Nanoscale Research Letters
·
2022
·Vol. 17
·期 1
·1-8
·
IF 5.418
Yuan Maohui,Yang Zining,Yang Xu,Wang Linxuan,Wang Rui,Lan Sheng,Han Kai,Wang Hongyan,Xu Xiaojun
Controlling the upconversion luminescence (UCL) intensity ratio, especially pumped at 808 nm, is of fundamental importance in biological applications due to the water molecules exhibiting low absorption at this excitation wavelength. In this work, a series of β-NaYbF 4 :Er microrods were synthesized by a simple one-pot hydrothermal method and their intense green (545 nm) and red (650 nm) UCL were experimentally investigated based on the single-particle level under the excitation of 808 nm continuous-wave (CW) laser. Interestingly, the competition between the green and red UCL can be observed in highly Yb 3+ -doped microcrystals as the excitation intensity gradually increases, which leads to the UCL color changing from green to orange. However, the microcrystals doped with low Yb 3+ concentration keep green color which is independent of the excitation power. Further investigations demonstrate that the cross-relaxation (CR) processes between Yb 3+ and Er 3+ ions result in the UCL competition. Graphical Abstract
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Min Lin,Changrun Guo,Jing Li,Ding Zhou,Kun Liu,Xue Zhang,Tianshu Xu,Hao Zhang,Liping Wang,Bai Yang
Aqueous Au nanoparticles (NPs) are employed as the building blocks to construct chainlike self-assembly architectures, which greatly enhance the photothermal performance at 808 nm. Biocompatible polypyrrole (PPy) is further adopted as the package material to coat Au NP chains, producing stable photothermal agents. As a result of contributions from chainlike Au, the PPy shell, as well as the Au–PPy composite structures, the capability of photothermal transduction at 808 nm is greatly enhanced, represented by the high photothermal transduction efficiency up to 70%. Primary animal experiment proves that the current composite photothermal agents are efficient in inhibiting tumor growth under an 808 nm irradiation, showing the potentials for in vivo photothermal therapy.
研究领域:
纳米医学
·
生物材料学
·
肿瘤治疗
✓ 已验证
DOI
高影响因子
Journal of Physical Chemistry C
·
2018
·
IF 4.484
Tao Wang,Haifeng Zhou,Zhichao Yu,Guangjun Zhou,Juan Zhou,Dapeng Huang,Leilei Sun,Peng Gao,Yuzhen Sun,Jifan Hu
NaGdF4: A (A = Eu, Tb)@NaGdF4: Yb, Tm@NaGdF4: Yb, Nd core–shell–shell is designed to achieve 808 nm excited upconversion emission tuning. On the basis of the above core–shell–shell nanostructure, intense upconversion emission has been realized for activators without long-lived intermediate states (Eu3+, Tb3+) through Gd3+-mediated energy migration under 808 nm irradiation, enriching the emission colors. The spatial separation, where sensitizer (Nd3+), accumulator (Tm3+), and activator (Eu3+, Tb3+) are doped into separated layers, effectively suppresses nonradiative decays so that the doping concentration of Nd3+ can reach to 40%, vastly enhancing the luminescence intensity. Notably, when Gd3+ ions are replaced by Nd3+ or inert Y3+ in NaGdF4: Yb, Nd outer shell, without Gd3+-mediated energy migration, the deleterious energy transfer from Tm3+ in the interlayer to surface quenchers is suppressed, and thus, more active energy is trapped by activators, which induces the further change of upconversion emission color. Furthermore, the multicolor upconversion tuning can also be realized via Tb3+-mediated energy migration. 808 nm excited multicolor upconversion tuning, overcoming low tissue penetration and overheating effect under 980 nm excitation, improves the feasibility of upconversion nanoparticles in multicolor imaging and multiplexed detection areas.
研究领域:
材料科学
·
光学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Wenjun Ni,Meng Li,Jiayi Cui,Zipeng Xing,Zhenzi Li,Xiaoyan Wu,Erlin Song,Mancheng Gong,Wei Zhou
The black TiO 2 nanoparticles are synthesized via a facile calcination method combined with an in-situ controllable solid-state reaction approach. The results indicate that the photocatalyst with a narrow band gap of ~ 2.32 eV extends the photoresponse to visible light and near infrared region. And thus more reactive oxygen species can be obtained to induce the cell-killing under 808 nm light triggering. The as-obtained black TiO 2 nanoparticles exhibiting low toxicity, good biocompatibility and high anticancer effect in vitro, is demonstrated as efficient photosensitizers for phototherapy to kill the bladder cancer cells. These findings suggest that the facile synthetic black TiO 2 nanomaterials will have broad application in biomedicine.
研究领域:
纳米技术
·
癌症研究
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生物医学工程
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材料科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2016
·
IF 3.014
Xia Hu,Xiao-Jie Zheng,Yan Li,Jing Zhang,De-Kun Ma
Various architectures of Cu 2 PO 4 OH including multibranches-like, rose-like, rod-like and brick-like were synthesized through a facile solvothermal route, employing different kinds of alcohols as solvents. It was found that the types of the alcohols, the ratios of alcohols to water, and the presence of PEG 2000 played key roles in the aspect of adjusting the growth of Cu 2 PO 4 OH architectures. All of the as-obtained products showed strong and wide absorption in the range of 600–1500 nm. Under the irradiation of a continuous 808 nm laser, the materials exhibited morphology-dependent photothermal performance. The present study not only develops a new strategy to synthesize Cu 2 PO 4 OH with various architectures but also provides a promising near-infrared (NIR) light-driven photothermal agent.
研究领域:
材料科学
·
化学
·
纳米技术
·
光热治疗
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2025
·
IF 5.4
Zuodong Liu,Tingting Xiong,Chengwei Zhang,Qiyue Pan,Guo Zhang,Rui Liu,Yongsheng Yu,Peng Liu,Qiangshan Jing
A series of SrF 2 phosphors co-doped with Er 3+ and Y 3+ possessing regular polygon shapes were fabricated after calcination as-synthesized particles at 600 °C for 2 h. the crystal structure and morphology of the Er, Y:SrF 2 phosphors were identified. By incorporating the non-active Y 3+ ions as buffers into Er:SrF 2 phosphors, intense green up-conversion luminescence with modulating emission colors from reddish-yellow towards the greenish area is achieved. The two-photon up-conversion mechanism was also identified by the quadratic dependence between the luminescence intensities and 808 nm excitation source powers. The up-conversion luminescence characteristics indicate that Y 3+ buffers significantly enhance the 2 H 11/2 / 4 S 3/2 → 4 I 15/2 transitions, leading to an approximately five-fold increase in the luminescence intensities ratio R(g/r) of the green to red emissions in Er:SrF 2 phosphors.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 37
·31031-31036
·
IF 3.289
Zichen Huang,Yafei Qi,Dexin Yu,Jinhua Zhan
MoS2, a typical transition-metal dichalcogenide, has attracted increasing attention in the field of biomedicine due to its preeminent properties. In this paper, MoS2 nanoparticles with radar-like shapes were demonstrated as 808 nm laser-induced photothermal agents with outstanding photothermal performance. According to our calculations, the radar-like morphology endowed the MoS2 nanoparticles with higher photothermal conversion efficiency (53.3%) compared to other morphologies including nanoflowers, microspheres and irregular nanoparticles. Cytotoxicity assay indicated that the radar-like nanoparticles were biocompatible. Results of in vitro photothermal therapy and apoptosis assay indicated that tumor cells treated with MoS2 radar-like nanoparticles can be seriously damaged. Photothermal therapy on tumor-bearing mice was carried out to further verify the anti-cancer properties of the MoS2 radar-like nanoparticles. All the aforementioned results suggested that the MoS2 radar-like nanoparticles exhibit enormous potential for cancer photothermal therapy.
研究领域:
生物医学
·
纳米材料科学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 48
·17451-17460
·
IF 7.393
Tao Wang,Fenglei Sun,Zike Jiang,Jing Wang,Yanyan Ma,Haitao Lin,Hongmin Lv,Shanshan Xu,Jinhua Li,Guangjun Zhou
pH sensors based on up-conversion nanoparticles (UCNPs) are widely studied due to their effective elimination of background signals. However, ratiometric pH measurement depending on blue and red luminescence under NIR irradiation has been seldom reported for the lack of simultaneous strong blue and red emissions for traditional UCNPs. In this work, we designed NaGdF4:Yb,Tm@NaYF4:Yb,Eu@NaYF4:Yb,Nd@NaYF4 core–triple shell (CTS) UCNPs as fluorescent materials to realize blue/red ratiometric pH measurement. On the basis of Gd3+-mediated interfacial energy transfer and Yb3+-mediated energy migration, CTS particles present intense luminescence and a high red/blue (615 nm/450 nm) peak intensity ratio of 0.47 at 808 nm excitation. Composed of these particles and pH indicator bromocresol green, the pH sensor exhibits ratiometric responses in a pH range of 4–7 according to blue/red luminescence intensity ratios, avoiding the common errors as well as potential mutual fluorescence signal interference. Owing to strong overall luminescence and additional red emission of CTS UCNPs distinctly improving the signal-to-noise ratio, this ratiometric sensor reveals high sensitivity. Moreover, the employed excitation wavelength of 808 nm can not only eliminate autofluorescence signals, but also alleviate severe temperature rise in biosamples under continuous irradiation, ensuring accurate pH determination. More intriguingly, a CCD RGB camera serves as a collector to record luminescence signals, further promoting commercial feasibility. The successful application of CTS UCNPs on sensors indeed realizes blue/red ratiometric measurement towards pH under 808 nm irradiation, also pointing out a novel way for pH sensors with high sensitivity and accuracy.
研究领域:
生物医学工程
·
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
DYES AND PIGMENTS
·
2025
·
IF 4.2
Guotao Xiang,Qinyu Xu,Ming Xiong,Zhiyu Yang,Yongjie Wang,Lu Yao,Xianju Zhou,Li Li,Xiaojun Wang,Jiahua Zhang
Photothermal therapy (PTT) integrated with the functionality of temperature self-monitoring has emerged as a prominent research focus in current scientific investigations. In this study, a bifunctional photothermal agent is developed based on the small-size β-NaLuF 4 nanoparticles (NPs) of about 40 nm, which can provide accurate optical thermometry through Nd 3+ -sensitized upconversion (UC) luminescence along with the ability of Cu 2 S-mediated photothermal conversion. The small-size β-NaLuF 4 NPs are synthesized by a sequential layer-by-layer coating strategy, resulting in the generation of β-NaYF 4 @β-NaLuF 4 : 20 % Yb 3+ /2 % Er 3+ @β-NaLuF 4 : 20 % Yb 3+ /2 % Nd 3+ NPs. Then, the temperature sensing performance is realized via the thermally coupled levels of Er 3+ : 2 H 11/2 / 4 S 3/2 under the excitation of 808 nm wavelength. Whereafter, the above NPs suffer from a surface functionalization process with Cu 2 S NPs, endowing the sample with efficient photothermal conversion property, which exhibits an obvious temperature increase from 293 K to 311 K under 808 nm near-infrared (NIR) light irradiation with a power density of 20 mW/mm 2 for 180 s. Meanwhile, an ex vivo experiment further demonstrates that the present NPs can implement efficient photothermal conversion and accurate optical temperature monitoring simultaneously within the biological tissues, while effectively preventing laser-induced overheating effect due to the weak absorption of water molecules for 808 nm NIR light. These findings highlight the promising potential of the prepared NPs for application in cancer treatment, offering a precise and safe approach to PTT with integrated temperature monitoring.
研究领域:
材料科学
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纳米技术
·
生物医学工程
·
光学
·
诊疗一体化
✓ 已验证
产品关联
DOI
高影响因子
OPTICS AND LASER TECHNOLOGY
·
2016
·
IF 1.879
Rong Chen,Ying Tian,Bingpeng Li,Feifei Huang,Caizhi Wang,Xufeng Jing,Junjie Zhang,Shiqing Xu
Nd 3+ /Ho 3+ co-doped silicate-germanate glass has been synthesized by high temperature melt-quenching method. Near infrared emission centered at 2 µm has been successfully obtained by incorporating Nd 3+ and Ho 3+ in present glass. The Judd-Ofelt intensity parameters Ω t (t=2, 4, 6), and radiative properties of Ho 3+ were calculated and discussed by using the Judd-Ofelt theory. The energy transfer processes and luminescence properties of Nd 3+ /Ho 3+ co-doped glasses were analyzed pumped by a conventional 808 nm laser diode . Desirable spectroscopic characteristics indicates that Nd 3+ /Ho 3+ co-doped silicate-germanate glass might be a good alternative matrix for 2 µm band mid-infrared laser.
研究领域:
光学材料
·
无机非金属材料
·
光子学
·
激光技术
·
固体物理
✓ 已验证
DOI
高影响因子
Nanoscale
·
2018
·Vol. 10
·期 22
·10641-10649
·
IF 7.233
Han Wang,Yi Liu,Zhaohui Wang,Man Yang,Yueqing Gu
NO (nitric oxide) has dual functions in cancer, promoting carcinogenesis in low concentrations and inducing tumor cell apoptosis at high concentrations. The dual-edged-sword functions of NO make it particularly appealing to develop a sensitive and specific chemical probe for its detection. However, most NO sensors suffer from poor Stokes shifts and are limited by ultraviolet (UV) or visible light excitation, which render it difficult to avoid the intrinsic background signal. In this study, an 808 nm laser-excited Nd3+-sensitized upconversion nanoprobe based on LRET (luminescence resonance energy-transfer) for NO detection was constructed for the first time. This probe was composed of Nd3+-sensitized core–shell upconversion nanoparticles (540 nm and 660 nm emission) as the energy donor and RhBs as the acceptor. In the presence of NO, RhBs was converted into Rhodamine B and its strong absorption subsequently quenched the 540 nm fluorescence of UCNPs, while the emission at 660 nm remained constant. The ratiometric detection of the fluorescence at 540 nm, as compared to 660 nm, can precisely respond to the difference in NO levels with a detection limit of 0.21 μM. Importantly, compared with conventional UCNPs excited at 980 nm, the 808 nm light excitation led to lower water absorption and deeper tissue penetration, thus avoiding overheating and allowing for long-term biological imaging. This strategy has been perfectly applied to detecting the NO levels in living cells to differentiate the tumor cells from normal cells based on varied intracellular NO concentration. Further, the nanosystem realized the real-time monitoring of NO during treatment with NO donor drugs, which could inspire the future application of this probe to guide NO therapy.
研究领域:
生物化学
·
纳米技术
·
癌症生物学
·
光学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 10
·期 7
·2600-2607
·
IF 7.393
Chen Zhang,Kaige Wang,Xueyuan Guo,Yanli Tang
A light-triggered treatment strategy has been considered as a powerful therapeutic modality for sterilization due to its attractive properties including noninvasiveness, negligible drug resistance and minimized adverse side effects. Herein, a cationic water-soluble conjugated polymer PDTPBT based on a donor–acceptor (D–A) structure is designed and synthesized for photothermal antibacterial therapy under near-infrared light irradiation. The electron-rich dithieno-pyrrole and electron-deficient benzothiadiazole served as the electron donor and acceptor, respectively. Also, quaternary ammonium groups are modified on the side chain to enhance the water solubility of PDTPBT, promoting the effective combination of PDTPBT with bacteria. PDTPBT demonstrates a strong absorption in the near-infrared region, excellent photostability and a high photothermal conversion efficiency of up to 71.1%. High bacterial mortality rates are obtained upon 808 nm laser irradiation. Consequently, the new cationic conjugated polymer PDTPBT with excellent photothermal performance exhibited effective antibacterial ability, serving as a promising agent for light-triggered treatment.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
光疗
·
抗菌治疗
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）