ADVANCED FUNCTIONAL MATERIALS
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2023
·Vol. 33
·期 21
·2300493
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IF 19
Shuo Song,Yuchen Lv,Bingqiang Cao,Wenzhi Wang
The poor stability of CsPbX 3 (X = Cl, Br, I) perovskite quantum dots (PQDs) in polar solvents such as water, seriously hinders their practical application. Herein, 5-Bromovaleric acid (BVA) is used to replace oleic acid (OA), the most common surface ligand in CsPbX 3 PQDs synthesis. Under the synergic action of oleylamine (OLA), CsPbX 3 PQDs with high water stability can be synthesized directly in water. Because the carboxyl ligands provided by BVA, and the long chain amines provided by OLA formed hydrophobic shells on the surface of CsPbBr 3 PQDs, the obtained CsPbBr 3 PQDs still has high luminescence intensity and photoluminescence quantum yield after being dispersed in water for several days, and the luminescence peak is always maintained at 518 nm. In contrast, the luminescence intensity of CsPbBr 3 PQDs synthesized with OA and OLA is <1% of the initial intensity after only 30 min. CsPbCl 3 and CsPbI 3 PQDs synthesized directly in water by this method also show high water stability. In this study, for the first time the synthesis method of CsPbX 3 PQDs with high water stability using BVA/OLA as surface ligands is proposed, which provides an effective way to explore the synthesis of PQDs that can maintain stability in water.
研究领域:
纳米材料
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钙钛矿量子点
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表面化学
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光电子学
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发光材料
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DOI
高影响因子
Cell Reports Medicine
·
2024
·
IF 11.7
Shiyi Zuo,Tian Liu,Lingxiao Li,Hezhen Xu,Jiayu Guo,Qing Wang,Yinxian Yang,Zhonggui He,Jin Sun,Bingjun Sun
Dimeric prodrug nanoassemblies (DPNAs) stand out as promising strategies for improving the efficiency and safety of chemotherapeutic drugs. The success of trisulfide bonds (-SSS-) in DPNAs makes polysulfide bonds a worthwhile focus. Here, we explore the comprehensive role of tetrasulfide bonds (-SSSS-) in constructing superior DPNAs. Compared to trisulfide and disulfide bonds, tetrasulfide bonds endow DPNAs with superlative self-assembly stability, prolonged blood circulation, and high tumor accumulation. Notably, the ultra-high reduction responsivity of tetrasulfide bonds make DPNAs a highly selective "tumor bomb" that can be ignited by endogenous reducing agents in tumor cells. Furthermore, we present an "add fuel to the flames" strategy to intensify the reductive stress at tumor sites by replenishing exogenous reducing agents, making considerable progress in selective tumor inhibition. This work elucidates the crucial role of tetrasulfide bonds in establishing intelligent DPNAs, alongside the combination methodology, propelling DPNAs to new heights in potent cancer therapy.
研究领域:
药学
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纳米技术
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癌症研究
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2026
·
IF 6.7
Yuxuan Li,Xinxin Kong,Yihao Liu,Xi-Ling Li,Mingshan Zheng,Toufeng Jin,Jun Zhe Min
Chemical derivatization technology significantly expands the detection scope and enhances the sensitivity of untargeted metabolomics. However, the complex adduct ion formations and diverse ionization patterns of derivatized products present substantial challenges for compound screening and data interpretation. Additionally, understanding the correlations between chiral metabolites and biological systems is essential for uncovering molecular mechanisms underlying physiological processes. To address these challenges, this study developed the ( S ), ( R )-(5-(2-(((1-((N,4-dimethylphenyl) sulfonamido) vinyl) oxy) carbonyl) pyrrolidin-1-yl)-5-oxopentyl) triphenylphosphonium (( S ), ( R )-TPP-BSA) and d15-( S )-TPP-BSA probes, establishing a relative quantitative non-targeted metabolomics strategy for chiral amine-containing metabolites (RQ-NMCA). RQ-NMCA facilitates the formation of stable [M] + adduct ions of amine derivatives in mass spectrometry, enabling effective identification and analysis of chiral amine metabolites. By leveraging isotope structures, relative quantitative analysis of amine-containing metabolites between groups is achievable. In serum samples from healthy volunteers (HV) and colorectal cancer (CRC) patients, 38 significant differential amine-containing metabolites were identified, including 15 chiral amines. RQ-NMCA introduces the fixed addition ion concept into chemical labeling non-targeted metabolomics, significantly enhancing ionization efficiency while simplifying the screening and identification processes. Furthermore, the integration of chiral recognition and relative quantification approaches is pivotal for understanding the relationship between chiral amine-containing metabolites and physiological or pathological states. This technology provides a robust platform for chiral non-targeted metabolomics research and will facilitate the identification of novel biomarkers for disease diagnosis.
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Junyang Yin,Jie Zhang,Wen Pan,Zhenzi Wu,Feng Wu,Jiangnan Dai,Jiajun Luo,Changqing Chen
Ongoing research on perovskite quantum dots (PQDs) spanning diverse areas such as crystallography and biology represents a rapidly expanding frontier in nanotechnology, yet is still limited by the poor water stability and inadequate biocompatibility. Herein, this study reports an ultra-simplified, eco-friendly, cost-effective, and industrial-grade fully aqua-mediated ripening (FAMR) technique for aqueous-PQDs (APQDs) with tunable spectra, achieved by directly stirring the raw precursors with zwitterionic ligands in water at a set pH via Ostwald ripening crystallization.These APQDs exhibit high photoluminescence quantum yields (PLQYs) of up to 82.8% (blue), 98.2% (green), and 92.4% (red), respectively. Owing to the highly efficient bidentate binding of zwitterionic ligands onto APQDs surfaces, as confirmed by theoretical studies, the APQDs demonstrate excellent water storage stability for over 1 month and can retain an impressive 83% of the initial PL intensity after 3 months when transferred to EtOH. With elevated exciton binding energy, extended carrier lifetimes, and lower defect density, APQDs also outperform conventional oil-phase PQDs in terms of thermal and UV irradiation stability. Based on this, water-soluble fluorescent nanoparticles (NPs) are synthesized through self-assembly of APQDs and DSPE-PEG 2000 using EtOH and water as biphasic solvents. Finally, the APQDs@NPs, possessing desired luminescence and biocompatibility, exhibited excellent bioimaging performance in U251 cells.
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DOI
高影响因子
Nanoscale
·
2017
·Vol. 9
·期 31
·11103-11118
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IF 7.367
Caixia Yue,Yuming Yang,Jie Song,Gabriel Alfranca,Chunlei Zhang,Qian Zhang,Ting Yin,Fei Pan,Jesús M. de la Fuente,Daxiang Cui
Lonidamine, an anticancer drug that acts on mitochondria, has poor water solubility. Mitochondria are the primary source of cellular reactive oxygen species (ROS), which are necessary for photodynamic therapy. Hence, a mitochondria-targeting drug delivery system loaded with Lonidamine and a ROS-produced photosensitizer could improve the bioavailability of Lonidamine and maximize photodynamic therapeutic efficiency. Here we report, for the first time, new IR-780 and Lonidamine encapsulated mitochondria-targeting thermosensitive liposomes (IL-TTSL). DSPE-PEG2000-NH2 was coupled with triphenylphosphine to form DSPE-PEG2K-TPP. The liposomes (IL-TTSL) were self-assembled from DPPC, DSPC, DSPE-PEG2K-TPP, cholesterol, IR-780 and Lonidamine. Coupled linker modified triphenylphosphine (TPP) is cationic and can selectively accumulate several hundred-fold within mitochondria. Once the liposomes are located inside mitochondria, 808 nm laser irradiation could trigger photosensitizer IR-780 to elevate the local temperature, which could be utilized in photothermal therapy and induce the release of Lonidamine from the thermosensitive liposomes. Meanwhile, IR-780 could release ROS for photodynamic therapy in mitochondria and increase photodynamic therapeutic efficiency. Our results showed that the surface modification of the liposomes with triphenylphosphine cations had good mitochondria-targeting ability. The liposomes exhibited good biocompatibility and all components of the empty liposomes were safe to be used in humans. Few reports were related to IR-780 being used in photodynamic therapy and we proved this function of IR-780. Overall, the stealth liposomes provide a promising new strategy to realize mitochondria-targeting thermosensitive chemo-, photodynamic and photothermal combination therapy with a single light source for lung cancer.
研究领域:
癌症治疗
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药物递送系统
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纳米医学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2021
·Vol. 5
·期 23
·8229-8237
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IF 6.482
Junjun Wang,Yize Zhang,Zhi-Peng Yu,Houshi Huang,Lei Chen,Xiaojiao Zhu,Jie Zhang,Lianke Wang,Jianhua Yu,Hongping Zhou
Phototheranostics, the integration of phototherapy and multimodal imaging into one nanoagent, is highly significant for precise cancer treatment, during which how the photo-energy is converted plays a critical role. The Förster resonance energy transfer (FRET) mechanism has opened up a new avenue for diversifying energy conversion, demonstrating great promise for enhanced phototheranostics. Herein, a theranostic nanoagent (HCY–TPA), based on single-molecule FRET, was designed, where the harvested photo-energy was not only transformed into near-infrared fluorescence but also acoustic energy for deep-seated tumor imaging, as well as enhanced thermal and type-I ROS generation for efficient treatment, realizing optimized phototheranostics. Furthermore, the dual cation endowed it with superior mitochondrial targeting ability for precise treatment. In vivo mouse model experiments demonstrated that the proliferation of tumors was effectively inhibited, compared to that by single HCY or TPA, which ultimately demonstrated a synergistic effect in multimodal imaging guiding synergistic cancer treatment.
研究领域:
生物医学工程
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纳米技术
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癌症研究
·
分子成像
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产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
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2022
·
IF 4.171
Hong Zhu,Chengdong Peng,Jiayi Li,Xuanyu Cao,Yuexiao Pan
The anion-exchange among halogen ions is an effective technique for tuning the chemical composition and emission color of all-inorganic halide perovskite CsPbX 3 (X = Cl, Br, and I) nanocrystals by tailoring their bandgaps. This work is focused on the rate of the reversible anion-exchange through finely tuning the luminescence color of perovskite nanocrystals (NCs) in any region between red and green. The luminescence color of the perovskite CsPb(I 1-x Br x ) 3 (0 ≤ x ≤ 1) has been finely tuned through tailoring its bandgap with the anion-exchange between CsPbI 3 and 4-bromo-butyric acid (BBA) instead of introducing of bromide salts as starting materials. The BBA could serve as triple functions to afford Br − ions source, short chain ligand with carboxyl group for surface passivation , and weak acid. A systematic study has been carried out to elucidate the effect of experimental parameters, on the color rangeability of the NCs and the anion-exchange rate between CsPbI 3 and BBAThe trace of water added into the system can hinder the spontaneous transformation from red CsPbI 3 to CsPbBr 3 with aging time. It is particularly valuable to realize the reversible processes from green to yellow and finally to red successively by increasing the concentration of the isolated I − ions from various inorganic iodides.
研究领域:
材料科学
·
化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）