JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2020
·
IF 3.306
Xiaoye Wen,Li Yan,Zhefeng Fan
A novel and simple probe (denoted LN-1) with AIE property based on malononitrile and 4-diethylaminobenzaldehyde was designed and synthesized. The use of two different mechanisms for the independent detection of Fe 3+ and CN − is more convenient and efficient than the continuous detection of anions and cations. The detection mechanism was verified by mass spectrometry (MS), nuclear magnetic resonance (NMR) spectrum, and particle size distribution. Under optimized experimental conditions, excellent calibration curves were obtained for the LN-1-Fe 3+ and the LN-1-CN − with detection limits of 0.17 and 0.39 μM, respectively. This method was successfully applied to detect the content of Fe 3+ and total inorganic iron in actual samples. Owing to its low cytotoxicity, good biocompatibility, and enhanced orange emission in aqueous solution, the LN-1 was successfully applied for CN − imaging in live cells. In addition, Fe 3+ and EDTA incorporation into the LN-1 changed the fluorescent intensity, which is beneficial in constructing ultrasensitive INHIBIT logic gate.
研究领域:
分析化学
·
生物医学
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Shibing Chen,Shengjie Jiang,Hongyu Guo,Fafu Yang
Previously reported fluorescent sensors for Th 4+ experienced emission quenching or generated false positive signal upon aggregate formation in aqueous media. Herein, a simple and novel thorium sensor ( CDB-BA ) based on cyanodistyrene structure was designed and synthesized, which integrated the highly emitting characteristic of AIE effect and off-on response of PET modulation for the first time to construct the “turn-on” fluorescent probe for Th 4+ . Besides excellent selectivity, CDB-BA exhibited remarkable fluorescent enhancement which was linearly related to the concentration of Th 4+ in the range of 0.25–8 μM. The detection limit was attained 0.074 μM, which was lower than that of most previously reported sensors. The mechanism of tris-chelate complex of CDB-BA with Th 4+ was confirmed by mass spectra, IR spectra and DFT calculation. The excellent Th 4+ sensing ability of CDB-BA was successfully applied to detecting Th 4+ on TLC plates, in real water samples and living-cell imaging. This work suggested that the combination of AIE and PET photophysical mechanism could offer the merits of minimized background and enhanced signal fidelity to develop novel “turn-on” fluorescent probe in complicated aqueous environment and biological research.
研究领域:
化学
·
生物医学
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 68
·63874-63879
·
IF 3.289
Liqiang Yan,Tingting Qing,Renjie Li,Zhongwei Wang,Zhengjian Qi
A series of schiff base derivatives with salicylaldehyde moieties were designed and synthesized. These materials exhibit typical AIE properties and high fluorescence quantum yields in an aggregated state based on the excited-state intramolecular proton transfer (ESIPT) mechanism. Then, the effect of substituted group types and positions on the fluorescence of these novel compounds was investigated through fluorescence spectra analysis and theoretical calculations. And it was found that the salicylaldehyde derivatives can be used as potential pH and Zn2+ sensors.
研究领域:
化学
·
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Nuanfei Zhu,Kuijing Yuan,Dinghui Xiong,Fengxiang Ai,Kun Zeng,Biying Zhao,Zhen Zhang,Hongjun Zhao
Dietary intake is an important exposure pathway of environmental bisphenols including bisphenol S (BPS, a typical emerging organic pollutant). However, available data on the occurrence and risk assessment of BPS in food samples are limited due to the lack of high-throughput analytical methods. Herein, based on H 2 O 2 inducing fluorescence turn-off signals, a sensitive and high-throughput fluorescence enzyme-linked immunosorbent assay (FELISA) was developed for BPS investigation in beverages. In this system, the fluorescence of copper nanoclusters in ZIF-8 (CuNCs-CS@ZIF-8) could be quenched with the presence of H 2 O 2 owing to the strong oxidation, being served as signal amplification in FELISA. Meanwhile, the aggregation-induced emission (AIE) fluorescence enhancement of CuNCs-CS through the conformational locking of ZIF-8 provided an effective strategy to overcome the intrinsic limitations of FELISA including high background, serious fluorescence quenching in the detection of real samples. Thus, the integration of AIE building blocks into porous ZIF-8 showed obvious advantages in enhancing the analytical performance of FELISA. Under optimized conditions, satisfactory results with good accuracy were achieved in this proposed FELISA, which was applied for the systematic investigation of BPS in foods and further health risk assessments. The results after 100 beverages analysis displayed an average detection frequency of 55%, and the detected concentration of BPS ranged from below the limit of quantification (LOQ) to 12.08 ng/mL with a mean value of 1.717 ng/mL. Besides, the estimated daily intake (EDI) of BPS was calculated to be 0.05449–4.483 ng/kg-bw/day, in which milk–tea drinks contributed to the majority of BPS daily intake (mean EDI = 4.483 ng/kg-bw/day). And the hazard quotient (HQ) according to EDI values indicated that BPS exposure in beverages might not make a considerable impact on human health.
研究领域:
环境科学
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食品科学
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免疫学
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2017
·
IF 3.473
Yafei Wang,Wanhui Liu,Zuoming Qu,Hua Tan,Yu Liu,Guohua Xie,Weiguo Zhu
To explore the structure-property of donor-acceptor (D-A) type blue emitter, in this contribution, four star-shaped compounds of p -TPA, m -TPA, p -TPA-TPE and m -TPA-TPE using spirotriphenylamine as the donor unit and triazine as the acceptor core were designed and prepared. The tetraphenylethene (TPE) unit was introduced into the D-A molecules to enhance the emission efficiency in solid state. The photophysical properties of all compounds were comparatively studied through experimental and theoretical methods. All these D-A compounds displayed blue emission (443–487 nm) both in solution and neat film. Compared to p -TPA and m -TPA, p -TPA-TPE and m -TPA-TPE possessed clear aggregated-induced emission (AIE) property and higher emission efficiency in the solid state. Both the doped and non-doped organic light-emitting diodes (OLEDs) based on m -TPA and m -TPA-TPE were fabricated by solution-processable approach. The m -TPA-TPE based non-doped device showed a satisfying performance with a high current efficiency of 4.2 cd/A and an external quantum efficiency of 1.8% in the bluish-green region. This research demonstrates that integrating AIE unit into D-A molecule is an effective strategy for design high efficient blue emitter in non-doped OLEDs.
研究领域:
材料科学
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光学
·
化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Bingyan Han,Dan Li,Xiangshan Lei,Qingdong Liu,Yajun Chen,Qifang Yan,Jiao Wang,Gaohong He
Aggregation-induced emission (AIE) materials have received a lot of attention in recent years, however, it remains a great challenge to develop a facile method for the conversion of aggregation-caused quenching (ACQ) molecules to AIE. In this paper, the ACQ molecule, 3,5-diacetyl-1,4-dihydro-2,6-lutidine (DDL), is successfully transformed from face-to-face stacking to slip stacking under the induction of H 2 O, achieving the transformation of ACQ molecule to AIE. Experimental analysis and theoretical calculations show that H 2 O is inserted into DDL molecules through hydrogen bonds, and its spatial configuration makes an angle between the H 2 O and DDL planes, thus increasing the horizontal and vertical distances between adjacent DDL molecules, so that DDL is arranged in a slip stacking pattern. Meanwhile, hydrogen bonds fix the DDL molecules in a relatively rigid structure, leading to the generation of other weak interactions, which further restrict the molecular motion and reduce the non-radiative transitions, so that the DDL possesses the AIE property, and the quantum yield increases from 0.95 % to 25.60 %. Based on the high fluorescence intensity of DDL-H 2 O, it has been successfully applied to the first-, second- and tertiary-level structures of latent fingerprints (LFPs) identification, which provides more possibilities for the practical application of ACQ molecules.
研究领域:
化学
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材料科学
·
法医学
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Guanlei Gao,Si-Yu Xu,Xinghui Qi,Jie-Ru Yang,Peiqi Lin,Jin Chen,Xiao-Ying Huang,Ke-Zhao Du
The strategy of organic ligand exchange is proposed to tune the optical properties of organic–inorganic hybrid cuprous halides. In this work, the chiral ligand (S)-(−)-2,2′-bis(di-p-tolylphosphino)-1,1′-binaphthyl ((S)-Tol-BINAP) and achiral triphenylphosphine (PPh3) are introduced into cuprous halides CuX-PPh3-[(S)-Tol-BINAP] (X = Cl, Br, I) through organic ligand exchange. As a result, the mixed organic ligands can enhance second harmonic generation (SHG) and aggregation-induced emission (AIE) optical properties. Moreover, the title compounds exhibit progressively enlarged SHG effects along with heavier halogen substitution due to their stronger polarizability. In the meantime, the reduced π–π stacking interaction of the organic ligand will improve their photoluminescence quantum yield. The experimental results combined with the theoretical calculation clarify the structure–property relationship well. Furthermore, the title compounds have been developed for the application of latent fingerprint detection.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science China-Chemistry
·
2016
·Vol. 59
·期 8
·1003-1009
·
IF 2.429
Chu Jun,Lv Qiulan,Guo Chunliang,Xu Dazhuang,Wang Ke,Liu Meiying,Huang Hongye,Zhang Xiaoyong,Wei Yen
The synthesis of amphiphilic aggregation-induced emission (AIE) dyes based organic nanoparticles has recently attracted increasing attention in the biomedical fields. These AIE dyes based nanoparticles could effectively overcome the aggregation caused quenching effect of conventional organic dyes, making them promising candidates for fabrication of ultrabright organic luminescent nanomaterials. In this work, AIE-active luminescent polymeric nanoparticles (4-NH 2 -PEG-TPE-E LPNs) were facilely fabricated through Michael addition reaction between tetraphenylethene acrylate (TPE-E) and 4-arm-poly(ethylene glycol)-amine (4-NH 2 -PEG) in rather mild ambient. The 4-NH 2 -PEG can not only endow these AIE-active LPNs good water dispersibility, but also provide functional groups for further conjugation reaction. The size, morphology and luminescent properties of 4-NH 2 -PEG-TPE-E LPNs were characterized by a series of techniques in detail. Results suggested that these AIE-active LPNs showed spherical morphology with diameter about 100–200 nm. The obtained 4-NH 2 -PEG-TPE-E LPNs display high water dispersibility and strong fluorescence intensity because of their self assembly and AIE properties of TPE-E. Biological evaluation results demonstrated that 4-NH 2 -PEG-TPE-E LPNs showed negative toxicity toward cancer cells and good fluorescent imaging performance. All of these features make 4-NH 2 -PEG-TPE-E LPNs promising candidates for biological imaging and therapeutic applications.
研究领域:
材料科学
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生物医学工程
·
分子影像学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Rong Wang,Kaiyue Song,Lixue Yang,Yue Sun,Xiaoxia Sun,Yu Hu
R-BTOBD exhibited significant aggregation-induced Emission (AIE) characteristics, including high brightness (αAIE ≈ 40), robust light stability, a substantial Stokes shift (128 nm), and a high signal-to-noise ratio, effectively overcoming aggregation-caused quenching (ACQ). Derived from the axially chiral R-H8–BINOL, R-BTOBD was synthesized via nucleophilic cyclization and exhibited pronounced self-assembly properties. Through robust intra- and intermolecular hydrogen bonding interactions, R-BTOBD formed diverse supramolecular structures, including spherical flower-like aggregates, hollow-core triangular tubules, hexagonal tubules, and irregular white block-like stacks. The specific morphology was influenced by factors such as solvent and pH. For fluorescence applications, R-BTOBD can be employed as an effective visual pH detector through an AIE-enhanced excited-state intramolecular proton transfer (AIE-ESIPT) mechanism. When incorporated into pH paper, it exhibited a bright yellow fluorescence across a wide pH range (pH 1–11), transitioning to an intense bright blue fluorescence under strongly basic conditions (pH 12–14). In chiral applications, R-BTOBD demonstrated potential as a chiral switching agent, leveraging the pronounced changes and inversions in its circular dichroism (CD) signals under varying aggregation states and pH conditions. Additionally, it serves as a specific chiral enantioselective fluorescence probe for l-lysine, demonstrating high efficiency and a low detection limit. Given its exceptional fluorescence and chiral properties, this fluorescent material has significant potential for diverse applications in fluorescence, chirality, and visual inspection.
研究领域:
材料科学
·
分析化学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 13
·6798-6804
·
IF 2.936
Junhuai Xu,Rui Yan,Haibo Wang,Zongliang Du,Jun Gu,Xu Cheng,Junjie Xiong
In this work, a novel and stable zwitterionic polymer (TPE-CB PUs) was prepared to realize a cellular imaging system. TPE was conjugated into the backbone of zwitterionic polyurethane, which could be well dispersed in aqueous solution and emitted strong blue fluorescence because the TPE segment was aggregated in the core of TPE-CB PUs micelles. More importantly, the TPE-CB PUs micelles showed significant stability in a large pH window and with different storage times. In addition, the micelles exhibited low cytotoxicity in HeLa cells and mainly distributed in the cytoplasm after being incubated with cells. The outstanding properties of TPE-CB PUs combining the merits of AIE and a zwitterionic segment highlight its potential for use as a cell imaging material with remarkable capability.
研究领域:
材料科学
·
生物医学工程
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Cheng Li,Yu Chen,Lijun Yang,Congrou Zhang,Bin Wang,Yong Wang
“Turn-on” fluorescent materials in the absence of metal and organic solvent are highly desirable as bioprobes to selectively and sensitively detect pyrophosphate (PPi) anion. In this work, we embedded tetraphenylethene (TPE) inside the relatively rigid hyperbranched poly(amido amine) (HPA) to afford highly water soluble TPE-HPA materials, where the TPE fluorescence was pre-quenched in water by the hyperbranched structure of HPA without participation of any metal or organic solvents. The obtained TPE-HPA could be directly used as fluorescence “turn-on” bioprobe under physiological conditions to selectively detect PPi. There was a good linearity between the photoluminescence enhancement and the PPi concentration in the range of 0–1.0 μM with a limit of detection (LOD) of 6.5 nM. Compared with the other reported AIE probes for PPi detection, TPE-HPA with the optimal TPE content showed the best comprehensive performance, that is metal-free, organic-solvent free and nanomolar level LOD. The extreme selectivity and sensitivity towards PPi allowed TPE-HPA to accurately detect the PPi concentration in human urine.
研究领域:
材料科学
·
分析化学
·
生物医学
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Wei Liu,Tengfei Wang,Liwen Wang,Yan Wang,Sheng Hu,Dating Tian
The development of fluorescent probes capable of detecting abnormal changes in cellular mitochondrial viscosity is of great significance, as these changes have been connected to many diseases. In this study, the conventional tetraphenylethylene (TPE) molecule was modified to fabricate a novel near-infrared fluorescent, TTPB, which was then used to measure the mitochondrial viscosity. Due to the introduction of TPE and pyridine groups, TTPB had an AIE effect and mitochondrial targeting function. Meanwhile, TTPB was extremely sensitive to variations in viscosity for the twisted intramolecular charge transfer (TICT) phenomenon. The logarithm of fluorescence intensity (log I 620 ) of the probe demonstrated an excellent linear connection with the logarithm of viscosity (log η ) in the viscosity range of 1.2 ∼ 956.0 cP, indicating the probe could quantitatively detect viscosity. Moreover, TTPB was able to visually track autophagy in addition to detecting the mitochondrial viscosity in the inflammatory cell model. These results showed that the probe was anticipated to be employed for the early diagnosis of related diseases.
研究领域:
生物化学
·
医学诊断
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）