Graphical In this study, we present the novel combination of AE-TPEA with RuMOF to construct an electrochemiluminescence (ECL) sensor using a TPEA-RuMOF composite material specifically for copper ions (Cu 2+ ) detection. Using K 2 S 2 O 8 as a co-reactant, we explored the ECL behavior of the TPEA-RuMOF modified electrode, enabling the quantitative detection of Cu 2+ . Remarkably, this sensor exhibited a wide linear range from 1×10 −5 to 1×10 −9 M (R 2 =0.998) and boasted a detection limit as low as 0.41 nM, which is considerably below the EPA (Environmental Protection Agency) permissible copper ion concentration in drinking water of <1.3 mg/L. our synthesized probe offers enhanced stability and selectivity in copper ion detection. This indicates its considerable potential for high-performance copper ion detectors. We further validated the analytical applicability of this sensor using river water samples. In this study, we present the novel combination of AE-TPEA with RuMOF to construct an electrochemiluminescence (ECL) sensor using a TPEA-RuMOF composite material specifically for copper ions (Cu 2+ ) detection. Using K 2 S 2 O 8 as a co-reactant, we explored the ECL behavior of the TPEA-RuMOF modified electrode, enabling the quantitative detection of Cu 2+ . Remarkably, this sensor exhibited a wide linear range from 1×10 −5 to 1×10 −9 M (R 2 =0.998) and boasted a detection limit as low as 0.41 nM, which is considerably below the EPA (Environmental Protection Agency) permissible copper ion concentration in drinking water of <1.3 mg/L. our synthesized probe offers enhanced stability and selectivity in copper ion detection. This indicates its considerable potential for high-performance copper ion detectors. We further validated the analytical applicability of this sensor using river water samples.
Cu 2+ serves as a significant biomarker in various physiological processes. This study presents the development of a novel Ru-UiO-TPEA functionalized metal-organic framework (MOFs) probe for Cu 2+ detection, employing both electrochemiluminescence (ECL) and electrochemical (EC) methods. Employing a dual ligand-assisted energy transfer approach, we synthesized Ru-UiO with optimal ECL and EC properties by adjusting the synthesis ratio of biphenyldicarboxylic acid to Ru(dcbpy) 3 2+ . This was followed by its conjugation with N-(2-aminoethyl)-N, N′, N′-tris(pyridin-2-ylmethyl) ethane-1,2-diamine (AE-TPEA) to form the highly conjugated Ru-UiO-TPEA probe for Cu 2+ detection. As the Cu 2+ concentration increased, the probe exhibited a diminished ECL signal and an enhanced differential pulse voltammetry (DPV) signal. The dual-mode detection method enabled cross-validation of the ECL and EC signals, enhancing accuracy and effectively minimizing errors. The ECL and EC methods had detection limits of 0.26 nM (range: 1 nM to 10 μM) and 0.65 nM (range: 2 nM to 80 μM), respectively. Meanwhile, these two methods can effectively detect Cu 2+ in rat brain microdialysis fluid. Notably, the measured concentrations correlated well with those determined by Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), highlighting its potential in biological and clinical bioelectronic sensing applications.
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