RSC Advances
·
2016
·Vol. 6
·期 37
·31031-31036
·
IF 3.289
Zichen Huang,Yafei Qi,Dexin Yu,Jinhua Zhan
MoS2, a typical transition-metal dichalcogenide, has attracted increasing attention in the field of biomedicine due to its preeminent properties. In this paper, MoS2 nanoparticles with radar-like shapes were demonstrated as 808 nm laser-induced photothermal agents with outstanding photothermal performance. According to our calculations, the radar-like morphology endowed the MoS2 nanoparticles with higher photothermal conversion efficiency (53.3%) compared to other morphologies including nanoflowers, microspheres and irregular nanoparticles. Cytotoxicity assay indicated that the radar-like nanoparticles were biocompatible. Results of in vitro photothermal therapy and apoptosis assay indicated that tumor cells treated with MoS2 radar-like nanoparticles can be seriously damaged. Photothermal therapy on tumor-bearing mice was carried out to further verify the anti-cancer properties of the MoS2 radar-like nanoparticles. All the aforementioned results suggested that the MoS2 radar-like nanoparticles exhibit enormous potential for cancer photothermal therapy.
研究领域:
生物医学
·
纳米材料科学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2016
·
IF 3.014
Xia Hu,Xiao-Jie Zheng,Yan Li,Jing Zhang,De-Kun Ma
Various architectures of Cu 2 PO 4 OH including multibranches-like, rose-like, rod-like and brick-like were synthesized through a facile solvothermal route, employing different kinds of alcohols as solvents. It was found that the types of the alcohols, the ratios of alcohols to water, and the presence of PEG 2000 played key roles in the aspect of adjusting the growth of Cu 2 PO 4 OH architectures. All of the as-obtained products showed strong and wide absorption in the range of 600–1500 nm. Under the irradiation of a continuous 808 nm laser, the materials exhibited morphology-dependent photothermal performance. The present study not only develops a new strategy to synthesize Cu 2 PO 4 OH with various architectures but also provides a promising near-infrared (NIR) light-driven photothermal agent.
研究领域:
材料科学
·
化学
·
纳米技术
·
光热治疗
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2018
·Vol. 16
·期 1
·1-15
·
IF 5.294
Fu Ji-jun,Chen Ming-yue,Li Jie-xia,Zhou Jun-hua,Xie Sheng-nan,Yuan Ping,Tang Bo,Liu Cheng-cheng
Background In order to explore the possibility of treating breast cancer by
local photo-therapy, a photothermal agents loaded in situ hydrogel was
established. In detail, The
Cu2MnS2 nanoplates were
prepared by one-pot synthesis and, the thermosensitive Pluronic F127 was used as
the hydrogel matrix. The Cu2MnS2
nanoplates and the hydrogel were characterized by morphous, particle size, serum
stability, photothermal performance upon repeated 808 nm laser irradiation as
well as the rheology features. The therapeutic effects of the
Cu2MnS2 nanoplates and the
hydrogel were evaluated qualitatively and quantitatively in 4T1 mouse breast
cancer cells. The retention, photothermal efficacy, therapeutic effects and
systemic toxicity of the hydrogel were assessed in tumor bearing mouse
model.Results The Cu2MnS2 nanoplates
with a diameter of about 35 nm exhibited satisfying serum stability, photo-heat
conversion ability and repeated laser exposure stability. The hydrogel
encapsulation did not negatively influence the above features of the
photothermal agent. The nanoplates loaded in situ hydrogel shows a phase
transition at body temperature and, as a result, a long retention in
vivo.Conclusion sThe photothermal agent embedded hydrogel played a promising
photothermal therapeutic effects in tumor bearing mouse model with low systemic
toxicity after peritumoral administration.
研究领域:
肿瘤学
·
纳米医学
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Xueke Wu,Lixuan Mu,Min Chen,Sen Liang,Yuan Wang,Guangwei She,Wensheng Shi
To realize a real-time thermal feedback, monitoring the temperature of the treated tissue is critical for photothermal therapy (PTT). The poor spatial resolution and low accuracy of current methods for the detection of tissue temperature limits the application of PTT. Herein, by assembling the temperature-responsive DNA stem-loop marked with Texas red (TR) onto the surface of gold nanobipyramids (AuNBPs), a bifunctional reagent (AuNBPs-DNA-TR) was fabricated for PTT and synchronously monitoring the temperature. In this configuration, the AuNBPs not only have a high efficiency for photothermal conversion but also could be quenchers to inhibit the fluorescence of TR. During PTT, the significant photothermal effect of the AuNBPs could elevate the temperature. Meanwhile, the increase of the temperature could open the DNA stem-loop assembled on the AuNBPs and as a result enlarge the distance between the TR and AuNBPs. As a result, the TR fluorescence quenched by the AuNBPs was sensitively recovered. The fluorescence intensity (FI) of the TR could be utilized to monitor the temperature during PTT. It was found that irradiating the cancer cells cultured with the AuNBPs-DNA-TR with an 808 nm laser could distinctly increase the system temperature, while the cells could be inactivated due to the remarkable photothermal effect of the AuNBPs-DNA-TR. Meanwhile, the fluorescence of the AuNBPs-DNA-TR for the measurement of the temperature was significantly enhanced. The results indicated that the variation of the fluorescence from the AuNBPs-DNA-TR could be used as thermal feedback to monitor the effect of PTT.
研究领域:
纳米技术
·
生物医学工程
·
癌症治疗
·
光学成像
✓ 已验证
产品关联
DOI
PubMed
OPTICS AND LASER TECHNOLOGY
·
2016
·
IF 1.879
Rong Chen,Ying Tian,Bingpeng Li,Feifei Huang,Caizhi Wang,Xufeng Jing,Junjie Zhang,Shiqing Xu
Nd 3+ /Ho 3+ co-doped silicate-germanate glass has been synthesized by high temperature melt-quenching method. Near infrared emission centered at 2 µm has been successfully obtained by incorporating Nd 3+ and Ho 3+ in present glass. The Judd-Ofelt intensity parameters Ω t (t=2, 4, 6), and radiative properties of Ho 3+ were calculated and discussed by using the Judd-Ofelt theory. The energy transfer processes and luminescence properties of Nd 3+ /Ho 3+ co-doped glasses were analyzed pumped by a conventional 808 nm laser diode . Desirable spectroscopic characteristics indicates that Nd 3+ /Ho 3+ co-doped silicate-germanate glass might be a good alternative matrix for 2 µm band mid-infrared laser.
研究领域:
光学材料
·
无机非金属材料
·
光子学
·
激光技术
·
固体物理
✓ 已验证
DOI
高影响因子
Nanoscale
·
2018
·Vol. 10
·期 22
·10641-10649
·
IF 7.233
Han Wang,Yi Liu,Zhaohui Wang,Man Yang,Yueqing Gu
NO (nitric oxide) has dual functions in cancer, promoting carcinogenesis in low concentrations and inducing tumor cell apoptosis at high concentrations. The dual-edged-sword functions of NO make it particularly appealing to develop a sensitive and specific chemical probe for its detection. However, most NO sensors suffer from poor Stokes shifts and are limited by ultraviolet (UV) or visible light excitation, which render it difficult to avoid the intrinsic background signal. In this study, an 808 nm laser-excited Nd3+-sensitized upconversion nanoprobe based on LRET (luminescence resonance energy-transfer) for NO detection was constructed for the first time. This probe was composed of Nd3+-sensitized core–shell upconversion nanoparticles (540 nm and 660 nm emission) as the energy donor and RhBs as the acceptor. In the presence of NO, RhBs was converted into Rhodamine B and its strong absorption subsequently quenched the 540 nm fluorescence of UCNPs, while the emission at 660 nm remained constant. The ratiometric detection of the fluorescence at 540 nm, as compared to 660 nm, can precisely respond to the difference in NO levels with a detection limit of 0.21 μM. Importantly, compared with conventional UCNPs excited at 980 nm, the 808 nm light excitation led to lower water absorption and deeper tissue penetration, thus avoiding overheating and allowing for long-term biological imaging. This strategy has been perfectly applied to detecting the NO levels in living cells to differentiate the tumor cells from normal cells based on varied intracellular NO concentration. Further, the nanosystem realized the real-time monitoring of NO during treatment with NO donor drugs, which could inspire the future application of this probe to guide NO therapy.
研究领域:
生物化学
·
纳米技术
·
癌症生物学
·
光学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yun Zeng,Yonghua Zhan,Xinyue Liu,Jingwen Ma,Huifang Liu,Hanrui Li,Tong Yi,Qingxia Zhu,Getao Du,Linfei Zhao,Dan Chen,Xueli Chen
Tumor metastasis is a major cause of poor cancer prognosis. Photothermal therapy (PTT) is a non-invasive, non-oxygen-dependent, and highly spatiotemporally precise treatment that may aid chemotherapy in suppressing tumor growth and metastasis. This article aims to develop and modify a CuS-based nanoplatform linking RGD-Acrk to actively target and internalize doxorubicin (DOX) into tumor cells, resulting in an alternating strategy of synergistic chemo/PTT. The nanoparticle’s shape, spectra, drug encapsulation efficiency, loading content, and controlled release are characterized, and a comparison of 808/980 nm lasers is used to irradiate the nanoplatform. The cell survival rate is used to determine the cytotoxicity of DOX and PTT, and the chemo/PTT is used to treat 4T1-Luc tumor-bearing mice. Simultaneously, bioluminescence and photoacoustic imaging are employed to assess therapy efficacy, as well as tumor size, weight, density, the bodyweight of mice, and survival curves. H&E, immunohistochemistry for HIF-1α, and TUNEL fluorescence staining confirm these findings, suggesting that the nanoplatform has a good active-targeted capacity and perform high-efficiency PTT caused by 980 nm laser irradiation. The synergistic effect is at least 3.53 times higher than chemo/PTT without synergistic effect and tumor liver metastasis is successfully suppressed, showing that it has the potential to be used for cancer treatment and prognosis improvement.
研究领域:
肿瘤学
·
纳米技术
·
诊疗学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 16
·11215-11224
·
IF 3.9
Haidi Feng,Lu Zhao,Zhiqiang Bai,Zhihui Xin,Chaoyu Wang,Lizhen Liu,Jinping Song,Haifei Zhang,Yunfeng Bai,Feng Feng
Active-targeted nanoplatforms could specifically target tumors compared to normal cells, making them a promising therapeutic agent. The aptamer is a kind of short DNA or RNA sequence that can specifically bind to target molecules, and could be widely used as the active targeting agents of nanoplatforms to achieve active-targeted therapy of tumors. Herein, an aptamer modified nanoplatform DOX@PCN@Apt-M was designed for active-targeted chemo-photodynamic therapy of tumors. Zr-based porphyrinic nanoscale metal organic framework PCN-224 was synthesized through a one-pot reaction, which could produce cytotoxic 1O2 for efficient treatment of tumor cells. To improve the therapeutic effect of the tumor, the anticancer drug doxorubicin (DOX) was loaded into PCN-224 to form DOX@PCN-224 for tumor combination therapy. Active-targeted combination therapy achieved by modifying the MUC1 aptamer (Apt-M) onto DOX@PCN-224 surface can not only further reduce the dosage of therapeutic agents, but also reduce their toxic and side effects on normal tissues. In vitro, experimental results indicated that DOX@PCN@Apt-M exhibited enhanced combined therapeutic effect and active targeting efficiency under 808 nm laser irradiation for MCF-7 tumor cells. Based on PCN-224 nanocarriers and aptamer MUC1, this work provides a novel strategy for precisely targeting MCF-7 tumor cells.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 48
·9487-9496
·
IF 4.543
Chen-Xi Huang,Hua-Jian Chen,Fei Li,Wan-Ni Wang,Dong-Dong Li,Xian-Zhu Yang,Zhao-Hua Miao,Zheng-Bao Zha,Yang Lu,Hai-Sheng Qian
Synergistic photodynamic and photothermal therapy of cancer cells is of considerable scientific and technological interest. In this work, we demonstrate a sacrificial template strategy to fabricate yolk–shell nanoparticles combining upconversion nanoparticles (UCNPs) and CuS nanoparticles. Lanthanide-doped upconversion nanoparticles of NaYF4:30% Yb,1% Nd,0.5% Er@NaYF4:20% Nd (also denoted as UCNPs) have been prepared as 808 nm light excited remote-controlled nanotransducers for in vitro cancer cell treatment. The upconversion fluorescence of the as-prepared UCNPs@CuS yolk–shell nanoparticles is completely quenched under the excitation of an 808 nm laser, which demonstrates that the energy transfer between the UCNPs and CuS is very efficient. In addition, the as-prepared UCNPs@CuS nanoparticles show higher production ability for hydroxyl radicals (˙OH) and singlet oxygen (1O2) compared to CuS hollow nanospheres of similar size. In particular, the excited shell layer (CuS) showed an enhanced photothermal effect while producing reactive oxygen species (ROS) including singlet oxygen (1O2) and hydroxyl radicals (˙OH) after being exposed to near infrared (NIR) light. Thus, the as-prepared UCNPs@CuS yolk–shell nanoparticles exhibited the synergistic effect of photothermal and photodynamic therapy of cancer cells, which resulted in significant cell death after exposure to an 808 nm laser. The synthetic strategy will provide an alternative method to fabricate other UCNP based core–shell nanoparticles for potential and important applications in bionanotechnology including theranostics, multimodal treatment, magnetic resonance imaging-guided photodynamic therapy, etc.
研究领域:
纳米技术
·
生物医学工程
·
癌症治疗
·
材料科学
·
生物纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Lu Jia,Yuzhu Wang,Tingting Hu,Chunyu Yang,Huiming Lin,Feng Zhang,Fengyu Qu,Liru Cui,Wei Guo
Photothermal therapy (PTT) has attracted considerable attention in the field of nanomedicine owing to its high efficiency, low invasiveness , and precise controllability. However, limited by the activation of the immune system by PTT and the low penetrating ability of near-infrared lasers, the use of a single PTT is usually ineffective. Herein, a unique injectable hydrogel system was strategically designed and fabricated using CoSnS x , L-arginine, chitosan (CTS), and carboxymethyl cellulose (CMC) for sonodynamic and dual-gas therapy cooperative PTT. CoSnS x with a hollow structure can not only produce a large amount of singlet oxygen ( 1 O 2 ) under ultrasonic (US) irradiation, but also produce H 2 S gas in an acidic environment, so as to achieve sonodynamic and gas therapeutic effects. Additionally, CoSnS x exhibited excellent photothermal conversion efficiency of 48.24% under 808 nm laser irradiation. As a precursor of NO, L-arginine is incorporated into the hydrogel to enable the controlled release of NO under US/laser irradiation, thereby enhancing the PTT effect. Such a multifunctional injectable hydrogel system can achieve high therapeutic efficacy through sonodynamic and dual-gas treatment-enhanced PTT, as demonstrated by both in vitro and in vivo experiments. Our designed injectable hydrogel system provides a unique solution for enhancing the PTT.
研究领域:
纳米医学
·
癌症治疗
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ChemMedChem
·
2025
·
IF 3.4
Zihan Zhu,Yan Zhang,Cui He,Yimin Jin,Wei Bian,Xinjing Tang,Jing Wang
Low cure rate and high death rate of cancers have seriously threatened human health. The combining multiple therapies is a promising strategy for cancer treatment. In this study, we construct a novel multinucleated nanocomplex loaded with carbon dots (CDs-SA@TAMn) that responds to tumor microenvironment for combined photothermal/chemodynamic cancer therapy. Fluorescence imaging results show that CDs-SA@TAMn can effectively accumulated in tumor sites. In acidic tumor microenvironment, CDs-SA@TAMn will release Mn2+, activating chemodynamic therapy and producing substantial reactive oxygen species (ROS) to kill tumor. Additionally, when irradiated by an 808 nm laser, CDs-SA@TAMn will exert the photothermal effect to realize high performance of cancer hyperthermia treatment. The nanocomplexes feather simple preparation, low toxicity, controlled release and imaging-guided therapy, showcasing the potential of precise and high performance anti-tumor combination therapy in biomedical applications.
研究领域:
肿瘤学
·
纳米技术
·
诊疗学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 23
·11222-11231
·
IF 3.3
Ying Li,Yujie Chen,Kaiyuan Wang,Yufeng Zhou,Wei Wei,Yuanjian Zhang,Songqin Liu
Nowadays, great progress has been achieved in improving the activity of nanozymes, nevertheless there are still huge challenges to skillfully modulate the catalytic functions of nanozymes. Herein, a nanozyme (CZIF/Au) is synthesized by chemically depositing Au nanoparticles (NPs) on a pyrolyzed zeolitic imidazolate framework-8 (CZIF). Surprisingly, the CZIF/Au presents enhanced peroxidase-like activity when irradiated with a 655 nm laser and improved catalase-like properties under 808 nm laser irradiation. The catalytic mechanisms of the CZIF/Au were investigated. Energy levels reveal that the 655 nm laser triggers the collective oscillation of the electrons in the 6sp band of Au NPs, called the intraband transition, whereas the 808 nm laser excites the valence electrons in the 5d band of the Au NPs into the 6sp band, named the interband transition, associated with a photothermal effect. The different electron transitions result in the two different photocatalytic functions. CZIF/Au with peroxidase-like performance to detect hydrogen peroxide (H2O2) exhibits an excellent detection limit (0.35 μM) and a wide detection range (2.5–500 μM). The molecular-level insights into the photocatalytic reactions provide a strategy to regulate the properties of nanozymes and prospects for the multi-faceted use of nanozymes in the future.
研究领域:
纳米技术
·
催化
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）