Inorganic and Nano-Metal Chemistry
·
2017
·
IF 0
Jiaxing Li,Meng Ni,Chaoyi Fan,Yan Li,Xiuqing Zhang
A new cobalt complex [Co3(SIP)2(4-PP)8(H2O)6]·4H2O·2(4-PP) (1) with 5-sulfoisophthalic acid sodium (NaH2SIP) and 4-phenyl pyridine (4-PP) as ligands has been synthesized in the mixed solvents of ethanol and water. It crystallized in monoclinic, space group P21/c, with a = 20.9642(9) Å, b = 15.6091(5) Å, c = 20.0126(8) Å, α = 90.00°, β = 115.493(6)°, γ = 90.00°, V = 5911.2(4) Å3, Z = 2, Dc = 1.346 g/cm−3, F(000) = 2494, the final GOOF = 1.038, Rint = 0.0258 and wR2 = 0.1793. The complex (1) was characterized by single-crystal X-ray diffraction, magnetic susceptibility and IR spectroscopy analyses. Single-crystal X-ray diffraction shows that complex (1) is trinuclear based on cobalt units. Magnetic susceptibility measurement indicates that complex (1) shows an antiferromagnetic coupling between the Co(II) ions.
研究领域:
无机化学
·
材料科学
✓ 已验证
DOI
RSC Advances
·
2016
·Vol. 6
·期 75
·71431-71440
·
IF 3.289
Di Lu,Lele Wen,Lixin Xue
For exploring more types of suitable polymeric membranes for application in alkaline fuel cells (AFCs), a series of 1,2-dimethylimidazolium functionalized poly(arylene ether sulfone)s containing 4-phenyl-pyridine units in the main chain (named as DIm-PPYPAES) were firstly synthesized as anion exchange membranes (AEMs) in this work. Proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared (FT-IR) spectroscopy were employed to characterize and confirm the chemical structure of the synthesized copolymers and the derived membranes. The DIm-PPYPAES membranes with different ionized levels ranging from 1.15 meq. g−1 to 1.77 meq. g−1, exhibited good thermal stability, solubility behavior and a relatively high level of hydroxide conductivity. The highest hydroxide conductivity of 83.35 mS cm−1 at 80 °C was achieved for the DIm-PPYPAES-4 membrane with a moderate IEC of 1.77 meq. g−1. Moreover, after 15 days of treatment with a 2 M NaOH solution at 60 °C, the DIm-PPYPAES membrane still exhibited relatively high ionic conductivity even above 10 mS cm−1 at 30 °C and retained their integrated shapes.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2021
·
IF 0.782
Fangmin Chen,Chichi Zhou,Yan Li,Xiuqing Zhang
Three coordination polymers—{[Ag2(SIP)(4-pp)]·[Ag(4-pp)2]·H2O}n, [Pb4(SIP)2(μ3-OH)2(H2O)2]n, and {[Zn2(SIP)2(4-pp)4][Zn(4-pp)2(H2O)4]·4H2O}n (SIP = 5-sulfoisophthalic acid anion, 4-pp = 4-phenylpyridine)—are constructed under hydrothermal or solvothermal conditions using sodium m-phthalate 5-sulfonate (NaH2SIP) and 4-phenylpyridine as ligands. The structures of the three complexes are determined by single-crystal X-ray diffraction, powder X-ray diffraction, thermogravimetric analyses, Fourier-transform infrared analysis, and photoluminescence. The fluorescent properties of the complexes in the solid state are investigated at room temperature, and the results indicate that they all show photoluminescent properties.
研究领域:
无机化学
·
材料科学
·
晶体学
✓ 已验证
DOI
高影响因子
CELLULAR SIGNALLING
·
2024
·
IF 4.4
Wentao Hu,Menghan Wang,Guifang Sun,Limin Zhang,Hong Lu
Parkinson's disease (PD) is a gradually debilitating neurodegenerative syndrome. Here, we analyzed GSE7621 chip data obtained from the Gene Expression Omnibus (GEO) database to explore the pathogenesis of PD. Early B Cell Factor 3 (EBF3), a member of the highly evolutionarily conserved EBF-transcription factor family, is involved in neuronal development. EBF3 expression is low in the substantia nigra of patients with PD. However, whether EBF3 is implicated in dopaminergic neuron death during PD has not yet been investigated. Therefore, we aimed to reveal the potential anti-apoptotic effect and molecular mechanism of EBF3 in PD. We established a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model in vivo and a 1-methyl-4-phenylpyridine (MPP + )-induced SH-SY5Y cell model in vitro . EBF3 was downregulated in the substantia nigra of PD mice and SH-SY5Y cells treated with MPP + , and the m6A methylation modification level was low. Fat mass and obesity-associated protein (FTO) siRNA upregulated m6A methylation modification of EBF3 and extended the EBF3 mRNA half-life. Functionally, as demonstrated by the results of the open-field test, pole test and gait analysis, EBF3 overexpression ameliorated MPTP-induced behavioral disorder. Further, EBF3 overexpression suppressed neuronal apoptosis in vivo , as evidenced by decreased TUNEL + cells, and the increased activation of caspase-3 and caspase-9. Similar results were obtained in vitro , as reflected by increased cell viability, decreased LDH activity and restored mitochondrial function, collectively protecting SH-SY5Y cells from MPP + -induced apoptosis. Mechanistically, the results of luciferase reporter, ch-IP and DNA pull-down assays confirmed that, as a transcription factor, EBF3 bound to the promoter of CNTNAP4 (a protein associated with neuronal differentiation) and directly regulated CNTNAP4 transcription. Strikingly, CNTNAP4 knockdown markedly abolished the effect of EBF3 on cell apoptosis, thus aggravating PD. In conclusion, the low level of m6A methylation modification may contribute to the low expression of EBF3 during PD. Additionally, EBF3 attenuates PD by activating CNTNAP4 transcription, suggesting that EBF3 may be a novel therapeutic target in PD.
研究领域:
神经科学
·
分子生物学
·
转化医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Regenerative Biomaterials
·
2016
·Vol. 3
·期 5
·299-307
·
IF 0
Sun Hong-Ji,Wang Yan,Hao Tong,Wang Chang-Yong,Wang Qi-Yu,Jiang Xiao-Xia
Glutathione (GSH) depletion has been an important contributor to the dysfunction of dopamine neurons. Polyamidoamine-GSH (PAMAM-GSH) was synthesized and the delivery effect of GSH into PC12 cells was tested. MTT assessment for cytotoxicity and reactive oxygen species (ROS) as well as nitrite oxide (NO) and intracelluar superoxide dismutase (SOD) detection for antioxidative ability were performed. Furthermore, the antiapoptotic ability was analysed by assessing caspase-3, JNK1/2 and Erk1/2 expression. Our data indicated that PAMAM-GSH is an effective agent to replenish GSH into PC12 cells. PAMAM-GSH developed its antioxidative and protective ability for 1-methyl-4-phenylpyridinium (MPP)-induced PC12 cells by reducing the intracellular levels of ROS and SOD activity as well as decreasing the release of NO. Meanwhile, PAMAM-GSH could inhibit caspase-3 activation and might show its antiapoptotic ability to MPP-induced PC12 cells through JNK2/Erk1/2 pathway. In summary, these studies suggest that PAMAM-GSH conjugate has an intrinsic ability to penetrate PC12 cells and deliver GSH into these cells which may provide a new strategy for clinical applications in the treatment of Parkinson’s disease.
研究领域:
神经科学
·
药理学
·
细胞生物学
·
疾病模型
✓ 已验证
产品关联
DOI
PubMed
Advanced Science
·
2023
·
IF 15.1
Qing Zheng,Hanghang Liu,Hao Zhang,Yaobao Han,Jiaxin Yuan,Tingting Wang,Yifan Gao,Zhen Li
Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting the therapy of PD. Herein, the remarkable promotion of mitochondrial biogenesis to ameliorate mitochondrial dysfunction of neurons and improve the treatment of PD by using mitochondria-targeted biomimetic nanoparticles, which are Cu 2- x Se-based nanoparticles functionalized with curcumin and wrapped with DSPE-PEG 2000 -TPP-modified macrophage membrane (denoted as CSCCT NPs), is reported. These nanoparticles can efficiently target mitochondria of damaged neurons in an inflammatory environment, and mediate the signaling pathway of NAD + /SIRT1/PGC-1 α /PPAR γ /NRF1/TFAM to alleviate 1-methyl-4-phenylpyridinium (MPP + )-induced neuronal toxicity. They can reduce the mitochondrial reactive oxygen species, restore mitochondrial membrane potential (MMP), protect the integrity of mitochondrial respiratory chain, and ameliorate mitochondrial dysfunction via promoting mitochondrial biogenesis, which synergistically improve the motor disorders and anxiety behavior of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice. This study demonstrates that targeting mitochondrial biogenesis to ameliorate mitochondrial dysfunction has a great potential in the treatment of PD and mitochondria-related diseases.
研究领域:
神经科学
·
纳米技术
·
药理学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Wenzhen Lv,Ying Tang,Chaofei Han,Zhenzhen Miao,Chengxi Sun,Ligang Xu,Guangbao Wu,Zhuang Liu,Ye Tao,Runfeng Chen
Thermochromic scintillators with high electron and hole generation capacity after X-ray irradiation have gained significant attention for anticounterfeiting and X-ray imaging applications. However, achieving luminescent compounds with highly efficient and reversible thermochromic luminescence and radioluminescence remains a significant challenge. In this study, we reported two novel and cost-effective zero-dimensional (0D) Mn(II)-based halide hybrids, designated as (4-PP)2MnX4 (4-PP = 4-phenylpyridine; X = Cl, Br), with bright narrow-band green emissions and remarkably high photoluminescence quantum yields of 90.7% and 94.6%, respectively. Notably, a distinct and reversible thermochromic behavior, shifting from green to red emission with temperature variation, was observed under ambient conditions. Furthermore, (4-PP)2MnX4 (X = Cl, Br) demonstrated impressive steady-state X-ray light yields of 42 000 and 48 000 photons MeV–1, alongside low detectable limits of 79.2 and 56.6 nGyair s–1. The combination of pronounced color changes and exceptional radiative properties positions these materials as promising candidates for anticounterfeiting applications and in situ thermally responsive X-ray imaging. This research marks a significant advance in the design of high-efficiency thermochromic materials, offering a blueprint for future research into multifunctional thermochromic scintillators tailored for advanced X-ray imaging technologies.
研究领域:
材料科学
·
光学材料
·
辐射探测
·
发光材料
·
X射线成像技术
·
智能响应材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2026
·
IF 3.9
Shen Wang,Wenjie Wei,Yaran Wang,Rui Ma,Yunya Wu,Yunxian Yang,Yuxin Zuo,Zhiqi Liu,Pengfei Cheng
Agricultural films have attracted considerable attention in recent years. Herein, four types of organic-inorganic complex red light conversion agents ( W-2L , W-8L , S-8L , H-8L ) were designed, the S-8L conversion agent exhibits an extremely broad ultraviolet absorption range of 200-400 nm. Contact angle (142.7°) tests confirmed its excellent hydrophobic properties, enabling better compatibility with LLDPE substrates. Meanwhile, its outstanding photothermal stability of S-8L was demonstrated by a long red fluorescence lifetime: 478.14 μs, an exceptional fluorescence quantum yield: 76.77 %, a high initial decomposition temperature and an extended ultraviolet aging resistance period. Furthermore, the S-8L1 conversion film was utilized to assist in the cultivation of Chlorella cells, demonstrating its excellent UV-blocking and red-light conversion capabilities, significantly increasing both biomass and chlorophyll content. This work proposed a potential way to develop highly efficient light conversion agents by regulating the inorganic-organic functional groups.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 91
·74977-74985
·
IF 3.84
Xin Xiao,Shunheng Tu,Chunxia Zheng,Huan Zhong,Xiaoxi Zuo,Junmin Nan
Large-scale synthesis of nanosized β-Bi2O3 is a significant challenge due to its metastable state. A facile L-asparagine-assisted reflux–calcination route was successfully developed for the large-scale preparation of β-Bi2O3 micro/nanostructures under mild conditions (low temperature, atmospheric pressure, and wide temperature windows). The composition, phase structure, morphology, surface area, and photoabsorption properties of as-synthesized β-Bi2O3 and its precursor were systematically characterized. The phase transformation conditions and possible formation mechanism of flower-like β-Bi2O3 were discussed. It is found that with a simple reflux process under atmospheric pressure at 100 °C, uniform monodisperse bismuth–asparagine complex microspheres with average diameters of ∼500 nm were produced and flower-like β-Bi2O3 micro/nanostructures were then conveniently obtained after precursor calcination at temperatures ranging from 340 °C to 420 °C. A surface CO32− coordination effect introduced from L-asparagine explained the formation of stabilized β-Bi2O3 at low temperatures (up to 420 °C). The as-synthesized β-Bi2O3 shows excellent photocatalytic activity toward the degradation of 4-phenylphenol under visible-light irradiation, which is 3.7 and 21.4 times faster than the removal rates of β-Bi2O3 nanospheres and a commercial β-Bi2O3, respectively, and allows for the elimination of 93.2% total organic carbon after 60 min of irradiation. In addition, the photogenerated reactive species were identified by radical scavenger experiments and electron paramagnetic resonance spectroscopy, and a possible visible-light-induced photocatalytic mechanism was then proposed.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Chao Liu,Lei Shi,Jiaxu Zhang,Jianmin Sun
A kind of pyridine-based ionic hyper-cross-linked polymers (Py-HCP-X, X = Cl, Br) with high surface area, plentiful hierarchical pores and abundant catalytic active units were prepared via a one-pot method. Adsorption measurements showed that the as-prepared Py-HCP-X exhibited high CO 2 capture capacity (up to 1.72 mmol g −1 , 273 K and 1 bar). Importantly, Py-HCP-Br displayed excellent catalytic activity for the cycloaddition of CO 2 to epoxides under metal/cocatalyst/solvent-free conditions. And the propylene carbonate was produced in 97% yield with an excellent selectivity of 99% at 120 °C and 2.0 MPa CO 2 for 8 h. The high performance of the present catalyst is ascribable to synergistic contributions of plentiful hierarchical pores and abundant nucleophilic bromide ions and pyridine-based active units in the Py-HCP-Br catalyst. Additionally, the catalyst is able to be simply separated by centrifugation and reused for four runs without significant loss in the performance, furthermore, the catalyst exhibits great structural stability and substrate universality.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）