GeroScience
·
2024
·
IF 5.3
Zhou Yiming,Chen Lijuan,Wang Meijing,Yang Yang,Hu Bin,Li Guolin,Wei Fang
Paroxetine, a selective serotonin reuptake inhibitor, is widely used in the clinical treatment of depression. While several antidepressants show promise as geroprotectors, the role of paroxetine in aging remains unclear. In this study, we evaluated the lifespan extension effect of paroxetine in Caenorhabditis elegans ( C. elegans ) and elucidated the underlying mechanisms. The results showed that paroxetine can prolong lifespan concomitant extension of healthspan as indicated by increasing mobility and reducing lipofuscin accumulation, as well as confer protection to nematodes against different abiotic stresses. Paroxetine upregulated ser-7 expression and downregulated dop-4 expression. dop-4 RNA interference (RNAi) mimicked the beneficial effect of paroxetine on lifespan. Conversely, ser-7 RNAi abolished paroxetine-induced lifespan extension and the expression changes of dop-4 and genes related to insulin/insulin-like growth factor 1 signaling (IIS). Moreover, paroxetine exhibited a comparable lifespan extension effect to that observed in daf-2 or age-1 mutants; however, this effect was abolished in daf-16 mutant. Taken together, these results suggest that paroxetine promotes health and longevity in C. elegans through the ser-7 - dop-4 -IIS pathway, underscoring its potential as a geroprotector.
研究领域:
生物学
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老年医学
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神经科学
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产品关联
DOI
PubMed
高影响因子
WATER AIR AND SOIL POLLUTION
·
2022
·Vol. 233
·期 9
·1-13
·
IF 2.984
Wu Wei,Duan Huike,Chen Jiabin,Xu Jie,Xu Fen,Huang Tianyin,Xu Xiaoyi
In this study, the azo dye acid orange 7 (AO7) was degraded by synergistic activation of persulfate (PMS) with cyclohexanone/chloride ion (Cl − ). The effects of cyclohexanone dosage, PMS concentration, Cl − concentration, initial pH, temperature, and aqueous natural organic matter (NOM) on the AO7 removal were investigated. Under alkaline conditions, the removal rate of AO7 increased with increasing cyclohexanone and Cl − concentrations. The degradation rate of AO7 was unaffected by the water matrix and NOM in the environment. As shown in radical quenching experiments and electron paramagnetic resonance spectroscopy analysis, the main reactive species generated in the reaction system were hypochlorous acid (HCIO) and singlet oxygen ( l O 2 ), which destroyed the azo bond and naphthalene ring structure in AO7. Judging from its ability to degrade AO7, the cyclohexanone/Cl − /PMS system is suitable for treating high-salt wastewater containing organic pollutants.
研究领域:
环境科学
·
化学
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DOI
高影响因子
JOURNAL OF APPLIED ELECTROCHEMISTRY
·
2022
·Vol. 53
·期 5
·1023-1032
·
IF 2.925
Luo Yuhua,Yao Haifeng,Zhang Yahui,Dong Yongping
Abstract In this paper, a sensitive electrochemiluminescence (ECL) method for the detection of Ba 2+ was proposed based on its apparent enhancing effect on the anodic luminol ECL at a cucurbit[7]uril (Q[7])-modified glassy carbon electrode (Q[7]/GCE). The cavity of the modified Q[7] could accommodate more dissolved oxygen at the electrode surface which reacted with luminol to generate strong anodic ECL signal compared with a bare GCE. Ba 2+ ions exhibited further enhancing effect on luminol ECL when they were immobilized at the portal of Q[7] through chelating with carbonyl group of Q[7]. The increment of ECL signal varied linearly with the concentration of Ba 2+ , as a result, an ECL sensor for the quantitative detection of Ba 2+ was constructed. Under the optimal condition, Ba 2+ could be sensitively detected in the range of 1.0 × 10 –7 to 1.0 × 10 –4 mol L −1 , and the detection limit was calculated as 10 nM (3σ). The proposed ECL sensor exhibited satisfactory analytical performance and could be used in real samples analysis, which provided a new strategy for metal ions detection. Graphic abstract
The encapsulation of dissolved oxygen by Q[7] can enrich oxygen concentration at
the electrode surface, which can react with luminol to emit enhanced ECL. The
presence of Ba 2+ can increase the amount of O2
•- at the electrode surface through the
formation of barium-peroxide species, which can further enhance luminol ECL. Thus,
an ECL sensor for the sensitive detection of Ba 2+ was built.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Guangyu Zhu,Fuyan Kang,Qianyun Tan,Huali Li,Gege Zhang,Min Wu,Yong Tan,Fa-Qian Liu
Marine biological pollution restricts the sustainable development of marine economy. Cu 2 O stands as a predominant antifouling agent for developing marine resources engineering. However, the problems of easy aggregation, rapid failure, and explosive release of copper ions limit the practical application of Cu 2 O. In this work, a novel copper-functionalized two-dimensional zeolitic imidazolate framework-7 nanocomposites ZIF-7@Cu 2 O was successfully fabricated by in-situ growth methodology. The emergence of ZIF-7@Cu 2 O nanocomposites solves the above problems in the use of Cu 2 O. Due to the huge specific surface area of the 2D ZIF-7 nanosheets and the electrostatic interactions, the cubic Cu 2 O, with a diameter of 250 nm, can be uniformly and firmly anchored on the surface of 2D ZIF-7 nanosheets, thus effectively avoiding the rapid dissolution of cuprous oxide and reducing the release rate of copper ions. Antibacterial experiments demonstrate that, in comparison to ZIF-7, Cu 2 O, and ZIF-7/Cu 2 O (physical mixture of ZIF-7 and Cu 2 O), ZIF-7@Cu 2 O exhibits superior antibacterial properties with 99.99 % against E. coli and the minimum inhibitory concentration (MIC) of 32 μg/mL. Furthermore, the reactive oxygen species (ROS) assay confirms ZIF-7@Cu 2 O could promote the generation of ROS. Antibiofilm formation results reveal that ZIF-7@Cu 2 O nanocomposites are effective in preventing biofilm formation of E. coli and P. aeruginosa at a low concentration (50 μg/mL). Finally, ZIF-7@Cu 2 O nanocomposites are employed as fillers to prepare ZIF-7@Cu 2 O/EP composite coating, the bactericidal kinetics and bacterial adherence on the coating surface are investigated. We believe this work could provide novel insights into the rational design of 2D ZIF-based material in the field of antifouling.
研究领域:
材料科学
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纳米技术
·
生物医学工程
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Guangyu Zhu,Fuyan Kang,Xiaoya Ding,Chunxiao Yin,Fa-Qian Liu
Biofouling has been a persistent challenge for offshore equipment, significantly affecting its longevity. In this study, two-dimensional (2D) ZIF-7 nanosheets were synthesized via a hydrothermal method and modified with polydopamine (PDA) to enhance their dispersibility. A multifunctional ZIF-7@PDA-CeO2 nanocomposite was then prepared through in situ growth, where CeO2 was uniformly and securely anchored onto the ZIF-7@PDA surface, facilitated by the large specific surface area and its electrostatic interactions between ZIF-7@PDA. UV–vis absorption spectra demonstrate that the ZIF-7@PDA-CeO2 exhibit haloperoxidase-like (HPO-like) catalytic activity, efficiently catalyzing the oxidation of NH4Br and H2O2 to generate HBrO. Antibacterial assays indicate that ZIF-7@PDA-CeO2 possesses strong bactericidal activity and effectively inhibits biofilm formation. Furthermore, ZIF-7@PDA-CeO2 are used as fillers to prepare ZIF-7@PDA-CeO2/EP composite coating, and the antibacterial and long-term corrosion resistance is also explored. We believe this work offers a sustainable solution to the challenges of biofouling and corrosion in marine environments.
研究领域:
材料科学
·
海洋工程
·
生物医学
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产品关联
DOI
PubMed
高影响因子
Cells
·
2023
·Vol. 12
·期 6
·831
·
IF 6
Xuehui Wang,Jiaying Wang,Zihui An,Aifen Yang,Mengsheng Qiu,Zhou Tan
Mounting evidence suggests that circular RNAs play important roles in the development and progression of cancers. However, their function in glioblastomas (GBM) is still unclear. By circRNA array analysis, we found that circXPO1 (hsa_circ_102737) was significantly upregulated in GBM, and qPCR analysis verified that the circXPO1 expression level was increased in both GBM tissues and cell lines. Functional studies demonstrated that the knockdown of circXPO1 in GBM cell lines repressed cell proliferation and migration; conversely, the overexpression of circXPO1 promoted the malignancy of GBM cells. In line with these findings, circXPO1 inhibition effectively suppressed gliomagenesis in the in situ transplantation model of nude mice. Through bioinformatic analyses and dual-luciferase reporter assays, we showed that circXPO1 directly bound to miR-7-5p, which acted as a tumor suppressor through the negative regulation ofRAF1. In conclusion, our studies suggest that the circXPO1/miR-7-5p/RAF1axis promotes brain tumor formation and may be a potential therapeutic target for GBM treatment.Keywords:circXPO1;glioblastomas;ceRNA;miR-7-5p;RAF1
研究领域:
肿瘤学
·
分子生物学
·
神经科学
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产品关联
DOI
PubMed
高影响因子
PROTEIN JOURNAL
·
2024
·
IF 1.9
Yuan Libo,Wang Ke,Fang Yuan,Xu Xiujuan,Chen Yingcun,Zhao Dongxin,Lu Kui
Cecropin A (1–7) is a cationic antimicrobial peptide which contain lots of basic amino acids. To understand the effect of basic amino acids on cecropin A (1–7), analogues CA2, CA3 and CA4 which have more arginine or lysine at the N-terminal or C-terminal were designed and synthesized. The interaction of cecropin A (1–7) and its analogs with DNA was studied using ultraviolet–visible spectroscopy, fluorescence spectroscopy and circular dichroism spectroscopy. Multispectral analysis showed that basic amino acids improved the interaction between the analogues and DNA. The interaction between CA4 and DNA is most pronounced. Fluorescence spectrum indicated that Ksv value of CA4 is 1.19 × 10 5 L mol −1 compared to original peptide cecropin A (1–7) of 3.73 × 10 4 L mol −1 . The results of antimicrobial experiments with cecropin A (1–7) and its analogues showed that basic amino acids enhanced the antimicrobial effect of the analogues. The antimicrobial activity of CA4 against E. coli was eightfold higher than that of cecropin A (1–7). The importance of basic amino acid in peptides is revealed and provides useful information for subsequent studies of antimicrobial peptides. Graphical Abstract
研究领域:
生物化学
·
分子生物学
·
微生物学
·
光谱学
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产品关联
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2020
·
IF 3.693
Ai Qiushuang,Fu Qiang,Liang Feng
Recognition tunneling technique owns the capability for investigating and characterizing molecules at single molecule level. Here, we investigated the conductance value of cucurbit[7]uril (CB[7]) and melphalan@CB[7] (Mel@CB[7]) complex molecular junctions by using recognition tunneling technique. The conductances of CB[7] and Mel@CB[7] with different pH values were studied in aqueous media as well as organic solvent. Both pH value and guest molecule have an impact on the conductance of CB[7] molecular junction. The conductances of CB[7] and Mel@CB[7] both showed slightly difference on the conductance under different measurement systems. This work extends the molecular conductance measurement to aqueous media and provides new insights of pH-responsive host-guest system for single molecule detection through electrical measurements.
研究领域:
生物物理学
·
纳米科学
·
分子电子学
✓ 已验证
DOI
PubMed
高影响因子
CLINICA CHIMICA ACTA
·
2023
·
IF 5
Yueyuan Zhang,Sha Xu,Jianxin Xu,Fuchao Xu,Geng Lu,Jiawei Zhou,Shuangshuang Gu,Jun Wang
Background Early evaluation of the severity of sepsis and estimation of its prognosis remains one of the main challenges in current therapeutic strategies. This study aimed to evaluate the prognostic value of plasma 7-ketocholesterol (7-KC) in sepsis. Methods We retrospectively measured by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) the plasma 7-KC concentration in 176 patients with sepsis and 90 healthy volunteers. A multivariate Cox proportional hazard model was introduced to identify independent factors, including plasma 7-KC and clinical features, for the 28-day mortality of sepsis, and a nomogram for predicting the 28-day mortality of sepsis was established. Decision curve analysis (DCA) was performed to assess the prediction model of death risk of sepsis. Results The area under the curve (AUC) of plasma 7-KC in diagnosing sepsis was 0.899 (95% CI = 0.862–0.935, P < 0.001), while it was 0.830 (95% CI = 0.764–0.894, P < 0.001) in diagnosing septic shock. The AUCs of plasma 7-KC in predicting the survival of sepsis patients in the training cohort and the test cohort were 0.770 (95% CI = 0.692–0.848, P < 0.05) and 0.869 (95% CI = 0.763–0.974, P < 0.05), respectively. In addition, high plasma 7-KC expression predicts poor prognosis in sepsis. Then, 7-KC and platelet count were identified as the two factors with significant differences by a multivariate Cox proportional hazard model, and the 28-day mortality probability ranged from 0.002 to 0.985 and was assessed using a nomogram. DCA results revealed that the combination of plasma 7-KC and platelet count showed the best prognostic efficiency of the risk threshold compared to a single factor in both the training cohort and test cohort. Conclusions Collectively, the elevated plasma 7-KC level is an indicator of sepsis and was identified as a prognostic indicator for sepsis patients, providing a landscape for predicting survival in early sepsis with potential clinical utility.
研究领域:
临床医学
·
生物化学
·
重症医学
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产品关联
DOI
PubMed
高影响因子
Materials
·
2023
·Vol. 16
·期 7
·2650
·
IF 3.4
Yaohui Xu,Liangjuan Gao,Jinyuan Yang,Qingxiu Yang,Wanxin Peng,Zhao Ding
A porous CeO2was synthesized following the addition of guanidine carbonate to a Ce3+aqueous solution, the subsequent addition of hydrogen peroxide and a final hydrothermal treatment. The optimal experimental parameters for the synthesis of porous CeO2, including the amounts of guanidine carbonate and hydrogen peroxide and the hydrothermal conditions, were determined by taking the adsorption efficiency of acid orange 7 (AO7) dye as the evaluation. A template−free hydrothermal strategy could avoid the use of soft or hard templates and the subsequent tedious procedures of eliminating templates, which aligned with the goals of energy conservation and emission reduction. Moreover, both the guanidine carbonate and hydrogen peroxide used in this work were accessible and eco−friendly raw materials. The porous CeO2possessed rapid adsorption capacities for AO7 dye. When the initial concentration of AO7 was less than 130 mg/L, removal efficiencies greater than 90.0% were obtained, achieving a maximum value of 97.5% at [AO7] = 100 mg/L and [CeO2] = 2.0 g/L in the first 10 min of contact. Moreover, the adsorption–desorption equilibrium between the porous CeO2adsorbent and the AO7 molecule was basically established within the first 30 min. The saturated adsorption amount of AO7 dye was 90.3 mg/g based on a Langmuir linear fitting of the experimental data. Moreover, the porous CeO2could be recycled using a NaOH aqueous solution, and the adsorption efficiency of AO7 dye still remained above 92.5% after five cycles. This study provided an alternative porous adsorbent for the purification of dye wastewater, and a template−free hydrothermal strategy was developed to enable the design of CeO2−based catalysts or catalyst carriers.Keywords:porous CeO2;template−free;adsorption;adsorption efficiency;acid orange 7
研究领域:
材料科学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Hong-Si Guo,Wenfeng Zhao,Qingmei Ge,Nan Jiang,Mao Liu,Hang Cong
A promising method for producing hydrogen from solar energy and converting it into chemical fuels is photoelectrochemical (PEC) water splitting. In this paper, a novel photoanode is prepared by hydrothermal growing of nanorod CdS/g-C 3 N 4 /Q[7] heterojunction on FTO substrate for photoelectrochemical water splitting to produce hydrogen. In this method, Q[7]-doped g-C 3 N 4 is tightly combined with CdS composite and substrate, which significantly improves the separation and migration of photogenerated carriers in g-C 3 N 4 /Q[7] and CdS, and effectively reduces the internal resistance of the photoanode. Compared with the free CdS NRs, the PEC performance of the heterojunction CdS/g-C 3 N 4 /Q[7]-10 is significantly enhanced with the improved photocurrent density of 1049.7 μA/cm 2 under AM 1.5 G (100 mW/cm 2 ) simulated sunlight, which is 3.6 times that of pristine CdS and 2.6 times that of FTO-CdS/g-C 3 N 4 under the same conditions. The external bias photocurrent conversion efficiency and photohydrogen conversion efficiency of CdS/g-C 3 N 4 /Q[7]-10 photoanode at 0.7 V (relative to RHE) are measured to be both 0.31 %, as 3.1 times high as that of the original CdS NRs (0.10 %), and 2.07 times high as that of FTO-CdS/g-C 3 N 4 (0.15 %). The generation of heterostructure with interfacial interaction reduces the recombination of photogenerated electron-hole pairs, to enhance the charge transfer of water oxidation kinetics, allowing electrons to quickly transfer through the external circuit to the counter electrode for H + reduction to produce H 2 . A schematic diagram of the photoelectrochemical water splitting hydrogen evolution process with the heterojunction CdS/g-C 3 N 4 /Q[7]-10 is systematically proposed.
研究领域:
材料科学
·
能源转换
·
光电化学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Xiaoxia Ye,Zhihong Zheng,Jinwei Zhu,Jie Chen,Jianfei Zhou,Bi Shi
Adsorptive removal of mercury ion from wastewater has become a hot topic due to the toxicity and persistence; acquiring adsorbent materials with high-capacity, rapid-kinetic, super-selective while low-cost features are highly demanded. Herein, based on the full functionality of collagen fiber (CF) from the leather waste, we proposed an innovative synthetic approach through exploiting amino-functionalized ZIF-7 (ZIF-7-NH 2 ) as functional groups to facilely in-situ incorporate with CF, affording low-cost but effective adsorbent materials of CF/ZIF-7-NH 2 composite maximizing both functions of CF and ZIF-7-NH 2 in the Hg(II) capture. Remarkably, it exhibits an ultra-high capacity as high as 909.09 mg g - 1 , fast kinetics that could remove 99.01 % of 200 mg·L -1 within 20 min, and significant selectivity of S Hg/M ( K d Hg / K d M ) as large as 522–1017 over Mg 2+ , K + , Ca 2+ , Cd 2+ , and Mn 2+ . We understand such an impressive adsorption is contributed by the synergistic action between functional groups including on the CF and ZIF-7-NH 2 . This study offers an effective method for removing heavy metal ions, achieving efficient removal of Hg(II) ions for pollution control, and promoting the reuse of waste CF to reduce waste accumulation in various aspects.
研究领域:
环境科学
·
材料科学
·
生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）