitment to the osteoblast lineage, whereas supP-nanofibrils lacked this osteoinductive potential. Additionally, we observed subtle positive and negative modulations of MSC osteogenic differentiation by l- and d-enantiomeric molecular chiralities, respectively. Our study presents a strategy for chiral hydrogel design and delineates how supramolecular chirality surpasses molecular chirality in directing MSC osteogenesis within 3D hydrogels, highlighting the potential of chiral biomaterials in bone tissue engineering.
研究领域:
生物材料学
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再生医学
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-15
·
IF 15.7
Li Bohan,Fu Qingyu,Lu Yan,Chen Cheng,Zhao Yingshuai,Zhao Yuanfeng,Cao Minghui,Zhou Wei,Fan Xiaoliang,Jiang Xiaoyu,Zhao Peng,Zheng Yijun
Mechanical forces play a critical role in regulating cancer cell behavior, particularly during metastasis. Here we present a three-dimensional hydrogel platform embedded with near-infrared-responsive macromolecular actuators that enable precise mechanical stimulation of specific integrin subtypes in cancer cells. By leveraging this system, we investigate how different force parameters—magnitude, frequency, and duration—affect the migration and invasion of ovarian cancer cell spheroids, focusing on the integrins αvβ3 and αvβ6. We find that mechanical stimulation enhances collective invasion at early stages and triggers a mesenchymal-to-amoeboid transition during later migration, especially when high-frequency, large-amplitude forces disrupt αvβ3-ligand interactions. In contrast, cells engaging αvβ6—through higher-affinity binding—show limited transition under similar conditions. Molecular simulations support these findings by revealing the underlying mechanics of integrin-specific responses. This 3D hydrogel platform provides a powerful tool for studying mechanotransduction in cancer cells and offers potential insights for developing targeted cancer therapies.
研究领域:
生物医学工程
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癌症生物学
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细胞力学
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产品关联
DOI
PubMed
高影响因子
APPLIED THERMAL ENGINEERING
·
2024
·
IF 6.1
Chenglong Guo,Chengcheng Ma,Tongxing Zhang,Yukun Tian,Ke Liu,Mohsen Mirzaei,Yejun Wang,Hongxia Cao
Solar desalination has been extensively researched as a promising way to address freshwater shortages. However, developing a salt resistant solar evaporator that can be easily extended and manufactured is still a challenge in practical applications. In this work, a 3D hydrogel-based salt resistant self-floating solar-driven interfacial evaporator with efficient water-lifting capacity was proposed using the prepared hydrogel with carbon black (CB) nanoparticles and extruded polystyrene (XPS) board as raw materials. The experimental results implied that the developed evaporator had the highest evaporation rate and evaporation efficiency at 0.05 g CB loading, which were 1.70 kg m − 2 h − 1 and 92.8 % at a light intensity of 1 kW m −2 . Moreover, the evaporator also displayed prominent salt resistance in the evaporation of brine with high salinity and outstanding stability after 10 cycles. Significantly, the outdoor experiment demonstrated that 1 m 2 evaporator can generate 5923.5 g freshwater per day, which was enough to meet the daily requirement of two adults for drinking water. In addition, the physical fields of the hydrogel with CB nanoparticles of the evaporator at evaporation equilibrium were simulated to analyze its long-term and high-performance operation capability. All in all, the 3D hydrogel-based salt resistant self-floating solar-driven interfacial evaporator with efficient water-lifting capacity presented an enormous application prospect in the field of solar desalination.
研究领域:
材料科学
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环境工程
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能源科学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 43
·8486-8491
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IF 4.726
Jinfeng Xing,Ling Liu,Xiaoyan Song,Yuanyuan Zhao,Ling Zhang,Xianzi Dong,Feng Jin,Meiling Zheng,Xuanming Duan
Hydrogels with precise 3D configuration (3D hydrogels) are crucial for biomedical applications such as tissue engineering and drug delivery, which require the improvement of the spatial resolution on both the microscopic and the nanometric scale. In this study, a water soluble two-photon polymerization (TPP) initiator (WI) with high initiating efficiency was prepared by using a poloxamer (PF127) to encapsulate 2,7-bis(2-(4-pentaneoxy-phenyl)-vinyl)anthraquinone via a hydrophilic–hydrophobic assembly. The threshold energy for WI was 6.29 mW at a linear scanning speed of 10 μm s−1, which was much lower than those reported previously. A lateral spatial resolution of 92 nm was achieved as the resolution breakthrough of 3D hydrogels. Finally, the microstructure with high accuracy simulating the morphology of adenovirus was fabricated at the laser power close to the threshold energy of TPP, further demonstrating the ultrahigh resolution of 3D hydrogels.
研究领域:
生物医学工程
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组织工程
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药物递送
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产品关联
DOI
PubMed
高影响因子
Advanced Sustainable Systems
·
2022
·Vol. 6
·期 10
·2200236
·
IF 6.737
Yunzheng Liang,Jiacheng Guo,Jing-Jing Li,Jian Mao,An-Quan Xie,Liangliang Zhu,Su Chen
Solar-driven interfacial steam generation serves as an alternative strategy to alleviate the emergency of the global freshwater shortage. Compared to traditional 2D evaporators, 3D evaporators have drawn further attention for their excellent evaporation performance. However, large volume 3D evaporators suffer from problems related to higher vulnerability to damage and less portable storage. Worse still, 3D evaporators equally behave poorly in dark conditions. Herein, a robust and flexible 3D hydrogel/fiber evaporator mounted with solid–solid phase change materials (SPCMs) for efficient photothermal desalination is reported. The hydrogel fills the spaces of fibers and not only forms a topology-like structure to strengthen the sunlight absorption (≈0.1% optical transmittance and ≈10% reflectance), but also reinforces the mechanical strength and elasticity of the evaporator (≈4 MPa tensile strength and ≈23 MPa Young's modulus). Notably, highly thermally-conductive SPCMs fulfill a dual function under light-dark conditions, facilitating a 3D evaporator for absorbing energy from high-temperature environment under daylight, and releasing latent heat to sustain evaporation when light is turned off, ultimately achieving evaporation rates of 3.80 and 0.31 kg m –2 h –1 under different conditions. Such a durable 3D hydrogel/fiber evaporator with dramatic evaporation performance opens up promising prospects for freshwater production in remote areas.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
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2024
·
IF 8.3
Peng-Cheng Guan,Qian-Jiao Qi,Yu-Qing Wang,Jia-Sheng Lin,Yue-Jiao Zhang,Jian-Feng Li
Traditional diagnostic methods, such as blood tests, are invasive and time-consuming, while sweat biomarkers offer a rapid physiological assessment. Surface-enhanced Raman spectroscopy (SERS) has garnered significant attention in sweat analysis because of its high sensitivity, label-free nature, and nondestructive properties. However, challenges related to substrate reproducibility and interference from the biological matrix persist with SERS. This study developed a novel ratio-based 3D hydrogel SERS chip, providing a noninvasive solution for real-time monitoring of pH and glucose levels in sweat. Encapsulating the probe molecule (4-MBN) in nanoscale gaps to form gold nanoflower-like nanotags with internal standards and integrating them into an agarose hydrogel to create a 3D flexible SERS substrate significantly enhances the reproducibility and stability of sweat analysis. Gap-Au nanopetals modified with probe molecules are uniformly dispersed throughout the porous hydrogel structure, facilitating the effective detection of the pH and glucose in sweat. The 3D hydrogel SERS chip demonstrates a strong linear relationship in pH and glucose detection, with a pH response range of 5.5–8.0 and a glucose detection range of 0.01–5 mM, with R2 values of 0.9973 and 0.9923, respectively. In actual sweat samples, the maximum error in pH detection accuracy is only 1.13%, with a lower glucose detection limit of 0.25 mM. This study suggests that the ratio-based 3D hydrogel SERS chip provides convenient, reliable, and rapid detection capabilities with substantial application potential for analyzing body fluid pH and glucose.
研究领域:
生物医学工程
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分析化学
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纳米技术
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可穿戴设备
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-26
·
IF 10.6
Qiu Shui,Cao Lili,Xiang Dingding,Wang Shu,Wang Di,Qian Yiyi,Li Xiaohua,Zhou Xiaoshu
To assess the efficacy of a novel 3D biomimetic hydrogel scaffold with immunomodulatory properties in promoting fracture healing. Immunomodulatory scaffolds were used in cell experiments, osteotomy mice treatment, and single-cell transcriptomic sequencing. In vitro, fluorescence tracing examined macrophage mitochondrial transfer and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). Scaffold efficacy was assessed through alkaline phosphatase (ALP), Alizarin Red S (ARS) staining, and in vivo experiments. The scaffold demonstrated excellent biocompatibility and antioxidant-immune regulation. Single-cell sequencing revealed a shift in macrophage distribution towards the M2 phenotype. In vitro experiments showed that macrophage mitochondria promoted BMSCs’ osteogenic differentiation. In vivo experiments confirmed accelerated fracture healing. The GAD/Ag-pIO scaffold enhances osteogenic differentiation and fracture healing through immunomodulation and promotion of macrophage mitochondrial transfer.
研究领域:
生物材料
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组织工程
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再生医学
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免疫学
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干细胞生物学
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DOI
PubMed
高影响因子
DYES AND PIGMENTS
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2017
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IF 3.473
Xing Huang,Xiaopu Wang,Yuxia Zhao
A series of water-soluble benzylidene cyclanone dyes T1 - T3 were synthesized. Their photo-physical properties were investigated using UV–Vis spectra, fluorescence spectra and two-photon absorption spectra. The maximum two-photon absorption cross-sections (σ 2 ) of T1 - T3 in deionized water were determined as 567 GM, 808 GM and 231 GM. Using T1 - T3 as photoinitiators (PIs) directly, 2D and 3D nano patterns based on two-photon crosslinking or polymerization of bovine serum albumin (BSA), water-soluble acrylic ester monomer (SR610) and hyaluronic acid derivative (HAGM) were successfully fabricated, respectively. Much lower threshold energies and wider fabrication windows were obtained in the formulations containing these PIs compared with commercial ones. Furthermore, the cytotoxicity study showed a favorable biocompatibility of these PIs, which indicated T1-T3 would have application prospects in 3D fabrication of biomaterials.
研究领域:
材料科学
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生物医学工程
·
光学
·
纳米技术
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2014
·Vol. 2
·期 27
·4318-4323
·
IF 0
Jinfeng Xing,Jinhao Liu,Tingbin Zhang,Ling Zhang,Meiling Zheng,Xuanming Duan
Hydrogels with a precise 3D configuration (3D hydrogels) are required for a number of biomedical applications such as tissue engineering and drug delivery. Two-photon polymerization (TPP) is an advanced method to fabricate 3D hydrogels. However, TPP of 3D hydrogels has been challenged by the lack of TPP initiators with high efficiency in aqueous medium. In this study, a water soluble TPP initiator (WI) with high fabrication efficiency was prepared by combining hydrophobic 2,7-bis(2-(4-pentaneoxy-phenyl)-vinyl)anthraquinone (N) with a C2v symmetrical structure and 2-hydroxypropyl-β-cyclodextrins through host–guest chemical interaction. Both one and two-photon optical properties of WI have been investigated. In aqueous medium, WI showed a two-photon absorption cross-section of around 200 GM at the wavelength of 780 nm which was much higher compared with those of commercial initiators. The threshold energy of TPP for the resin with WI as a photoinitiator (the molar ratio of N in resin is 0.03%) was 8.6 mW. 3D hydrogels with a woodpile microstructure were further fabricated by using an average power of 9.7 mW and a scanning speed of 30 μm s−1.
研究领域:
材料科学
·
生物医学工程
·
高分子化学
·
组织工程
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DOI
PubMed
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