SEPARATION AND PURIFICATION TECHNOLOGY
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2019
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IF 5.107
Meng He,Honghong Sun,Haixiang Sun,Xiujie Yang,Peng Li,Q. Jason Niu
Conventional nanofiltration membrane fabrication generally includes the usage of toxic organic solvent that poses threats to the environment and public health. Herein, we explored preparing nanofiltration membrane through a non-organic solvent method utilizing the highly reactive natural product, tannic acid (TA), along with cyclohexane-1,4-diamine (CHD). Fabrication process was carried out through sequential immersion of a polyethersulfone (PES) support in two aqueous monomer phases. The absence of a solvent interface facilitated the diffusion and mixing of the two monomers, and the highly reactive quinone derivative of TA enabled the rapid film formation via Michael addition and Schiff base formation. Membrane performance was optimized through investigation of fabrication parameters. The TA-CHD membrane exhibited a negatively charged surface, with a molecular weight cut-off (MWCO) of 600 Da. The membrane prepared at optimal conditions showed approximate 97% and 50.7% rejections towards Na 2 SO 4 and NaCl, with a water flux at approximate 35 L m −2 h −1 (10 bar). Fouling behaviour of the TA-CHD membrane was studied and a chemical cleaning test under two extreme pH was performed to demonstrate the chemical stability. The proposed non-organic solvent method here provides an eco-friendly way to utilize the potential of polyphenol natural products in water purification membrane preparation.
研究领域:
环境科学
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材料科学
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水处理
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产品关联
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
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2024
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IF 6.8
Yi Huang,Fengling Liu,Shuhua Ren,Yuanqing Ding,Man Chi,Weiwei Huang,Wenjing Gu,Hewen Qian,Yaxia Yuan,Shurong Hou,Xiabin Chen,Lei Ma
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease with an elusive etiology. Aberrant activation of c-Jun N-terminal kinase 1 (JNK1) has been implicated in its pathogenesis. Through a combination of structure-based drug design and structure–activity relationship (SAR) optimization, a series of pyrimidine-2,4-diamine scaffold derivatives have been developed as potent JNK1 inhibitors. Compound E1 was identified with low nanomolar JNK1 inhibitory potency (IC50 = 2.7 nM). The introduction of a dimethylamine side chain has significantly enhanced the ability of E1 to inhibit c-Jun phosphorylation, surpassing the clinical candidate CC-90001. Molecular dynamics simulations revealed a binding free energy of −50.46 kcal/mol for E1. Moreover, E1 displayed satisfactory pharmacokinetic properties, with a bioavailability of 69% in rats. Furthermore, compound E1 exerted significant antifibrotic effects in a bleomycin-induced IPF mouse model and prevented a TGF-β-induced epithelial-to-mesenchymal transition in vitro. These findings position E1 as a promising lead for further drug development targeting IPF.
研究领域:
药理学
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药物化学
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肺科学
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药物发现
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产品关联
DOI
PubMed
高影响因子
POLYMER
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2020
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IF 4.231
Haoji Lao,Nafeesa Mushtaq,Guofei Chen,Hongyu Jiang,Yang Jiao,Anjiang Zhang,Xingzhong Fang
Two series of optically transparent polyamide-imides (PAIs) were prepared by copolymerization of trimelletic acid chloride (TMAc), p -phthaloyl chloride (TPC), 2,2′-bis(trifluoromethyl)-[1,1′-biphenyl]-4,4′-diamine (TFDB) and 4,4’-(9-fluorenylidene) diamine (FDA). These series of PAIs displayed high glass transition temperatures ( T g s) ranging from 340 to 441 °C, 5% weight loss temperatures ( T 5% s) in nitrogen with 459–505 °C, and low coefficient of thermal expansion (CTE) of 21–56 ppm/K, which greatly affected by the feed ratio of rigid TPC units and cardo diamine in the polymer main chain. The transmittances at 500 nm (T 500nm ) of the PAI films were found in the range of 70.0–87.7%, All polymers demonstrated good organosolubility and mechanical properties with tensile strengths of 77–146 MPa, tensile moduli of 2.9–5.8 GPa and elongations at break of 2.9–8.2%. PAI-7-8 presented the best combination of high T g of 401 °C and high tensile modulus of 5.0 GPa, low CTE value of 24 ppm/K, and high transparency (T 500nm ) of 87.2%.
研究领域:
聚合物科学
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材料科学
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2024
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IF 3.8
Meiyu Gao,Jiarui Sun,Qinwen Xiao,Yuanyuan Zhai,Yuan Tian,Zunjian Zhang,Fengguo Xu,Pei Zhang
The mevalonate (MVA) pathway plays a crucial role in the occurrence and progression of various diseases, such as osteoporosis, breast cancer, and lung cancer, etc. However, determining all the MVA pathway intermediates is still challenging due to their high polarity, low concentration, chelation effect with metal compartments, and poor mass spectrometric response. In this study, we established a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method coupled with N 2 , N 2 , N 4 , N 4 -tetramethyl-6-(4-(piperazin-1-ylsulfonyl) phenyl)-1,3,5-triazine-2,4-diamine (Tmt-PP) labeling for the simultaneous analysis of all MVA intermediates in biospecimens. Chemical derivatization significantly improved the chromatographic retention, peak shape, and detection sensitivity of the analytes. Moreover, we employed a method named mass spectrum calculation to achieve the absolute quantification of the isomers, i.e., isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). The established method was fully qualified and applied to explore the difference of these metabolites in cisplatin-resistant non-small cell lung cancer (NSCLC) cells. Additionally, several MVA intermediate analogs, including isopentenyl monophosphate or dimethylallyl monophosphate (IMP/DMAMP), geranyl monophosphate (GMP), 5-triphosphomevalonate (MTP), and isopentenyl triphosphate or dimethylallyl triphosphate (ITP/DMATP), were identified for the first time using a knowledge-driven prediction strategy. We further explored the tissue distribution of these novel metabolites. Overall, this work developed a sensitive quantification method for all MVA intermediates, which will enhance our understanding of the role of this pathway in various health and disease conditions. The novel metabolites we discovered warrant further investigations into their biosynthesis and biological functions.
研究领域:
生物化学
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分析化学
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药理学
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肿瘤学
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代谢组学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）