Food Bioscience
·
2024
·
IF 4.8
Jiaxin Wen,Yuxin Guo,Xiangyu Li,Bingyang Wang,Huifang Wang,Xianghua Gao,Baolong Niu,Wenfeng Li
Antimicrobial packaging films are an effective means to avoid food infections. PVA has good film-forming and mechanical properties, but its water resistance and antimicrobial properties are insufficient. In this study, a rod-shaped Ag-MOF with photocatalytic properties was synthesized as an antimicrobial agent by a hydrothermal method using citrate esterified PVA as a film-forming substrate. The MICs of Ag-MOF against Escherichia coli and Staphylococcus aureus were 16 μg/mL and 32 μg/mL, respectively, and it had good biocompatibility. Under blue light irradiation, Ag-MOF induced the production of ROS, which increased the inhibition rate by more than 83.78%. The antimicrobial mechanism experiments showed that it caused irreversible damage to the bacterial cell membrane through the synergistic effect of Ag + and ROS. The best mechanical properties of the films were obtained at 3% citric acid content, with the water vapor transmission rate, water solubility and swelling rate reduced by 0.19 g·mm·m −2 ·h −1 ·kPa −1 , 65.33% and 11.26%, respectively. The antimicrobial rate of the composite film could reach more than 98% by adding only 1 MIC of Ag-MOF. In conclusion, photocatalytic antimicrobial agents have great potential for application in food packaging.
研究领域:
食品科学
·
材料科学
·
微生物学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Meng Zhang,Yuqi Zheng,Yang Jin,Dong Wang,Guohui Wang,Xin Zhang,Yanxin Li,Shaoxiang Lee
Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation is utmost important, since bacterial infections and oxidation can cause food spoilage. Ag-Metal−organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film. The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared. The results showed that the surface of P-CS/Ag@MOF bilayer was relatively smooth and its tensile strength (TS) was higher (27.67 MPa). Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity. In addition, the P-CS/Ag@MOF bilayer film had good UV-blocking properties and transparency. P-CSNPs/Ag@MOF bilayer film had higher antibacterial activity and cytotoxicity.
研究领域:
食品科学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2021
·
IF 6.901
Da Wang,Ying Zhu,Weiting Yu,Zhiqiao He,Feilong Dong,Yi Shen,Tao Zeng,Xiaohui Lu,Jun Ma,Lizhang Wang,Shuang Song
Ag-based electrodes have emerged as important candidates for the industrial electrochemical CO 2 reduction reaction (eCO 2 RR) to form CO. Herein, an intrinsic versatile Ag electrode has been derived in situ from Ag-MOF on Ag foam (denoted as ER-AF), which exhibits the highest current density (57.2 mA cm −2 ) at a potential of −1.15 V vs. RHE reported to date for the formation of CO in a commonly used H-type cell. ER-AF has multiple-roles: The 3D dendrite structure promotes mass diffusion; the rich edges sites favor CO 2 adsorption and conversion, and the highly exposed (111) facet facilitates the desorption of CO. Their cooperating functions result in the remarkable performance of ER-AF in the eCO 2 RR to form CO. This work offers an effective strategy to achieve high eCO 2 RR activity and selectivity by assembling the active and stable sites together on the MOF-derived materials.
研究领域:
电化学
·
材料科学
·
催化
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产品关联
DOI
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2025
·
IF 6.1
Xinyuan Xie,Kai Wei,Dahai Gao,Minmin Zou,Dongmei Zeng,Ting Zhang,You Zhang
Ag-MOF nanoparticles were successfully synthesized using a convenient and mild liquid-phase route, employing AgNO 3 , imidazole, and trimesic acid (H 3 BTC) as a unique multifunctional organic ligand, which, unlike conventional Ag-MOF systems based on simple imidazole, enables the formation of a more stable and highly coordinated framework structure, thereby facilitating uniform particle distribution and improved functionality. This study investigated its antibacterial mechanism and effectiveness when the nanoparticles were integrated into acrylic coatings on AA2024 aluminum alloy substrates. The synthesized Ag-MOF particles demonstrated significant antibacterial activity, which is attributed to the sustained release of Ag + ions and its stable dispersion within the coating matrix. The reduction in E. coli and S. aureus populations was observed to be 95.9 % and 87.2 %, respectively. Benefiting from both the physical barrier effect and the controlled delivery of corrosion inhibitors, the coating exhibits improved durability against corrosion. Additionally, a bifunctional composite coating, featuring a cerium-doped sol-gel application as a bottom layer, was prepared to further improve antibacterial and anticorrosion properties. Electrochemical tests confirm that the composite coating shows the higher impedance modulus and the smaller corrosion current density across the low-frequency domain than neat coating, which was the contribution of the combined action of the inhibitor and the coating's barrier properties. According to the electrochemical impedance after 7 days immersion, the composite coating showed superior corrosion resistance comparing to the neat acrylic coating during immersion of seven days.
研究领域:
材料科学
·
纳米技术
·
表面工程
·
电化学
·
生物医学工程
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yiting Liu,Wenjie Chen,Jie Yang,Ning Cai,Jumei Li
Exploring robust, sensitive and reliable surface-enhanced Raman spectroscopy (SERS) substrates largely depends on creating a high density of hot spots. Hererin, we present the fabrication of a unique core-satellite composite, consisting of sandwich Ag/MOF/Ag nanoshells, achieved by constructing two layers of dense Ag satellites with a MOF interlayer on PMAA nanospheres. These innovative sandwich Ag/MOF/Ag nanoshells create two distinct types of plasmonic nanogaps: the interstitial space between the Ag nanoshell layers and the internanogaps between adjacent Ag satellites. This structure significantly increases the number of hot spots compared to traditional core-monolayer metal satellites, leading to enhanced SERS activity. As expected, the composites exhibit an impressive enhancement factor of 3.85 × 10 6 and a low detection limit (LOD) of 10 −9 mol/L for methylene blue. The SERS sensing performance is further validated by successfully quantifying ciprofloxacin (CIP) and paraquat (PQ) in real milk samples with LODs of 3.28 × 10 −7 mol/L for CIP and 1.71 × 10 −8 mol/L for PQ, demonstrating strong potential for ultra-sensitive detection of hazardous pollutants in foods.
研究领域:
分析化学
·
纳米技术
·
食品安全
·
光谱学
·
环境监测
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Zi-Kang Tan,Ji-Lai Gong,Si-Yuan Fang,Juan Li,Wei-Cheng Cao,Zeng-Ping Chen
Biofouling was a considerable issue in the water treatment by membrane technology. In this study, high anti-bacterial property Ag-MOF was synthesized followed by embedding into polyamide layer with vacuum-assisted interfacial polymerization process to prepare an Ag-MOF incorporated membrane. The successful preparation of Ag-MOF and membranes was verified by FT-IR, FESEM, XPS, XRD, BET, zeta potential and contact angle test. On account to the strong hydrophility, porous structure, electronegativity and antibacterial property of Ag-MOF, modified membranes showed excellent performance for dyes, salts and bacteria. The water permeability of modified membranes was increased from 9.2 to 14.3 L m -2 h −1 bar −1 and the rejection rate of MO, MB and RB of the optimum membranes were 95.4%, 87.8% and 99.3%, respectively. The rejection rate of Na 2 SO 4 and MgSO 4 were increased from 54.0% and 36.6% to 84.1% and 73.1%. The sterilization rate of modified membranes to E. coli and S. aureus both exceeded 99%. The leaching test of Ag + evaluated the potential mechanism of anti-bacterial property. Moreover, dynamic bio-fouling test were used to detect the actual status in the filtration process. Those results suggested that modified membranes showed a strong resistance to bio-foulants thus enlarged the scope of application of membranes for water treatment.
研究领域:
材料科学
·
环境工程
·
化学工程
·
水处理
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Jun Zan,Yang Shuai,Jun Zhang,Jiachi Zhao,Bingxin Sun,Liuyimei Yang
Intrauterine adhesion (IUA) is a common gynecological disease caused by endometrial injury, which might result in abnormal menstruation, miscarriage, and even fetal deaths. Nevertheless, existing treatment strategies such as intrauterine device and uterine cavity balloons only provide a physical barrier, and not circumvent inflammation of endometrial microenvironment and retrograde infection. In this study, a slow-controlled bifunctional nanostructure was developed via encapsulating hyaluronic acid (HA) on surface of silver-metal organic framework (Ag-MOF), and then loaded in poly lactic- co -glycolic acid scaffold to prevent IUA. In therapy, macro-molecule of HA provided anti-inflammatory function by the adjustment of signal transduction pathways of macrophage surface receptors, whereas Ag-MOF inactivated bacteria by destroying bacterial membrane and producing reactive oxygen. Significantly, the coated HA effectively avoided burst release of Ag + , thus achieving long-term antibacterial property and good biocompatibility. Antibacterial results showed antibacterial rate of the scaffold reached 87.8 % against staphylococcus aureus . Anti-inflammatory assays showed that the scaffold inhibited the release of inflammatory cytokines and promoted the release of anti-inflammatory cytokines. Moreover, in vitro cell tests revealed that the scaffold effectively inhibited fibroblast growth, indicating its good ability to prevent IUA. Taken together, the scaffold may be a promising candidate for IUA treatment.
研究领域:
妇科学
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纳米医学
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生物材料
·
药剂学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Shiqiong Dai,Rui Cui,Hong Wu,Shuguang Wang,Yuyue Qin,Charles Brennan,Mingwei Yuan,Minglong Yuan
CMC/Ag-MOFs-CIN exhibited excellent mechanical and antioxidant capability. • CMC/Ag-MOFs-CIN exhibited controlled-release capability. • The film inhibited the growth of spoilage microorganisms in Lactifluus volemus . • The composite film can extend the shelf life of Lactifluus volemus . To extend shelf life of Lactifluus volemus, Ag@MOF loaded with cinnamaldehyde (CIN) was prepared and embedded into carboxymethyl cellulose (CMC) to develop antimicrobial films. The physicochemical properties of composite films were evaluated, along with their practical performance in Lactifluus volemus preservation. Compared with the CMC film, the CMC/Ag@MOF-CIN film exhibited better performance, including enhanced mechanical strength, barrier property, and antioxidant capacity, while showing reduced moisture content and water solubility. The CMC/6Ag@MOF-CIN composite film demonstrated 16.71% increase in tensile strength and 55.47% increase in elongation at break. The water vapour permeability decreased to 0.22 ± 0.01 g·mm/m 2 ·h·kPa, while oxygen permeability dropped to 18.67 ± 0.29%. Notably, antimicrobial and antioxidant properties improved by 68% and 45.49%, respectively. The composite films also exhibited controlled-release functionality. When applied to Lactifluus volemus preservation, the composite films effectively reduced weight loss, maintained higher activities of antioxidant enzymes, suppressed the activities of lipid peroxidation-related enzymes, and inhibited the growth of spoilage microorganisms. These findings demonstrated the potential of the CMC/Ag@MOF-CIN composite films as active packaging materials for Lactifluus volemus mushroom and other perishable foods.
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DOI
高影响因子
Polymers
·
2021
·Vol. 13
·期 18
·3151
·
IF 4.329
Meng Zhang,Guohui Wang,Xin Zhang,Yuqi Zheng,Shaoxiang Lee,Dong Wang,Yang Yang
In this paper, polyvinyl alcohol/Ag-Metal-organic framework (PVA/Ag@MOF) and polyvinyl alcohol/chitosan (PVA/CS) were used as the inner and outer layers to successfully prepare a bilayer composite hydrogel for tissue engineering scaffold. The performance of bilayer hydrogels was evaluated. The outer layer (PVA/CS) has a uniform pore size distribution, good water retention, biocompatibility and cell adhesion ability. The inner layer (PVA/Ag@MOF) has good antibacterial activity and poor biocompatibility. PVA, PVA/0.1%Ag@MOF, PVA/0.5%Ag@MOF, and PVA/1.0%Ag@MOF show anti-microbial activity in ascending order. However, its use as an inner layer avoids direct contact with cells and prevents infection. The cell viability of all samples was above 90%, indicating that the bilayer hydrogel was non-toxic to A549 cells. The bilayer hydrogel scaffold combines the advantages of the inner and outer layers. In summary, this new bilayer composite is an ideal lung scaffold for tissue engineering.
研究领域:
生物材料学
·
医学工程
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Long Bai,Beibei Lv,Xiuxiu Wu,Haohao Chen,Jinsong Yu,Ziqing Ye,Min Yuan,Hui Cao,Liling Hao,Fengqin Yin,Bing Bai,Tai Ye,Fei Xu
Excessive multi-site confinement impairs induced-fit Cd 2+ aptamer binding. • Ag-MOF/Pen co-regulation balances structural rigidity and binding flexibility. • Interfacial anchoring and H-bond regulation enhance apparent affinity 16.1-fold. • Label-free fluorescence enables accurate Cd 2+ analysis in pea seedling tissues. Aptamer immobilization can improve structural stability, but excessive confinement may restrict the conformational rearrangements required for induced-fit target recognition. A key challenge is therefore to stabilize recognition-competent conformations while preserving the structural adaptability required for binding. Using a Cd 2+ aptamer as a model, we first demonstrated that conventional multi-site immobilization increased the apparent dissociation constant by approximately eightfold relative to the free aptamer. To address this issue, we developed a surface-imprinting strategy that confines the aptamer within hydrogel through single-point tethering of the aptamer while modulating its local microenvironment. The Cd 2+ -bound aptamer was first assembled on Ag-MOF, followed by hydrogel polymerization in the presence of penicillamine. During imprinting, Ag-MOF promoted localized aptamer anchoring, while penicillamine regulated the hydrogen-bonding network surrounding the Cd 2+ -aptamer complex. Subsequent Cd 2+ removal generated an imprinted microenvironment that partially preserved the preorganized recognition conformation without over-constraining flexible regions required for rebinding. The optimized hybrid exhibited an apparent dissociation constant of 0.19 μM, corresponding to a 16.1-fold decrease relative to the free aptamer, and reached binding equilibrium within 10 min. Integration with label-free Tb 3+ -sensitized fluorescence enabled Cd 2+ detection with a limit of detection of 0.7 nM, approximately 1.1–1114-fold lower than nine representative reported methods, while maintaining satisfactory selectivity and reproducibility. The method was further validated by quantifying Cd²⁺ in different tissues of hydroponically grown pea seedlings and food matrices, with results consistent with ICP-MS. These results establish moderate, microenvironment-assisted confinement as a general design principle for balancing conformational stabilization and induced-fit adaptability at aptamer recognition interfaces. Download: Download high-res image (212KB) Download: Download full-size image
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DOI
高影响因子
OPTICS AND LASER TECHNOLOGY
·
2023
·
IF 5
Yaru Li,Weihao Liu,Runcheng Liu,Jinjuan Gao,Jingwen Feng,Shicai Xu,Zhen Li,Shouzhen Jiang,Xuejian Du
The development of portable biosensors exhibiting outstanding performance for fast and convenient detection of human glucose levels takes on critical significance to human health testing. A two-dimensional metal-organic framework (Cu-TCPP 2D MOF)-sensitized arrayed resonant cavity silver film (ARC/Ag) optical fiber surface plasmon resonance (SPR) sensor was developed in this study. The ARC/Ag 3D structure overcame weak coupling and non-uniform plasmon resonance, and the resulting strong hotspots effectively extended the sensing region. Moreover, the coated MOF is considered as a prominent SPR sensitized layer for its plasmonic property and highly ordered structure. The results of the simulations confirmed the local electric field enhancement that was attributed to the plasmonic synergistic effect of MOF with ARC/Ag. The normalized transmission spectra were collected in ethanol solutions with the refractive index (RI) of 1.340 to 1.352, and the sensitivity and the figure of merit (FOM) of the sensor were demonstrated to be increased by 73.98% and 68%, respectively. The sensor exhibited a linear response factor of 9.99 nm/(mg/mL) over a glucose concentration range of 0.1–1.2 mg/mL by covalently immobilizing glucose oxidase (GOD) on MOF. Accordingly, the proposed highly integrated and portable biosensor provides a piece of promising evidence for label-free glucose detection at point of care (POC).
研究领域:
生物医学工程
·
光学
·
材料科学
·
传感技术
·
医疗健康
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Dangge Gao,Fangxing Wang,Chi Zheng,Bin Lv,Jianzhong Ma
Cotton textiles with persistent antibacterial qualities are crucial in halting the spread of bacteria and other infections. However, fugitive bacteria and drug-resistant pathogens have rendered tremendous challenges in the development of cotton fabrics with long-lasting antibacterial efficacy. The work aimed to innovatively propose a functional cotton fabric integrating intelligent bacteria-capturing and dual antibacterial properties for efficacious personal health management. The functional cotton fabric was created by modifying the surface of cotton fabric with the quaternized carboxymethyl chitosan (Q-CF) and then covalently grafting the silver@Zr-based porphyrin metal–organic skeleton (Ag@MOF-545) prepared via the “bottle-around-the-boat” method on the surface of Q-CF (AM/Q-CF). In this process, the functional cotton fabric could capture bacteria via positive charges on the surface of the quaternized carboxymethyl chitosan. Due to the synergistic effect of broad-spectrum antibacterial silver nanoparticles (AgNPs) and the visible light-driven antibacterial Zr-based porphyrin metal–organic skeleton (MOF-545), the metabolism of bacteria and drug-resistant strains was well inhibited, which endowed the AM/Q-CF with lasting dual antibacterial properties. After repeated laundering cycles, abrasion cycles, simulated sweat soaking, and long-term storage, the antibacterial rates of AM/Q-CF were over 85%. Altogether, the results provided a potential antibiotic-free alternative for the preparation of durable antibacterial cotton fabrics.
研究领域:
材料科学
·
微生物学
·
纺织工程
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）