GREEN CHEMISTRY
·
2022
·Vol. 25
·期 3
·1056-1066
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IF 11.034
Fengan Han,Yanting Liu,Guangyi Li,Lin Yuan,Aiqin Wang,Feng Wang,Tao Zhang,Ning Li
Selective hydrodeoxygenation (HDO) of lignocellulose-derived ketones to olefins is a promising method for upgrading lignocellulosic biomass-derived molecules. Herein, zinc molybdate (ZnMoO4–E) with a disordered layered stacking structure was first prepared using a facile and environmentally friendly evaporation method and it exhibited outstanding catalytic performance for the selective HDO of lignocellulose-derived ketones to olefins. Using it, 4-heptanone, a representative of lignocellulose-derived ketones, was totally converted, and a high carbon yield of heptene (90%) was achieved at 673 K. On the basis of the characterization results, the outstanding catalytic performance of ZnMoO4–E was attributed to its porous structure, higher oxygen vacancy (or the Mo5+ species) concentration and higher acidity. Analogously, ZnMoO4–E also exhibited good catalytic performances for the selective HDO of other lignocellulose-derived ketones (such as acetone, butanone, 2-pentanone, 3-pentanone, cyclohexanone, acetophenone and 5-nonanone) to their corresponding olefins.
研究领域:
催化
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化学工程
·
材料科学
·
可再生能源
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CATALYSIS
·
2019
·
IF 4.914
Yaxuan Jing,Yu Xin,Yong Guo,Xiaohui Liu,Yanqin Wang
Aldol condensation is of significant importance for the production of fuel precursors from biomass-derived chemicals and has received increasing attention. Here we report a Nb 2 O 5 catalyst with excellent activity and stability in the aldol condensation of biomass-derived carbonyl molecules. It is found that in the aldol condensation of furfural with 4-heptanone, Nb 2 O 5 has obviously superior activity, which is not only better than that of other common solid acid catalysts (ZrO 2 and Al 2 O 3 ), more importantly, but also better than that of solid base catalysts (MgO, CaO, and magnesium-aluminum hydrotalcite). The detailed characterizations by N 2 sorption/desorption, NH 3 -TPD, Py-FTIR and DRIFTS study of acetone adsorption reveal that Nb 2 O 5 has a strong ability to activate the C=O bond in carbonyl molecules, which helps to generate a metal enolate intermediate and undergo the nucleophilic addition to form a new C–C bond. Furthermore, the applicability of Nb 2 O 5 to aldol condensation is extended to other biomass-derived carbonyl molecules and high yields of target fuel precursors are obtained. Finally, a multifunctional Pd/Nb 2 O 5 catalyst is prepared and successfully used in the one-pot synthesis of liquid alkanes from biomass-derived carbonyl molecules by combining the aldol condensation with the sequential hydrodeoxygenation .
研究领域:
催化
·
化学工程
·
可再生能源
·
有机化学
✓ 已验证
产品关联
DOI
高影响因子
Separations
·
2025
·Vol. 12
·期 11
·303
·
IF 2.7
Ruiyi Sun,Fan Li,Yu Xie,Na Sui,Yong Li,Junlian Wang
In this study, two γ-carbon-substituted dialkylphosphinic acids—symmetrical di-(3,5,5-trimethylhexyl)phosphinic acid (P355) and unsymmetrical (2-ethylhexyl)(3,5,5-trimethylhexyl)phosphinic acid (P227-355)—were synthesized via a precise free radical addition method. Their chemical structures were fully characterized using ESI-HRMS,1H NMR,31P NMR, and FT-IR. Their middle REE extraction/separation performance, anti-emulsification behavior, and underlying mechanisms were investigated. Key results showed that P355 had better Dy saturation capacity (357.51 mg/L) and good selectivity for middle REEs (their average value ofβN + 1/N= 3.18), while P227-355 showed higher back-extraction efficiency (≈90% Dy stripping at ≥0.02 mol/L H2SO4). Methyln-pentyl ketone (MNPK) eliminated emulsification and boosted saturation capacity (324.18 mg/L Sm and 357.51 mg/L Dy for P355). Mechanistically, the extraction followed cation exchange (Sm3++ 2(HL)2↔ Sm·L3·(HL) + 3H+); MNPK formed hydrogen-bonded associates (HL·MNPK) with free extractants, slightly reducing the effective concentration of (HL)2but not altering the core cation exchange mechanism.
研究领域:
湿法冶金
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稀土元素分离
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溶剂萃取
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无机合成
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配位化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of the American Chemical Society
·
2026
·
IF 16.6
Xiaofei Xin,Yifu Lyu,Huanyu Qin,Jinyu Dai,Di Wu,Yu Ding,Qiang Tian,Chao Qin,Na Li,Lifang Yin
The rational design of nonlamellar, multicompartment lipid nanoparticles (LNPs) offers a promising strategy for advancing nucleic acid delivery and immunotherapy. In this study, imidazole-based LNPs (A3-DM/DL-LNPs) with a mesoscopically disordered internal structure resembling the sponge phase were developed, enabling efficient codelivery of mRNA and STAT3-targeting siRNA (siSTAT3). Small-angle scattering analysis revealed a unique quasi-periodic arrangement in A3-DM/DL-LNPs, characterized by broader interdomain spacing and higher membrane heterogeneity compared to benchmark ALC-0315-LNPs, suggesting enhanced endocytosis efficiency and more favorable RNA encapsulation. The “M-shaped” polar headgroup, formed by a piperazine ring flanked by two imidazole moieties, promoted membrane interaction, cellular uptake, and transfection efficiency. In contrast, alternative LNPs with linear polar head structures (A3-SS/SM/SL-LNPs and A4-SS/SM/SL-LNPs) showed inferior delivery performance. Raman spectroscopy revealed that lipid spatial localization correlated with RNA expression in the spleen and lymph nodes, highlighting the importance of LNP structure in immune activation and targeting specific immune organs. Functionally, A3-DM/DL-LNPs restored dendritic cell (DC) antigen presentation, alleviated endoplasmic reticulum (ER) stress, and reversed T cell exhaustion in acute myeloid leukemia (AML), triggering strong immune responses and enhancing natural killer (NK) cell and T cell-mediated antileukemic activity, thereby improving therapeutic outcomes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Qianchun Zhang,Yuxian Zhao,Zhaoru Ban,Li Jiang,Shan Tang
Cataluminescence (CTL) sensors are among the most simple, inexpensive, sensitive, and selective tools for gas sensing. This study presented a highly efficient and selective CTL sensor system based on mesoporous SiO2 nanomicrospheres for the quick and sensitive analysis of isobutyraldehyde. Furthermore, its response intensity was 12.7 times higher than that of a nonmesoporous SiO2-based sensor. The constructed CTL sensor exhibited a good linear range (R2 = 0.997) for detecting isobutyraldehyde, spanning 3.11–311 ppm, with a low detection limit of 1.1 ppm. This enabled successful analysis of trace isobutyraldehyde in real samples. Finally, the CTL mechanism of this sensor was further explored. This study presents an approach for the quality detection of an important volatile organic compound, isobutyraldehyde, by a mesoporous-based CTL sensor.
研究领域:
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
Surfaces and Interfaces
·
2024
·
IF 5.7
Hongyan Wang,Zixuan Li,Yin Liu,Linfeng Cui,Bo Liu
The introduction of methodologies to amalgamate, shear, or fabricate structures could potentially lead to exceptionally remarkable architectures. In this work, three similar perylene-based molecules, PDI 1–3 , each modified with different alkyl chains, were synthesized to investigate the pathway complexity via hetero-seeded self-assembly. Delightfully, a type of remarkably active metastable nanowires assemblied from perylene-based molecule PDI 1 was obtained. Based on this, hierarchical heterojunction microsheets were fabricated using metastable nanowires derived from PDI 1 , initiated by hetero-seeds sourced from the perylene-based molecule PDI 2 in a "bottom-up" approach. Furthermore, the decomposition of the microsheet seed derived from PDI 3 was achieved, resulting in the formation of heterogeneous nanowires induced by the metastable nanowires from PDI 1 in a "top-down" approach. The decomposition and fabrication of the microsheet architectures were unveiled to be governed by the competitive π-interactions between seeds and monomers during the self-assembly process. This research is a powerful novel approach for assembling complex architectures and has enhanced the understanding of the molecular assembly growth process at the interface.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2021
·
IF 6.057
Zhenyu Lu,Xiaotian Lu,Ling Xia,Yanhui Zhong,Gongke Li,Yufei Hu
In this work, a catalytic material of cobalt doped nitrogenous porous carbon (Co/NPC) was fabricated from covalent organic frameworks (COFs) and cobalt ion via directly carbonization . Attribute to the excellent selective catalytic performance towards n -hexane, Co/NPC was employed in cataluminescence (CTL) for rapid and sensitive determination of n -hexane. Moreover, the detection conditions of CTL were evaluated, including temperature, flow rate and detecting wavelength. Under optimized conditions, a good linear relation between signal intensity of CTL and n -hexane concentration was obtained in the linear range of 0.4–250.0 mg/L and the limit of detection (LOD, S/N = 3) was 0.13 mg/L. Furthermore, the Co/NPC based CTL sensor was successfully applied to the determination of n -hexane in edible oil samples with the recoveries in the range of 92.0%–104.0%. The method comparison results of GC/MS and CTL on real sample analysis further proved the accuracy of the developed Co/NPC based CTL method. Additionally, the possible catalytic mechanism of n -hexane on the surface of Co/NPC was investigated, assisting by GC/MS on intermediation products identification. Overall, the Co/NPC based CTL sensor has been confirmed excellent performance in the n -hexane determination, which revealing extensive application in rapid residual n -hexane analysis in edible oil .
研究领域:
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Chemical Neuroscience
·
2022
·
IF 5.78
Sijia Hao,Yayu Yang,Ailing Han,Jianan Chen,Xiaoyu Luo,Guozhen Fang,Jifeng Liu,Shuo Wang
Polyphenols are the class of naturally synthesized compounds in the secondary metabolism of plants, which are widely distributed in fruits and vegetables. Their potential health treatment strategies have attracted wide attention in the scientific community. The abnormal aggregation of Aβ to form mature fibrils is pathologically related to Alzheimer’s disease (AD). Therefore, inhibiting Aβ40 fibrillogenesis was considered to be the major method for the intervention and therapy of AD. Glycosides, as a cluster of natural phenolic compounds, are widely distributed in Chinese herbs, fruits, and vegetables. The inhibitory effect of glycosides (phloridzin, salidroside, polydatin, geniposide, and gastrodin) and their corresponding small molecules (phloretin, 4-hydroxyphenyl ethanol, resveratrol, genipin, and 4-hydroxybenzyl alcohol) on Aβ40 aggregation and fibrils prolongation, disaggregation against mature fibrils, and the resulting cytotoxicity were studied by systematical biochemical, cell biology and molecular docking techniques, respectively. As a result, all inhibitors were observed against Aβ40 aggregation and fibrils prolongation and disaggregated mature Aβ40 fibrils in a dose-dependent manner. Besides, the cell validity experiments also showed that all inhibitors could effectively alleviate the cytotoxicity induced by Aβ40 aggregates, and the glycoside groups played important roles in this inhibiting process. Finally, molecular docking was performed to study the interactions between these inhibitors and Aβ40. Docking showed that all inhibitors were bound to the similar region of Aβ40, and glycoside group formed hydrogen bonds with the pivotal residues Lys16. These results indicated that the glycoside groups could increase the inhibitory effects and reduce cytotoxicity. Glycosides have tremendous potential to be developed as an innovative type of aggregation inhibitor to control and treat neurodegenerative diseases.
研究领域:
神经生物学
·
药理学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RENEWABLE ENERGY
·
2022
·
IF 8.634
Shanshan Shao,Pengfei Zhang,Xianliang Xiang,Xiaohua Li,Huiyan Zhang
Ketonization of bagasse pyrolysis gas was performed over red mud-based oxides. The maximum yield of ketones in the catalytic conversion of bagasse pyrolysis gas over original red mud was 18.66% at 420 °C. To promote the oxidability of red mud and obtain a higher yield of ketones, the effect of metal oxides (CeO 2 , MnO 2 , TiO 2 , CaO, ZrO 2 ) loading and loading amount of CeO 2 on red mud on ketonization of bagasse pyrolysis gas were studied. The highest yield of ketones of 27.86% was obtained over red mud-based oxides with 40 wt% CeO 2 loading. The oxidability of the catalyst was enhanced greatly by the high loading of CeO 2 , leading to the peroxidation of acetone as the side reaction. To control the oxidability and cut costs, bimetallic oxides were loaded on red mud. The yield of ketones reached 30.12% over the composite red mud catalyst with the loading of 20 wt% CeO 2 and 20 wt% MnO 2 . The rough coating of MnO 2 on the surface of red mud was beneficial to the loading of CeO 2 , resulting in smaller and more uniform grains. This study provides the efficient utilization of red mud and biomass as solid wastes for high-valued chemicals and fuels.
研究领域:
能源与环境科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS COMMUNICATIONS
·
2023
·
IF 3.7
Zhao Yang,Yan Xiong,Ting Li,Zhiqing Yang,Bing Hui Chen
Carbon supported Ru-Sn bimetallic catalyst shows excellent performance in room-temperature hydrogenation of acetone, 100% acetone conversion with 100% product selectivity to isopropyl alcohol can be achieved within a short reaction time. Catalyst structure-function relationship reveals a synergetic behavior between Ru and Sn sites, demonstrating the essential correlation between Sn/Ru atomic ratio and the resultant variation in catalytic performance. Room temperature hydrogenation of 4-heptanone was also studied, verifying the consistency of the established structure-function relationship in ketones hydrogenation reactions.
研究领域:
催化化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）