Biosensors-Basel
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2025
·Vol. 15
·期 7
·426
·
IF 5.6
Kai Hua,Liang Li,Pei Liang
MXenes are a class of two-dimensional materials exhibiting excellent surface-enhanced Raman scattering (SERS) performance. Currently, the SERS studies of MXenes have been primarily focused on those with M2X and M3X2structural motifs. In order to expand the SERS sensing application based on MXenes, in this paper, a SERS sensor made of Ta4C3@AgNP nanocomposite material was fabricated by electrostatic self-assembly. Tests such as different concentrations of R6G probe molecules showed that the minimum detection limit of this SERS sensor was 10−8M, demonstrating excellent sensitivity. When different test areas are selected, the relative error of intensity under the same wave number is less than 10.7%, showing good repeatability and consistency. Furthermore, the Ta4C3@AgNP nanocomposite SERS sensor was used to detect the pesticide Ziram, and a quantitative model was established. Application detection indicates that this sensor has good sensitivity for the pesticide Ziram, and the minimum detection limit was 10−6M, which exceeded national standard requirements. The findings of this study have potential application value in the fields of food safety and environmental protection.
研究领域:
分析化学
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材料科学
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食品安全
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环境监测
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PubMed
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Xinpeng Chen,Aijing Li,Ping Yao,Jiapeng Wang,Tieling Xing,Guoqiang Chen
In this work, sea urchin-like magnetic Fe3O4@CA/BNNS/AgNP composite microspheres were successfully prepared. The photocatalytic performance of composite microspheres for the organic dye rhodamine B (RhB) was systematically investigated under different conditions, and the catalytic degradation rate of RhB was as high as 95% within 60 min; after three cycles of recycling, the degradation rate of RhB was reduced by only 8%. The main active agents in the reaction are e– and •O2–. Fe3O4@CA/BNNS/AgNP microspheres prepared in this study exhibit photocatalytic and electrochemical properties, making them easy to separate. This work is not limited to the development of Fe3O4-based catalysts but also is expected to provide ideas for the research and progress of photocatalytic composite catalysts with electrochemical properties.
研究领域:
材料科学
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环境科学
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纳米技术
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化学工程
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高影响因子
Advanced Materials Technologies
·
2019
·Vol. 4
·期 9
·1900414
·
IF 5.395
Shuai Zhao,Rong Zhu
Flexible pressure sensors attract wide attentions in recent years for their significant applications in wearable electronics and health monitoring. It is strongly desired that a pressure sensor possesses both low detection limit and wide measuring capability, covering a broad pressure range from Pa to hundred kPa, to meet diverse demands in different applications. This paper proposes a novel flexible pressure sensor based on thermosensation, using a multilayered and graded-porosity polydimethylsiloxane/silver nanoparticle sponge as piezo-thermic transduction. The sensor exhibits a high sensitivity, a low detection limit of 4.1 Pa, and a wide measuring range up to 200 kPa, which leads to a high range-to-limit ratio of about 50 000. The pressure sensor is monolithically integrated with a temperature sensor and dissolves temperature-compensation. The unique combination of properties makes it feasible to monitor various human signals from subtle wrist pulse to finger tapping pressure and foot stepping pressure by a single device, which shows competent capabilities for multifarious applications in wearable electronics and health monitoring.
研究领域:
生物医学工程
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传感器技术
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可穿戴设备
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健康监测
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柔性电子
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转化医学
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DOI
高影响因子
Biosensors-Basel
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2025
·Vol. 15
·期 8
·536
·
IF 5.6
Yulin Li,Junbo Li,Haisu Wang,Shaorui Qi,Zhehao Zhang,Yaqiu Wang,Ying Wang,Wei Ji
Acanthopanax senticosusis an essential medicinal herb in traditional Chinese medicine, with its pharmacological properties largely attributed to bioactive flavonoids. The types and amounts of these flavonoids act as vital quality markers for both the raw materials and the resultant products. In this work, we introduce a TiO2@AgNP nanocomposite designed as a surface-enhanced Raman scattering (SERS) sensor aimed at the preliminary quantification and identification of flavonoids. This is achieved by leveraging the effective molecular adsorption properties of TiO2alongside the ‘hot spots’ generated by AgNPs. By optimizing SERS performance through adjustment of the molar ratio between TiO2and Ag, we can quantitatively evaluate four flavonoids—luteolin, kaempferol, quercetin, and rutin—with low detection concentrations of 10−6M, 10−5M, 5 × 10−6M, and 10−6M, respectively. Additionally, we observe a nearly linear relationship between the SERS signals and the flavonoid concentrations, allowing for dual or multiplex analysis of these compounds. Furthermore, we successfully differentiatedAcanthopanax senticosussamples from six different geographical regions in China based on the detection of significant flavonoid constituents. This serves as a proof of concept for practical applications that can enhance the identification and distinction of traditional Chinese medicine, as well as assess quality and medicinal efficacy.
研究领域:
分析化学
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纳米技术
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药学
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光谱学
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中药学
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PubMed
高影响因子
Advanced Healthcare Materials
·
2023
·Vol. 12
·期 21
·2300075
·
IF 10
Lu Zheng,Xiaoyun Li,Changliang Xu,Yidi Xu,Yukai Zeng,Manseng Tam,Huan-Tian Zhang,Xiaoying Wang
Chitin is a popular hemostatic material, but there are still many deficiencies in its ability to effectively stop bleeding, prevent infection, and fit wounds. Herein, AgNP@zeolite/chitin/bamboo (AgZ-CB) composite sponges with shape recovery are prepared to minimize blood loss, kill bacteria, and promote wound healing. Notably, the bamboo powder is used for the first time to remarkably enhance the softness of the composite sponge (volumetric expansion ratio >5). The fabricated AgZ-CB sponge exhibits an excellent killing effect (≈100% bactericidal rate) against both Escherichia coli and Staphylococcus aureus and activates internal and external coagulation pathways to accelerate hemostasis without causing thermal damage (≈5 °C temperature difference). Moreover, the AgZ-CB sponge shows less blood loss (26 mg) and a shorter time to hemostasis (42 s) than the commercial polyvinyl formal sponge (84 mg and 76 s) in the full-thickness liver injury model. The in vivo wound healing and biodegradation experiment indicate that AgZ-CB with excellent biocompatibility can close wounds efficiently. Overall, the AgZ-CB sponge has great potential in combating a series of obstacles in wound healing.
研究领域:
材料科学
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生物医学工程
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伤口护理
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高影响因子
Journal of Materials Chemistry B
·
2016
·Vol. 5
·期 6
·1155-1158
·
IF 4.872
Zuguang Shen,Guocheng Han,Xiaoying Wang,Jiwen Luo,Runcang Sun
This study reported the direct utilization of bagasse as an ultra-light aerogel with AgNPs for the first time. Firstly, AgNPs were synthesized in situ using a green route with bagasse, a by-product of the refined sugar industry. During the reaction, the crystalline region of cellulose in bagasse was destroyed, and some groups of bagasse were partly oxidized into CO of ketone, which confirms the reducing capacity of bagasse. Then, the obtained bagasse–AgNP composite was dissolved in EmimAc to prepare an aerogel with AgNPs. The aerogel piled up in slices, and its weight after swelling in water was about 19 times the dry weight, and the aerogel did not crush a flower branch because its density was only 0.035 g cm−3, although the mole and mass ratios of the Ag atom were 5.26% and 29.94% in the aerogel, respectively. Furthermore, the obtained aerogel showed a strong antibacterial effect, especially against E. coli and P. aeruginosa. This study not only provides an interesting way for bagasse to be applied directly, but also develops an antibacterial biomass-based ultra-light aerogel without AgNP dissociation.
研究领域:
材料科学
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环境科学
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微生物学
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PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 31
·6528-6535
·
IF 4.726
Wei Liu,Jiangnan Zheng,Shihua Li,Ruirui Wang,Zian Lin,Huanghao Yang
Selective separation of intact phosphoproteins from complex biological samples is essential for ongoing, top-down phosphoproteomics but challenges still remain. Herein, aluminium glycinate functionalized silica nanoparticles (denoted as AGNP) were synthesized by a facile approach and applied for the specific capture of phosphoproteins. The selectivity and binding capacity of AGNP were evaluated using caseins (α-casein and β-casein) as phosphoproteins and bovine haemoglobin, bovine serum albumin, horseradish peroxidase, myoglobin and lysozyme as nonphosphoproteins. The results indicated that AGNP showed high binding capacity and selectivity for phosphoproteins (α-casein 1190 mg g−1 and β-casein 1060 mg g−1). In addition, AGNP was used to selectively capture and enrich phosphoproteins from protein mixtures and drinking milk samples. The good results demonstrate the potential of AGNP in phosphoproteomics analysis.
研究领域:
蛋白质组学
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纳米技术
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分析化学
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DOI
PubMed
高影响因子
TALANTA
·
2024
·
IF 5.6
Jing Li,Shenglan Hu,Lingling Zheng,Lixin Xu,Yusheng Wu,Biyang Deng
In this study, we used meso-tetra (4-carboxyphenyl) porphyrin (TCPP) as an organic ligand to modify a lanthanide-based metal-organic framework as an electrochemiluminescence (ECL) platform to sensitively detect anti-Müllerian hormone (AMH). La-MOF amplified the ECL signal by suppressing the aggregation-caused quenching created by TCPP self-aggregation. Utilizing the reversible cycling of the mixed-valence transition metal ion (Cu + /Cu 2+ and Mo 4+ /Mo 6+ ) and the electrical conductivity of Cu 2 MoS 4 and silver nanoparticle (AgNP), Cu 2 MoS 4 –AgNP as a dual co-reaction promoter constantly generated sulfate radical anions (SO 4 •– ) and thus amplified the ECL signal. Based on this strategy, we built a sandwich-type ECL immunosensor for the sensitive detection of AMH with a linear range of 1 × 10 −4 to 50 ng/mL and a limit of detection of 24 fg/mL. This study provides a novel approach for the sensitive and selective detection of AMH, demonstrating its high potential and practical value for the sensitive detection of AMH.
研究领域:
生物医学工程
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分析化学
·
免疫学
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DOI
PubMed
高影响因子
Materials
·
2024
·Vol. 17
·期 17
·4289
·
IF 3.1
Xingda Liu,Jiawen Sun,Jizhou Duan,Kunyan Sui,Xiaofan Zhai,Xia Zhao
Biofouling poses a significant challenge to the marine industry, and silicone anti-biofouling coatings have garnered extensive attention owing to their environmental friendliness and low surface energy. However, their widespread application is hindered by their low substrate adhesion and weak static antifouling capabilities. In this study, a novel silicone polymer polydimethylsiloxane (PDMS)-based poly(urea-thiourea-imine) (PDMS-PUTI) was synthesized via stepwise reactions of aminopropyl-terminated polydimethylsiloxane (APT-PDMS) with isophorone diisocyanate (IPDI), isophthalaldehyde (IPAL), and carbon disulfide (CS2). Subsequently, a nanocomposite coating (AgNPs-x/PDMS-PUTI) was prepared by adding silver nanoparticles (AgNPs) to the polymer PDMS-PUTI. The dynamic multiple hydrogen bonds formed between urea and thiourea linkages, along with dynamic imine bonds in the polymer network, endowed the coating with outstanding self-healing properties, enabling complete scratch healing within 10 min at room temperature. Moreover, uniformly dispersed AgNPs not only reduced the surface energy of the coating but also significantly enhanced its antifouling performance. The antibacterial efficiency against common marine bacteriaPseudomonas aeruginosa(P.sp) andStaphylococcus aureus(S.sp) was reduced by 97.08% and 96.71%, respectively, whilst the diatom settlement density on the coating surface was as low as approximately 59 ± 3 diatom cells/mm2. This study presents a novel approach to developing high-performance silicone antifouling coatings.
研究领域:
材料科学
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海洋生物学
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环境科学
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高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2013
·Vol. 169
·期 6
·1811-1821
·
IF 1.893
Wang Ting,Li Bin,Lin Li
A novel functional material of β -cyclodextrin ( β -CD) grafting cellulose beads containing immobilized silver nanoparticles (AgNPs) is presented in this paper. The morphology was characterized by scanning electron microscopy, energy-dispersive X-ray, and X-ray photoelectron spectroscopy. Phenolphthalein probe molecule technique was used to detect the activity of the grafting β -CD, and the results demonstrated that the deposition of AgNPs had no influence on its encapsulation ability. Acid resistance of the AgNPs on the bead material was studied by atomic absorption spectrometry. The stability of the AgNPs was enhanced due to the grafting of β -CD. Tube dilution method was applied to study the bacteriostatic effect, and the minimal inhibitory doses of the novel material against Escherichia coli and Staphylococcus aureus were 12.5 and 25 mg, respectively. The minimal bactericidal doses for the two bacteria were 25 and 25 mg, respectively.
研究领域:
材料科学
·
微生物学
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PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 4
·期 4
·635-648
·
IF 4.726
Yanfang Wang,Pengfei Li,Ping Xiang,Jueting Lu,Jiang Yuan,Jian Shen
Keratin based biomaterials have emerged as potential candidates for various biomedical and biotechnological applications due to their intrinsic biocompatibility, biodegradability, mechanical durability, and natural abundance. The objective of this study is to combine the merits of polyurethane, keratin, and silver nanoparticles (AgNPs) together and develop a novel nanofibrous mat for wound dressing. Herein, keratin was first extracted from human hair and chemically modified with iodoacetic acid to afford S-(carboxymethyl) keratin. The modified keratin was examined using Raman spectroscopy, infrared spectroscopy, and SDS-PAGE. The keratin was then blended with polyurethane (PU) and electrospun. Subsequently, AgNPs were formed in situ to afford antibacterial PU/keratin/AgNP mats. These mats were characterized using field emission scanning electron microscopy (FE-SEM), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), water contact angle measurements, and X-ray photoelectron spectroscopy (XPS). MTT results indicated that the introduction of keratin could accelerate fibroblast cell proliferation, while the loaded AgNPs did not weaken cytocompatibility. Antibacterial test results showed that PU/keratin/AgNP mats exerted good antibacterial property. The results from a wound healing test and a histological examination suggested that these biocomposite mats could remarkably accelerate wound recovery as compared to the conventional gauze sponge dressing. Given their excellent biocompatibility, antibacterial properties, and very mild inflammatory responses, PU/keratin/AgNP mats have great potential for wound dressing applications.
研究领域:
生物材料学
·
医学工程
·
组织工程
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PubMed
高影响因子
Regenerative Biomaterials
·
2025
·
IF 8.1
Ullah Ihsan,Ju Jian,Song Yapei,Chen Siyi,Chen Mengshi,Wang Siran,Zhang Wenzhen,Chen Wenhui,Zhifeng You,Li Huaqiong,Wen Feng,Zuo Wei
Bioinert poly (methyl methacrylate) (PMMA) is widely employed as a bone cement material in orthopedic and trauma surgery applications; however, its susceptibility to bacterial infection and bioinert nature limits its clinical applications. In this study, we developed a PMMA-based bone cement incorporating a silver nanoparticle-carbon dots (AgNP@CDs) nanocomposite (∼70 nm) at concentrations (2 wt %) with a Young’s modulus （324.74 ± 7.08 MPa）to simultaneously combat bacterial infections, minimize cytotoxicity, and support tissue regeneration. The CDs stabilize and functionalize AgNPs, improving their dispersion and bioavailability while enabling the controlled and sustained release of antimicrobial ions through incorporation with bone cement. The antibacterial efficacy of the composite was thoroughly evaluated, revealing its ability to disrupt bacterial cell membranes, generate reactive oxygen species and inhibit bacterial growth. These mechanisms collectively contribute to a significant reduction in bacterial growth of up to ∼ 90% in both in vitro and in vivo studies. The incorporation of AgNP@CDs ensures sustained antimicrobial activity, preventing bacterial colonization by controlling the leaching of Ag ions. Biocompatibility assessments showed that the PMMA composite (PMMA@2Ag-CDs) significantly improved cell proliferation, adhesion, and migration compared with pure PMMA bone cement. Additionally, histological analysis revealed that the PMMA group showed a fibrous layer thickness of 699 ± 35.32 µm, indicative of inflammation, while the PMMA@2Ag-CDs group reduced this thickness from 301.18 ± 22.42 µm on day 7 to 198.07 ± 15.21 µm on day 14, significantly decreasing inflammation. The PMMA@2Ag-CDs composite demonstrated better tissue integration, with organized collagen deposition and enhanced angiogenesis, indicating more efficient tissue regeneration. The reduced inflammation and improved tissue remodeling suggest that this composite promotes a more favorable tissue regeneration environment and minimizes complications. This study demonstrates that the PMMA@2Ag-CDs composite offers a promising solution for the prevention of infections and mitigation of inflammatory responses. Functionalization of bone cement through the incorporation of Ag nanoparticle-carbon dot nanocomposites is a promising strategy with potential practical applications in orthopedic and trauma surgery.
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高影响因子
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