Advanced Healthcare Materials
·
2025
·
IF 9.6
Yibing Shi,Xiaoyi Zhu,Qingyuan Xu,Yanling Wu,Yishuo Sun,Xin Zhao,Yulong Liu,Wei Feng,Youhua Xie,Tianlei Ying,Zhenlin Yang
The oral administration of immunofluorophores has been limited by gastrointestinal degradation. To address this, a novel immunofluorophore (ICGM-B9-FCS), based on a single-domain antibody-dye targeting the CEACAM5 antigen, is coated with trifluoromethyl chitosan (5 mg kg −1 ) for NIR-II bioimaging of colorectal cancer and its distant metastases. ICGM-B9-FCS demonstrates unique advantages over existing intraoperative tumor-guidance bioagents, including resistance to liver metabolism, well-retained bioaffinity (EC 50 = 58.09 nmol L −1 ), enhanced relative quantum yield (up to 12 equivalents), significant redshifts in absorption (from 783 to 957 nm), effective oral delivery to colonic metastases, and in situ exploration of the capillary-lymphatic network transportation. These findings establish a regulatory pathway for modifying immunofluorophores as orally administered bioagents, offering innovative methods for preoperative diagnosis and intraoperative guidance in colorectal cancer.
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ACS Applied Polymer Materials
·
2025
·
IF 4.7
Ting Huang,Aoqian Xi,Ningning Zhang,Wenpei Chen,Yanning Zeng
Developing high thermal stability and degradable biobased covalent adaptable networks (CANs) continues to pose significant challenges in sustainable materials science. In this study, we synthesized a fully biobased dialdehyde monomer derived from salicylaldehyde and 2,5-furandicarboxylic acid, which was subsequently reacted with ditrimethylolpropane (DTMP) and bismaleimide (BMI) to construct networks containing dual dynamic covalent bonds. The resulting CANs, incorporating dynamic acetal bonds and Diels–Alder (DA) bonds, exhibited enhanced thermal stability, tunable mechanical properties, and efficient self-healing and reprocessing performance. Notably, the strategic incorporation of dynamic acetal bonds enabled degradation under acidic conditions, achieving 100% mass loss within 120 h, at 80 °C. Furthermore, carbon fiber-reinforced polymer composites fabricated from the CANs exhibited exceptional tensile strength (635 MPa) and closed-loop recyclability, maintaining 95.6% of their initial mechanical strength. This work advances a sustainable paradigm for CANs synthesis using renewable salicylaldehyde and 2,5-furandicarboxylic acid precursors while offering critical design principles for next-generation recyclable high-performance composites.
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CHEMISTRY & BIODIVERSITY
·
2025
·
IF 2.5
Shaobin Xu,Jiaxuan He,Genqiang Chen,Xiaobo Huang,Yuee Tian,Zhiping Che
18β-Glycyrrhetinic acid (GA) is a pentacyclic triterpenoid compound mainly extracted from the roots of the leguminous plant licorice. To discover botanical pesticides, twelve 3β-acyloxy-18β-glycyrrhetinic acid derivatives ( 3a – l ) were synthesized, and their structures were characterized by 1 H NMR, 13 C NMR, and HR–MS. In addition, we assessed the bioactivities of these title compounds as anti-oomycete and insecticidal agents against two serious agricultural pests, Phytophthora capsici and Mythimna separata . Amongst all tested target compounds, (1) Six compounds 3d , 3e , 3h , 3i , 3j , and 3k indicated promising anti-oomycete activity against P. capsici , with EC 50 values of 28.27, 29.36, 23.88, 20.03, 23.07, and 25.93 mg/L, respectively. (2) Six compounds showed significant insecticidal activity, the final mortality rates of 3b , 3c , 3f , 3g , 3i , and 3l were 66.7%, 55.6%, 63.0%, 60.7%, 51.9%, and 75.6%, respectively. The anti-oomycete and insecticidal activities of the title compounds were closely related to R, which has a significant impact on its activity. Graphical
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MOLECULAR PHARMACEUTICS
·
2025
·
IF 4.5
Zheng Sun,Zhiyong Li,Teng Hao,Xuecun Liu,Yuanyuan Jiang,Songyuge Ping,Na Dong,Ruiling Guo,Xin Yang,Hui Xu
Hepatocellular carcinoma (HCC) is one of the leading causes of death worldwide, accounting for about 90% of all primary liver malignancies. The emergence of natural antitumor compounds provides a new strategy for the treatment of HCC, but their delivery in vivo has become a major problem. In this study, the copolymer of the natural product glycyrrhetinic acid (AMGA) was prepared and served as a carrier for encapsulation of the natural active ingredient Icariside II (AMGA@ICAII). The results show that AMGA still retains the interaction with GA-R and achieves active targeting by interacting with GA-R. In addition, GA-modification changes the physical chemistry nature of the carrier, providing it with better colloidal stability. AMGA@ICAII significantly inhibited the proliferation of the human hepatoma cell line HepG-2 in vitro compared with other treatment groups. Furthermore, AMGA@ICAII improved the distribution of ICAII in the C57BL/6J mouse Hepa1–6 hepatoma model and showed a significant antitumor effect. This work demonstrated that small molecule target modification in the hydrophobic segment of block copolymer will do benefit to improve the performance of the carrier, while retaining ligand–receptor-mediated targeting properties and providing a reference for the targeted delivery of anticancer agents.
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Colloid and Interface Science Communications
·
2025
·
IF 4.7
Zhanglong Huang,Shiwei Ding,Lili Zhong,Chenxi Liu,Xiaofei Li,Dan He
Combination therapy holds great promise for enhancing antitumor efficacy by achieving tumor-targeted and sequentially synergistic cytotoxicity. We developed a tumor-targeted hybrid micellar nanoplatform that co-delivers the chemotherapeutic agent pemetrexed (PEM) and carbon monoxide (CO) for synergistic chemo-gas therapy. PEM and Fe₃(CO)₁₂ were covalently conjugated to D-α-tocopheryl polyethylene glycol succinate (TPGS), yielding two amphiphilic prodrugs—TPGS-PEM and TPGS-CO—which were co-assembled into hybrid micelles. The presence of PEM enabled folate receptor-mediated active targeting, resulting in efficient uptake by 4T1 breast cancer cells. Intracellular esterase-catalyzed cleavage of the ester bond released PEM, which elevated reactive oxygen species (ROS) levels. The increase in ROS triggered site-specific CO release from the Fe–CO complex. This sequential mechanism enabled a cascade of tumor-selective chemotherapy and gas therapy, leading to enhanced apoptosis and reduced tumor proliferation. The hybrid micelles exhibited superior tumor suppression, reduced systemic toxicity, and prolonged survival in tumor-bearing mice.
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Journal of Energy Storage
·
2025
·
IF 9.8
Changhai Zhang,Zhiqi Zhou,Xue Zhang,Xu Tong,Chao Wang,Tiandong Zhang,Wenju Wu,Qingguo Chi
High-temperature applications demand polymer dielectrics with a high glass transition temperature ( T g ), wide bandgap, and high dielectric constant for superior energy storage performance. However, inherent trade-offs among these key parameters in existing polymers lead to soaring leakage currents and increased energy losses at elevated temperatures, severely limiting further performance enhancement. To address this issue, this paper uses polyisopren-imide (PNI) as the matrix material, attempting to decouple the T g , bandgap, and dielectric constant using fluorination modification and the creation of physical-chemical double-crosslinked networks. First, electron-withdrawing fluorine atoms were incorporated into PNI to form FPNI 50 , enhancing the polymer's bandgap and thereby inhibiting charge excitation and reducing leakage current. Subsequently, dicyclopentadiene (DCPD) was employed as a chemical crosslinking agent to construct a covalent-bonded crosslinked network (FPNI 50 D 5 ) which effectively restricted molecular chain mobility and reduced dielectric loss. Finally, 4,4-dihydroxy dicyclohexane (BCHD) was introduced to form physical crosslinking via hydrogen bonding between hydroxyl groups and fluorine atoms. BCHD, featuring high polarity and a wide bandgap (8.84 eV), enhances the dielectric constant of the polymer while simultaneously suppressing carrier transition. Consequently, the FPNI 50 D 4.5 B 0.5 achieves complete decoupling of T g (250.4 °C), bandgap (4.229 eV), and dielectric constant (4.01), while exhibiting outstanding high-temperature energy storage performance. At 150 °C and an electric field strength of 600 MV/m, it delivers an energy storage density of 6.5 J/cm 3 with an efficiency of 90 %. The performance not only surpasses that of the pure polymer PNI but also demonstrates strong competitiveness among reported polymer composites.
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Biomaterials Science
·
2025
·
IF 5.7
Yong Li,Yuanyuan Zhou,Lifang Wu,Quanyuan Gao,Wei Wang
Hepatic stellate cells (HSCs) activation is a key driver of fibrogenesis, while perisinusoidal collagen Ⅰ deposition establishes biophysical barriers that impede therapeutic delivery. To address this challenge, we developed a cationic liposome nanomicelle system (LIP/RSC) based on a polyenyl phosphatidylcholine (PPC) matrix, functionalized with collagenaseⅠ and dual silybin B-retinoic acid (silybin-RA) moieties. In this design, retinoic acid (RA) was covalently conjugated to two distinct components: (i) silybin B to form a targeted therapeutic complex (silybin-RA), and (ii) DSPE-PEG2000-NH2 to construct a long-circulating carrier (RA-DSPE-PEG2000). The resultant system embodies an innovative HSCs-ECM dual-targeting strategy through integration of dual RA modification technology -combining silybin-B targeting modification with DSPE-PEG2000 long-circulation modification -and spatiotemporally controlled silybin B release. The LIP/RSC system demonstrated cell-selective drug release profiles, with a 4-fold greater release of silybin B in CCl4-activated HSCs (LX-2-CCl4) than in hepatocytes (WRL68), accompanied by collagen normalization.The system conferred dual pharmacodynamics: slow-release kinetics prolonged circulation time (≥ 72 h) while enabling receptor-mediated HSCs targeting, and collagenaseⅠ activity enhanced fibrotic barrier penetration, resulting in a 2.1fold increase in silybin B release efficiency in 8-72 h post-injection and an 85% reduction in total collagen content in fibrotic murine models. This study validates LIP/RSC as an integrated nanoplatform that synergizes matrix remodeling with targeted drug delivery, thereby demonstrating enhanced therapeutic efficacy against hepatic fibrosis.
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DRUG DELIVERY
·
2025
·
IF 8.1
Liqing Chai,Xiaomin Niu,Xiaoning Li,Jingjing Han,Fugui Guo,Rongrong Wang,Xiaohui Zhou,Xiaozhou Dong,Guoshun Zhang,Ruili Wang,Guolian Ren
Malaria remains a global health crisis, with Plasmodium resistance underscoring the urgent need for advanced drug delivery strategies. To overcome the limitations of oral antimalarials, such as hepatic first-pass metabolism and insufficient drug accumulation in parasites, intestinal M cell-mediated lymphatic transport and Plasmodium-triggered drug release are effective strategies. Plasmodium parasites maintain a weakly acidic intracellular environment with high levels of glutathione (GSH). Polydopamine (PDA) remains stable in the gastrointestinal tract and degrades in the parasite’s weakly acidic, GSH-rich environment, making PDA nanoliposomes (PNLs) a promising oral delivery system for Plasmodium-responsive drug release. Additionally, cyclic arginine–glycine–aspartic acid (cRGD) can specifically target intestinal M cells, promoting lymphatic transport and thereby reducing the first-pass effect. We developed cRGD- and PDA-modified nanoliposomes (cRPNLs) to address the challenges associated with oral administration and loaded them with a disulfide bond (–SS–)-modified dihydroartemisinin (DHA) prodrug (DSSC) to simultaneously deplete GSH and induce lethal oxidative stress, thereby offering an enhanced antimalarial mechanism. In vitro, cRPNLs exhibited pH- and GSH-responsive DHA release. Ex vivo fluorescent imaging confirmed that cRPNLs targeted Peyer’s patches with minimal distribution in the liver. Crucially, both PNLs and cRPNLs reduced GSH levels in infected erythrocytes and elevated ROS by 2.0-fold, outperforming unmodified DHA. Pharmacokinetic and in vivo antimalarial pharmacodynamic studies revealed that cRPNLs exhibited significantly higher exposure and Plasmodium inhibition rates compared to PNLs and free DHA. These results highlight cRPNLs as a potent oral nanoplatform that combines M cell-mediated lymphatic uptake with parasite-triggered drug release, significantly improving antimalarial efficacy.
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EUROPEAN POLYMER JOURNAL
·
2026
·
IF 6.8
Xueying Wang,Sheng Huang,Shuanjin Wang,Lehui Hu,Liang Wang,Dongmei Han,Min Xiao,Yuezhong Meng
A series of CO 2 -based polycarbonate methacrylates (PPC(P)MAs) were synthesized in one step from CO 2 -based polycarbonate macrodiols (PPC(P)DLs) and methacrylic anhydride. These PPC(P)MAs were formulated with hydroxy urethane methacrylate (HUMA) prepolymer, reactive diluent and photoinitiator to produce a series of CO 2 -based non-isocyanate polyurethane (NIPU) UV-curable coatings. The resulting coatings exhibited excellent curing performance, with gel contents exceeding 94%, and 5% mass loss thermal decomposition temperature up to 286℃. When applied to polycarbonate (PC) substrates, all coatings displayed outstanding luminous transmittance (∼90%), adhesion (5B) and flexibility (1 mm). Notably, the coating prepared from PPCPMA achieved a pencil hardness of 4H. Furthermore, formulations incorporating TMPTA showed remarkable long-term water resistance, maintaining their appearance and adhesion unchanged after immersion in 60℃ water for ten days. This work provides not only a high-performance protective solution for PC-based components but also a viable green synthesis route for sustainable coatings.
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DYES AND PIGMENTS
·
2026
·
IF 3.9
Shen Wang,Wenjie Wei,Yaran Wang,Rui Ma,Yunya Wu,Yunxian Yang,Yuxin Zuo,Zhiqi Liu,Pengfei Cheng
Agricultural films have attracted considerable attention in recent years. Herein, four types of organic-inorganic complex red light conversion agents ( W-2L , W-8L , S-8L , H-8L ) were designed, the S-8L conversion agent exhibits an extremely broad ultraviolet absorption range of 200-400 nm. Contact angle (142.7°) tests confirmed its excellent hydrophobic properties, enabling better compatibility with LLDPE substrates. Meanwhile, its outstanding photothermal stability of S-8L was demonstrated by a long red fluorescence lifetime: 478.14 μs, an exceptional fluorescence quantum yield: 76.77 %, a high initial decomposition temperature and an extended ultraviolet aging resistance period. Furthermore, the S-8L1 conversion film was utilized to assist in the cultivation of Chlorella cells, demonstrating its excellent UV-blocking and red-light conversion capabilities, significantly increasing both biomass and chlorophyll content. This work proposed a potential way to develop highly efficient light conversion agents by regulating the inorganic-organic functional groups.
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Nano Today
·
2026
·
IF 10.7
Yan Zhang,Lingxin Peng,Baotong Ye,Guodong Lu,Sichen Li,Jingjing Zhou,Mihail Barboiu,Jinghua Chen
Nanoparticles (NPs) have been extensively investigated in modern cancer chemotherapy for their advantages in targeted drug delivery, enhanced efficacy and reduced toxicity. However, clinical evidence continues to indicate modest therapeutic efficacy of these nanomedicines, largely attributed to insufficient drug accumulation and poor tissue penetration in tumors. In the current study, we discovered that synergetic and precise control over nanoparticle shape and surface functionalization improves tumor penetration and enhances chemotherapy outcomes. Specifically, supramolecular nanospheres/nanorods self-assembled from scaffolding Fmoc-FF, hepatocyte targeting Fmoc-monosaccharides and the anti-tumor drug doxorubicin (DOX) have been associated via the synergetic control of their nanostructured morphologies and the surface presentation of bioactive signals. These pH-sensitive self-assembled nanoparticles enable controlled nanostructure shape and multivalent carbohydrate-functionalized surfaces, allowing activation in the acidic tumor microenvironment for triggered drug release. In vitro experiments demonstrated that the galactose-modified nanorod FGal 1–2 , measuring approximately 250 nm in length and of 25 nm in diameter, displayed the highest toxicity towards HepG2 cells and significantly enhanced cellular uptake. Additionally, nanorod FGal 1–2 demonstrated the deepest penetration (> 80 μm) in a 3D tumor spheroid model, surpassing the nanosphere FGal 1–1 and longer nanorod FGal 1–3 . Moreover, in vivo animal studies further revealed higher tumor accumulation of nanorod FGal 1–2 compared to the corresponding nanosphere, along with the strongest tumor inhibition, markedly reduced cardiotoxicity of DOX, and an 85% reduction in tumor volume. This work offers new insights into the design of nanoparticles with functional/morphological effects in their properties for advanced anti-tumor drug delivery.
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Vaccines
·
2026
·Vol. 14
·期 2
·192
·
IF 3.5
Huimin Yang,Zeyu Liao,Yingjie Zhong,Qi Gao,Hangqi Zhang,Chengli Zong
Background/Objectives: Polysaccharide-protein conjugate vaccines have proven highly effective, yet they remain limited by manufacturing complexity, cost, and variable performance across serotypes, while carrier proteins can add unwanted immunological and production burdens. To address these constraints, we explored a carrier-protein-free conjugate vaccine concept in which a broadly MHC class II-binding helper epitope (PADRE) replaces the conventional protein carrier to provide T-cell help for a pneumococcal capsular polysaccharide antigen. Methods: Using serotype 15C CPS as a model, we generated CPS–PADRE conjugates and compared designs with or without a putative cleavable motif (RR) at the junction, alongside a conventional protein conjugate as a benchmark. Results: In mice, the CPS–protein conjugate induced the strongest CPS-specific IgG response, whereas CPS–PADRE conjugates elicited clear but overall lower antibody levels. Notably, incorporation of the cleavable motif did not improve immunogenicity and instead reduced humoral responses relative to the non-cleavable design. Conclusion: These findings support the feasibility of carrier-protein-free polysaccharide-peptide conjugate vaccines, while highlighting that cleavable junctions are not universally advantageous and must be empirically optimized for polysaccharide-helper epitope architectures.
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