APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Di Zhang,Pin Ma,Shuo Wang,Mingpeng Xia,Sidong Zhang,Dongmei Xie,Xiaowen Zhou,Yuan Lin
Recently, the pre-synthesized oil-soluble quantum dots (QDs) have triggered great interests due to advantages of monodispersity, stability and easy synthesis. Aggregation of QDs is the reason for low loading and poor efficiency during the in situ ligand exchange linker-assisted assembly process of preparing photovoltaic devices. In this work, we modify TiO 2 films with 4-mercaptobenzoic acid (MBA) as linkers and adjust modification time (MT) of MBA on the surface of TiO 2 films. As the MT increases from 0 to 6 min, even 360 min, loading amount of QDs and photovoltaic performance improve first and then decrease. The results of line scan in cross-sectional view of photoanodes show that QDs uniformly distribute throughout the short-MT films thickness, while obvious aggregation occur in the surface of long-MT films. The best device with 3 min of MBA modification exhibits an optimal efficiency of 5.58%.
研究领域:
材料科学
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纳米技术
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS SCIENCE FORUM
·
2020
·
IF 0
Wan Ying Li,Jia Hao Li,Jing Hong Ma,Jing Hua Gong
Surface-enhanced Raman scattering (SERS) spectroscopy technology has broad application prospects in food safety, environmental monitoring, surface science and material analysis because of the characteristics of ultra-high sensitivity and non-destructive testing. However, there are still some challenges in the preparation of SERS substrates. As SERS substrates, the common colloidal noble metal nanoparticles usually show low storage stability and poor repeatability of analytical results. In order to overcome these limitations, a coaxial microfluidic spinning device was designed to prepare flexible SERS substrates in this paper. Based on the microfluidic spinning and subsequent in-situ reduction reaction of AgNO3, novel gel fibers uniformly loaded with AgNPs were successfully prepared. The effects of the concentration of AgNO3 solution and UV irradiation duration on the formation of AgNPs were investigated. Transmission electron microscopy (TEM) showed that the average particle size was about 2.7 nm. The gel fibers loaded with AgNPs were used as SERS substrates to detect 4-mercaptobenzoic acid (4-MBA), which showed obvious Raman enhancement effect and good repeatability. The relative standard deviation of 10 test results was 4.75%, and the detection line range was 10-14-10-5 mol·L-1.
研究领域:
材料科学
·
分析化学
✓ 已验证
DOI
ACS Applied Nano Materials
·
2021
·
IF 5.097
Lin Guo,Zhu Mao,Chao Ma,Jiawei Wu,Lin Zhu,Bing Zhao,Young Mee Jung
Nanoscale materials have an irreplaceable advantage in solar energy utilization because of their perfect match with visible light wavelength on the length scale. Charge transfer (CT) between a metal nanoparticle and contacted nanoscale semiconductor plays a significant role in photoinduced energy transfer. Here, we fabricated a new complex, a gold nanorod-4-mercaptobenzoic acid@Cu2O (Au NR-MBA@Cu2O) core–shell nanostructure, and used surface-enhanced Raman scattering (SERS) spectroscopy of the interlayer MBA molecules to investigate the CT process occurring between the Au NRs and Cu2O. In our system, different surface plasmon absorption bands were adjusted by tuning the thicknesses of the Cu2O shells on the Au NR core to explore the influence of plasmon absorption at different incident Raman laser lines. By analyzing the SERS spectra, the degree of CT was calculated, and the consequences can be fully explained by photoexcitation across interface electron transfer and plasmon-induced interfacial charge transfer transition at laser excitation wavelengths of 633 and 785 nm. This experiment introduced a simple, effective, and intuitive approach to observe the CT process in metal semiconductors by SERS. The results of our study will improve in photocatalytic efficiency and photoelectric devices.
研究领域:
材料科学
·
光催化
·
光电设备
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2019
·Vol. 11
·期 40
·5142-5149
·
IF 2.378
Yan Kang,Hai-Xin Gu,Xin Zhang
A novel surface-enhanced Raman scattering (SERS) probe was developed for the selective determination of patulin using gold nanobipyramids as the SERS substrate. Patulin undergoes a selective chemical reaction with sulfhydryl groups of 4-mercaptobenzoic acid (4-MBA) to form new compounds. A substantial change of the SERS spectrum of 4-MBA was observed and a new peak at 1641 cm−1 appeared. A significant increase in the intensity of the SERS signal at 1641 cm−1 was observed upon addition of more targets. This feature was exploited for sensitive quantification of patulin in aqueous solution by ratioing the intensities of the new peak at 1641 cm−1 and the peak of 4-MBA at 1586 cm−1. This method displayed excellent selectivity for patulin. Under optimal conditions, the ratioed signal intensity is related to the concentration of patulin in the range between 10 μg L−1 and 3000 μg L−1, with a detection limit of 6 μg L−1. This method was successfully used for the determination of patulin in juice.
研究领域:
分析化学
·
食品安全
·
纳米技术
✓ 已验证
DOI
高影响因子
Analytical Methods
·
2017
·Vol. 9
·期 17
·2517-2522
·
IF 1.9
Chenmeng Zhang,Xiu Liang,Tingting You,Nan Yang,Yukun Gao,Penggang Yin
An ultrasensitive “turn off” Surface Enhanced Raman Spectroscopy (SERS) sensor was developed for the detection of heparin based on the anti-aggregation of 4-mercaptobenzoic acid stabilized gold nanoparticles. In this paper, protamine, a small protein molecule with positive charges, could induce the aggregation of 4-MBA functionalized gold nanoparticles via surface electrostatic interaction. However, in the presence of heparin, the aggregation of 4-MBA functionalized gold nanoparticles decreased due to the fact that heparin has a strong affinity toward protamine, further causing the loss of the Raman enhanced effect. The normalized SERS intensity of the Raman reporter was proportional to the concentration of added heparin and a good linear detection range was obtained from 0.05 to 20 ng mL−1 (R2 = 0.999) with a calculated detection limit of 0.03 ng mL−1. Moreover, the developed highly selective method is also successfully demonstrated in fetal bovine serum. Our method is specific, simple and cheap, which could be applied to other further research studies of heparin.
研究领域:
生物医学工程
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Food Measurement and Characterization
·
2022
·Vol. 16
·期 5
·3501-3511
·
IF 3.006
Chen Hongshuo,Liu Haibin,Cui Chuanjin,Zhang Xuechao,Yang Wei,Zuo Yueming
To effectively cut off the transmission of Brucella to humans through milk, a novel biosensor for detection of Brucella was constructed using cysteamine functionalized nanogold (Cys-Au) and 4-Mercaptobenzoic acid (4-MBA) modified gold electrode as the platform. The morphology of the prepared nanomaterials was characterized by laser particle sizer, XPS and SEM, and the results showed the 4-MBA film was modified on the gold electrode surface, and the diameter of successfully prepared nanogold and Cys-Au are about 55 and 65 nm, respectively. The electrochemical performance of the biosensor was tested in Brucella antigen solution by square wave voltammetry (SWV). The results showed the reproducibility and stability of the biosensor were good, the spiked recovery in milk was in the range of 95.12–105.27%, and the minimum detection limit (S/N = 3) was 5.12 × 10 2 cfu/mL with a linear range from 1.6 × 10 2 to 1.6 × 10 8 cfu/mL. In addition, the minimum detection limit was reduced from 5.12 × 10 2 cfu/mL to 7.0 × 10 1 cfu/mL after processing the SWV data by second-order derivative transformation, which showed Second-order derivative transformation is very helpful to further optimize the performance of the sensor. Compared with the previously reported test methods, the prepared biosensors have a wider linear range and lower limit of detection (LOD). Therefore, the constructed biosensor can be used as a promising tool for the trace detection of Brucella in milk samples.
研究领域:
食品科学
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微生物学
·
生物传感技术
✓ 已验证
DOI
高影响因子
Alexandria Engineering Journal
·
2025
·
IF 6.8
Yinan Hu,Tao Liu,Bo Guo,Miao Ni,Yanrong Li
This study presents a novel surface-enhanced Raman spectroscopy (SERS) method for detecting CA19–9 in colorectal adenocarcinoma using 4-thiobenzoic acid (4-TBA) functionalized gold nanoparticles (nanospheres). The optimized SERS probes exhibited a maximum enhancement at pH 7 and 50 μM 4-TBA concentration, with stable signal achieved after 2 hours of incubation. The assay demonstrated a wide dynamic range of 1–100 U/mL, with a lower limit of quantification of 1.0 U/mL. Excellent selectivity was observed against common serum interferents, with normalized SERS intensities within 10 % of CA19–9 alone. Recovery studies in spiked serum samples yielded results ranging from 94.5 % to 105.2 %, indicating minimal matrix effects. Clinical validation using 70 serum samples (50 colorectal adenocarcinoma patients, 20 healthy volunteers) showed strong agreement with a commercial ELISA kit (Pearson's r = 0.987, p < 0.0001). Bland-Altman analysis revealed a mean bias of −0.37 U/mL between SERS and ELISA methods. The SERS-based approach offers advantages including rapid analysis (<1 hour), small sample volume requirements (5–10 μL), and potential for multiplexing. This method shows promise for early detection, disease monitoring, and treatment response evaluation in colorectal adenocarcinoma, with potential applications in both clinical and research settings.
研究领域:
肿瘤学
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医学诊断
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纳米技术
·
光谱学
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Yaxian Chen,Huiting Wang,Jie Zhou,Dongxue Lin,Ling Zhang,Zhiqiang Xing,Qian Zhang,Lixin Xia
L-cysteine, an indispensable amino acid present in natural proteins, plays pivotal roles in various biological processes. Consequently, precise and selective monitoring of its concentrations is imperative. Herein, we propose a Surface-enhanced Raman Scattering (SERS) sensor for detecting L-cysteine based on the anti-aggregation of 4-mercaptobenzoic acid (4-MBA) and histidine (His) functionalized silver nanoparticles (Ag NPs). The presence of Hg 2+ ions can induce the aggregation of Ag NPs@His@4-MBA due to the unique nanostructures of Ag NPs@His@4-MBA, resulting in a robust SERS intensity of 4-MBA. However, in the presence of L-cysteine, the stronger affinity between L-cysteine and Hg 2+ reduces the concentration of free Hg 2+ , causing the dispersion of the aggregated functionalized Ag NPs and the reduction of the SERS signal intensity of 4-MBA. The developed SERS platform demonstrates excellent performance with a low detection limit of 5 nM (S/N = 3) and linear detection capabilities within the range of 0.01–100 μM for L-cysteine. Additionally, the method was successfully employed for the determination of L-cysteine in spiked serum samples, yielding recoveries ranging from 95.0 % to 108.1 % with relative standard deviations of less than 3.3 %. This study not only presents a novel approach for fabricating highly sensitive and specific SERS biosensors for biomolecule detection but also offers a significant strategy for the development and construction of SERS substrates using anti-aggregation design.
研究领域:
分析化学
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生物传感
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
·
2022
·Vol. 36
·期 17
·e9342
·
IF 2.586
Wenya Shao,Ying Sun,Hang Su,Qianqian Sun,Zian Lin
Rationale Cesium ions (Cs + ) and strontium ions (Sr 2+ ), which enter the human body mainly through drinking water, are an important determinant of health. They are widely distributed on Earth and extremely soluble in water. In order to assist assessment of the drinking safety, it was essential to develop a rapid analytical method for quantification. We have established a 4-mercaptobenzoic acid (MBA)-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) method for the rapid detection and sensitive quantification of Cs + and Sr 2+ in the aqueous environment. Methods Using MBA as the matrix, the rapid detection and quantification for Cs + and Sr 2+ were conducted by MALDI-TOF-MS. At first, the concentration of MBA was optimized. Then, salt tolerance, detection limit and reproducibility of this method were evaluated by standard solutions. Finally, the calibration curves were constructed and applied to the rapid determination of Cs + and Sr 2+ in six commercially available bottled waters for drinking. Results For the MBA-assisted MALDI-TOF-MS method, the optimal concentration of MBA was 2 mg/mL. The signal-to-noise (S/N) ratio of Cs + was up to 971 in 1000 mmol/mL NaCl solution. The detection limits of the method for Cs + and Sr 2+ were 3 pg/mL and 10 pg/mL, respectively. Furthermore, this developed method was applied to the rapid analysis of Cs + and Sr 2+ in six commercially available drinking waters, and the results correlated well with the results obtained from a validated inductively coupled plasma mass spectrometry (ICP-MS) method. Conclusions The MBA-assisted MALDI-TOF-MS method has high sensitivity, fast detection speed, less background interference, and high reproducibility in the analysis of Cs + and Sr 2+ . Because of the physiological functions and general toxic effects, detection of Cs + and Sr 2+ in water is of major importance for drinking safety.
研究领域:
分析化学
·
环境科学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2021
·Vol. 146
·期 5
·1543-1547
·
IF 4.616
Qianqian Sun,Shasha Zhang,Weini Huang,Ran Wang,Zihan Chen,Zongwei Cai,Zian Lin
4-Mercaptobenzoic acid (MBA) is introduced as a matrix for laser desorption/ionization time-of-flight mass spectrometry (MS) analysis of metals, exhibiting matrix-interference-free background, greatly enhanced MS signal intensity, and excellent reproducibility. The developed method was successfully extended for the rapid screening and sensitive determination of ultratrace metals in fine particulate matter (PM2.5).
研究领域:
分析化学
·
环境科学
·
质谱技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Kaiqiang Wang,Jinjie Li
The fabrication of sensitive and reliable interfacial plasmonic platform for measuring chemical contaminants in various phases is an exciting topic in the food industry and for environment monitoring. In this study, a high-performance surface-enhanced Raman spectroscopy (SERS) analytic platform was developed through self-assembly of the gold@4-mercaptobenzoic acid@silver nanoparticles (Au@4-MBA@Ag NPs) at the cyclohexane/water interface. By addition of the inducer ethanol, the Au@4-MBA@Ag NPs in aqueous phase was effectively migrated to the biphasic interface, forming a large-scale close-packed nanoparticle array. The average gap between adjacent nanoparticles was smaller than 3 nm, where intensive SERS “hot spots” were created for high-sensitive detection. Furthermore, using the sandwiched 4-MBA molecule as the internal standard to correct the Raman signal fluctuations, the point-to-point and batch-to-batch reproducibility of Au@4-MBA@Ag array were improved with lower relative standard deviation (RSD) values of 8.84% and 14.97%, respectively, and pesticides (thiram and thiabendazole) analysis in both aqueous and organic phases were achieved with higher accuracy (R 2 of 0.986 and 0.990) as compared with those without 4-MBA correction (R 2 of 0.867 and 0.974). The high-throughput fabrication of the self-assembled nanoparticle array is a promising approach for development of a sensitive and reliable SERS platform for chemical contaminants monitoring in multiphase.
研究领域:
食品科学
·
环境监测
·
纳米技术
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2020
·
IF 5.339
Yayan Tong,Qingxiang Zhou,Yi Sun,Xueying Sheng,Boyao Zhou,Jingyi Zhao,Jinghan Guo
Polyamidoamine dendrimer decorated Fe 3 O 4 magnetic nanoparticles was synthesized and grafted with 4-mercaptobenzoic acid (4-MBA). The resulting material was utilized to develop an effective magnetic solid phase extraction method in combination with high performance liquid chromatography for trace determination of polycyclic aromatic hydrocarbons including phenanthrene (PHE), anthracene (ANT), fluoranthene (FLT), pyrene (PYR) and benzo(a)pyrene (BaP). The MNPs@G3.0@4-MBA exhibited to be an efficient extracting medium due to the existence of terminal benzene ring groups, the internal pores, and strong hydrophobic interactions and π-π interactions. The experiments demonstrated that the proposed method possessed excellent linearity in the concentration range of 0.1–300 μg L −1 with correlation coefficients (R) larger than 0.997, and the limits of detection (LODs, S/N = 3) according to the ratio of signal to noise equal to three of PHE, ANT, FLT, PYR and BaP were 0.014 μg L −1 , 0.032 μg L −1 , 0.055 μg L −1 , 0.027 μg L −1 and 0.039 μg L −1 , respectively. The proposed method was applied to real water samples and the spiked recoveries were over the range of 92–99%. The results showed that the method earned good repeatability and high sensitivity, and the as-prepared materials were stable and reusable, which displayed that the proposed method would have a wonderful application prospect.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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