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ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES · 2022 ·Vol. 77 ·期 9 ·643-649 · IF 1.115

Two zinc and cadmium coordination polymers constructed with bis(4-(1H-imidazol-1-yl)phenyl)methanone and naphthalene-1,4-dicarboxylate ligands: synthesis and structural characterization

Gao-Feng Wang,Hai-Ying Yang,De-Qun Peng,Shu-Wen Sun

Two coordination polymers, [Zn 2 (bipmo) 2 (1,4-nda) 2 ] n ( 1 ), {[Cd(bipmo)(1,4-nda)]·(H 2 O)} n ( 2 ), (bipmo = bis(4-(1 H -imidazol-1-yl)phenyl)methanone, H 2 (1,4-nda) = naphthalene-1,4-dicarboxylic acid), were synthesized under solvothermal conditions. The complexes have been characterized by elemental analyses, IR spectroscopy and single-crystal X-ray diffraction. Complex 1 possesses 3D 2-fold interpenetrating nets with the Schläfli symbol {6 5 ·8}. Complex 2 consists a 3D net with the Schläfli symbol {4 4 ·6 10 ·8}. The luminescent properties of complexes 1 and 2 have been investigated.

研究领域: 化学 · 材料科学

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BIOMACROMOLECULES · 2021 · IF 6.988

Hypoxia-Sensitive Zwitterionic Vehicle for Tumor-Specific Drug Delivery through Antifouling-Based Stable Biotransport Alongside PDT-Sensitized Controlled Release

Tingjie Yin,Xuxin Chu,Jiejie Cheng,Jinlai Liang,Jianping Zhou,Meirong Huo

A hypoxia-sensitive zwitterionic vehicle, DHigh-PEI-(A+P), with the ability for antifouling-mediated, stable biotransport and a photodynamic therapy (PDT)-sensitized hypoxic response for spatiotemporal controlled drug release, was developed for the tumor-specific delivery of chemotherapeutics and biomacromolecules. The amphiphilic DHigh-PEI-(A+P) was constructed from a betaine monomer (DMAAPS), a photosensitizer (PpIX), and an azobenzene-4,4′-dicarboxylic acid-modified polyethylenimine. Herein paclitaxel (PTX) was selected as a common model drug to verify the functions of the designed polymer. First, DHigh-PEI-(A+P) was demonstrated to spontaneously coassemble with PTX in aqueous solution with high drug loading (>35%). The desirable antifouling ability of DHigh-PEI-(A+P) was independently verified by efficient 4T1 endocytosis in serum alongside systemic tumor targeting. Furthermore, PpIX-mediated PDT was verified to aggravate and homogenize a hypoxic microenvironment at the cell and tissue levels for a sharp responsive disassembly of DHigh-PEI-(A+P) and thus a robust drug release in a well-controlled manner. As a result, DHigh-PEI-(A+P) amplified the therapeutic outcome of PTX on orthotopic 4T1 mouse models with minimal collateral damage. We proposed that DHigh-PEI-(A+P) may serve as a tailor-designed universal vehicle for the tumor-specific delivery of drugs with distinct physicochemical properties.

CAS / MDL: 9048-46-8 787-70-2 4091-99-0 1120-71-4

研究领域: 癌症治疗 · 药物递送系统 · 生物医学工程 · 纳米技术 · 药学科学

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Two zinc and cadmium coordination polymers constructed with bis(4-(1H-imidazol-1-yl)phenyl)methanone and naphthalene-1,4-dicarboxylate ligands: synthesis and structural characterization

Hypoxia-Sensitive Zwitterionic Vehicle for Tumor-Specific Drug Delivery through Antifouling-Based Stable Biotransport Alongside PDT-Sensitized Controlled Release