POLYMER ENGINEERING AND SCIENCE
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2026
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IF 3.6
Qinglong Zhang,Wen Zheng,Wangyang Lu,Wenxing Chen
In traditional polyphosphoric acid (PPA) systems, polybenzoxazole (PBO) synthesis suffers from long reaction times and high energy consumption. To address this, a rapid model-reaction–based screening protocol using the terephthalic acid (TPA)/o-aminophenol (OAP) system was developed to qualitatively rank catalyst activity. Fourteen imidazole-based derivatives were evaluated, revealing structure–activity trends and enabling selection of two optimal catalysts, 4,5-dimethyl-2-phenyl-1 H -imidazole (Cat-2) and 2-methyl-1 H -benzimidazole (Cat-3). Both accelerated polymerization of aromatic AB-type monomers (3,4-AHBA, 4,3-AHBA, 3,4-AHPA·HCl, ACBP), yielding polymers with higher intrinsic viscosities within the same reaction times. The resulting PBOs maintained intact benzoxazole backbones and exhibited excellent thermal stability under nitrogen ( T 5% = 598°C–654°C; char yield 67%–72%). Solid-state 13 C NMR, FT-IR, XPS, and TGA, together with viscosity measurements, support a plausible mechanism in which imidazole catalysts may form N-acyl-imidazole intermediates, facilitating acyl transfer and lowering the early condensation barrier. Overall, this work proposes an efficient catalytic strategy and mechanistic insights for the investigated aromatic AB-type PBO monomers, providing guidance for catalyst design in related PBO and heterocyclic polymer systems. Highlights TPA/OAP model enables qualitative catalyst screening. Cat-2 and Cat-3 boost AB-type PBO polymerization. A plausible N-acyl-imidazole pathway is proposed. Polymers show high thermal stability under N 2 .
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CHEMICAL PAPERS
·
2026
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IF 2.7
Chen Jun,Xiao Ke,Cai Shaoyu,Xu Mao,Kang Luo,Pei Shuchen
Antibacterial carbon dots (CDs) were synthesized from Tieguanyin tea to expand the functional applications of tea resources. The morphological, structural, and chemical properties of the CDs were systematically characterized by TEM, FT-IR, and XPS. These analyses confirmed that the CDs possess a well-defined graphite-like lattice and surface functional groups essential for interacting with bacterial cells. Notably, the tea-derived CDs exhibited potent antibacterial activity against clinically relevant drug-resistant pathogens, effectively overcoming existing resistance mechanisms. They showed strong inhibitory effects against S. aureus (MIC = 1.00 mg/mL) and E. coli (MIC = 1.20 mg/mL). The antimicrobial mechanism is attributed to the generation of reactive oxygen species (ROS) under illumination and electrostatic disruption of bacterial membranes driven by the cationic surface charge of the CDs. This study demonstrates the potential of tea as a promising platform for designing sustainable antibacterial nanomaterials, offering new insights into the integrated valorization of biomass resources and the mitigation of antibiotic resistance.
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JOURNAL OF LUMINESCENCE
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2023
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IF 3.6
Shuchen Pei,Xiang Huang,Lin Lai,Wanlin Sun,Shuiqin Chai,Jun Chen
In this work, a green and economical strategy to prepare silanized carbon dots (Si-CDs) based on Ficus virens leaves was carried out. The prepared difunctional Si-CDs showed high water-solubility and favorable photostability. The morphology and surface functional groups were analyzed by TEM, FT-IR, and XPS. Si-CDs had amorphous nature with no crystal lattice and the average diameter of 1.95 nm. Some functional groups like nitrogen groups , oxygen groups, and silicon groups were discovered. Attributing to the small size of Si-CDs, positive charges, and the generation of singlet oxygen and hydrogen radicals, Si-CDs possessed effective antibacterial activity . The minimum inhibitory concentration of Si-CDs against Escherichia coli and Staphylococcus aureus was 0.078 mg/mL. Moreover, Si-CDs exhibited selective and sensitive fluorescence quenching response to Fe 3+ through static quenching process. The limit of detection was 0.84 μmol/L in the liner range of 5–50 μmol/L. Analysis of real samples led to 99.8–102.0% recoveries and <1% relative standard deviation. Consequently, this work discovered a new, green, economical silanized carbon dot with the potential application as a potent antibacterial agent and an effective fluorescent sensor of iron ion .
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Foods
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2022
·Vol. 12
·期 1
·94
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IF 5.561
Jingling Guo,Pan Wang,Yifan Cui,Xiaosong Hu,Fang Chen,Chen Ma
Resveratrol (RSV), a polyphenolic stilbene, has been widely studied for its protective effects against non-alcoholic fatty liver disease (NAFLD) by modulating intestinal microbiota. The microbial metabolites after RSV supplement would contribute to the bioeffects of RSV, while their impacts on NAFLD were unclear. Therefore, this study aimed to investigate the beneficial effects of the main microbial metabolites from RSV on lipid metabolism by combining in vitro and in vivo models. The mice were fed a high-fat diet and injected with RSV, 3-hydroxyphenyl propionic acid (3-HPP), and 4-HPP for 13 weeks (n= 6). Body weight, serum parameters, histological analysis, and gene expression involved in lipid metabolism were quantified. Our results suggested that 100 μM of 3-HPP and 4-HPP inhibited lipid accumulation more significantly than parent RSV in an oleic acid-induced HepG2 cell line. Furthermore, 3-HPP, 4-HPP, and RSV effectively reduced liver weight and body weight, improved hepatic steatosis, and alleviated systemic inflammation in NAFLD mice. In addition, the results of quantitative real-time PCR showed that 3-HPP and 4-HPP altered the expression of cholesterol influx and efflux genes to a stronger extent than RSV. These results indicate that 3-HPP and 4-HPP are effective in regulating hepatic lipid metabolism.Keywords:NAFLD;microbial metabolites;3-hydroxyphenyl propionic acid;4-hydroxyphenyl propionic acid;lipid metabolism
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
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IF 5.895
Hui-Ying Wang,Cheng Qu,Meng-Ning Li,Chao-Ran Li,Run-Zhou Liu,Zifan Guo,Ping Li,Wen Gao,Hua Yang
Efficient characterization of xenobiotic metabolites and their dynamics in a changing complex matrix remains difficult. Herein, we proposed a time-series-dependent global data filtering strategy for the rapid and comprehensive characterization of xenobiotic metabolites and their dynamic variation based on metabolome data. A set of data preprocessing methods was used to screen potential xenobiotic metabolites, considering the differences between the treated and control groups and the fluctuations over time. To further identify metabolites of the target, an in-house accurate mass database was constructed by potential metabolic pathways and applied. Taking the extract of Ginkgo biloba (EGB) co-incubated with gut microbiota as an example, 107 compounds were identified as flavonoid-derived metabolites (including 67 original from EGB and 40 new) from 7468 ions. Their temporal metabolic profiles and regularities were also investigated. This study provided a systematic and feasible method to elucidate and profile xenobiotic metabolism.
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BIOMEDICINE & PHARMACOTHERAPY
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2022
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IF 7.419
Yao Liu,Ruifang Sun,XiaoPing Lin,Lanlan Wu,Hengying Chen,Siwen Shen,Yan Li,Yuanhuan Wei,Guifang Deng
Gestational Diabetes Mellitus (GDM) has an effect on the health of pregnant women and fetuses. Procyanidins (PA) is a flavonoid with anti-diabetic activity, but its effects and mechanisms on GDM have not been defined. Herein, we studied further the functions and mechanisms of PA on insulin resistance (IR) in GDM mice, as well as on postpartum and offspring mice. GDM mice model was built by feeding a high-fat-high-sucrose diet, and PA intervention (27.8 mg/kg/d) was performed from 4 weeks before pregnancy to delivery. Intestinal flora deficient (IFD) mice model was established by broad spectrum antibiotics. PA decreased the gestational weight gain, and the levels of fasting blood glucose, insulin, homeostasis model of assessment for IR index, yet increased the levels of HOMA for insulin sensitivity index. Interestingly, in IFD mice the effect of PA on improving IR was significantly weakened. PA inhibited inflammation by decreasing the levels of IL-6, TNF-α, IL-17 and CRP, which also been blocked in the IFD mice. Moreover, PA improved glycometabolism and reduced the secretion of inflammatory factors and hepatic inflammation infiltration of mice at 4 weeks postpartum, but had no significant effect on offspring mice. Mechanistically, PA treatment suppressed the nuclear factor‐κB (NF‐κB) p65 nuclear translocation and nucleotide‐binding domain like receptor protein 3 (NLRP3) inflammasome activation. In vitro studies, 4-hydroxyphenylacetic acid and 3-(4-hydroxyphenyl) propionic acid, main intestinal flora metabolites of PA restrained NF‐κB/NLRP3 activation. In conclusions, PA improved IR via NF-κB/NLRP3 pathway in GDM and postpartum mice, which partly through its metabolites by gut microbiome.
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SCIENCE OF THE TOTAL ENVIRONMENT
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2023
·
IF 9.8
Wenfang Song,Hong Lu,Qiansheng Li,Xiaolei Wang,Ze Fu,Jiti Zhou
Ketoprofen (KTP) as a non-steroidal anti-inflammatory drug has been detected in coastal environment due to its wide usage. However, little information is available about the fate of KTP in marine environment. In the present study, the aerobic degradation of 20 mg L −1 KTP using the enriched marine consortia was investigated. Results showed that CA consortium cultured with casamino acids exhibited a higher KTP-degrading ability than those cultured with glucose, yeast extract and mixed vitamins. During CA consortium-mediated degradation of KTP, additional casamino acids resulted in the production of H 2 O 2 and OH. Fe(III) could be also reduced to Fe(II) by CA consortium. This result indicated the occurrence of Fenton-like reaction. Further studies found that both biogenic Fenton-like reaction and enzyme-catalyzed reactions were involved in the initial hydroxylation reaction of KTP, then the subsequent mineralization of KTP was only performed via enzyme-catalyzed reactions. High-throughput sequencing analysis showed that Halomonas , Marinobacter , Owenweeksia and Oceanimonas were significantly enriched in CA consortium. As these genera contain amino acid oxidases, and the former two genera are capable of reducing Fe(III), it is assumed that these genera participated in biogenic Fenton-like reaction. The involvement of biogenic Fenton-like reaction provides a new insight into understanding the fate of KTP and other similar organic pollutants in marine environment containing amino acids and iron.
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Science China-Chemistry
·
2021
·Vol. 65
·期 1
·153-161
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IF 9.445
Shen Saiji,Wu Chu,Shang Yinghui,Shen Hongdou,Liao Yue,Guo Yuting,Hu Min,Wang Xia,Li Gang,Wang Qigang
There are several natural materials which have evolved functional gradients, ingeniously attaining maximal efficacy from limited components. Herein, we utilized the spatiotemporal distribution of initiator acetylacetone to regulate the multienzyme polymerization and fabricate a chitosan-polymer hydrogel. The temporal priority order of acetylacetone was higher than phenol-modified chitosan by density functional theory calculation. The acetylacetone within the gelatin could gradually diffuse spatially into the chitosan hydrogel to fabricate the composite hydrogel with gradient network structure. The gradient hydrogel possessed a transferring topography from the two-dimensional pattern. A continuously decreased modulus along with acetylacetone diffusion was confirmed by atomic force microscope-based force mapping experiment. The water-retaining ability of various regions was confirmed by low-field nuclear magnetic resonance (NMR) and thermogravimetric analysis (TG) analysis, which led to the spontaneous actuation of gradient hydrogel with maximum 1821°/h curling speed and 227° curling angle. Consequently, the promising gradient hydrogels could be applied as intelligent actuators and flexible robots.
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JOURNAL OF MOLECULAR STRUCTURE
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2023
·
IF 3.8
Wanlin Sun,Junlin Chen,KangLi Yan,Yuting Chi,Shaoyu Cai,Xue Li,Shuchen Pei,Shuiqin Chai,Fang Chen
In this work, a green and economical strategy to prepare carbon dots (E-CDs) based on Embryonic chrysanthemums was carried out. The prepared difunctional E-CDs showed high water-solubility and favorable photostability. The morphology and surface functional groups were analyzed by TEM, FT-IR, and XPS. Moreover, E-CDs possessed effective antibacterial activity. The minimum inhibitory concentrations of E-CDs against Escherichia coli and Staphylococcus aureus are 0.93 mg/mL and 0.78 mg/mL, respectively. In addition, E-CDs are used as a fluorescent probe with a limit of detection of 0.101 μM (3σ/k) for ciprofloxacin and a linear range of 0–1.0 μM. Consequently, this work discovered a new, green, economical carbon dot with the potential application as a potent antibacterial agent and an effective fluorescent sensor of ciprofloxacin.
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npj Parkinsons Disease
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2026
·
IF 8.5
Li Zhihong,Cui Peijing,Zhang Lei,Huang Xiaojun,Zhou Yifan,Xu Siqi,Mao Yanfei,Wang Yanping,Liu Li,Zhang Yu
Parkinson’s disease (PD) lacks reliable non-invasive early diagnostic biomarkers with strong discriminative capacity, representing a major unmet clinical demand. We developed a dansylation workflow coupled to trapped ion mobility spectrometry–quadrupole time-of-flight mass spectrometry (TIMS-Q-TOF-MS) for targeted profiling of the urinary amine–phenol submetabolome. Urine samples from 21 patients with PD, 21 patients with Alzheimer’s disease (AD), and 21 healthy controls (HCs) were analyzed, yielding annotations for 196 metabolites: 143 amine-containing species, 49 phenolic metabolites, and 4 dual-function metabolites carrying both amine and phenolic moieties. Partial least squares discriminant analysis (PLS-DA) confirmed the stability of our analytical pipeline. Screening with thresholds VIP > 1.2 and p < 0.05 identified 47 differentially abundant metabolites linked to PD, enriched in cysteine/methionine metabolism, phenylalanine–tyrosine–tryptophan biosynthesis, pyrimidine metabolism, and tryptophan metabolism. PD was characterized by elevated dopamine 3-O-sulfate—indicative of accelerated peripheral dopamine inactivation—and reduced tryptophan and its hydroxylated derivatives. Receiver operating characteristic (ROC) analysis validated a three-metabolite signature (4-amino-1-piperidinecarboxylic acid, dopamine 3-O-sulfate, methylacetylenic putrescine) with an AUC of 0.923 (95% CI: 0.828–0.986) to discriminate PD from HCs. This panel captures PD-specific neurotransmitter metabolic dysregulation and achieves robust patient stratification. This study’s advantages lie in targeted quantification of pathophysiologically relevant amine–phenol metabolites, convenient non-invasive urinary sampling, and enhanced detection sensitivity via 4D metabolomics. Collectively, our results establish a novel urine-based diagnostic strategy for PD and delineate divergent metabolic signatures that differentiate PD from AD and other prevalent neurodegenerative disorders.
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ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Feiyu Wang,Biaobiao Yan,Zirong Li,Ping Wang,Man Zhou,Yuanyuan Yu,Jiugang Yuan,Li Cui,Qiang Wang
Enzymatic antibacterial finishing is an eco-friendly alternative to develop functional silk-based materials. However, the low accessibility of tyrosine residues distributed in fibroin chains restricts the laccase-mediated functionalization of silk fibers (SF). To address this issue, a highly reactive p-hydroxyphenylacetic acid-modified polyethyleneimine (mPEI) was enzymatically grafted onto fibroin using laccase, aiming at constructing an antibacterial matrix of mPEI on the fiber surface. Subsequently, in situ deposition of silver nanoparticles (i.e., AgNPs) into the newly built mPEI network was performed to form a rapid antibacterial layer. The results indicated that laccase efficiently catalyzes the mPEI coupling, the zeta potential of SF-g-mPEI increases from −32 to 21.70 mV, and the silver content reaches 1.81% after AgNP embedment. Based on the combined two-step treatments, the obtained silk fabric exhibited excellent antibacterial abilities against two bacteria, including Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The antibacterial rates of both bacteria reached 99.9% within 30 min of contact, remaining over 99.9% within 18 h of contact even after washing 10 times. The present work provides an enzyme-mediated method for construction of silk fabric with durable and rapid antibacterial activity.
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FOOD CHEMISTRY
·
2020
·
IF 6.306
Xu Yu,Li Yu,Fei Ma,Peiwu Li
In the present work, a rapid, accurate and cost-effective method has been developed for the simultaneous quantification of phenolic compounds in oil using mixed-mode solid-phase extraction (SPE) coupled with chemical labeling UHPLC-MS/MS. Mix-mode SPE weak cation cartridges were selected to enrich and purify phenolic compounds in oil, and hydroxyl moiety was dansylation as stable-isotope internal standard. The major parameters that affected the extraction and chemical labeling efficiency were investigated, and the method was fully validated. The limit of quantifications and the limit of detections were 0.002 µg kg −1 ~ 0.10 µg kg −1 and 0.006 µg kg −1 ~ 0.30 µg kg −1 , respectively. The recoveries were 61.2% ~ 129.3% with intra-day and inter-day precision less than 12%. The results for 38 rapeseed oils revealed that 14 phenolic compounds, including canolol, phenolic acids, phenolic alcohols, tyrosol and vanillin from trace levels to relatively high content.
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