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An anti-fouling photoelectrochemical immunosensor based on zwitterionic peptide and Z-scheme PEDOT/ZnIn2S4 heterojunction for highly sensitive detection of Aβ40

Ximei Hu,Xiaoqi Chen,Jinlan Li,Jiawei Zhou,Xiaohua Zhu,Meiling Liu,Ying Liu,Youyu Zhang,Yang Liu

Amyloid-beta peptide (Aβ) is considered a promising biomarker for the diagnosis of Alzheimer’s disease (AD). Herein, we developed an anti-fouling photoelectrochemical (PEC) immunosensor for sensitive Aβ40 detection based on Z-scheme heterojunction poly (3,4-ethylenedioxythiophene) (PEDOT)/ZnIn 2 S 4 and zwitterionic peptide. Due to the excellent electrical conductivity of PEDOT, the Z-scheme PEDOT/ZnIn 2 S 4 heterojunction exhibited a high photocurrent response, which can promote the separation and transfer of photogenerated electron/hole pairs. The zwitterionic peptide with hydrophilicity and electrical neutrality was used as a blocking agent to reduce nonspecific adsorption. The proposed PEC immunosensor showed outstanding performance for Aβ40 with high selectivity, stability, wide liner range (from 10 pg mL −1 to 5 ng mL −1 ), and a low detection limit (4.7 pg mL −1 ). Moreover, the integration strategy of heterojunction with zwitterionic peptide provides a promising way for protein detection in practical applications.