Interdisciplinary Medicine
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2026
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IF 13.6
Changxu Zhu,Yin Li,Qiyun Deng,Ruixin Guo,Yu Huang,Wenyan Guo,Xi Chen,Ben Zhong Tang,Zhiming Wang,Lidan Chen,Zhaohui Sun
Drug-resistant bacterial biofilm-associated infections pose a significant threat to human health, as the physical barrier and protective matrix of biofilms enable bacterial evasion of antibiotic effects, leading to refractory infections. To address this challenge, we develop a novel photosensitizer PY and its sulfonated zwitterionic derivative PYSO 3 . Both photosensitizers exhibit aggregation-induced emission (AIE) properties coupled with exceptional photodynamic and photothermal performance in aggregates. Sulfonated zwitterionic modification significantly enhance the biological activity of PYSO 3 , demonstrating potent bactericidal efficacy against methicillin-resistant Staphylococcus aureus (MRSA) and mature biofilms under laser irradiation. Mechanistically, PYSO 3 -mediated combinational photodynamic therapy and photothermal therapy disrupt critical bacterial survival pathways, including quorum sensing systems, glycolysis/gluconeogenesis pathways, and oxidative stress homeostasis, thereby inhibiting normal bacterial metabolism and biofilm formation. In vivo experiments reveal remarkable antibacterial performance with accelerated wound healing rates and favorable biosafety profiles. This AIE-active zwitterionic photosensitizer not only holds great promise for combating MRSA infections but also provides new design strategies for developing multifunctional antimicrobial agents targeting drug-resistant pathogens.
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高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Dongxue Feng,Yuxin Zhou,Yao Tong,Jian Yang,Jinlou Gu
The assembly of covalent organic frameworks (COFs) in enzyme-compatible media is highly desirable yet challenging. Herein, we proposed an electron donor–acceptor (EDA)-complex-assisted strategy for the aqueous ambient construction of β-ketoenamine COFs under additive-free condition simultaneously with the in situ encapsulation of enzymes. EDA complexes, formed by an electron-rich 2,2′-bipyridine-5,5′-diamine (Bpy) with electron-deficient 1,3,5-triformylphloroglucinol (Tp), prearranged monomers in specific orientation and significantly lowered the reaction activation energy, thus enhancing the error correction and yielding highly crystalline TpBpy COFs. Beyond affording a protective scaffold, the Bpy units within COFs also served as anchoring sites for the chelation of various metallic ions to establish biomimetic enzymatic centers. On this basis, a spatially coupled nanoreactor was designed by encapsulating the natural creatinine deiminase (CD) followed by biomimetic laccase (Bpy-Cu) installation within COFs. The product generated by the encapsulated CD activated the neighboring Bpy-Cu within the adjacent pores, creating a proximity-induced cascade amplification and enabling the entire cascade to respond specifically to one of the key chronic kidney disease (CKD) biomarkers of creatinine. The constructed detection platform exhibits a wide linear range, with a detection limit as low as approximately 7.7 μM. This platform can provide valuable supporting information for the assessment of kidney function and holds promise for applications in the early screening and disease course monitoring of CKD. By simply altering the encapsulated natural enzymes and biomimetic active sites, this modular and generalizable platform is expected to offer a promising tool for early diagnosis of various diseases.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
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IF 12.5
Xiaokun Fa,Ruichen Geng,Zhihan Zhang,Yinglong Wang,Fengbin Zheng,Shuli Yin
Slow natural degradation of polylactic acid (PLA) bioplastics leads to carbon resource waste and CO 2 emissions, underscoring the urgent need for advanced upcycling methods beyond conventional recycling. This study addresses this challenge by developing high-entropy alloys (HEAs) PdPtAuCuAg nanowires with multi-atom catalytic sites prepared by a straightforward one-pot approach. These unique nanowires integrate the multi-metallic synergy, structural stability, and lattice distortion inherent to HEAs with the high electrochemical surface area and abundant active sites provided by the nanowire morphology. As high-performance electrocatalysts, PdPtAuCuAg nanowires efficiently convert PLA-derived lactic acid into valuable acetic acid via the lactic acid oxidation reaction (LOR) in alkaline media, achieving acetic acid selectivity of 94.74% and faradaic efficiency of 94.75% at 1.60 V vs. RHE. The excellent activity originates from multi-atom catalytic sites within the HEAs, optimizing electron regulation and specifically facilitating the reaction pathway towards acetic acid. This work presents an efficient and sustainable electrocatalytic strategy for transforming waste PLA plastic into a valuable chemical commodity, offering a promising solution for plastic waste management and enhanced resource circularity.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
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IF 9.1
Min Li,Juan Li,Tingyan Ye,Shuangjiang Li,Wenjun Zhang,Yutong Zhang,Yunfei Zhi,Pingyan Wang,Donghui Liu,Tianding Hu,Shaoyun Shan,Na Li,Yi Liu
The utilization of CO 2 as a sustainable carbon feedstock is an attractive strategy toward carbon neutrality, while the development of efficient heterogeneous catalysts under mild and co-catalyst-free conditions remains challenging. Herein, three porous organic polymer catalysts (PLZ, PLY, and PL-YZ) were synthesized through a one-step bidirectional polymerization strategy to systematically investigate the individual and synergistic roles of hydrogen-bond donor site (HBDs), Lewis basic N sites, and nucleophilic Cl − sites in CO 2 cycloaddition. Among them, PL-YZ exhibited the highest catalytic activity, affording chloropropylene carbonate in 93.1% yield with nearly 100% selectivity under optimized mild conditions (80 °C, 0.5 MPa CO 2 , 8 h) without any co-catalyst. In addition, PL-YZ maintained over 86% yield after five consecutive cycles and displayed broad substrate applicability toward various terminal epoxides. Kinetic analysis, in situ FT-IR spectroscopy, and DFT calculations consistently revealed that the cooperative interactions among HBD sites, Lewis basic N sites, and nucleophilic Cl − sites promote epoxide activation and ring-opening, facilitate CO 2 insertion, and accelerate cyclic carbonate formation. This study demonstrates the high product yields, selectivity, and recyclability of multifunctional porous polymer catalysts under mild conditions and establishes a practical design principle for integrating complementary active sites toward sustainable CO 2 conversion.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
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IF 12.5
Yanping Wang,Dezhen Fang,Kexin Li,Xiushen Ye,Wenjie Han,Pengrui Zhang,Zhijian Wu,Guosheng Shi,Haining Liu
APPW adsorbent designed via 4-aminopyridine (4-AP) tuning of the adsorption energy window. • Achieves ultra-high Cs + selectivity with an Rb + /Cs + separation factor of 11,122. • Enables one-step Cs + separation without Rb + interference. • Shows strong resistance to coexisting ions in salt lake brines and ore leachates. • Establishes a new strategy of adsorption energy window modulation for ion separation. Efficient separation of Cs + from Rb + remains a critical bottleneck due to their similar ionic properties. This work fabricates a 4-aminopyridinium phosphotungstate (APPW) adsorbent by substituting conventional NH₄ + in phosphotungstic acid (HPW) with tailored4-Amino pyridinium ion (4-AP + ) cations to construct a tunable adsorption energy window. DFT calculations confirm the binding energy order ΔE (Rb + -PW) > ΔE (4-AP + -PW) > ΔE (Cs + -PW) , which thermodynamically enables exclusive exchange of 4-AP + by Cs + and suppresses Rb + adsorption. APPW delivers an ultrahigh Rb + /Cs + distribution coefficient of 11,122, outperforming previously reported adsorbents. At Rb + /Cs + molar ratio of 10:1 mimicking natural brine, APPW still achieves selective Cs + capture with negligible Rb + uptake and stable performance across pH 2–11. Coexisting Li + , Na + , K + , Ca 2+ , Mg 2+ barely interfere with Cs + selectivity. Adsorption follows Langmuir monolayer chemisorption and pseudo-second-order kinetics, and the endothermic process proceeds spontaneously. After five regeneration cycles with 4-aminopyridine eluent, APPW retains 87.9% initial Cs + capacity. Practical treatment of oilfield brine achieves 81.91% Cs + recovery under high-salinity complex matrices. This study overcomes the poor Cs + selectivity limitation of traditional heteropolyacid materials and establishes a universal molecular design strategy via adsorption energy window modulation, offering a recyclable high-performance adsorbent for one-step Cs + separation from salt lake brines, ore leachates and radioactive wastewater.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Congfei Zhu,Bingru Wang,Yasen Dai,Yujia Liu,Shuhang Ren,Zhigang Lei,Minjie Gao,Weize Wu
Carbon dioxide (CO 2 ) removal from syngas is an essential pretreatment in chemical production to control syngas quality and utilize carbon resource. Current decarbonization technologies are effective, however, they always consume large amounts of energy and require more economical absorbent in industry. This work introduced a deep eutectic solvent (DES) (4-aminopyridine: ethylene glycol, AP:EG), which was demonstrated to absorb CO 2 mainly by physical absorption (high capacity) and secondly by chemical absorption (thorough residual removal) at high pressures. At 303.15 K and 1 MPa, AP:EG (1:3) DES exhibited the best performance, and the total absorptive ability was 0.242 g CO 2 /g DES (30.34% chemical, 69.66% physical). The DES released absorbed CO 2 completely within 20 min under N 2 purging and maintained 99.3% capacity after five cycles, suggesting a scalable route toward low-energy high-pressure CO 2 capture. Owing to the predominantly physical mechanism, the regeneration energy was only 1.57 GJ/t CO 2 , markedly lower than typical aqueous amine systems (0.36 g CO 2 /g MEA, 3.5 GJ/t CO 2 ), while avoiding the low-temperature operation and volatility concerns associated with methanol-based physical absorption processes. Molecular simulations revealed that hydrogen bonding between EG and AP activated the amine site and reduced steric hindrance, enabling synergistic physiochemical uptake.
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2026
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IF 2.1
Minjie Gao,Congfei Zhu,Yasen Dai,Bingru Wang,Shuhang Ren,Weize Wu
Deep eutectic solvents (DESs) show great potential in the field of CO2 capture; however, the lack of systematic physicochemical property data remains a bottleneck constraining their rational design and industrial application. This study prepared six representative DESs and systematically characterized their key fundamental properties as absorbents: density, viscosity, thermal stability, and specific heat capacity. The results indicate that the chemical structure of the hydrogen bond acceptor has a decisive influence on the properties of the DESs. The viscosity and density of all DESs decreased significantly with increasing temperature. Thermogravimetric analysis revealed their varying thermal stabilities, with the onset decomposition temperature ranging from 366.52 K (menthol–ethylene glycol) to 415.17 K (choline chloride–ethylene glycol). The measurement of specific heat capacity data provides a key basis for evaluating solvent regeneration energy consumption. This study fills the gap in systematic property data of various DESs. Comprehensive analysis indicates that the choline chloride-ethylene glycol system achieves the best balance among viscosity, thermal stability, and specific heat capacity, making it a highly promising candidate based on its physicochemical property profile for CO2 capture among the studied systems. This work provides solid data support and theoretical guidance for the screening, design, and energy optimization of DESs in CO2 capture processes.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Jiacong Wu,Xinnan Ma,Ting He,Juan Han,Yan Zhu,Chunmei Li,Yun Wang
The structural limitation of the photocatalyst itself is the main reason for the difficulty in increasing the enzyme loading amount in the photo-enzyme coupling system. Hereon, a g-C 3 N 4 -based photocatalyst ACN 45 with high enzyme loading amount was synthesized. Abundant 5 nm channels match well with the size of horseradish peroxidase (HRP) molecules, which enables the loading amount to reach 6.3 times that of pure g-C 3 N 4 . Meanwhile, the microenvironment provided by channels of ACN 45 significantly improves the activity and stability of the immobilized enzyme, and reduces the leaching of the enzyme molecules inside it. The internal immobilization of HRP did not affect the absorption of visible light by the photocatalyst, and high loading amount of photo-enzyme coupling system enhance the photocatalytic degradation of BPA. The degradation rate reached 94 % within 1 h, which is 5.9 times that of pure g-C 3 N 4 . The research findings open avenues for designing a photo-enzyme coupling system with high enzyme loading and high stability through simple steps.
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高影响因子
Journal of Cleaner Production
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2022
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IF 11.072
Wei-Dong Xiao,Ling-Ping Xiao,Wen-Zhe Xiao,Qiang Wang,Shang-Ru Zhai,Run-Cang Sun
The uniquely interconvertible transformation of cellulose pulp and paper shows great potential as smart materials for environment remediation. However, performing liquid-phase catalytic reactions involving hydrogenation steps under mild conditions and ambient temperature remains challenging. Herein, we report a facile and eco-friendly strategy to fabricate low-cost, highly effective, and stable pulp-supported silver nanoparticles (AgNPs/pulp). The pulp phase is used to maintain the high catalytic efficiency of the AgNPs/pulp catalyst, while the paper phase remains high stability as the filling material in the reaction column. The as-prepared AgNPs/pulp catalyst exhibits excellent catalytic activity toward NaBH 4 -mediated reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) with a turnover frequency of 605.1 h −1 and a k value of 24.9 × 10 −3 s −1 at room temperature, which outperforms most of reported cellulose-supported catalysts. Impressively, the AgNPs/pulp catalyst shows outstanding durability during a continuous operation for 72 h. Such excellent performance can be attributed to the uniform dispersion of the AgNPs/pulp in solution and uniform distribution of Ag NPs on the fiber surface of cotton pulp, which greatly improve the accessibility of reactants and active sites as well as metal-support interactions. This work provides new insights into the understanding of catalytic hydrogenation of 4-NP, which could pave the way for rational design of novel cellulose-based catalysts for organic wastewater treatment .
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Chongfu Wu,Zhenhua Sun,Changshen Ye,Zhaoyang Qi,Jie Chen,Zhixian Huang,Ting Qiu
The development of catalysts with excellent performance in oxidative desulfurization (ODS) at room temperature will greatly facilitate the advancement of desulfurization technology. An efficient novel strategy, 4-aminopyridine molecular bridging combined with manual grinding, was presented to encapsulate HPW into UiO-66 for achieving stable loading of PW and to produce abundant defects that contribute to the formation of active complexes with strong oxidation ability. The prepared catalyst showed outstanding catalytic activity in the ODS system, achieving full desulfurization in 15 min at room temperature and a low O/S molar ratio. Further investigations reveal that the synergistic catalytic effect of the faulty UiO-66 and PW is mostly responsible for superior catalytic performance. UiO-66 rich in defects promote the decomposition of H 2 O 2 into radicals, and PW can combine with the radicals to form more stable active peroxide intermediates, then exerting the catalytic ability of ODS at room temperature. Such a synergistic catalytic mechanism provides a guide to improving the oxidation ability of PW-based catalysts at room temperature.
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高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2022
·Vol. 98
·期 3
·583-590
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IF 3.709
Junxiu Ye,Gufeng Li,Yao Zhang,Shiju Ji,Min Yang,Lijun Luo,Hongbin Wang,Jiaxiong Li,Guizhen Li
BACKGROUND The adsorption removal of phenol onto bentonite that was prepared by the traditional hydrothermal method has been widely studied; especially, surfactant-modified bentonite has achieved an exclusive position on effective removal to phenol. However, the adsorption performance of the bentonite functionalized by double-carbon chain surfactants in a microwave field for phenol is relatively low. The study on the fabrication of organobentonite by microwave-assistance to remove organic pollutants still needs to be investigated. RESULTS The adsorption performance of bentonite was enhanced after functionalizing with Dihexadecyldimethylammonium Bromide (D1621). FTIR and XRD patterns revealed that D1621 was successfully intercalated into bentonite, and the interval space was increased by 1.54 to 1.84 nm. The optimized preparation condition was obtained at a molar ratio (D1621: Bentonite) of 0.36, solid–liquid ratio (D1621 + Bent: water) of 0.12, microwave mode of Med, and thermal radiation for 6 min based on the indicator of phenol adsorption uptake. An excellent removal rate for phenol was observed at pH 2 to 7 and room temperature in adsorption tests. The adsorption process was spontaneous at room temperature according to thermodynamic parameters, and it agrees with Freundlich ( R 2 = 0.9781) and pseudo-second-order ( R 2 = 0.9999) models, validating a chemisorption process. CONCLUSION The D1621-Bent perpetrated by using the microwave-assisted heating method was proven to be a reliable adsorbent for phenol in water. The adsorption performance of bentonite on phenol was remarkably enhanced after the introduction of organic modifiers. © 2022 Society of Chemical Industry (SCI).
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高影响因子
Journal of Environmental Chemical Engineering
·
2022
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IF 7.968
Hai-Fang Mao,Hong-Qing Fu,Ji-Bo Liu,Yun Zhao
A novel iron-pyridine-based chelate Fe-PYPA was synthesized via a facile and green strategy. The chelate served as a highly efficient catalyst toward CO 2 cycloaddition . A 95.7% PO conversion and a 98.4% PC selectivity were achieved under moderate conditions. Even under solvent-free conditions, Fe-PYPA could achieve a 93.6% conversion and 98.2% selectivity, acting as a robust and efficient catalyst toward CO 2 cycloaddition. Moreover, the as-prepared catalyst showed desirable catalytic activity , good recyclability , remarkable thermo-stability and ideal compatibility to a variety of epoxy substrates. In-situ ATR-IR spectroscopy was used as a powerful tool to gain process understanding for the whole conversion from CO 2 to cyclic carbonate under atmospheric pressure in the presence of TBAI. The process of PO’s ring opening, activation and insertion of CO 2 and the formation of cyclic carbonate were illuminated explicitly through the change of characteristic absorption peaks, providing direct and visual evidence for the mechanism proposed. The present work paves a new way for theoretical and experimental explorations on novel catalyst design and process understanding for highly-efficient greenhouse gas re-utilization.
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高影响因子
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