THERMOCHIMICA ACTA
·
2013
·
IF 1.989
Haisu Gao,Liping Chen,Wanghua Chen,Shilong Bao
The thermal stability of β-artemether under dynamic, isothermal and adiabatic conditions were investigated by differential scanning calorimeter (DSC) and accelerating rate calorimeter (ARC), respectively. The dynamic DSC measurements at various heating rates (1, 2, 4 and 8 °C min −1 ) displayed that β-artemether experienced polymorph transformation in the melting process. According to the isothermal DSC results at different temperatures 86, 88, 90 and 92 °C, β-artemether decomposed after the completion of the melting and the polymorph transformation, and the thermal decomposition of β-artemether is hazardous for its characteristic of autocatalytic decomposition. The kinetics analysis dynamically and isothermally described by Friedman method indicated the thermal decomposition of β-artemether did not comply with a single mechanism. The ARC results showed that the pressure increased with the increase of temperature, and indicated obvious linear relationship. Based on the ARC data, the value of SADT of β-artemether in 50 kg package was obtained.
研究领域:
药学
·
化学
✓ 已验证
DOI
高影响因子
NEUROPHARMACOLOGY
·
2020
·
IF 4.431
Kaiyang Ma,Xiao Ding,Qiqi Song,Zhitao Han,Hang Yao,Jianhua Ding,Gang Hu
In recent years, with the discovery and research of lactate-specific receptor HCAR1(hydroxycarboxylic acid receptor 1), lactate is not only as a product of Glycolysis in astrocytes, but also as a signaling molecule which has gradually received attention. Studies have found that lactate can be used as an intercellular signaling molecule involved in synaptic plasticity , and so that peripheral administration of lactate can produce antidepressant effects. Here, we focus on HCAR1 on the most widely distributed astrocytes in the brain, found and verified that lactate could cause Arc/arg3.1 protein overexpression in astrocytes through HCAR1. However, the expression of Arc/arg3.1 does not depend on the Gi protein pathway of HCAR1, and we found that lactate enhanced the expression of Arc/arg3.1 protein through the HCAR1-β-arrestin2 pathway. In summary, lactate acts on HCAR1 of astrocytes. It enhances the expression of MAPK-dependent Arc through β-arrestin2, thereby reducing the influx of calcium ions when astrocytes are exposed to glutamate damage, achieving the role of protecting astrocytes and indirectly enhancing the absorption of glutamate by astrocytes. These results also demonstrate that HCAR1 in the brain is a potential therapeutic target in an experimental in vitro model of glutamate damage, which is strongly associated with many neurodegenerative diseases .
研究领域:
神经科学
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药理学
·
细胞生物学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
THERMOCHIMICA ACTA
·
2021
·
IF 3.115
Jihe Zhao,Xuefeng Gui,Wenhai Zhang,Shudong Lin,Yuanyuan Tu,Jiwen Hu,Daguang He,Xiaohua Huang
Thermal runaway primarily occurs during the course of copolymerization due to the release of large amounts of heat. In this paper, the thermal risk associated with styrene-methyl methacrylate bulk copolymerization was firstly investigated by differential scanning calorimetry (DSC) and accelerating rate calorimetry (ARC). The result found that the exothermic behavior was greatly affected by the initiator concentration, in contrast the exothermic enthalpy was not. This exothermic behavior was firstly illustrated via polymerization mechanism. The temperature and pressure have changed dramatically during the adiabatic runaway copolymerization, which demonstrated a great potential risk of thermal runaway. Kinetic parameters, such as T NR , T SADT was calculated accordingly, which provided guidance for the safety of storage and transportation. This study will provide a helpful safety assessment for the styrene-methyl methacrylate bulk copolymerization, which is widely used in industry.
研究领域:
化学工程
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材料科学
·
安全科学
✓ 已验证
产品关联
DOI
高影响因子
BRAIN RESEARCH BULLETIN
·
2020
·
IF 3.37
Zuotian Wu,Gaohua Wang,Huiling Wang,Ling Xiao,Yanyan Wei,Can Yang
Background Recent studies indicate that antidepressants treatment restores neuronal plasticity. In contrast, some researchers claim that serotonergic antidepressants, including fluoxetine (FLU), may exacerbate neuronal plasticity, which is contradictory and rarely studied. Since almost those studies exposed cells with drugs for 1–2 days as treatment models of antidepressants, it is possible that FLU exposure for longer periods would have opposite effects on neuronal plasticity. Results In the present study, we examined the effects of FLU exposure (up to 3 days) on the neuronal plasticity in differentiated PC12 cells. The cell viability shown a slight decrease at day 2 (93.5 ± 3.5 %), followed by a highly significant decrease at day 3(71.4 ± 4.4 %). As previously reported, neuronal plasticity was significantly upregulated by FLU exposure at day 1. However, the neurite length, activity-regulated cytoskeleton-associated protein (Arc) and c-Fos mRNA were inhibited with FLU exposure at day 3. Similarly, the expression of tubulin, which play important roles in the neuronal plasticity, was the same result. Furthermore, we found α-tubulin interacted with collapsing response mediator protein 2(CRMP2), which is related to neuronal plasticity, and the regulation of CRMP2 activity influenced the neurite length, Arc, c-Fos and tubulin expression. Conclusions The results demonstrated that neuronal plasticity was increased by FLU exposure at day 1, but exposure with FLU for more than 2 days had opposite effect on it. The reduction in neuronal plasticity with FLU exposure for more than 2 days might be involved in some aspects of the therapeutic effect of antidepressant on depression.
研究领域:
神经科学
·
药理学
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产品关联
DOI
PubMed
高影响因子
RARE METAL MATERIALS AND ENGINEERING
·
2016
·Vol. 45
·期 7
·1664-1668
·
IF 0.236
Zhang Lingjie,Shen Tao,Shen Qianhong,Zhang Ji,Chen Lawson,Fan Xianping,Yang Hui
La 2 Sn 2 O 7 /SnO 2 composite powder was synthesized by chemical co-precipitation, and Ag-La 2 Sn 2 O 7 /SnO 2 electrical contact material was prepared by a powder metallurgy method. Anti-arc erosion properties, mass loss and Vickers hardness of the Ag-La 2 Sn 2 O 7 /SnO 2 composite were investigated, and its anti-arc erosion mechanism was discussed. Results show that the welding force of Ag-La 2 Sn 2 O 7 /SnO 2 composite is much better than that of Ag-SnO 2 , because the new phase La 2 Sn 2 O 7 can increase the viscosity of melt pool and improve wettability between silver and tin oxide to some extent. Meanwhile, Flatter arcing area and “beads-like” particles embedded scatteredly in the surface could decentralize arc energy via “pinning effect”, which decreases temperature rise and weakens the damage of surface structure, and better anti-welding property is obtained. Ag-La 2 Sn 2 O 7 /SnO 2 composite could be a leading candidate material for electrical contacts in the future.
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DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2024
·
IF 3.9
Wei Wei,Fengjian Chu,Guanru Chen,Shiwen Zhou,Cuirong Sun,Hongru Feng,Yuanjiang Pan
The abiotic synthesis of peptides, widely regarded as one of the key chemical reactions on the prebiotic Earth, is thermodynamically constrained in solution. Herein, a simulation of the lightning phenomenon on the sea surface using bubble bursting and arc plasma under ambient conditions enables dipeptide formation of six amino acids with conversion ratios ranging from 2.6% to 25.5%. Additionally, we observed the formation of biologically active tripeptides and investigated the stereoselectivity of the dipeptide formation reaction. By utilizing a mixture of 20 amino acids in the reaction, 102 possible dipeptides were generated. These results establish experimental constructions to mimic achievable prebiotic conditions and provide a credible pathway for endogenous biopolymer synthesis on prebiotic Earth.
研究领域:
前生物化学
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生命起源
·
生物化学
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产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2022
·
IF 7.033
Yuqi Zhou,Guifang Wang,Tianqi Wang,Jiajia Wang,Xutao Wen,Haishui Sun,Lei Yu,Xiaoying Liu,Juanjuan Zhang,Qin Zhou,Yan Sun
Introduction The nanostructural modification of the oral implant surface can effectively mimic the morphology of natural bone tissue, allowing osteoblasts to achieve both proliferation and differentiation capabilities at the bone interface of the dental implant. To improve the osteoinductive activity on the surface of titanium implants for rapid osseointegration, we prepared a novel composite coating (MAO-PDA-NC) by micro-arc oxidation technique and immersion method and evaluated the proliferation, adhesion, and osteogenic differentiation of osteoblasts on this coating. Methods The coatings were prepared by micro-arc oxidation (MAO) technique and immersion method, and characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM) for different coatings; the loading of PDA was examined using Fourier transform infrared spectroscopy (FTIR); the ion release capacity of the coatings was determined by inductively coupled plasma emission spectrometry (ICP-OES); the interfacial bonding of the coatings was examined using nanoscratch experiment strength. The cytotoxicity of the coating was examined by live/dead staining kit; cell proliferation viability was examined by CCK-8 kit; adhesion and osteogenic effect of the coating were examined by immunofluorescence staining and RT-PCR; osteogenic differentiation was examined by alkaline phosphatase staining. Results The surface morphology of titanium implants was modified by micro-arc oxidation technology, and a new MAO-PDA-NC composite coating was successfully prepared. The results showed that the MAO-PDA-NC coating not only optimized the physical and chemical properties of the titanium implant surface but also significantly stimulated the biological properties of osteoblast adhesion, proliferation, and osteogenic differentiation on the coating surface. Conclusion These results show that MAO-PDA-NC composite coating can significantly improve the surface properties of titanium implants and achieve a stable bond between implant and bone tissue, thus accelerating early osseointegration.
研究领域:
生物材料
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组织工程
·
口腔种植学
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材料科学
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产品关联
DOI
PubMed
高影响因子
ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE
·
2018
·
IF 2.819
Joshua E. Siegel,Shane Pratt,Yongbin Sun,Sanjay E. Sarma
We examine methods for detecting and disrupting electronic arc faults , proposing an approach leveraging Internet of Things connectivity, artificial intelligence, and adaptive learning. We develop Deep Neural Networks (DNNs) taking Fourier coefficients , Mel-Frequency Cepstrum data, and Wavelet features as input for differentiating normal from malignant current measurements . We further discuss how hardware-accelerated signal capture facilitates real-time classification, enabling our classifier to reach 99.95% accuracy for binary classification and 95.61% for multi-device classification, with trigger-to-trip latency under 220 ms . Finally, we discuss how IoT supports aggregate and user-specific risk models and suggest how future versions of this system might effectively supervise multiple circuits.
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS A-PHYSICAL
·
2024
·
IF 4.1
Guangyue Shen,Shunpeng Zhang,Xingyan Li,Yujun Fu,Xiang Li,Jiandong Jiang,Zhenli Wen,Qi Wang,Deyan He
Artificial vision systems have been extensively reported for processing unstructured data, performing pattern recognition, and performing visual simulations. Photonic synapses have become the core of most artificial vision systems due to their advantages such as low energy consumption and ultra-fast signal transmission. However, their integration is difficult, the integration difficulty of photon synapses is higher than that of crossbar arrays. Moreover, due to the hybrid drive of light and external power supply, low energy consumption and weight update under full optical control cannot be achieved. Here, we designed a fully light-controlled multifunctional artificial vision reflex arc system. The solar cell and oscillator generate presynaptic voltage signals that are then transmitted to a lithium-ion-based memristor for the stimulation of different wavelengths and light intensities. The results show that our artificial vision system can distinguish wavelength and light intensity information and has good weight update symmetry and repeatability. Finally, the deformation experiment of the shape memory alloy demonstrated that the system can be used for controlling artificial muscles under different light signals.
研究领域:
光电子学
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神经形态工程
·
人工智能
·
智能材料
·
光子计算
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Zhenwu Liu,Ri Zou,Yiheng Zhou,Lei Wang,Chengfa Mu,Shuyan Yang,Tao Shen,Qianhong Shen,Zhong-kang Han,Hui Yang
Arc-induced erosion in electrical contacts poses a significant challenge to the reliability of power systems. Traditional particulate reinforcements in silver-based contact materials suffer from hydrodynamic instability and segregation within the molten pool, compromising their performance. In this study, we introduce a novel “skeleton effect” approach by engineering the reinforcement morphology of La 0.5 Sr 0.5 Co 0.84 Cu 0.16 O 3- δ (LSCCu 0.16 ) within a silver matrix. We synthesized LSCCu 0.16 in three distinct morphologies: fibers, sheets, and particles, and systematically investigated their effects on arc erosion resistance through electrical life testing and Finite Element Method (FEM) simulations. Our results show that while particles segregate due to buoyancy-driven flotation and fibers are susceptible to stress-induced failure, the sheet morphology forms a rigid skeletal network that effectively constrains the molten pool. This network suppresses liquid splashing, resulting in a 111% increase in electrical service life (15,893 ± 215 cycles) and significantly improved contact resistance stability compared to particulate-based composites. The study demonstrates that transforming reinforcement architecture from simple particle dispersion to interlocking skeletal structures can be a transformative strategy for designing next-generation erosion-resistant electrical contacts.
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DOI
高影响因子
International Journal of Applied Ceramic Technology
·
2023
·Vol. 20
·期 3
·1919-1927
·
IF 2.1
Rong Tu,Jiaojiao Li,Mingpu Jia,Qizhong Li,Meijun Yang,Song Zhang,Takashi Goto
B 4 C–CrB 2 composites were prepared by arc-melting using B 4 C and CrB 2 powders as raw materials. The eutectic composition of B 4 C–CrB 2 system was 30B 4 C–70CrB 2 (mol%) with a labyrinth-like irregularly layered eutectic microstructure, composed of B 4 C phase about 1–2 μm in thickness dispersing in CrB 2 matrix, much smaller than raw powders. The interface of the eutectic composite was well bonded, and there were edge dislocations at the interface to alleviate the interface mismatch. The eutectic temperature of B 4 C–CrB 2 composites was approximately 2200 K. At the eutectic composition, the B 4 C–CrB 2 composites showed the maximum Vickers hardness (24.6 GPa) and fracture toughness (4.3 MPa m 1/2 ) at room temperature.
研究领域:
材料科学
·
机械工程
✓ 已验证
产品关联
DOI
高影响因子
NEUROBIOLOGY OF DISEASE
·
2024
·
IF 5.1
Lu Deng,Hong Jiang,Jingjing Lin,Di Xu,Ailin Qi,Qing Guo,Ping-Ping Li,Xinshi Wang,Judy S. Liu,Xiaoqin Fu,Peijun Li
Summary Epilepsy is a brain disorder affecting up to 1 in 26 individuals. Despite its clinical importance, the molecular mechanisms of epileptogenesis are still far from clarified. Our previous study showed that disruption of Clock in excitatory neurons alters cortical circuits and leads to generation of focal epilepsy. In this study, a GAD-Cre;Clock flox/flox mouse line with conditional Clock gene knockout in inhibitory neurons was established. We observed that seizure latency was prolonged, the severity and mortality of pilocarpine-induced seizure were significantly reduced, and memory was improved in GAD-Cre;Clock flox/flox mice. We hypothesize that mice with CLOCK knockout in inhibitory neurons have increased threshold for seizure, opposite from mice with CLOCK knockout in excitatory neurons. Further investigation showed Clock knockout in inhibitory neurons upregulated the basal protein level of ARC, a synaptic plasticity-associated immediate-early gene product, likely through the BDNF-ERK pathway. Altered basal levels of ARC may play an important role in epileptogenesis after Clock deletion in inhibitory neurons. Although sEPSCs and intrinsic properties of layer 5 pyramidal neurons in the somatosensory cortex exhibit no changes, the spine density increased in apical dendrite of pyramidal neurons in CLOCK knockout group. Our results suggest an underlying mechanism by which the circadian protein CLOCK in inhibitory neurons participates in neuronal activity and regulates the predisposition to epilepsy.
研究领域:
神经科学
·
分子生物学
·
昼夜节律
·
癫痫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）