INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2016
·
IF 2.567
Yapeng Hu,Xiangmei Wang,Juan Li
An exfoliated montmorillonite (E-MMT) was prepared by introducing Ni2+ and melamine formaldehyde into layers of MMT. The E-MMT was applied to regulate the flame retardant properties of polypropylene (PP)/intumescent flame retardant (IFR) composites. The IFR used consists of ammonium polyphosphate (APP) and a charring agent, 1,3,5-triazine-2,4,6-trimorpholinyl (TTM). The results revealed that the E-MMT has good synergistic effect on flame retardancy of PP/IFR composites. The PP composites with 16 wt % IFR and 3 wt % E-MMT can pass the UL94 V-0 test. Moreover, the E-MMT not only improves the char residues of IFR and PP/IFR blend but also changes the micromorphology of char, turning the compact surface char produced by PP/IFR into microporous char. This microporous char is so good for isolating heat and mass between PP and the outside that a better flame retardant property is obtained.
研究领域:
材料科学
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高分子科学
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消防安全工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Meiyu Gao,Jiarui Sun,Qinwen Xiao,Yuanyuan Zhai,Yuan Tian,Zunjian Zhang,Fengguo Xu,Pei Zhang
The mevalonate (MVA) pathway plays a crucial role in the occurrence and progression of various diseases, such as osteoporosis, breast cancer, and lung cancer, etc. However, determining all the MVA pathway intermediates is still challenging due to their high polarity, low concentration, chelation effect with metal compartments, and poor mass spectrometric response. In this study, we established a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method coupled with N 2 , N 2 , N 4 , N 4 -tetramethyl-6-(4-(piperazin-1-ylsulfonyl) phenyl)-1,3,5-triazine-2,4-diamine (Tmt-PP) labeling for the simultaneous analysis of all MVA intermediates in biospecimens. Chemical derivatization significantly improved the chromatographic retention, peak shape, and detection sensitivity of the analytes. Moreover, we employed a method named mass spectrum calculation to achieve the absolute quantification of the isomers, i.e., isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). The established method was fully qualified and applied to explore the difference of these metabolites in cisplatin-resistant non-small cell lung cancer (NSCLC) cells. Additionally, several MVA intermediate analogs, including isopentenyl monophosphate or dimethylallyl monophosphate (IMP/DMAMP), geranyl monophosphate (GMP), 5-triphosphomevalonate (MTP), and isopentenyl triphosphate or dimethylallyl triphosphate (ITP/DMATP), were identified for the first time using a knowledge-driven prediction strategy. We further explored the tissue distribution of these novel metabolites. Overall, this work developed a sensitive quantification method for all MVA intermediates, which will enhance our understanding of the role of this pathway in various health and disease conditions. The novel metabolites we discovered warrant further investigations into their biosynthesis and biological functions.
研究领域:
生物化学
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分析化学
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药理学
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肿瘤学
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代谢组学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2023
·Vol. 191
·期 1
·1-12
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IF 5.7
Zhang Mingxia,Tan Wei,Wu Xiaodan,Wan Chengan,Wen Chen,Feng Lei,Zhang Feng,Qu Fengyu
The present study selected 5, 5′-((6-(ethylamino)-1, 3, 5-triazine-2, 4-diyl) bis(azanediyl))diisophthalic acid (H 4 EATDIA) as ligand and an amino-functionalized cuprum-based MOF (EA-JUC-1000), successfully synthesized by microwave-assisted method, for proton conduction and dopamine sensing applications. In order to enhance the proton-conducting potential of EA-JUC-1000, the Brönsted acid (BA) encapsulated composites (BA@EA-JUC-1000) are dopped into chitosan (CS) to form a series of hybrid membranes (BA@EA-JUC-1000/CS). The impedance results display that the best proton conductivity of CF 3 SO 3 H@EA-JUC-1000/CS-8% reaches up to 1.23 × 10 –3 S∙cm −1 at 338 K and ~ 98% RH, 2.6-fold than that of CS. Moreover, the EA-JUC-1000 is in-situ combined with reduced graphene oxide (rGO) (rGO/EA-JUC-1000), which makes EA-JUC-1000 have a wide detection range (0.1 ~ 500 μM) and a low limit of detection (50 nM), together with good anti-interference performance, reproducibility and repeatability. In addition, the electrochemical sensing method has been successfully applied to detect DA in bovine serum samples. The dual-functional MOF-based hybrid membrane and composites including proton conduction and DA sensing would provide an example of practical application for MOFs. Graphical abstract
研究领域:
材料科学
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电化学
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分析化学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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