CHINESE JOURNAL OF CHEMICAL PHYSICS
·
2023
·Vol. 36
·期 2
·231-231
·
IF 1
Liu Xu-hao,Liu Yang-yang,Zhu Rong-zhi,Liu Lu-jie,Xu Chen-xin,Cao Hui
Metal-halide perovskite solar cells (PSCs) have attracted considerable attention during the past decade. However, due to the existence of non-radiative recombination losses, the best power conversion efficiency (PCE) is still lower than the theoretical limit defined by Shockley-Queser theory. In this work, we investigate 1,2,3-oxathiazin-4(3h)-one, 6-methyl-2,2-dioxide (acesulfame potassium, abbreviated as AK) as a additional dopant for the 2,2′,7,7′-tetrakis( N , N -di-p-methoxyphenyl-amine)-9,9′-spirobifluorene (Spiro-OMeTAD) and fabricate PSCs in the air. It is found that 12 mol% fraction of AK relative to lithium bis((trifluoromethyl)sulfonyl)-amide (Li-TFSI) reduces the non-radiative recombination from 86.05% to 69.23%, resulting in an average 0.08 V of V oc enhancement. The champion solar cell gives a perovskite solar cells up to 21.9% and over 84% retention of the initial value during 720 h aging in dry air with 20%–30% humidity.
研究领域:
材料科学
·
可再生能源
·
光伏技术
✓ 已验证
DOI
高影响因子
Food & Function
·
2021
·Vol. 12
·期 8
·3692-3704
·
IF 5.396
Shufen Wu,Yue Sun,Di Chen,Huanhuan Liu,Zhenjing Li,Mianhua Chen,Changlu Wang,Lei Cheng,Qingbin Guo,Xin Peng
Monascin (MS) and ankaflavin (AK), as typical yellow lipid-soluble pigments identified from Monascus-fermented products, have been confirmed to possess diverse biological activities such as anti-oxidation, reversing diabetes, and anti-atherosclerosis, and have received increasing attention in recent years. Certainly Monascus-fermented product with a high content of MS/AK is also a concern. The current work explored interactions between MS/AK and human serum albumin (HSA) as well as their influence on the anti-oxidant properties of MS/AK. Moreover, the anti-glycation potential of Monascus-fermented products rich in MS and AK (denoted as Mps) was assessed. The results showed that the fluorescence emission of HSA was quenched by MS/AK through a static quenching mechanism, and MS–HSA and AK–HSA complexes were mainly formed by van der Waals forces and hydrophobic interactions, but AK showed a higher binding affinity than MS. Although the DPPH radical-scavenging abilities of MS–HSA and AK–HSA complexes declined, Mps significantly reduced the formation of fructosamine, α-dicarbonyl compounds and advanced glycation end products (AGEs) in the in vitro glycation model (HSA–glucose). Notably, approximately 80% of fluorescent-AGEs were suppressed by Mps at a concentration of 0.95 mg mL−1, while aminoguanidine (AG, a reference standard) caused only 65% decrease at the same concentration. Although radical scavenging and metal chelating activities could justify the observed anti-glycation activity of Mps, in-depth research on the structures of other functional compounds present in Mps except MS/AK and reaction mechanisms should be performed. Overall, the present study proved that Mps would be promising sources of food-based anti-glycation agents because of their superior inhibitory effect on AGEs.
研究领域:
食品科学
·
生物化学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
BIOORGANIC CHEMISTRY
·
2025
·
IF 4.7
Tianyu Liu,Yong Nian,Ying Liu,Simin Xu,Chujie Lu,Wei Yang,Wei Chen,Wei Lin
The resistance of nontuberculous mycobacteria (NTM) to conventional anti-tuberculosis drugs and its growing infection rate year by year urgently require new treatment strategies. Structure-based virtual screening, which can greatly improve efficiency and reduce costs in the early stage of drug development, is an indispensable part of modern drug discovery. In this study, the crystal structure of the mycothiol disulfide reductase from Mycobacterium abscessus ( Mab Mtr) was determined. Through virtual screening, compound AK-968/11492032 was identified as a promising candidate capable of fitting well into the potential MSSM-binding pocket of Mab Mtr. It was discovered that AK-968/11492032 and its derivatives ( Y6B and Y6C ) could produce antimicrobial effects on the Mycobacterial type strain Mycobacterium smegmatis . Moreover, microscale thermophoresis analysis was employed to evaluate the high binding affinity of the compounds to Mab Mtr. Furthermore, the key residues (S14, I47, H451) of Mab Mtr involved in the interaction with AK-968/11492032 were predicted and confirmed through molecular docking and mutational analysis, Mab Mtr was verified as the target for it to exert antibacterial effects through in vitro enzyme activity and in vivo gene knockout, complementation, and overexpression. These findings provide a potential development target to develop effective and specific anti-NTM drugs.
研究领域:
结构生物学
·
药物发现
·
微生物学
·
计算生物学
·
生物化学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
Advanced Science
·
2024
·
IF 14.3
Kaijun Gu,Yu Tan,Sitong Li,Siyue Chen,Bing Fang,Kaili Lin,Yanmei Tang,Min Zhu
Maxillofacial bone defects exhibit intricate anatomy and irregular morphology, presenting challenges for effective treatment. This study aimed to address these challenges by developing an injectable bioactive composite microsphere, termed D-P-Ak (polydopamine-PLGA-akermanite), designed to fit within the defect site while minimizing injury. The D-P-Ak microspheres biodegraded gradually, releasing calcium, magnesium, and silicon ions, which, notably, not only directly stimulated the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) but also activated sensory nerve cells to secrete calcitonin gene-related peptide (CGRP), a key factor in bone repair. Moreover, the released CGRP enhanced the osteogenic differentiation of BMSCs through epigenetic methylation modification. Specifically, inhibition of EZH2 and enhancement of KDM6A reduced the trimethylation level of histone 3 at lysine 27 (H3K27), thereby activating the transcription of osteogenic genes such as Runx2 and Osx. The efficacy of the bioactive microspheres in bone repair is validated in a rat mandibular defect model, demonstrating that peripheral nerve response facilitates bone regeneration through epigenetic modification. These findings illuminated a novel strategy for constructing neuroactive osteo-inductive biomaterials with potential for further clinical applications.
研究领域:
生物材料
·
组织工程
·
表观遗传学
·
骨再生
·
神经生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）