Advanced Healthcare Materials
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2023
·
IF 10
Yu-ying Yang,Yuan Zheng,Jun-jin Liu,Zhuang-peng Chang,Yue-hua Wang,Yun-yun Shao,Rui-gang Hou,Xiao Zhang
Surgical resection is the most common approach for the treatment of osteosarcoma. However, two major complications, including residual tumor cells and large bone defects, often arise from the surgical resection of osteosarcoma. Discovering new strategies for programmatically solving the two above-mentioned puzzles has become a worldwide challenge. Herein, a novel one-step strategy is reported for natural phenolic acid planted nanohybrids with desired physicochemical properties and steerable photothermal effects for efficacious osteosarcoma suppression and bone healing. Nanohybrids are prepared based on the self-assembly of chlorogenic acid and gold nanorods through robust Au-catechol interface actions, featuring precise nanostructures, great water solubility, good stability, and adjustable hyperthermia generating capacity. As expected, on the one hand, these integrated nanohybrids can severely trigger apoptosis and suppress tumor growth with strong hyperthermia. On the other hand, with controllable mild NIR irradiation, the nanohybrids promote the expression of heat shock proteins and induce prominent osteogenic differentiation. This work initiates a brand-new strategy for assisting osteosarcoma surgical excision to resolve the blockage of residual tumor cells elimination and bone regeneration.
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Journal of Physical Chemistry C
·
2022
·
IF 4.177
Haoqi He,Yumin Zhang,Shuo Zhu,Jian Ye,Li Lin
Surface-enhanced Raman scattering (SERS) nanotags have garnered much attention for in vivo and intraoperative imaging due to their high sensitivity and intrinsic fingerprint spectrum. Recently, in vivo bioimaging at the second biological near-infrared (NIR-II) window has demonstrated significant advances with better spatial resolution and deeper tissue penetration. The development of SERS nanotags at the NIR-II window are therefore highly desired. The resonant strategy, i.e., the use of resonant substrates and resonant molecules, can be helpful in fabricating bright SERS nanotags at the NIR-II window; however, this strategy has not been demonstrated with the lack of quantitative assessments. Here we report a quantitative study on the Raman enhancements of the resonant strategy in preparing NIR-II SERS nanotags. By comparing the resonant and nonresonant plasmonic nanorod substrates, the resonant substrates have been shown to provide an enhancement factor of up to 4 orders of magnitude. When using the resonant Raman reporter molecules, SERS intensities can be further increased by 25–546 times. This work demonstrates the potential of the resonant strategy in fabricating ultrasensitive NIR-II SERS nanotags and provides insights into the design of related plasmonic devices.
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JOURNAL OF CATALYSIS
·
2022
·
IF 8.047
Fengxia Tong,Chen Cui,Xizhuang Liang,Zeyan Wang,Yuanyuan Liu,Peng Wang,Hefeng Cheng,Ying Dai,Zhaoke Zheng,Baibiao Huang
Plasmonic nanostructures with strong light absorption and high catalytic activity are ideal platform to realize efficient light-driven catalysis. This work developed a laser-induced-reshaping route (pulse width 10 ns, wavelength 1064 nm) to improve the efficiency of energy transfer between non-plasmonic material (Pt) and plasmonic Au nanorods (NRs). The catalytic performance for 4-nitrophenol (4-NP) hydrogenation was increased by 2-fold using laser-modified Pt-Au NRs (L-Pt-Au NRs) compared to original Pt-Au NRs. Very impressively, the relationship between laser-induced reshaping and resulting optical properties was investigated at single-particle level. Finite difference time domain (FDTD) simulation and single-particle photoluminescence (PL) quenching (48.6%) after laser induced reshaping, indicated the redistributed Pt atoms on Au NRs surfaces largely promoted hot electron transfer and decreased radiative photon re-emission. Further, the mechanism of plasmon-enhanced nitroreduction was studied in situ at the single-particle level. This work provides insight into the design and application of plasmonic nanostructures at single-particle level.
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Journal of Nanomaterials
·
2021
·
IF 2.986
Asmita Pandey,Sujan Khadka,Ying Wan
PEGylation refers to the process of functionalizing nanoparticles with polyethylene glycol (PEG) to avoid unspecific uptake by the mononuclear phagocyte system and prolong the circulation half-life of nanomedicines. Immunogenicity and nonbiodegradability are the major limitations in PEGylation that can be resolved by substituting PEG with biofriendly polymers, such as hydroxyethyl starch (HES). In the current study, thiolated hydroxyethyl starch (HES-SH, 130/0.4) was harnessed to stabilize gold nanorods (AuNRs) and compared with PEG-SH-coated AuNRs at different aspects of characterization and photothermal analysis. Our results confirm that AuNRs were functionalized successfully with both HES-SH and PEG-SH, where the initial spectra and colloidal stability of gold nanorods were restored after functionalization. In addition, the photothermal conversion stability of gold nanorods was maintained during both HESylation and PEGylation without affecting the heat generation. In summary, we presume that HES-SH can be used as a surface modifier to stabilize gold nanorods and might be used as a promising alternative to PEG.
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MICROCHEMICAL JOURNAL
·
2021
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IF 4.821
Xiao-Li Yin,Yun Qing Liu,Hui-Wen Gu,Qi Zhang,Zhao Wei Zhang,Hui Li,Pei-Wu Li,Yu Zhou
A multicolor enzyme-linked immunosorbent sensor was constructed to detect organophosphates pesticides (OPs) on base of TMB 2+ -mediated AuNRs etching. As the etching progresses, a rainbow-like color responses was generated. The naked eye limit of detection (LOD) of the sensing system is 0.25 ng mL −1 . In particular, the longitudinal localized surface plasmon resonances (LSPR) peak shift of AuNRs is linearly correlated with the logarithm of OPs concentration in range of 10 4 to 5 × 10 6 pg mL −1 for parathion-methyl and fenitrothion, 5 × 10 4 to 10 7 pg mL −1 for fenthion, respectively. Compared with reported methods, this sensor displayed satisfactory linear ranges and detection limits. Average recoveries of this method ranged from 73.28% to 98.08% and relative standard deviations (RSDs) were below 8.0% as for food samples analysis without complicated pretreatments. Remarkably, the developed multicolor enzyme-linked immunosorbent sensor is capable of providing accurate and reliable assay for OPs in complex food samples.
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MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 10
·1-8
·
IF 6.232
Si Zhaozhao,Li Yansong,Han Shujuan,Liu Yunqing,Hu Pan,Lu Shiying,Ren Honglin,Zhao Baoling,Liang Xiongyan,Yang Yuying,Wang Fang,Zhou Yu
Based on the etching of gold nanorods (GNRs) and enzyme-linked immunosorbent assay (ELISA), a multicolor immunosensor for visual detection of enterovirus 71 infection is proposed. Once the immunocomplex is formed, the horseradish peroxidase bound to the ELISA plate oxidizes 3,3′,5,5′-tetramethylbenzidine (TMB) into TMB 2+ in the presence of hydrogen peroxide. Subsequently, TMB 2+ quantitatively etches GNRs to the short GNRs, leading to a blue shift of longitudinal localized surface plasmon resonance and corresponding color responses. This change is used to develop two types of cut-off standards, which respond to the human anti-enterovirus at a concentration of 71 IgM antibody. The method has been validated with clinical serum samples and showed high sensitivity and specificity . This visual immunosensor has an important application value for point-of-care detection of EV71, especially in areas lacking detection equipment.
Graphical abstract
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CHEMICAL PHYSICS
·
2019
·
IF 1.822
Fangying Juan,Fan Xu,Mei Wang,Mingxu Wang,Guozhi Hou,Jun Xu,Haoming Wei,Yinghua Wang,Yangqing Wu,Bingqiang Cao
Plasmonic Au nanorods/CsPbBr 3 quantum dots film has been prepared via spin-coating. It is found that photoluminescence intensity of Au nanorods/CsPbBr 3 quantum dots film exhibits 2-fold enhancement compared with pristine CsPbBr 3 quantum dots film. Time-resolved photoluminescence decay curves show that the lifetime of CsPbBr 3 quantum dots film decreases from 6.15 ns to 4.78 ns after combining with Au nanorods. The finite-difference time-domain simulation indicates that Au nanorods arouse a localized surface plasmon resonance around 500 nm, which enhances the emission intensity of CsPbBr 3 quantum dots film.
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RSC Advances
·
2019
·Vol. 9
·期 28
·16028-16034
·
IF 3.049
Weiwei Zou,Hao Xie,Yang Ye,Weihai Ni
In many applications, the optical cross sections of gold nanorods (AuNRs) are required to be tailored at a fixed target longitudinal surface plasmon resonance (LSPR) wavelength depending on the excitation source and the photodetector. In this work, we demonstrate the fine tailoring of optical cross sections of AuNRs at a fixed target resonance wavelength, on the basis of AuNR overgrowth using a binary surfactant mixture consisting of 5-bromosalicylic acid (BSA) and cetyltrimethylammonium bromide (CTAB). A systematic study was performed on the sum effects of the BSA concentration and the volume of the growth solution, which gives a formula for quantitative instructions. Based on the formula, we gave examples for the successful synthesis of AuNRs with different optical cross sections at target LSPR wavelengths. From simulation, a nonlinear relationship was further derived to understand the relationship between the aspect ratio and the width of the AuNRs at a target LSPR wavelength for the dimension design of AuNRs. The ratio of optical against physical cross sections was calculated and plotted as a function of the width. The results clearly indicate that AuNRs with a width of 30 nm possess the highest efficiency in terms of optical per physical cross section. Our study provides reliable methods for the synthesis, as well as guidelines for the dimension design of AuNRs, for use in a variety of applications.
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Sustainable Materials and Technologies
·
2018
·
IF 0
Jianhua Zhou,Yufei Gu,Ziyang Deng,Lei Miao,Hui Su,Pengfei Wang,Jiaqi Shi
Plasmonic metal/graphene oxide hybrid structures driven by either solar light or laser exhibit strong absorption and multiple functions to realize photothermal therapy, surface enhancement Raman scattering , and solar steam generation. We decorated graphene oxide (GO) by gold nanorods , forming a plasmonic nanofluid with strong optical absorption and enhanced solar steam generation performance. GO nanosheets were modified by using glucose as an environment-friendly ligand and stabilizer in the Au-GO dispersion. The Au-GO dispersions showed an increased absorption in a broad band reaching near infrared region. Owing to the coupling effects between Au NRs and GO NSs, and 2D platform for localized heating, water evaporation can be accelerated by Au-GO dispersions. The solar steam generation efficiency reached 84.1% under 1 kW m −2 illumination, about 20% enhancement compared with GO dispersion alone. This work shows the feasibility of the approach with functionalized nanofluids for efficient solar energy harvesting and utilization.
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BIOSENSORS & BIOELECTRONICS
·
2018
·
IF 8.173
Danni Wang,Rui Guo,Yunyun Wei,Yingzhi Zhang,Xiayu Zhao,Zhangrun Xu
Detection of telomerase activity is crucial for the telomerase-related early diagnosis of cancer and drug screening. Herein, a multicolor visual telomerase detection method with high sensitivity was developed based on the etching of hexadecyl trimethyl ammonium bromide-stablized Au nanorods (Au NRs) by the oxidation state 3,3′,5,5′-tetramethylbenzidine sulfate (TMB 2+ ). In order to meet the demand of bare-eye inspection, an enzyme-free signal amplification strategy of catalytic hairpin assembly (CHA) was incorporated. After the introduction of telomerase, telomerase extension products specifically triggered cyclic CHA and led to the successive formation of G-quadruplex/hemin DNAzyme, which catalyzed the H 2 O 2 -mediated oxidation of TMB. The Au NRs were gradually etched as the concentration of catalysate TMB 2+ increased, resulting in the decrease of aspect ratio of the Au NRs. Correspondingly, the longitudinal localized surface plasmon resonance peak of Au NRs was blue-shifted, with the concomitant generation of a series of color transition. Under optimal conditions, a highly sensitive detection toward telomerase was realized down to 15 HeLa cells . Compared to previous colorimetric method for telomerase determination, multiple colors corresponding to telomerase activity was the most attractive virtue of our approach. More strikingly, telomerase-induced cyclic CHA significantly enhanced the accumulation of G-quadruplex/hemin DNAzyme, thus the signal amplification was effectively realized. Our approach exhibited excellent sensitivity and convenient signal readout, which is expected to provide great potential application in cancer diagnosis and therapy.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Ling Li,Pu Zhang,Wensheng Fu,Mingfei Yang,Yi Wang
Seed-mediated growth has been proved to be a powerful means in the controlled synthesis of nanomaterials. In this work, using Au nanorods (AuNRs) as seeds, we successfully apply the principle of seed-mediated growth of bimetallic NRs in antioxidant assay. Specifically, evolution of the analytical probe from AuNRs to Au@Ag core-shell NRs is well regulated by seed-mediated growth, where trace amount of antioxidants play important roles in this process. Based on the localized surface plasmon resonance (LSPR) shift that directed by this evolution, a simple, reliable, highly sensitive and selective analytical method for antioxidant is developed. According to the linear relationship between LSPR peak shift and the concentration of antioxidant, the present method achieves a detectable range of 0.01–30 μM, with a limit of detection as low as 6.4 nM. Moreover, it has also been successfully applied in the detection of antioxidants in green tea. This work provides new insights into establishing sensitive sensing methods through precisely manipulating the evolution of analytical probe by seed-mediated growth.
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PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2018
·Vol. 35
·期 5
·1700379
·
IF 4.384
Xiaotong Li,Junshu Zhang,Shufang Kou,Xianfeng Yang,Xia Guo,Jian Yang
Pt/Co and Au are organized into well-defined nanostructures by a simple and mild method, such as dumbbell-like nanorods and core–shell nanorods. The resultant dumbbell-like nanorods show a superior performance in the electrooxidation of formic acid, as compared with core–shell nanorods, Pt-tipped gold nanorods, and commercial Pt/C. This result can be attributed to electronic effect between Au and Pt, heteroatom effect of Co, irregular surface at the tips, and the interface effect.
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