MEDICAL SCIENCE MONITOR
·
2018
·
IF 1.894
Gang Wang,Qi Xiao,Wenxiu Wu,Yao Wu,Yingjie Wei,Yue Jing,Zhunan Gong
Background Asiatic acid (AA; 2α,3β,23-trihydroxyurs-12-ene-28-oic acid) is an active compound derived from Centella asiatica, a traditional medicinal plant used widely in many Asian countries, particularly for the treatment of cancer. However, the modified AA derivative N-(2α,3β,23-acetoxyurs-12-en-28-oyl)-l-proline methyl ester (AA-PMe) has shown markedly better anti-tumor activity than AA. Material/Methods We evaluated the toxicity of AA and AA-PMe on zebrafish morphology, mortality, and hatching rate and determined the effect on SGC7901 cancer cells by acute toxicity assay. AA-PMe absorption in vitro in SGC7901 cells and in vivo in zebrafish was determined by establishing a highly accurate and reproducible HPLC protocol. Results In zebrafish, the toxicity of AA-PMe was lower than AA, with an acute toxic dose of AA-PMe above 25 μM, compared to acute toxicity at doses above 10 μM for AA. However, chronic toxicity of AA-PMe began occurring at doses below 25 μM but became apparent for AA at doses below 10 μM. Although low doses of AA-PMe were tolerated acutely, it became chronically toxic during zebrafish development, resulting in morphological abnormalities, including peripheral and abdominal edema, hemorrhage, abnormal body shape, enlarged yolk sac, and reduced motility. At low concentrations, absorption of AA-PMe by cells and zebrafish embryos occurred in a dose-dependent manner, but this stabilized as the concentration increased. Conclusions This pharmacokinetic study outlines the cellular and organismal effects of AA-PMe and suggests a theoretical basis that may underlie its mechanism of action.
研究领域:
药理学
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毒理学
·
肿瘤学
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DOI
PubMed
高影响因子
AUSTRALIAN JOURNAL OF CHEMISTRY
·
2013
·Vol. 67
·期 1
·134-141
·
IF 1.869
Yiheng Wang,Mengge Xia,Yongtao Wu,Meifang Zhu
Functionalized magnetic microspheres were prepared by anchoring cross-linked core–shell poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) nanoparticles onto silica-coated magnetic microspheres (Fe3O4@SiO2). First, the smaller polystyrene/P(NIPAM-co-AA) core–shell nanoparticles were synthesized through seed emulsion polymerization and adhered to the surface of amino-modified Fe3O4@SiO2 micorspheres, which were made using the modified Stöber method through electrostatic interaction under appropriate preparation conditions. An amidation reaction between the carboxylic and amino groups on the respective surfaces was then catalyzed. Finally, the novel architecture magnetic microspheres with multiresponsive functionalities were obtained, and their polymerization conditions, environmental sensitivity, and magnetic properties were discussed and optimized. The superparamagnetism and temperature/pH dual responsivity and excellent dispersibility of the P(NIPAM-co-AA) functionalized magnetic microspheres provide them with high potential to be used in the fields of controlled drug delivery, bioseparation, and catalysis.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
SYNTHETIC METALS
·
2025
·
IF 4.6
Yu Lin,Gen Li,Juan Teng,Haibo Wang,Ximei Liu
As a crucial component of flexible electronic devices, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)-based hydrogels for strain sensors have garnered extensive attention for their potential in the field of wearable sensors due to their inherent conductivity and flexibility. However, challenges such as poor mechanical strength, limited sensitivity, and poor durability have hindered the widespread application of PEDOT:PSS hydrogels in high-performance strain sensors. In this study, we develop a novel PEDOT:PSS-P(HEMA-co-AA) hydrogel that addresses common limitations in hydrogel applications, demonstrating remarkable stretchability, low hysteresis, and reliable conductivity. The hydrogel is synthesized using a semi-interpenetrating polymer network (SIPN) strategy, combining the linear conducting polymer PEDOT:PSS with a chemically cross-linked network based on 2-hydroxyethyl methacrylate (HEMA) and acrylic acid (AA). This hybrid structure notably contributes to the hydrogel's mechanical properties, achieving a stretchability of 195 %, while maintaining a rapid response time of 0.20 seconds and exceptional cyclic stability over 1000 cycles under 100 % strain. Moreover, the hydrogel demonstrates promising strain-sensing capabilities, positioning it as a strong candidate for future applications in wearable electronics and flexible sensors. The adoption of the SIPN strategy, along with the synergistic combination of PEDOT:PSS and P(HEMA-co-AA), paves a new pathway for enhancing the mechanical performance and sensing properties of hydrogels in strain-sensing technologies.
研究领域:
材料科学
·
柔性电子
·
生物医学工程
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产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2011
·Vol. 29
·期 3
·288-295
·
IF 0.478
Xu Gao-fei,Zhu Wei-pu
P(AA-MA) copolymers composed of acrylic acid and methyl acrylate with different molecular weights and sequence structures were synthesized by combination of ATRP and selective hydrolysis. These copolymers were used as membrane materials to separate benzene/cyclohexane mixture by pervaporation. The effects of molecular weight and sequence structure of the copolymers on the pervaporation performance were investigated in detail. For the random copolymers, the permeate flux decreased rapidly with the increasing of molecular weight. The separation factor was also influenced by the molecular weight, which was changed from no selectivity to cyclohexane selectivity with increasing the molecular weight. Contrarily, the block copolymer membrane showed good benzene selectivity with separation factor of 4.3 and permeate flux of 157 g/(m 2 h) to 50 wt% benzene/cyclohexane mixture.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 40
·19032-19042
·
IF 3.591
Chengmin Hou,Hanxiao Ma,Congjun Cao,Xiaojian Ding,Jingting Duan
The composite particles (St/Fe3O4) of starch and Fe3O4 were prepared by a co-precipitation method. Then AA and HEMA were grafted and cross-linked on St/Fe3O4 by a one-step method to obtain St/Fe3O4-g-p(AA-r-HEMA). The effects of the adsorbent dosage, pH value, initial Cu(II) concentration, time and temperature on adsorption were studied. Experiments showed that St/Fe3O4-g-p(AA-r-HEMA) showed a good adsorption performance for Cu(II), with a unit adsorption capacity of 75.5 mg g−1 and a maximum removal rate of 95.0%. The adsorption process followed the Langmuir model and the pseudo-second-order kinetic model, was dominated by chemical adsorption, and belonged to single-layer adsorption. Renewable performance studies showed that after 8 adsorption cycles, 91.2% of the first adsorption effect was still retained.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Zhuangzhuang Cai,Zhendong Mo,Qing Zhou,Xujie Zhou,Feng Huang,Jiaqi Jiang,Hang Li,Shunqing Tang
Chitosan-based hydrogels are considered to be ideal materials for promoting wound healing due to their nontoxic, biodegradable, and biocompatible properties. However, the weak mechanical strength, hemostatic properties, and adhesive properties of chitosan hydrogels limit their potential applications. In this study, we synthesized methacrylimide-chitosan (MAC)-4-arm polyethylene glycol (PEG)-dopamine (DMA) (MAC-PEG-DMA) hybrid hydrogels containing A-chain homodimers of platelet-derived growth factor (PDGF-AA) through one-pot photo-crosslinking. The resulting hydrogel exhibited improved mechanical strength and hemostatic properties as demonstrated by both in vitro blood clotting assay and rat liver hemorrhage assay. Furthermore, The PDGF-AA loaded hydrogel was also able to accelerate cell migration and proliferation. Data from skin wounds treated with this hybrid hydrogel showed faster wound closure and collagen maturation. Therefore, MAC-PEG-DMA (PDGF-AA) has great potential as a dressing to promote wound healing.
研究领域:
生物材料
·
组织工程
·
伤口愈合
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF RARE EARTHS
·
2017
·
IF 2.429
Feng WANG,Wenbo WANG,Yongfeng ZHU,Aiqin WANG
CTS- g -(AA- co -SS)/ISC hybrid hydrogel adsorbent with crosslinked network structure and superior adsorption performance for rare-earth metal ions was successfully synthesized in aqueous solution by a simple one-step free-radical grafting polymerization reaction among acrylic acid (AA), sodium p -styrenesulfonate (SS) and chitosan (CTS) using illite/smectite clay (ISC) as the inorganic additive. The structure of the as-prepared CTS- g -(AA- co -SS)/ISC hydrogel adsorbent was characterized, and the reaction parameters such as AA/SS molar ratio and ISC content were optimized, and the effects of pH values, initial concentration and contact time on the adsorption performance for Ce(III) and Gd(III) were systematically evaluated. It was found that the maximum adsorption capacities of the hydrogel adsorbent toward Ce(III) and Gd(III) reached 174.05 and 223.79 mg/g, respectively, and the adsorption quickly achieved equilibrium within 15–20 min. The adsorbed Ce(III) and Gd(III) could be easily desorbed for recovery, and the used adsorbent was able to be regenerated for reuse. After five adsorption-desorption cycles, the regenerated adsorbent could still retain the adsorption capacities that were close to the initial value. The adsorption process was well described by pseudo-second-order kinetic mode and the Langmuir isotherm model, and the chemical complexation between ions and –COO – was mainly responsible for the high adsorption capacity. As a whole, the hybrid hydrogel adsorbent was potential to be used for the adsorption and recovery of Ce(III) and Gd(III) from water.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2018
·Vol. 296
·期 4
·745-752
·
IF 1.967
Wang Jianying,Ma Xiaofei,Wei Lai,Zhu Xiang,Zhu Yuhua,Wang Gang,Mei Tao,Li Jinhua,Wang Xianbao
A novel kind of p(HEMA-co-AA) fluorescent hydrogels with high strength are first generated through one-step photopolymerization of 2-hydroxyethyl methacrylate (HEMA), acrylic acid (AA), and HEMA-modified carbon dots (HMCDs). Herein, HMCDs are used as new nontoxic fluorescent crosslinking centers. The novel HMCDs-based fluorescent hydrogels not only display stable photoluminescence, but have high mechanical strength. The fluorescent properties of the HMCDs-based hydrogel films are similar as that of CDs solution and stable for a prolonged duration. Besides, the fluorescent intensity of HMCDs-based hydrogels can be changed by controlling the HMCD content. The tensile strength of the fluorescent hydrogels with 1 wt% HMCD content can reach up to ~ 12 MPa, higher than that of the conventional hydrogels. More importantly, the mechanical properties can be adjusted by changing the water content and HMCD content. The enhanced mechanical strength is probably attributed to the relatively ordered hierarchical microstructure.
研究领域:
材料科学
·
高分子化学
·
纳米技术
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产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2019
·Vol. 30
·期 35
·355604
·
IF 3.399
Keju Zhang,Dong Zhou,Zhiguo Wang,Yuhong Zhang,Peixin He
The synthesis of drug delivery systems based on surface-modified mesoporous silica hollow structures remains a huge challenge. In this paper, we have obtained hollow mesoporous silica nanoparticles (MSNs) by surfactant directed sol-gel assisted hydrothermal treatment. The MSNs have the inorganic-organic hybrid frameworks with uniform diameter distribution (260 nm), and their specific surface area, mesoporous size and pore volume are 540 m2 g−1, 3.7 nm, 0.58 cm3 g−1, respectively. It was proved that the preparation of hollow ethane-bridged nanospheres with two silicon source was due to the high crosslinking of the silicone interface and hydrothermal treatment, providing a new approach for the study of drug-loaded and controlled release behavior. Based on the synthesis of MSNs, MSNs were modified by methacryloxy propyl trimethoxyl silane (MPS) on the surface of MSNs. Then N-isopropylacryamide (NIPAM) and acrylic acid (AA) were grafted onto the surface of modified MSNs. The hollow ethane-bridged PNA–MSNs (poly (NIPAM-co-acrylic acid)-MSNs) with two silicon source were prepared successfully. Due to their distinctive hollow structure, PNA–MSNs demonstrated high drug encapsulation efficiency (70.4% ± 2.9%). The experiment results proved that the modified hollow nanoparticles not only had good biocompatibility and stability, but also possessed pH-/thermal-dual responsiveness in drug release.
研究领域:
材料科学
·
生物医学工程
·
药学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 110
·108583-108589
·
IF 3.289
Zhiming Chen,Leilei Liu,Xiaodong Wu,Renchun Yang
Core–shell Fe3O4/P(St-AA) (Fe3O4/polystyrene–poly acrylic acid) nanoparticles modified with carboxylic acid groups were synthesized and employed as magnetic carriers for Candida rugosa lipase (CRL) and porcine pancreas lipase (PPL) immobilization. The loading amount of CRL on the Fe3O4/P(St-AA) nanoparticles was calculated to be 87.7 mg protein per g particles. Effects of solution pH and reaction temperature on the relative activity of immobilized CRL were measured and compared with the free CRL. The hydrolytic kinetics of the free and immobilized CRL was also investigated. Hydrolytic activity tests indicated that the stability of the immobilized CRL was strengthened. It should be mentioned that the immobilized CRL retained more than 56.1% of its initial activity after reuse 10 times. Most importantly, the immobilized PPL can tolerate organic media and maintain high esterification activity in n-hexane solution. This work provided a facile and general approach to synthesize magnetic functional nanocomposites for applications in biological and biocatalytic fields.
研究领域:
生物化学
·
生物催化
·
材料科学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Lin Li,Hui Liu,Ran Wang,Qing Li,Lexin Zhang,Zhiwei Liu,Tifeng Jiao
To reduce mortality rate caused by life-threatening bacterial infections, advanced antibacterial materials have attracted widespread attention from researchers worldwide. In this study, the antibacterial P(AA-AM)/CA/GA nanofiber membranes with pH-responsive properties were successfully prepared by facile electrospinning technology. A series of characterizations of the obtained nanofiber membranes showed the addition of P(AA-AM) improves the surface wettability of the as-spun fibers in comparison to those of CA and CA/GA nanofiber membranes. High-temperature treatment was found to enhance the mechanical properties of the P(AA-AM)/CA/GA membranes due to the crosslinking reactions. The prepared P(AA-AM)/CA/GA nanofiber membrane exhibits a pH-responsive effect which is evident by the change in GA’s release rate in solutions with different pH values. The cellulose acetate (CA) spinning nanofiber structure formed by P(AA-AM) coated GA also extended the release process of GA and improved the antibacterial timeliness of nanofiber membranes. The antibacterial experiments on E. coli and S. aureus showed that the electrospun nanofiber membranes containing GA had potent antibacterial properties , which were further enhanced by increasing the GA content in the P(AA-AM)/CA/GA blends. This study provides an insight into the design and preparation of pH-sensitive antibacterial materials using facile electrospinning technology.
研究领域:
材料科学
·
生物学
·
医学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2016
·Vol. 133
·期 33
·
IF 1.866
Xin Tang,Bin Yuan,Yuanguang Yang,Yingquan Xie
A new water-soluble polymer was prepared and evaluated as a filtrate reducer for oil well cementing. The filtrate reducer (WSP) was synthesized from 2-acrylamido-2-methylpropane sulfonic acid (AMPS), acrylic acid (AA), dimethyl acrylamide (DMAA), and sodium allylsulfonate (SA) by aqueous free radical polymerization. The synthesis conditions were optimized by orthogonal experiment. The molecule structure of the synthesized copolymer (WSP) was verified by Fourier transformer infrared spectrum (FTIR) and nuclear magnetic resonance hydrogen spectroscopy ( 1 H-NMR). The molecule weight of the synthesized copolymer was determined by gel permeation chromatography (GPC). The thermal stability of the synthesized copolymer was tested by thermogravimetry and differential thermogravimetry (TG and DTG). When the dosage of WSP is up to 3% in fresh water cement slurry, the FL API can be controlled within 58 mL. In 37% salt water cement slurry, the FL API can be controlled within 90 mL when the dosage of WSP is 5%. The thermal degradation of WSP is not obvious before 289 °C. Compared with a commercial filtrate reducer BS-100L and a reported copolymer HTF200C, the WSP has better performance. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43824.
研究领域:
材料科学
·
石油工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）