ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19.9
Zhen Jiang,Xingyu Zhu,Haiguang Zhu,Ze Li,Rui Li,Junlong Geng,Xun Yuan
Psoriasis is a chronic inflammatory skin disease driven by oxidative stress, necessitating advanced antioxidant nanozymes capable of broad-spectrum reactive oxygen species (ROS) elimination. Here, we address this challenge through the rational design of a ternary synergistic nanocluster, Ag 14–20 Au 5–11 @FeTP, engineered via “atomic engineering” of an optimal AgAu alloy core and “molecular engineering” via Fe‑porphyrin ligand grafting. This dual-level engineering creates a metal–ligand synergistic interface that confers excellent multi-enzyme mimetic activity for scavenging H 2 O 2 , •O 2 − , and •OH. Coupled with enhanced skin penetration, the nanozyme demonstrates both therapeutic and preventive efficacy in a psoriasis mouse model, rivaling the first-line clinical drug betamethasone/calcipotriol, without observable systemic toxicity. Transcriptomic profiling reveals that its potent effect originates from a dual-pathway immunomodulation: simultaneous suppression of the pro-inflammatory IL‑23/Th17/IL‑17 and NF‑κB axes and enhancement of the anti-inflammatory Treg/Th2 pathways. This work establishes a generalizable “precision synergy” paradigm for designing high-performance nanocluster-based therapeutics against oxidative stress-related inflammatory diseases.
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高影响因子
CHINESE JOURNAL OF CHEMISTRY
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2026
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IF 5.7
Xinxin Pan,Zhou Huang,Qi Chen,Zhongxiang Zuo,Xun Yuan,Manxi Zhang,Moshuqi Zhu,Qing Tang,Yang-Yang Yu,Hui Yang,Qiaofeng Yao,Wenping Hu
Comprehensive Summary Electrocatalytic two-electron oxygen reduction reaction (2 e – ORR) represents a green and sustainable way for H 2 O 2 production, while its practical applications in industry are largely hindered by the unwieldy proton transfer kinetics. Herein, we develop a biomimetic interface engineering strategy to precisely regulate proton transfer kinetics for enhanced 2 e – ORR. Using atomically precise Au 25 ( p -MBA) 18 nanoclusters (NCs, p -MBA = 4-mercaptobenzoic acid) as model catalysts, we introduced a series of quaternary ammonium ionic liquid (IL) cations onto the cluster surface via combined electrostatic and π-π stacking interactions. The hydrophobic tails and controlled hydrolysis of IL cations disruptthe long-range interconnected hydrogen-bonding networks, which are ubiquitous in alkaline electrolytes and bring about an overwhelming proton transfer rate. Instead, a mild biomimetic proton relay mechanism favoring 2 e – ORR can be established and fine-adjusted, leveraging deprotonation and protonation equilibrium of IL cations. By this way, the optimized system can bring down the mean electron transfer number ( n ) to 2.45 and promote the H 2 O 2 selectivity to 90% or higher, evidencing a pronounced shift toward the 2 e – ORR pathway under alkaline conditions. This work underscores the usefulness of atomically precise interfacial engineering in optimizing the electrocatalytic performance of inorganic nanocatalysts.
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MOLECULAR PHARMACEUTICS
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2025
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IF 4.5
Xiangjun Chen,Xinzhong Zhang,Qing Fan,Menglin Cao,Sai Zhang,Wenting Li,Rui Ma,Xiuping Zhang,Wei Hong
The effective treatment of infections induced by biofilms has remained a substantial challenge in clinical practice. Presently, there is an imperative demand for innovative antimicrobial strategies that can not only eliminate biofilms but also incorporate controlled delivery and intelligent release mechanisms. In this research, the charge-reversible nonantibiotic nanodelivery system (MPDA/AuNCs/ICG@Lip NPs) is synthesized. Initially, AuNCs and indocyanine green (ICG) were introduced onto MPDA NPs via adsorption and mesoporous loading, followed by the modification of the phospholipids on the exterior surface. Within the biofilm microenvironment, the surface charge was reversed, thereby improving its affinity for methicillin-resistant Staphylococcus aureus (MRSA) and facilitating enhanced biofilm permeability. Owing to the ultrasmall AuNCs, they were internalized by the bacteria and, in conjunction with ICG, contributed to the elevation of local ROS concentrations under the 808 nm laser. As anticipated, the in vitro findings confirmed that MPDA/AuNCs/ICG@Lip NPs demonstrated superior biofilm-clearing capabilities and antibacterial effect. In vivo experiments corroborated that MPDA/AuNCs/ICG@Lip NPs successfully targeted the cyst site and remained localized for an extended period, resulting in excellent therapeutic efficacy. This discovery offers a novel perspective for the development of nonantibiotic nanoplatform for clearing MRSA.
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PubMed
高影响因子
Materials Today Bio
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2022
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IF 10.761
Zesong Ruan,Chunlei Zhang,Tingwang Shi,Zhiyuan Luo,Yuna Zhang,Zanxia Cao,Rentai Huang,Yunfeng Chen,Daxiang Cui
Restoring skin integrity after wound infection remains a tougher health challenge due to the uncontrolled antibiotic-resistant pathogens caused by antibiotic abuse. Herein, an injectable hydrogel with dual antibacterial and anti-inflammatory activities composed of gold nanoclusters (GNCs) and carbomer (CBM) is developed for wound dressing to overcome multidrug-resistant infection. Firstly, both experimental investigations and molecular dynamics simulation validate the protonation state of 6-mercaptohexanoic acid (MHA) ligands play an important role in its antibacterial action of GNCs. The self-organizing GNCs-CBM composite hydrogel is then spontaneously cross-linked by the dimeric hydrogen bonds (H-bonds) between the MHA ligands and the acrylic acid groups of CBM. Benefitting from the dimeric H-bonds, the hydrogel becomes thickening enough as an ideal wound dressing and the GNCs exist in the hydrogel with a high protonation level that contributes to the enhanced bactericidal function. In all, by combining bactericidal and immunomodulatory actions, the GNCs-CBM hydrogel demonstrated excellent synergy in accelerating wound healing in animal infection models. Hence, the dimeric H-bonds strengthening strategy makes the GNCs-CBM hydrogel hold great potential as a safe and effective dressing for treating infected wounds.
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PubMed
高影响因子
ACS Nano
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2022
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IF 18.027
Chunlei Zhang,Guangyu Chu,Zesong Ruan,Ning Tang,Cunfeng Song,Qichao Li,Wenjie Zhou,Jiale Jin,Hossam Haick,Yunfeng Chen,Daxiang Cui
Materials in nature feature versatile and programmable interactions to render macroscopic architectures with multiscale structural arrangements. By rationally combining metal–carboxylate and metal–organophosphate coordination interactions, Au25(MHA)18 (MHA, 6-mercaptohexanoic acid) nanocluster self-assembled structural color coating films and phytic acid (PA)–metal coordination complexes are sequentially constructed on the surface of titanium implants. The Lewis acid–base coordination principle applies for these metal–organic coordination networks. The isotropic arrangement of nanoclusters with a short-range order is investigated via grazing incidence wide-angle X-ray scattering. The integration of robust M–O (M = Ti, Zr, Hf) and labile Cu–O coordination bonds with high connectivity of Au25(MHA)18 nanoclusters enables these artificial photonic structures to achieve a combination of mechanical stability and bacteriostatic activity. Moreover, the colorless and transparent PA–metal complex layer allows the viewing of the structural color and surface wettability switching to hydrophilic and makes feasible the interfacial biomineralization of hydroxyapatite. Collectively, these modular metal–organic coordination-driven assemblies are predictive and rational material design strategies with tunable hierarchy and diversity. The complete metal–organic architectures will not only help improve the physicochemical properties of the bone–implant interface with synergistic antibacterial and osseointegration activities but also can boost surface engineering of medical metal implants
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