KEY ENGINEERING MATERIALS
·
2013
·
IF 0
Yun Xia Jiang,Hu Jin Zuo,Yong Jia Shen,Feng Ping Yi
The Friedel-Crafts acylation reaction between 5-cyanoindole and 4-chlorobutyryl chloride was conducted in ionic liquid 1-buty-3-methylimidazolium chloroaluminate ([bmiCl/AlCl3), the major product was 5-cyano-3-(4-chlorobuty) indole. The structure of the product was characterized by Mass and 1H NMR spectra. When the molar ratio of AlCl3 to [bmiCl in [bmiCl/AlCl3 is at 1:1 or less, no 5-cyano-3-(4-chlorobuty) indole could be obtained. The suitable molar ratios of AlCl3 to [bmiCl in [bmiCl/AlCl3 were from 2:1 to 3:1, the yields of the major product were from 68% to 70%, respectively. When the molar ratio of [bmiCl/AlCl3 to 5-cyanoindole was less than 2:1, the acylation reaction was difficult to carry out, because 5-cyanoindole would be not totally dissolve in [bmiCl/AlCl3 under the situation.
研究领域:
有机化学
·
合成化学
✓ 已验证
DOI
MOLECULES
·
2024
·Vol. 29
·期 16
·3837
·
IF 4.2
Yanru Hu,Peng Liu
The diselenide bond has attracted intense interest for drug delivery systems (DDSs) for tumor chemotherapy, owing to it possessing higher redox sensitivity than the disulfide one. Various redox-responsive diselenide-containing carriers have been developed for chemotherapeutics delivery. However, the premature drug leakage from these DDSs was significant enough to cause toxic side effects on normal cells. Here, a pH/redox co-triggered degradable polyprodrug was designed as a drug self-delivery system (DSDS) by incorporating drug molecules as structural units in the polymer main chains, using a facile one-pot two-step approach. The proposed PDOX could only degrade and release drugs by breaking both the neighboring acid-labile acylhydrazone and the redox-cleavable diselenide conjugations in the drug’s structural units, triggered by the higher acidity and glutathione (GSH) or reactive oxygen species (ROS) levels in the tumor cells. Therefore, a slow solubility-controlled drug release was achieved for tumor-specific chemotherapy, indicating promising potential as a safe and efficient long-acting DSDS for future tumor treatment.
研究领域:
生物医学工程
·
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 54
·期 20
·13298-13313
·
IF 3.442
Zhang Liuwei,Qian Ming,Wang Jingyun,Xia Jing,Cui Hongyan,Chen Qixian
Photo-responsive nitrophenyl moieties were proposed to conjugate as pendants of the pullulan backbone through labile carbamate linkage to yield amphiphilic pullulan derivatives. Note that the hydrophobicity of the conjugated nitrophenyl components in the amphiphiles enable facile their self-assembly with the hydrophobic chemotherapeutic drug (doxorubicin) as the internal drug reservoirs, whereas the hydrophilic pullulan segments existed as the biocompatible surroundings. Upon photo-illumination, the carbamate linkage was susceptible to cleavage for departure of the nitrophenyl components from the pullulan backbone owing to the photo-responsive nitrophenyl moieties. Simultaneously, the nitrophenyl components transformed into water-soluble aldehyde-terminalized nitrosophenyl derivatives, leadingly accounting for structural disassembly and liberation of the cytotoxic doxorubicin payloads. Therefore, our proposed photo-responsive strategy could address the reluctant intracellular drug release drawbacks of the conventional amphiphile-based drug delivery systems. Notably, markedly lower IC 50 (half maximal inhibitory concentration) index of our constructed doxorubicin delivery systems was determined to be approximately 1.0 μg/mL upon photo-illumination, in contrast to IC 50 index of 5.6 μg/mL in the absence of photo-illumination (approximate fivefold), thereby representing as a facile spatiotemporal artifice to execute on-demand drug release to the photo-imposed cells.
研究领域:
药学
·
材料科学
·
纳米技术
·
癌症治疗
✓ 已验证
产品关联
DOI
高影响因子
POLYMER BULLETIN
·
2018
·Vol. 76
·期 5
·2215-2231
·
IF 1.589
Yu Lili,Yao Lin,Li Li,Liu Shaojing,Jia Zhengxuan,Wu Di
The cationic photo-responsive polymeric micelles (mPEG-b-p(DEMA-co-MMA-CL)) with light-switchable cross-linker were designed and fabricated by atom transfer radical polymerization and quaternization. These micelles were well dispersed spherical with positive charge. The efficient release of encapsulated contents can be triggered by light irradiation. No significant toxicity was observed of copolymer and its photolysis residues at concentrations up to 250 μg/mL. The antitumor activity of camptothecin (CPT) in micelles demonstrated that light triggered the release of CPT, which dramatically improves the cytotoxicity after UV irradiation.
研究领域:
药学
·
高分子化学
·
纳米技术
·
药物递送系统
·
癌症治疗
✓ 已验证
产品关联
DOI
高影响因子
INTEGRATED FERROELECTRICS
·
2017
·
IF 0.457
Xin-Feng Zhang,Shu-Jing Yang,Hong-Wei Yao,Xu-Feng Chen,Xiao-Jun Zheng,Ze-Jing Li,Hai-Lin Cong
Fullerene (C60) was successfully grafted on cellulose following with the modification of cellulose by acid chlorination and subsequently azidation. The structures of modified cellulose made by sulfonation, acylating chlorination, Azidation, ionization and fullerenated were determined by infrared spectroscopy. The results show that the raw cellulose can obtain good dissolution property when the methyl imidazole-chloropropylene ionic liquid is used as the solvent system. The choice of intermediates has an important effect on the modification. The better grafting efficiency can be obtained with acyl chlorinated cellulose, and the reactivity and reactivity control of the azided chlorinated cellulose fibers are more easily to obtain. The azided chlorinated cellulose can be grafted by fullerene successfully.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 3
·1-10
·
IF 2.8
Chen Junye,Lu Guanbin,Zhang Yuan,Cheng Yuanrong,Xiao Fei
Additives are essential for damascene copper electroplating to achieve defect-free deposition in nanoscale interconnect on chips. A hybrid additive named 1000EQ with capabilities of both suppressor and leveler has been synthesized and analyzed. The additive contains polyether segment and nitrogen cation which are typical functional groups of suppressor and leveler, respectively. Electrochemical measurements reveal that 1000EQ has strong inhibition toward copper deposition and is more resistant to the desorption of accelerator than traditional suppressor polyethylene glycol (PEG, Mw = 10,000). 1000EQ and bis-(sodium sulfopropyl)-disulfide (SPS) were used as additives to achieve a defect-free filling of features with 70 nm in width and an aspect ratio above 3. The ratio of copper film thickness over dense and sparse patterned area is close to 1 and the root mean square roughness (Rq) of the film is 9.4 nm, acting as a solid proof of its hybrid characteristic. The resistivity of the copper film is 1.80 ± 0.02 µΩ cm. The characterizations establish that 1000EQ is a promising candidate which can serve as both suppressor and leveler for damascene copper electrodeposition and is able to simplify the bath used in copper electrodeposition process.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）