ChemistrySelect
·
2024
·Vol. 9
·期 36
·e202401875
·
IF 1.9
Haonan Li,Chenping Gao,Qingjie Liu,Yanchun Guo,Yufen Zhao
Graphical We report here a new I 2 /H 2 O 2 co-catalyzed oxidative [4+1] cyclization of benzaldehyde with 2-(aminomethyl)pyridine or o -phenylenediamine/2-aminothiophenol to provide various substituted imidazo[1,5- a ]pyridines and benzimidazoles/thiazole via C(acyl)−N bond construction. Some of heterocyclic products exhibit blue luminescence properties, as well as large Stokes shifts, eminent fluorescence quantum yields (64 %) and long fluorescence lifetimes. An efficient I 2 (10 mmol %)/H 2 O 2 mediated oxidative formal [4+1] cyclization of 2-pyridinemethylamine or o -phenylenediamine (2-aminobenzenethiol) with benzaldehyde via C−N bond formation has been developed. This strategy provides a straightforward approach to imidazo[1,5- a ]pyridines, iodo-substituted imidazo[1,5- a ]pyridines and benzimidazole (benzothiazole) derivatives in yields ranging from 60 % to 98 %, respectively. Several heterocyclic products exhibit promising blue luminous performance with satisfactory fluorescence quantum yields of up to 64 %, large Stokes shifts, and a longer lifetime (7.35 ns). The band gap energies obtained from DFT are also consistent with the absorption spectra.
研究领域:
有机化学
·
光物理化学
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DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Wen Li,Hexiang Wang,Yuan Zhang,Limin Zhao,Pengfeng Guo,Hua Cao,Xiang Liu
Pyridinium 1,4-zwitterionic thiolates were regarded as powerful and versatile building blocks to prepare nitrogen- and sulfur-containing heterocycles. Herein, we reported a copper-catalyzed formal [4 + 1] annulation of pyridinium 1,4-zwitterionic thiolates and diazo compounds without any additives to access a library of trifunctionalized indolizines in good yields. Besides, isoquinolinium 1,4-zwitterionic thiolates and imidazolium 1,4-zwitterionic thiolates were also applied to this formal [4 + 1] annulation reaction. Of particular note is that various functional groups such as −CO2R, −CO2NR2, −CF3, −CN, and −(O)P(OR)2 could be easily introduced into cycloaddition products indolizines by this strategy.
研究领域:
有机化学
·
合成化学
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DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Qing Kang,Yidi Liu,Xiubing Cui,Jianming Chu,Tong Lin,Jingbo Jiao,Xinjun Du,Shuo Wang
Herein, we developed a novel “4 + 1” biosensing platform based on cascaded nucleic acid amplification and nanozyme activity, enabling fluorescence-colorimetric dual-mode detection and efficient inactivation of Salmonella Typhimurium (S. typhimurium). The “4 + 1” system incorporates a multi-component strategy featuring multivalent aptamers for enhanced target recognition, coupled with a quadruple signal amplification strategy involving exponential amplification reaction (EXPAR), hybridization chain reaction (HCR), multivalent aptamers, and functional nanozymes (Fe3O4 and Fe-PDs), thereby achieving synergistic antibacterial effects. It achieves a wide linear range of 3 × 101–3 × 107 CFU/mL, with detection limits of 7.7 CFU/mL for fluorescence and 8.7 CFU/mL for colorimetry. Furthermore, the system exhibits antibacterial capability by catalytically generating reactive oxygen species (ROS), reducing the risk of secondary contamination. When applied to spiked milk samples, the biosensor showed satisfactory recovery rates and reproducibility. The study provides a high-precision, low-cost analytical solution for detecting and inactivating foodborne pathogens, demonstrating significant potential for rapid on-site food safety monitoring.
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DOI
PubMed
高影响因子
PROCESS BIOCHEMISTRY
·
2021
·
IF 3.757
Huabiao Miao,Rui Jiang,Nanyu Han,Yu Ma,Qian Wu,Yuelin Mu,Zunxi Huang
Amylases have been widely applied for starch saccharification in the food, paper, pharmaceutical, and textile industries. In the present study, α-amylase DL-3-4−1 from B. amyloliquefaciens was successfully expressed in B. subtilis. The enzymatic activity exhibited high stability in a pH range from 4.0 to 11.0 and moderate thermostability. Furthermore, excellent stability was observed when incubated with metal ions, detergents, inhibitors, and organic solvents. Resistance against ethanol, urea, and guanidine−HCl was also observed. More importantly, a strategy to enhance the extracellular expression of α-amylase DL-3-4−1 was developed using 173 Sec-type signal peptides (SPs) as a library based on a fast and sequence-independent method. Fourteen SPs were identified with significantly increased yields of DL-3-4−1 via a high-throughput assay. Specifically, the enzymatic activity of the α-amylase-producing strain containing the signal peptide SP5D10 (YomL) was 3.74-fold higher than that of the strain with the wild type signal peptide (87.30 U/OD). In brief, the maximum specific activity of an α-amylase-producing strain containing the YomL signal peptide was 326.45 U/OD. This is the first report of an α-amylase that exhibits ethanol, urea, and guanidine−HCl tolerance. Hence, this α-amylase represents a promising candidate for future use in industry.
研究领域:
生物技术
·
酶学
·
微生物学
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DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2021
·Vol. 31
·期 4
·1125-1132
·
IF 2.217
Wu Chuqiao,Lin Xin,Wang Qianming
The new design strategy will provide the possibility for preparing a dynamic sensor by employing the inhibition of C = N isomerization. In this work, the functional probe 4-(1 H-imidazo [4,5-f] [1,10]-phenanthrolin-2-yl) benzaldehyde oxime (compound 4 ) has been synthesized and such molecule gives rise to blue emission. Due to the incorporation of hypochlorite, the oxime group can be oxidized to the structure of aldehyde. As a result, the molecular motif exhibits sharp emission change from blue to green due to the addition of hypochlorite with enough sensitivity and selectivity (detection limit = 53 nM, linear range 0.5-8.0 µM). It has also been used for monitoring ClO − by employing solution color change and the absorption signal difference could effectively rule out the effects of interference species. To our knowledge, it will be the first case of a highly selective hypochlorite sensor derived from oxime isomerization reaction based on phenanthroline backbone.
研究领域:
化学
·
分析化学
·
生物医学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2015
·Vol. 3
·期 31
·8066-8073
·
IF 4.696
Shunyu Jin,Yan Tian,Fei Liu,Jun Chen,Shaozhi Deng,Ningsheng Xu
Although 9,10-bis(4-(1,2,2-triphenylvinyl)styryl)anthracene (TPE-An) with excellent aggregation-induced emission (AIE) properties can effectively enhance the luminescence efficiency of light-emitting materials, the practical TPE-An-emitting electroluminescent (EL) devices have not been successfully fabricated until now. In our paper, the energy-band diagram of TPE-An is determined by the combination of ultraviolet-visible (UV-Vis) spectroscopy and cyclic voltammetry (CV) techniques. Subsequently, the space-charge-limited-current (SCLC) method is firstly used to obtain the hole mobility of TPE-An and design a better EL device structure. By calculation, the maximum hole mobility of the 50 nm TPE-An film can arrive at 4.00 × 10−4 cm2 V−1 s−1 at 0.1 MV cm−1 field. Finally, TPE-An-emitting EL devices have been, respectively, fabricated on glass and flexible PET substrates. Both of these two EL devices exhibit an intense green-light emission at 515 nm. Moreover, the maximum luminance of the EL device on glass can reach 24721.8 cd m−2 at 10.0 V, and its maximum current efficiency is as high as 14.7 cd A−1 at 131.6 mA cm−2. It is noted that the flexible EL device on the PET substrate maintains a stable emission and nice working performance even if the bending angles arrive at 140°. Therefore, it suggests that TPE-An should have a promising future in EL device applications.
研究领域:
材料科学
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光学
·
电子工程
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DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2021
·
IF 7.446
Jinxin Che,Xiaoyang Dai,Jian Gao,Haichao Sheng,Wenhu Zhan,Yang Lu,Dan Li,Zizheng Gao,Zegao Jin,Binhui Chen,Peihua Luo,Bo Yang,Yongzhou Hu,Qiaojun He,Qinjie Weng,Xiaowu Dong
Rash is one of the primary dose-limiting toxicities of Akt (protein kinase B) inhibitors in clinical trials. Here, we demonstrate the inhibition of Akt2 isozyme may be a driver for keratinocyte apoptosis, which promotes us to search for new selective Akt inhibitors with an improved cutaneous safety property. According to our previous research, compound 2 is selected for further optimization for overcoming the disadvantages of compound 1, including high Akt2 inhibition and high toxicity against HaCaT keratinocytes. The dihedral angle-based design and molecular dynamics simulation lead to the identification of Hu7691 (B5) that achieves a 24-fold selectivity between Akt1 and Akt2. Hu7691 exhibits low activity in inducing HaCaT apoptosis, promising kinase selectivity, and excellent anticancer cell proliferation potencies. Based on the superior results of safety property, pharmacokinetic profile, and in vivo efficacy, the National Medical Products Administration (NMPA) approved the investigational new drug (IND) application of Hu7691.
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DOI
PubMed
高影响因子
TALANTA
·
2013
·
IF 3.498
Zhiwei Sun,Xiaoxiang Wang,Yiping Cai,Junqing Fu,Jinmao You
A new pair of derivatization reagents, d 0 -4-(1-methyl-1 H -phenanthro[9,10- d ]imidazol-2-yl)phenlamine (d 0 -MPIA) and d 3 -4-(1-methyl-1 H -phenanthro[9,10- d ]imidazol-2-yl)phenlamine (d 3 -MPIA) have been designed and synthesized. It was successfully used to label aliphatic aldehydes and the aldehyde derivatives were analyzed by high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS). The new isotope-coded reagents could easily label aldehydes under acidic conditions in the presence of NaCNBH 3 . The target derivatives exhibited intense [M+H] + and regular product ions with electrospray ionization source in positive mode. The d 0 /d 3 -MPIA-aldehydes were monitored by the transitions of [M+H] + → m/z 322 and [M+H] + → m/z 165, and the obtained detection limits were in the range of 0.18–15.9 pg/mL at signal to noise ratio of 3. The global isotope internal standard technology was employed for quantification analysis with d 3 -MPIA-aldehyde as internal standard for corresponding d 0 -MPIA-aldehyde. Excellent linear responses for relative quantification were observed in the range of 1/10–10/1 with coefficients >0.998. The developed method has been applied to the quantification of aliphatic aldehydes in selected aquatic products with RSD<3.6% and recoveries >85.2%.
研究领域:
分析化学
·
食品科学
·
生物化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2018
·
IF 6.578
Yujian Yao,Meng Li,Xingzhong Cao,Peng Zhang,Wen Zhang,Junfeng Zheng,Xuan Zhang,Lianjun Wang
A new sulfonated diamine monomer , 4,4′-((1,4-phenylenebis(methylene))bis(azanediyl))dibenzenesulfonic acid (PMABSA) was synthesized and used as the sole aqueous reactant to fabricate a novel reverse osmosis (RO) membrane with trimesoyl chloride (TMC), in place of conventional m -phenylene diamine (MPD). The separation performance of the PMABSA/TMC membrane was optimized by the response surface method (RSM) by means of evaluating the pure water permeability (PWP) and salt rejection (R) to NaCl, and optimal results of PWP of 1.18 ± 0.03 L m −2 h −1 bar −1 , and R of 98.2 ± 0.4%, respectively, were achieved at 1.55 MPa. Owing to the rigid benzene ring in the center of the molecule, which may have a blocking effect during the interfacial polymerization (IP) process, the resulting barrier layer was less compact and had low thickness. Both molecular dynamics (MD) simulation and positron annihilation spectroscopy (PAS) revealed the creation of sufficient free volumes in the sulfonated polyamide matrix. Regardless of the slightly lower water permeation, the PMABSA/TMC membrane exhibited a superior rejection ability to all the ions compared to that of commercial SW30HR (Dow Chemical) in a model seawater separating test. Overall, all the results indicated the great potential of the novel membrane as a new choice of non-MPD RO membrane for seawater desalination.
研究领域:
材料科学
·
化学工程
·
环境科学
·
水处理
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DOI
高影响因子
危险品化学品经营许可证（带存储）