JOURNAL OF SUPERCRITICAL FLUIDS
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2023
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IF 3.9
Jie Wang,Yingxi Gao,Jiayi Shi,Shichao Tian,Zhiyong Zhou,Chencan Du,Zhongqi Ren
In this study, the kinetics, thermodynamics, and optimization of the subcritical butane extraction of Acer truncatum seed oil were investigated. The effects of experimental parameters on the extraction yield and efficiency was studied and optimized by response surface methodology, with the optimum time, temperature, and liquid/solid ratio (mL/g) of 44 min, 52 °C, and 3.4, respectively. The extraction efficiency could reach up to 94.50 % after twice extraction under optimized conditions. The extraction kinetics was determined by a modified Fick’s law model and the activation energy of the effective diffusion coefficient was obtained as 23.26 kJ/mol. The enthalpy change and the entropy change were both positive with values of 20.06 kJ/mol and 70.02 J/(mol·K), respectively, while The Gibbs free energy change was negative in the temperature range. Finally, the comparisons of extraction efficiency, fatty acid composition , and properties were made for subcritical extraction and other three methods.
研究领域:
食品科学
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化学工程
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植物资源开发
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产品关联
DOI
高影响因子
Food & Function
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2023
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IF 6.1
Dekun Cheng,Zhangtie Wang,Xin Guo,Yiwen Guo,Yu Zhang,Yuanhui Zhao,Ruijie Liu,Ming Chang
Dietary nutritional support for special populations is an effective and feasible method to improve quality of life of patients and reduce medical pressure. The effects of ATSO on chemotherapy population were evaluated by a zebrafish model of demyelination. The results showed that 100 μg/mL ATSO reversed tail morphology damage, axon degeneration, touch response delay, ROS level upregulation and the expression of myelin basic protein decrease in chemotherapy-induced zebrafish. In addition, the expression of myelin markers (including sox10, krox20, pmp22) in oxaliplatin-induced cells was markedly reversed by ATSO and its active components (gondoic acid, erucic acid, nervonic acid). ATSO and its active components could reverse demyelination by ameliorating mitochondrial dysfunction. Conversely, linoleic acid and linolenic acid promoted demyelination by exacerbating mitochondrial dysfunction. Moreover, the Pink1/Parkin pathway was recognized as the main reason for ATSO and its active components to improve mitochondrial function by activating mitophagy and restoring autophagic flow. Taken together, this study demonstrated that ATSO and its active components could be further developed as novel functional food ingredients to antagonize demyelination.
研究领域:
神经科学
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药理学
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营养学
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细胞生物学
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分子生物学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Jiangping Huang,Meiting Li,Chengyun Han,Zhongwei Zhang,Xiang Liu,Zhixuan Ying,Peipei Yin,Lingguang Yang
Acer truncatum is a multifunctional tree species with broad applications in ornamental, healthy drink, and seed oil. In the present study, proanthocyanidins were isolated from the seed coats of A. truncatum , which were largely discarded as industrial wastes in seed oil production. Meanwhile, structural features, effects and mechanisms of anti-tyrosinase, anti-melanogenesis, and anti-browning of A. truncatum seed coat proanthocyanidins (ASPs) were systematically investigated. The joint application of FT-IR, MALDI-TOF-MS, hiolysis-coupled reverse-phase LC-ESI-MS, together with normal-phase LC confirmed that ASPs were predominately constituted by procyanidins with a mean polymerization degree of 12.09. Furthermore, ASPs powerfully inhibited both monophenolase and diphenolase activities of tyrosinase, and the inhibition of diphenolase was proved to be reversible and competitive−uncompetitive mixed type. Analyses of fluorescence quenching, UV spectra, and copper-ion chelation indicated that ASPs could inhibit tyrosinase in varied stages, and molecular docking and dynamic simulation further revealed the interaction mode between ASPs and tyrosinase. Cell assays further suggested that ASPs exhibited a strong inhibition against intracellular tyrosinase activity and melanin production through suppressing the expression of tyrosinase and microphthalmia transcription factor (MITF) at transcription level and caused apoptosis in B16F10 cells at higher concentrations. Antioxidant and anti-browning studies demonstrated that ASPs possessed high capacities of antioxidant, and potently suppress the browning of fresh-cut potatoes. Therefore, this study confirmed that seed coats of Acer truncatum is a potential natural source of tyrosinase, melanogenesis, and browning inhibitor, which provided a theoretical basis for the utilization of ASPs in the cosmetics, pharmaceutical, and food industries.
研究领域:
药理学
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生物化学
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化妆品科学
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食品科学
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植物科学
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产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
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2022
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IF 6.449
Lingyan Zhu,Qifan Wang,Haotian Wang,Fei Zhao,Dongbing Li
Activated carbons were produced from Acer truncatum seed shells with KOH activation in one step (direct activation) or two steps (activation preceded with carbonization). The effects of activation mode and temperature on the surface/physicochemical properties and electrochemical characteristics of the resulting activated carbons were thoroughly investigated. One-step activation at 800 °C outperformed other operating conditions and the resulting activated carbon (OAAS-800) featured a large surface area of 2210.7 m 2 g –1 and a total pore volume of 1.23 cm 3 g −1 . The OAAS-800 based capacitor delivers a high specific capacitance of 361 F g −1 at 0.5 A g −1 in a 6 mol L −1 KOH electrolyte, 82% capacitance retention after increasing current density from 0.5 to 20 A g –1 , and excellent cycle stability (98.6% capacitance retention after 10,000 cycles). The OAAS-800-based symmetric supercapacitor could offer a superior energy density of 27.78 W h kg –1 at 250 W kg –1 power density. The excellent performance was attributed to an interconnected three-dimensional porous structure. The simple yet very effective one-step activation opens up a new avenue for the production of high-performance supercapacitor electrode materials from low-cost oilseed plant residues .
研究领域:
材料科学
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环境科学
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能源研究
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产品关联
DOI
高影响因子
Frontiers in Nutrition
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2026
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IF 5.5
Duoduo Ren,Xuejun Chai,Chenyao Xiang,Yongkang Zhao,Penghao Sun,Mengli Wang,Jing Li,Jiayue Wu,Chenju Yi,Shulin Chen,Enyao Li,Shanting Zhao
This study aimed to clarify the neuroprotective effect of Acer truncatum Bunge seed oil (ASO) and its interactions with the gut microbiota in transgenic mice with 5 × Familial Alzheimer's disease (5 × FAD). The AD-transgenic mice were fed with standard diet supplemented with 4% ASO from one to six months of age. The result show that ASO intervention can alleviate learning and memory impairment, enhance motor coordination and endurance, and reduce Aβ deposition in the brains. It also inhibit the proliferation of microglia and astrocytes, decrease the levels of IL-1β, IL-6, and TNF-α in the hippocampus and serum. Then, ASO could increase the Chao1 index and Shannon index, alter the gut microbiota composition, specifically, enhance the growth of gut bacteria correlated with the production of SCFAs, including Ruminococcaceae, Butyricicoccus, Sutterella and others, particularly those related to butyrate production. Additionally, ASO can increase the concentrations of SCFAs in fresh feces and serum, particularly butyric acid. ASO could primarily modulate the biosynthesis of unsaturated fatty acids, glycerophospholipid metabolism, and sphingolipids metabolism in serum. At the same time, Fecal microbiota transplantation (FMT) could reduce Aβ deposition, enhance learning and memory. Finally, Supplementation of sodium Buty also mitigate learning and memory impairments. This study highlights the gut microbiota might be a potential therapeutic target for AD and provides a scientific foundation for developing novel pharmaceuticals or nutraceuticals.
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产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2025
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IF 3.7
Yingxi Gao,Tong Wei,Jie Wang,Yuming Tu,Zhiyong Zhou,Chencan Du,Zhongqi Ren
Nervonic acid (NA) is a long-chain monounsaturated fatty acid with significant potential for neural fiber repair. In this study, a mixed fatty acid methyl ester was synthesized as the raw material through saponification of Acer truncatum Bunge seed oil. Based on the differences in boiling points and relative volatilities of various components, a four-stage vacuum batch distillation process was employed to enrich the nervonic acid methyl ester (NAME). The effect of distillation process parameters on enrichment efficiency was investigated, including distillation temperature, operating pressure, and reflux ratio. The purity of NAME achieved as 91.20% under optimal conditions and the corresponding yield was 48.91%. To further increase the purity, a low-temperature crystallization process was adopted and a final purity of NAME was obtained as 97.56%. Simulation of the above four-stage batch distillation was conducted using Aspen Plus software, and a continuous distillation processes was further simulated to establish a theoretical basis for future industrial-scale production. The results of experiments and simulation demonstrate that the integrated process of vacuum distillation and low-temperature crystallization exhibits remarkable separation performances, providing robust guidance for the production of high-purity NA.
研究领域:
生物化学
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食品科学
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产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2016
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IF 2.711
Peng Hu,Xuebing Xu,Liangli Lucy Yu
This study obtained trans -free fats containing nervonic acid, a fatty acid with beneficial effects for mental health. Four fats containing 1.28–2.41% (w/w) nervonic acid were prepared by chemical or enzymatic interesterification of palm stearin (PS), Acer truncatum oil (ATO) and palm kernel oil (PKO). The chemical procedure was catalyzed using MeONa, whereas the enzymatic procedure was catalyzed with a 1,3–specific lipase. As a result, the interesterified fats showed a similar fatty acid profile to their corresponding physical blends measured by gas chromatography , but contained more nervonic acids at the sn -2 position, which was more conducive to metabolism and absorption. The content of tripalmitoylglycerol (PPP) and 1,3-dipalmitoyl-2-oleoyl glycerol (POP) or 1,2-dipalmitoyl-3-oleoyl glycerol (PPO) in the interesterified fats decreased significantly, resulting in improved plasticities. All interesterified fats showed a satisfactory content of tocopherols and oxidative stability. A combination of differential scanning calorimetry , X-ray diffraction spectroscopy and polarized light microscopy results suggested that the interesterified fats formed spherulitic needle-like crystals in the β′ form, while the physical blends formed dendritic crystals in the β form. These data indicated that the trans -free interesterified fats rich in nervonic acid may have a great potential in margarine applications.
研究领域:
食品科学
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营养学
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生物化学
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产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2022
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IF 3.898
Yingxi Gao,Jiayi Shi,Jie Wang,Fan Zhang,Shichao Tian,Zhiyong Zhou,Zhongqi Ren
Nervonic acid is the world's first and only potent substance that can repair damaged nerve fibers and promote nerve cell regeneration with high nutritional value. The wide variety of fatty acids in plant oils and fats with similar structures makes the large-scale separation and purification of high-purity nervonic acid very difficult. A new combined process of molecular distillation, urea inclusion and solvent crystallization was established to prepare high-purity nervonic acid with the mixed fatty acids obtained after saponification and acidification of Acer truncatum Bunge oil as raw materials. First, according to the difference in the mean free path of fatty acids, molecular distillation was used to separate and remove C16 saturated fatty acid of palmitic acid and four C18–C20 fatty acids of stearic, oleic, linoleic, and linolenic acids. The content of C16–C20 fatty acids decreased from 72.92% to 19.22% after two-stage molecular distillation processes, in which the contents of saturated fatty acid of palmitic acid decreased to about 0.5%. Then, according to the difference in carbon chain length and saturation of fatty acid, the contents of C22–C24 saturated fatty acids of tetracosanoic and docosanoic acids decreased to 0.21% and 0.07% by urea inclusion with urea/free fatty acid preparation by saponification (SPOMFs) ratio as 0.6. In addition, all saturated fatty acids were basically separated. Finally, according to the difference in the solubility of fatty acids in solvents, the C18–C20 unsaturated fatty acids of oleic, linoleic, and linolenic acids and C22 unsaturated fatty acid of erucic acid were removed by solvent crystallization. The content of C18–C20 unsaturated fatty acids decreased to less than 5% with pentanol as the solvent after the first stage solvent crystallization. The content of erucic acid decreased to 3.47% with anhydrous ethanol as the solvent after the second to fifth stage solvent crystallization. The combined process of molecular distillation, urea inclusion and low temperature crystallization innovatively adopted an efficient, simple and easy-to-industrial solvent crystallization method to separate erucic and nervonic acids, obtaining nervonic acid with purity of 96.53% and final yield of 47.99%.
研究领域:
食品科学
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生物化学
✓ 已验证
产品关联
DOI
高影响因子
Food & Function
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2025
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IF 5.4
Yaojun Ju,Yichen Yan,Xinhui Wang,Shan Li,Jialei Wang,Zixiao Wang,Yuling Dong,Junping Wang
This study investigated the therapeutic potential and mechanisms of Acer truncatum Bunge seeds oil (ATSO) against cuprizone-induced white matter injury and cognitive decline. A comprehensive analysis integrating techniques from animal behavior, histopathology, immunology and network pharmacology was performed. The results showed that ATSO ameliorated the cuprizone-induced cognitive impairment, corpus callosum demyelination, synaptic loss, and inflammatory activation of microglia and astrocytes. Mechanistically, ATSO reversed the cuprizone-induced demyelination by enhancing sphingomyelin metabolism and activating TREM2-APOE signaling pathway. The network pharmacology study revealed that the cognitive protection, sphingomyelin metabolism regulation, and anti-inflammatory effects of ATSO were mediated by its unsaturated fatty acids components. Validated by experimental data, the core targets of ATSO were found to center on the TREM2 network. In conclusion, ATSO ameliorates cuprizone-induced cognitive impairment and brain white matter lesions by improving sphingomyelin metabolism and alleviating neuroinflammation through activation of TREM2 signaling pathway.
研究领域:
神经科学
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药理学
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营养生物化学
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神经免疫学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）